EKS-TEN-00511

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00511

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	535.7	6.4E-161	593	926	334

Status

Unreviewed

Ensembl Protein

ENSTNIP00000003543

UniProt Accession

H3C5M3;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

KIT (1 of 2)

Gene Synonyms/Alias

KIT (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000017656	ENSTNIP00000020806	ENSTNIT00000021039
ENSTNIG00000017656	ENSTNIP00000003543	ENSTNIT00000003772
ENSTNIG00000017656	ENSTNIP00000001393	ENSTNIT00000001599

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

986

Protein Sequence
(FASTA)

FRGKRRENAN LFILICQTAR APGKQSPNTN PSDTKPSITP AGPYVVVLLN APFELQCLGE 60

KAMQWQRERL KVRGEKKVDG KSTLYFPKAQ PAHMGRYICL EEASQETASI YVYVKDPNNP 120

FRKPMVSNII SGEGSITFIP CLATDPSLEN LQLKTCSSKA LAPGLEFSSS LEQGIIIHNT 180

QKSYEGCYVC TGRLKETNVR SHDYFLTVRP VPVAPPAIML QAPKRVILIC NESLYLTCNT 240

TNVNGNIKLK WVTPLGSQPA KVDGSSRILT ENFTHACSAT LHITAVQIQD TGRYQCEAQN 300

EKGVSTQSVW LDVYEKGFMY SSPVNNGTIQ VRAGESLSLS VSLEAYPKPH TISWSFMGRG 360

LRNTTDHVIT THSHDYTFRY SSELKLVRLK MTEGGVYTFQ ASNGDASVNH TFTIFVISKP 420

EIVSHEGPVD GQVRCVAEGF PAPQITWYYC EQPYARCSQQ VNATQEEHNV ITVTLFSPLF 480

GKTEVESRVN VSRGRFSTLE CVATVEGEQA YTLFSISERS VSHDLFSPLL IGSVSAAGIL 540

CLVLIVLFYK YMQKPKYQIQ WKVIEGIHGN NYVYIDPTQL PYDHQWEFPR KNLRFGKTLG 600

SGAFGKVVEA TAYGLASADS TMTVAVKMLK SSAHSTEKEA LMSELKVLIY LGNHINIVNL 660

LGACTVGGPT LVITEYCCFG DLLNFLRRKR ESFICFKLEE DCHYRNVMLQ REMAGSDSLN 720

GYMTMRPSAA GTLSPSFSSE KKRSLRKGSQ YVEADSESEM FDEDSLSLDT EDLLSFSYQV 780

AKGMEFLTSK NCIHRDLAAR NILLTQGRVA KICDFGLARD INTDSNYVVK GNARLPVKWM 840

SPESIFECVY TFESDVWSYG ILLWEIFSLG NSPYPGMPVD AKFYKLIKEG YRMDAPEFAP 900

SEMYQIMRSC WDADPLNRPP FRKVVERIEQ QLSDTTKHIY LNFSSRVPVM PRGREESSAQ 960

STPAQPFSSA INNSPPCQPL LLHHEV 986

Nucleotide Sequence
(FASTA)

TTTAGAGGCA AGAGGCGTGA AAATGCCAAT TTGTTTATCT TGATATGTCA AACCGCCCGC 60

GCGCCTGGAA AGCAGTCTCC AAACACAAAC CCCAGCGACA CCAAGCCTTC CATCACCCCC 120

GCAGGCCCCT ACGTTGTTGT CTTGCTTAAC GCCCCTTTCG AGCTGCAGTG CCTGGGCGAG 180

AAAGCCATGC AGTGGCAGCG AGAGCGTCTA AAGGTGCGGG GGGAGAAAAA GGTGGACGGG 240

AAGTCAACTC TGTACTTTCC CAAGGCTCAG CCTGCTCATA TGGGTCGTTA CATCTGCTTG 300

GAGGAGGCCA GCCAGGAGAC GGCCTCCATT TACGTCTACG TGAAAGATCC AAATAATCCC 360

TTTAGAAAAC CAATGGTGTC CAACATTATC AGTGGCGAGG GAAGCATCAC TTTCATTCCC 420

TGCCTGGCAA CCGATCCGAG TCTGGAAAAC TTGCAGCTGA AAACATGTTC CAGTAAAGCT 480

CTGGCCCCTG GTCTCGAGTT TTCTTCCAGC CTGGAGCAAG GCATCATTAT CCACAACACA 540

CAAAAGTCCT ACGAGGGCTG TTATGTCTGC ACAGGAAGGC TGAAGGAAAC AAACGTCCGA 600

TCACATGACT ACTTCCTAAC AGTGAGACCA GTTCCTGTTG CTCCCCCTGC AATTATGCTG 660

CAGGCTCCCA AAAGAGTGAT TCTGATCTGC AACGAGAGCC TGTACCTCAC CTGCAACACC 720

ACTAACGTCA ATGGAAACAT TAAGCTAAAG TGGGTCACGC CGCTTGGCTC GCAACCAGCA 780

AAGGTTGACG GCTCTTCTCG TATCCTGACG GAGAACTTTA CCCACGCATG CAGCGCCACC 840

TTGCACATCA CGGCGGTCCA GATTCAAGAC ACTGGGAGGT ACCAGTGTGA AGCCCAGAAC 900

GAGAAAGGGG TCAGCACACA GTCGGTGTGG CTGGATGTTT ACGAGAAAGG CTTCATGTAC 960

TCGAGTCCCG TTAACAACGG AACCATCCAA GTGCGTGCGG GTGAGAGTTT ATCCCTCAGC 1020

GTCAGCCTGG AGGCCTATCC AAAGCCGCAC ACCATCTCTT GGAGCTTCAT GGGCCGCGGG 1080

CTGCGCAACA CAACCGACCA CGTCATCACC ACGCACAGCC ATGATTACAC ATTTAGGTAC 1140

AGCAGTGAGC TGAAGCTGGT GCGTCTGAAA ATGACAGAAG GCGGCGTTTA TACCTTTCAA 1200

GCCTCCAACG GTGATGCTTC AGTAAACCAC ACGTTCACCA TCTTTGTCAT CAGTAAACCG 1260

GAGATTGTGT CCCACGAGGG CCCAGTGGAC GGACAGGTGC GCTGCGTGGC GGAGGGGTTC 1320

CCCGCTCCGC AGATCACCTG GTACTACTGT GAACAGCCGT ACGCCAGGTG TTCGCAGCAG 1380

GTGAACGCCA CCCAGGAAGA GCACAACGTA ATCACCGTCA CACTCTTCAG CCCTCTGTTT 1440

GGAAAGACGG AGGTGGAGAG CCGGGTCAAC GTCAGCAGAG GACGGTTCAG CACTCTGGAA 1500

TGCGTGGCCA CGGTCGAGGG AGAGCAGGCC TACACGCTCT TCTCTATCAG CGAGAGAAGC 1560

GTCTCCCATG ATCTATTCTC CCCTCTACTA ATTGGCTCTG TATCGGCGGC AGGCATCCTC 1620

TGCCTTGTCC TTATCGTGTT GTTCTACAAG TACATGCAGA AGCCCAAATA CCAGATCCAG 1680

TGGAAAGTCA TCGAGGGTAT CCATGGAAAC AACTACGTAT ACATCGACCC CACCCAGCTG 1740

CCCTACGACC ATCAGTGGGA GTTTCCTCGA AAAAACTTGC GCTTCGGGAA GACGCTGGGG 1800

TCTGGCGCAT TCGGAAAAGT GGTGGAAGCC ACCGCGTACG GACTCGCCAG CGCAGATTCA 1860

ACGATGACCG TGGCTGTTAA AATGCTAAAA TCAAGCGCTC ATTCCACAGA GAAGGAGGCG 1920

CTGATGTCTG AGCTGAAGGT CCTCATTTAC CTGGGAAACC ACATAAATAT CGTCAACCTG 1980

CTGGGAGCCT GCACTGTCGG AGGCCCAACA CTGGTGATCA CAGAGTACTG CTGCTTCGGT 2040

GACCTCCTGA ACTTTCTGCG CAGAAAACGA GAATCCTTCA TCTGCTTCAA GCTGGAGGAA 2100

GACTGTCACT ACCGCAACGT CATGCTGCAA CGAGAGATGG CGGGCAGTGA CAGCTTGAAC 2160

GGCTACATGA CCATGAGGCC GTCTGCTGCT GGCACCCTGT CACCCAGTTT TTCCTCTGAG 2220

AAAAAGCGAT CACTACGCAA AGGTAGCCAG TATGTTGAGG CAGATTCTGA AAGCGAGATG 2280

TTTGATGAGG ACAGTCTGTC CCTGGACACG GAAGACCTTC TCAGCTTCTC ATATCAAGTT 2340

GCCAAAGGCA TGGAGTTTTT AACATCCAAA AATTGCATCC ACAGAGATCT GGCTGCCAGA 2400

AACATCCTAC TAACTCAAGG CAGAGTGGCA AAGATCTGTG ACTTTGGCCT GGCCCGGGAC 2460

ATCAACACTG ACTCAAACTA TGTAGTCAAA GGCAATGCCC GTCTGCCAGT CAAATGGATG 2520

TCGCCTGAAA GTATCTTTGA GTGTGTGTAC ACATTTGAGA GTGATGTTTG GTCCTATGGC 2580

ATTTTGCTCT GGGAAATCTT CTCGCTAGGA AATAGTCCCT ATCCCGGCAT GCCTGTGGAC 2640

GCCAAATTCT ACAAACTGAT TAAAGAAGGC TATAGAATGG ATGCTCCGGA ATTTGCGCCC 2700

AGTGAAATGT ATCAGATTAT GAGGTCCTGC TGGGACGCTG ACCCCTTAAA CCGACCCCCA 2760

TTCAGGAAGG TTGTGGAAAG AATCGAACAA CAGCTGTCCG ACACAACCAA ACATATCTAT 2820

CTGAACTTCA GCTCCAGAGT TCCTGTGATG CCCAGAGGCA GGGAGGAGTC CAGCGCTCAG 2880

AGCACGCCGG CCCAGCCTTT CAGCTCGGCC ATCAACAACA GCCCGCCCTG CCAGCCCTTG 2940

CTGCTCCACC ACGAAGTC 2958

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l++Gk+lGsGafGkvveatayGl+ +d++++vavkmlks+a+s+ekealmselk+l +lG

Q: 593   LRFGKTLGSGAFGKVVEATAYGLASADSTMTVAVKMLKSSAHSTEKEALMSELKVLIYLG  652

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h nivnllGact+gGp++viteycc+Gdlln+lrrkresf+  +le      e++++++

Q: 653   NHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRKRESFICFKLE------EDCHYRN  706

         ******************************************55444......4677776

S: 121   lladkslrsksslssesseeyvdlkkdvsd.vsss.kadklas.ekkksalerevkaale  177

         +    +l+++    s+s + y+ ++++ +  +s+s +++k++s +k ++++e + ++++

Q: 707   V----MLQRE-MAGSDSLNGYMTMRPSAAGtLSPSfSSEKKRSlRKGSQYVEADSESEMF  761

         6....44444.4566999********9665144331333333315557899*********

S: 178   eedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardi  237

         +eds +l+ edllsfsyqvakGmefl sknc+hrdlaarn+llt+G+v+kicdfGlardi

Q: 762   DEDSLSLDTEDLLSFSYQVAKGMEFLTSKNCIHRDLAARNILLTQGRVAKICDFGLARDI  821

         ************************************************************

S: 238   mkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvds  297

          +dsnyvvkGnarlpvkwm+pesif+++yt++sdvwsyGillweifslG +pypg++vd+

Q: 822   NTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIFSLGNSPYPGMPVDA  881

         ************************************************************

S: 298   kfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342

         kfyklikeGyrm+ p++a++e+y+im++cw+a+p +rp+f+++ve

Q: 882   KFYKLIKEGYRMDAPEFAPSEMYQIMRSCWDADPLNRPPFRKVVE  926

         *****************************************9986

Domain Sequence
(FASTA)

LRFGKTLGSG AFGKVVEATA YGLASADSTM TVAVKMLKSS AHSTEKEALM SELKVLIYLG 60

NHINIVNLLG ACTVGGPTLV ITEYCCFGDL LNFLRRKRES FICFKLEEDC HYRNVMLQRE 120

MAGSDSLNGY MTMRPSAAGT LSPSFSSEKK RSLRKGSQYV EADSESEMFD EDSLSLDTED 180

LLSFSYQVAK GMEFLTSKNC IHRDLAARNI LLTQGRVAKI CDFGLARDIN TDSNYVVKGN 240

ARLPVKWMSP ESIFECVYTF ESDVWSYGIL LWEIFSLGNS PYPGMPVDAK FYKLIKEGYR 300

MDAPEFAPSE MYQIMRSCWD ADPLNRPPFR KVVE 334

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 4.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013