EKS-TEN-00466

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00466

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	427.3	2.1E-128	248	498	251

Status

Unreviewed

Ensembl Protein

ENSTNIP00000020756

UniProt Accession

H3DJR0;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000017609	ENSTNIP00000020756	ENSTNIT00000020989

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

AGRMGCIKSR LDGGVSKGVE EKSSPQTVRT QLARYVRDPT SDINHNINNS LLPGQRFQTL 60

EEKGVEKIVI ALYPYEALHP DDLGFKKGER MKILEERGEW WRAKSLSTNR EGFIPSNYVG 120

QADTMETEDW FFKDISRKDA ERQLLAPANR AGSYLIRESE TAKGSFSLSV RDVDDGGTDL 180

VKHYKIRLLD NGGYYISPKI SFTDISSMIK HYHSKADGLC RKLDRPCVKP KAEKPWDKDA 240

WEISKDSIRM VKRLGAGQFG EVWMAYYNNI TRVAVKTLKP GTMTVEAFMD EANLMKKLQH 300

DRLVRLYAVV TKTEPIYIIT EYMANGSLLD FLKSDLGCSL QIPKLIDFSA QIAEGMAYIE 360

RRNYIHRDLR AANVLVSECL LCKIADFGLA RVIEDDEYSA REGAKFPIKW TAPEAINYGS 420

FTIKSDMWSF GVLLYEIITY GKIPYPGMTK GEVISSIQRG YRMPQPDSCP SELYHMMLDC 480

WKDKPDARPT FEYMQSVLND FYTATESQYQ QQP 513

Nucleotide Sequence
(FASTA)

GCAGGCAGGA TGGGCTGCAT AAAGTCCAGA CTGGATGGAG GTGTGAGCAA AGGTGTGGAG 60

GAGAAGAGCA GCCCGCAGAC TGTACGTACT CAGCTAGCGC GTTATGTCAG AGACCCCACC 120

TCCGATATTA ATCACAACAT AAATAACTCC CTGTTACCTG GTCAGAGGTT CCAAACACTG 180

GAAGAGAAAG GGGTTGAAAA AATAGTCATC GCGCTCTACC CATATGAAGC TTTGCATCCG 240

GATGACTTGG GATTCAAAAA AGGAGAGAGA ATGAAAATCT TAGAAGAGCG TGGGGAGTGG 300

TGGCGAGCCA AGTCCCTGAG CACCAACAGG GAGGGTTTCA TCCCGTCCAA CTACGTGGGC 360

CAGGCCGACA CCATGGAGAC AGAGGACTGG TTTTTCAAAG ACATCAGCAG AAAGGACGCG 420

GAGAGGCAGC TGCTGGCCCC AGCCAACCGA GCAGGCTCCT ATCTGATCAG GGAGAGCGAA 480

ACAGCCAAAG GAAGTTTCTC CTTGTCAGTC AGAGACGTGG ACGACGGCGG TACAGACTTA 540

GTCAAACACT ACAAGATCAG GCTGTTGGAT AATGGCGGCT ACTACATCTC TCCTAAGATC 600

TCCTTCACCG ACATCAGCAG CATGATCAAA CACTACCACA GTAAGGCGGA TGGACTGTGT 660

CGGAAGCTGG ACCGGCCCTG TGTCAAACCA AAGGCCGAGA AGCCCTGGGA CAAAGACGCC 720

TGGGAGATCT CCAAGGACTC CATTAGGATG GTGAAGAGAC TGGGAGCAGG CCAGTTTGGA 780

GAAGTCTGGA TGGCGTACTA CAACAACATC ACCAGAGTAG CAGTGAAGAC CCTGAAGCCG 840

GGGACCATGA CTGTGGAGGC CTTCATGGAT GAAGCCAACC TGATGAAGAA GCTGCAGCAC 900

GACAGGCTGG TGCGCCTCTA CGCCGTGGTC ACCAAGACGG AACCCATCTA CATCATCACC 960

GAGTACATGG CGAATGGGAG TCTGCTGGAC TTTCTGAAGA GCGACCTGGG GTGCTCGCTG 1020

CAAATACCCA AACTGATCGA CTTCTCGGCA CAGATTGCAG AGGGGATGGC GTACATCGAG 1080

AGAAGGAACT ACATCCACCG CGACCTGAGG GCCGCCAACG TCCTGGTCTC CGAGTGTCTG 1140

CTCTGCAAAA TTGCTGACTT CGGACTGGCC CGAGTCATCG AGGATGACGA GTATTCTGCC 1200

AGAGAAGGGG CCAAATTCCC CATCAAGTGG ACTGCTCCAG AGGCCATCAA CTACGGCTCC 1260

TTCACCATCA AATCAGACAT GTGGTCGTTC GGGGTTCTCC TCTATGAGAT TATCACCTAT 1320

GGGAAAATCC CGTATCCAGG AATGACGAAG GGAGAGGTCA TCTCCTCCAT ACAGCGTGGC 1380

TACAGGATGC CTCAGCCGGA CAGCTGTCCC AGCGAACTCT ACCACATGAT GCTGGACTGC 1440

TGGAAGGACA AACCTGATGC CAGACCCACC TTTGAGTACA TGCAGAGCGT CCTCAATGAC 1500

TTTTACACCG CCACCGAGAG TCAGTACCAG CAGCAGCCGT AG 1542

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +++vk+lG+GqfGevw++++++ ++vavktlk+gt++ eaf++ea+++kkl+h++lv+ly

Q: 248   IRMVKRLGAGQFGEVWMAYYNNITRVAVKTLKPGTMTVEAFMDEANLMKKLQHDRLVRLY  307

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyi+te+ma+Gslldflk++ g +l++pkl+d++aq+aeGmay+e++n+ihr

Q: 308   AVVTKTEPIYIITEYMANGSLLDFLKSDLGCSLQIPKLIDFSAQIAEGMAYIERRNYIHR  367

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+e l++k+adfGlar+ieddey+a+egak+PikWtaPeai++g+ftiksd+

Q: 368   DLRAANVLVSECLLCKIADFGLARVIEDDEYSAREGAKFPIKWTAPEAINYGSFTIKSDM  427

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+ll+ei+t+Gk+PypGmt+ ev+++++rgyr+p+p++cp+ely+++l cwk +p+

Q: 428   WSFGVLLYEIITYGKIPYPGMTKGEVISSIQRGYRMPQPDSCPSELYHMMLDCWKDKPDA  487

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q+vl

Q: 488   RPTFEYMQSVL  498

         *******9976

Domain Sequence
(FASTA)

IRMVKRLGAG QFGEVWMAYY NNITRVAVKT LKPGTMTVEA FMDEANLMKK LQHDRLVRLY 60

AVVTKTEPIY IITEYMANGS LLDFLKSDLG CSLQIPKLID FSAQIAEGMA YIERRNYIHR 120

DLRAANVLVS ECLLCKIADF GLARVIEDDE YSAREGAKFP IKWTAPEAIN YGSFTIKSDM 180

WSFGVLLYEI ITYGKIPYPG MTKGEVISSI QRGYRMPQPD SCPSELYHMM LDCWKDKPDA 240

RPTFEYMQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013