EKS-TEN-00586

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00586

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	314.4	7.2E-94	20	311	292

Status

Unreviewed

Ensembl Protein

ENSTNIP00000020735

UniProt Accession

H3DJN9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000017589	ENSTNIP00000020735	ENSTNIT00000020968

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

666

Protein Sequence
(FASTA)

MAKPDAPITL HGFDLAGHFV DLRPLGVGVT GLVLSAVDQR TRQRVAIKKL LMRDAVTVKH 60

ALREAKITQR LRHENVVRVH EVAAPFGQPL PRDPTQLSAL YVVQECMETD LARLLEQGPL 120

DTDHATLLFY QLLRGLKFIH SANVLHRDLK PANIFINTEQ LLLKIGDFGL ARIVDPHYSH 180

KGYLSEALVT KWYCSPRLLL SPNNYTKAID MWAAGCILAE MLTGRMLFAG AHELEQMQLI 240

LDTVPVLREE DRQDLLQVMP SYISHGWKVK RPFCELLPDA DSQAVDFLER ILTFNPMDRL 300

TAEAALSHPF LLQYSCPEDE PTSPHPFRIE DELEDSLVTE QSLSNSNSQV SSMHWERSGH 360

FCSVDLYLKC MSGSSCRCIT PSYGASDVGD ATEDEEVQRD PRASSTLLLE EAQVDPRKYS 420

HSSSAERFLE NSHSSLDRAC GSGYGDVDFG HSCDYKVGSP SYLDKIAWRE GKPQHYSEPK 480

LILDLSHWKR NSNCFPAEPL DGSVEDPGQK KKEESEKTGD LFQEISRWVE NTHVRLQSTS 540

PPLEPRSLSC CTISPPLPLS PSDLPTPVFH YGEVFQQPSA EYDEDHLSPL PPVISSSNSP 600

PLLFPSSPTS PPPPASPQKA SPANSDSFES LPVKQRERLF DLDMFISRAL KLCRQNDLKP 660

SSSDLK 666

Nucleotide Sequence
(FASTA)

ATGGCCAAGC CGGACGCCCC CATCACGCTC CACGGCTTCG ACCTAGCTGG TCACTTCGTC 60

GACCTTCGAC CTCTCGGTGT AGGTGTCACG GGCCTGGTGC TGTCGGCTGT GGACCAGCGC 120

ACCAGACAGC GCGTGGCCAT TAAGAAGCTG CTGATGCGCG ATGCGGTGAC GGTGAAACAT 180

GCCCTGCGGG AGGCGAAGAT CACTCAGCGG CTGCGCCACG AAAACGTGGT GAGGGTTCAC 240

GAGGTGGCGG CTCCGTTTGG ACAGCCGCTG CCCAGGGACC CCACCCAGCT GAGCGCCCTG 300

TACGTCGTCC AGGAGTGCAT GGAGACGGAT CTGGCTCGGC TGCTGGAGCA GGGGCCCCTA 360

GACACAGATC ACGCGACCCT GCTGTTCTAC CAGCTGCTGC GGGGGCTGAA GTTCATCCAC 420

TCCGCTAACG TCCTGCACAG AGATCTGAAA CCTGCCAACA TATTCATCAA CACAGAGCAG 480

CTCCTGCTCA AGATCGGAGA TTTTGGACTG GCCAGGATCG TCGACCCTCA TTATTCCCAT 540

AAGGGCTATC TGTCTGAGGC TCTGGTCACT AAGTGGTATT GCTCCCCCCG TCTGCTCCTG 600

TCTCCCAACA ACTACACCAA GGCCATAGAC ATGTGGGCCG CCGGCTGCAT ACTGGCTGAG 660

ATGCTCACTG GACGCATGCT GTTTGCAGGG GCTCACGAGC TGGAGCAGAT GCAGTTGATT 720

CTGGACACGG TGCCGGTGCT GAGAGAGGAG GACAGGCAGG ACCTGTTACA GGTGATGCCT 780

TCATACATCA GTCATGGGTG GAAAGTGAAA AGGCCCTTTT GTGAATTGCT GCCAGACGCG 840

GATTCTCAAG CTGTGGACTT CCTGGAACGC ATCTTGACCT TCAACCCTAT GGACCGGTTA 900

ACGGCAGAGG CAGCCCTGTC CCACCCCTTC CTCCTGCAGT ACTCCTGCCC GGAGGATGAG 960

CCCACGTCCC CGCATCCGTT CCGCATCGAG GACGAGCTGG AGGACAGCCT CGTCACCGAG 1020

CAGAGCCTCA GCAACAGCAA CAGTCAAGTG TCCAGCATGC ACTGGGAGAG GAGTGGACAT 1080

TTCTGTTCAG TAGATTTGTA TTTAAAATGC ATGTCGGGCA GCAGTTGTCG CTGCATTACA 1140

CCCAGTTATG GCGCCTCTGA CGTGGGAGAT GCTACTGAGG ATGAGGAGGT GCAGAGAGAC 1200

CCTCGAGCCA GCTCCACCTT GCTGTTAGAG GAGGCTCAGG TTGATCCACG GAAGTACTCC 1260

CACAGCAGTT CAGCGGAGCG CTTCCTGGAG AACTCCCACT CCTCCCTGGA CCGAGCCTGT 1320

GGTTCAGGGT ACGGGGACGT GGACTTTGGC CACTCCTGTG ACTACAAAGT AGGCTCGCCT 1380

TCGTATCTGG ACAAAATTGC CTGGAGGGAG GGCAAGCCGC AGCACTACTC AGAGCCGAAG 1440

CTGATCCTTG ACCTTTCTCA CTGGAAGCGC AACTCCAACT GCTTCCCTGC GGAACCGCTG 1500

GACGGCAGTG TCGAGGACCC GGGACAGAAA AAGAAGGAGG AATCAGAGAA GACGGGGGAT 1560

TTATTTCAGG AAATCTCCCG CTGGGTGGAA AACACCCATG TACGCCTGCA GTCAACCAGT 1620

CCCCCCTTGG AGCCACGGTC CCTCTCCTGC TGTACCATCT CTCCCCCTCT CCCTCTCTCC 1680

CCAAGTGACC TTCCGACTCC AGTGTTTCAT TACGGAGAAG TCTTTCAGCA GCCATCAGCT 1740

GAGTATGATG AAGACCATCT AAGCCCACTC CCACCTGTGA TATCTTCCTC CAATTCCCCT 1800

CCCTTGCTTT TTCCCTCATC CCCCACATCT CCACCTCCTC CTGCTTCACC CCAGAAAGCG 1860

TCTCCAGCAA ACAGCGACTC TTTTGAGTCG CTGCCTGTGA AGCAGAGGGA GCGACTGTTT 1920

GACTTGGACA TGTTCATATC ACGAGCGCTG AAGCTGTGCA GGCAGAATGA TTTAAAACCC 1980

AGCTCATCAG ACCTGAAA 1998

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNii  61

          +l+plg G  g+v+savd+rt++rvaikkl   +++++++k++lRE k+ ++l+heN++

Q: 20    VDLRPLGVGVTGLVLSAVDQRTRQRVAIKKLL--MRDAVTVKHALREAKITQRLRHENVV  77

         5789***************************9..9*************************

S: 62    klldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglk  116

         ++ +v  p       + ++l+ +Y+v+e metdL++++++  l+ +h+ ll+yq+lrglk

Q: 78    RVHEVAAPFGqplprDPTQLSALYVVQECMETDLARLLEQGPLDTDHATLLFYQLLRGLK  137

         *****9997766777899******************************************

S: 117   ylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwYraPe  173

         ++Hsanv+HrDlKP+N+++n++   lki dFGlar+ d+++++k  l+e ++t+wY +P+

Q: 138   FIHSANVLHRDLKPANIFINTEQLlLKIGDFGLARIVDPHYSHKgyLSEALVTKWYCSPR  197

         ********************987548***************9999***************

S: 174   illslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkies  233

         +lls ++ytka+D+W++GCIlaE+ltg++lf+g++e++q+++il++++  +ee+ +++ +

Q: 198   LLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILDTVPVLREEDRQDLLQ  257

         ***********************************************************9

S: 234   eearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

           + +yi++ +k k+ +f el+p+a+++a+d+le++L+++p++R+++e aL+hp+l

Q: 258   V-MPSYISHGWKVKR-PFCELLPDADSQAVDFLERILTFNPMDRLTAEAALSHPFL  311

         5.9****99998887.**************************************97

Domain Sequence
(FASTA)

VDLRPLGVGV TGLVLSAVDQ RTRQRVAIKK LLMRDAVTVK HALREAKITQ RLRHENVVRV 60

HEVAAPFGQP LPRDPTQLSA LYVVQECMET DLARLLEQGP LDTDHATLLF YQLLRGLKFI 120

HSANVLHRDL KPANIFINTE QLLLKIGDFG LARIVDPHYS HKGYLSEALV TKWYCSPRLL 180

LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GAHELEQMQL ILDTVPVLRE EDRQDLLQVM 240

PSYISHGWKV KRPFCELLPD ADSQAVDFLE RILTFNPMDR LTAEAALSHP FL 292

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013