EKS-TEN-00509

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00509

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	576.0	3.6E-173	578	932	355

Status

Unreviewed

Ensembl Protein

ENSTNIP00000020807

UniProt Accession

H3BZA2;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRA

Gene Synonyms/Alias

PDGFRA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000017657	ENSTNIP00000020807	ENSTNIT00000021040
ENSTNIG00000017657	ENSTNIP00000001318	ENSTNIT00000003200

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1072

Protein Sequence
(FASTA)

SLPAPTAVMF PPSSAPLLLP QSEELVVPLH TAFTLTCQGE ATIAWDTPLD VPEKTQEDNS 60

GLFVTTISVD TATAMHSGYY TCFYSRNDTD REDDMMQSAI YVYVPDPDMP FVPSVVPFGN 120

HVLSDHEEME IQCRVSDPSA NVTLINVDTQ QPVPCVYDSK RGALGIFTAG TYVCKALING 180

EEHYSEEYIV HGWIGGSGLH VELTAKRTVL LVGDTITVNC LARGSEILED HWKYPGKVTN 240

RAVKNVHENK KDQEILYTLT VPQASVKDTG IYSCSITDIV TNKSQTKQIA IRVYASEFMS 300

IQPEFREYES AELDEVSEFR AYISSFPTAR VTWLKDGVPL SDVTAEISSS LRQLNETSYI 360

SVLTLIRAKE EDSGNYTMRV ENGDQSRTVG LILEVKVPAV IVDLLDIHHG SATGQSVVCI 420

TRGQPTPLVE WFVCKNIKSC TNDTSSWVPL PVNATEVTMD SRFDEDNNLE TQVMFGHLES 480

TLAVRCLARN EMAAVSREIK LVSTGPHPEL TVAAAVLVLL VIVIISLIVL VVIWKQKPRY 540

EIRWRVIESV SPDGHEYIYV DPMQLPYDSR WEFPRDRLVL GRILGSGAFG KVVEGTAYGL 600

SRSQPVMKVA VKMLKPTARS SEKQALMSEL KIMTHLGPHL NIVNLLGACT KSGPIYIITE 660

YCFYGDLVNY LHKNRENFLN PKAEKNNKKE LDIFGINPAD ESSRSYVILS FESKGDYMDM 720

KQADNTQYVP MLERSNTSKY SDLQGSNYDH PPSQKGSNAD GEMDELLSDN VNEGLTTKDL 780

LSFTYQVAKG MEFLASKNCV HRDLAARNVL LSQGKIVKIC DFGLARDIMH DNNYVSKGST 840

FLPVKWMAPE SIFDNLYTSL SDVWSYGILL WEIFSLGGTP YPGMIVDSSF YNKIKSGYRM 900

SKPEHAPQDV YDMMMRCWNS EPEKRPSFLG LSDTVASLLP SSYKRHYERV NQEFLKSDHP 960

AVTRVCMDND DAYIGITYKN QGKLKDRESG FDEQRLSSDS GYIIPLPDLD PISDEEYGKR 1020

NRHSSQTSEE SAIETGSSSS TYAKREGETL EDITLLDEMC LDCSDLVEDS FL 1072

Nucleotide Sequence
(FASTA)

TCTCTTCCAG CGCCCACCGC GGTGATGTTC CCACCATCCT CAGCTCCGTT GCTCCTGCCA 60

CAGTCGGAGG AGCTGGTGGT TCCCCTCCAC ACGGCCTTCA CCTTGACATG TCAGGGGGAG 120

GCAACAATCG CCTGGGACAC ACCGCTGGAC GTGCCAGAGA AGACGCAGGA AGACAACAGC 180

GGCCTCTTTG TCACCACCAT TAGCGTGGAC ACCGCCACCG CCATGCACAG CGGCTACTAC 240

ACCTGCTTCT ACAGCAGGAA CGACACAGAC AGAGAAGACG ACATGATGCA GAGCGCCATC 300

TACGTCTACG TGCCAGATCC CGACATGCCC TTTGTCCCTT CGGTGGTGCC CTTCGGCAAC 360

CACGTCCTGT CTGACCACGA GGAGATGGAG ATCCAGTGTC GCGTGTCAGA TCCCAGCGCT 420

AACGTGACGC TGATCAACGT CGACACTCAG CAGCCCGTGC CCTGCGTGTA TGACAGCAAG 480

AGGGGAGCTC TGGGCATATT CACAGCGGGG ACGTACGTCT GCAAGGCCCT CATCAACGGA 540

GAGGAGCACT ACAGCGAGGA GTACATCGTC CACGGCTGGA TAGGGGGCTC CGGGCTGCAC 600

GTTGAGCTGA CGGCCAAGCG TACGGTCCTG CTGGTGGGGG ACACCATCAC GGTCAACTGT 660

TTGGCTCGGG GATCAGAGAT TTTGGAAGAC CACTGGAAAT ATCCGGGAAA AGTGACTAAC 720

CGTGCCGTTA AGAATGTTCA CGAGAACAAA AAGGATCAGG AGATTCTTTA CACCCTGACA 780

GTCCCGCAGG CTTCAGTCAA GGACACGGGC ATCTACTCGT GTTCCATCAC CGACATAGTA 840

ACTAACAAAA GTCAGACGAA GCAGATCGCA ATTCGTGTTT ATGCGAGCGA GTTCATGTCC 900

ATCCAGCCTG AGTTCAGGGA GTACGAATCG GCCGAGCTGG ATGAGGTCAG TGAGTTCAGG 960

GCCTACATCA GCTCCTTCCC AACCGCTCGG GTCACCTGGC TCAAGGACGG CGTCCCGCTC 1020

AGCGACGTGA CGGCAGAGAT TTCCAGCAGC CTCCGCCAGC TCAACGAGAC CAGCTACATA 1080

AGCGTCCTGA CTTTGATCCG GGCCAAGGAG GAGGACAGTG GGAACTACAC CATGCGAGTG 1140

GAGAACGGAG ACCAGAGTCG CACCGTCGGA CTGATCCTGG AGGTTAAAGT GCCTGCAGTC 1200

ATCGTGGACC TGCTGGACAT CCACCATGGG TCAGCTACAG GCCAGTCTGT GGTGTGCATC 1260

ACCAGAGGTC AGCCCACGCC GCTGGTGGAG TGGTTCGTCT GCAAGAACAT CAAAAGCTGC 1320

ACCAACGACA CCTCTTCCTG GGTGCCGCTT CCCGTCAACG CCACCGAGGT CACCATGGAC 1380

TCGCGCTTTG ACGAGGACAA CAACCTGGAG ACCCAGGTCA TGTTTGGTCA CCTGGAGAGC 1440

ACGCTGGCGG TGCGCTGCCT GGCCAGAAAT GAGATGGCCG CCGTCAGCAG GGAGATCAAA 1500

CTGGTGTCCA CTGGCCCTCA TCCAGAGCTG ACTGTCGCTG CTGCTGTGTT GGTGCTCCTG 1560

GTCATTGTCA TCATCTCACT CATTGTCTTG GTTGTGATCT GGAAACAGAA ACCACGTTAT 1620

GAAATCCGCT GGAGGGTTAT TGAGTCCGTT AGCCCGGATG GACATGAGTA CATCTATGTG 1680

GATCCCATGC AGCTTCCCTA CGACTCCAGA TGGGAGTTCC CCCGTGACAG ACTTGTGCTC 1740

GGCCGTATCC TGGGCTCTGG TGCCTTTGGA AAAGTCGTTG AGGGCACCGC CTACGGTCTC 1800

AGCCGCTCTC AGCCTGTCAT GAAGGTGGCA GTAAAGATGC TCAAACCGAC AGCGCGCTCC 1860

AGTGAAAAAC AGGCCCTGAT GTCTGAGCTG AAGATCATGA CCCATCTGGG ACCACACCTC 1920

AACATTGTTA ACCTGCTGGG AGCGTGCACC AAGTCAGGCC CCATCTACAT CATTACTGAG 1980

TACTGTTTCT ATGGCGACCT GGTCAACTAC CTGCACAAGA ACCGAGAGAA CTTTCTCAAC 2040

CCGAAAGCTG AGAAGAACAA CAAGAAAGAG CTGGACATTT TTGGAATCAA CCCTGCAGAC 2100

GAGAGCAGCA GGAGTTATGT GATCCTGTCC TTCGAGAGCA AAGGCGACTA CATGGACATG 2160

AAGCAGGCCG ACAACACTCA GTACGTGCCC ATGCTGGAGA GAAGCAACAC CTCCAAGTAC 2220

TCTGACCTCC AGGGCTCCAA CTACGACCAC CCACCCTCGC AGAAAGGATC AAATGCAGAC 2280

GGTGAGATGG ACGAACTGCT GTCAGACAAC GTGAACGAGG GTCTCACCAC CAAAGACCTG 2340

CTGAGCTTTA CCTACCAGGT GGCCAAAGGG ATGGAGTTCC TGGCTTCTAA AAACTGTGTC 2400

CACCGGGATC TGGCTGCCAG GAACGTCCTG CTCTCTCAGG GCAAAATAGT GAAGATCTGC 2460

GACTTTGGAC TGGCCCGAGA CATCATGCAC GACAACAACT ACGTCTCCAA AGGAAGCACG 2520

TTCCTGCCGG TGAAGTGGAT GGCACCGGAG AGCATTTTTG ACAACCTGTA CACCTCGCTC 2580

AGCGACGTTT GGTCGTACGG CATCCTGCTG TGGGAGATTT TCTCTTTAGG TGGCACGCCA 2640

TACCCAGGAA TGATTGTGGA TTCAAGCTTC TATAACAAGA TCAAGAGTGG CTACAGGATG 2700

TCCAAACCAG AGCACGCTCC TCAGGATGTG TATGACATGA TGATGAGGTG CTGGAACAGC 2760

GAACCGGAGA AGAGGCCCTC CTTCCTGGGA CTCAGCGACA CCGTCGCCTC TTTGCTGCCC 2820

TCCAGCTATA AGAGGCATTA CGAGAGGGTG AACCAGGAGT TCCTGAAGAG CGACCACCCT 2880

GCCGTGACCA GAGTGTGCAT GGACAACGAC GACGCGTACA TCGGCATCAC CTACAAAAAC 2940

CAGGGGAAGT TGAAGGACAG GGAAAGTGGT TTTGATGAGC AGCGACTGAG CTCCGACAGC 3000

GGCTACATCA TCCCGCTGCC TGACCTGGAC CCCATATCTG ACGAGGAATA TGGGAAGAGG 3060

AACAGACACA GCTCTCAGAC ATCTGAGGAG AGCGCCATTG AGACCGGCTC CAGCAGCTCC 3120

ACCTACGCAA AGCGTGAGGG TGAGACGCTG GAGGACATCA CGCTATTGGA CGAGATGTGT 3180

CTGGACTGTA GCGACCTGGT GGAGGACAGC TTTTTGTGA 3219

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG

Q: 578   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  637

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++re+fl+ ++ek  ++++eld+++

Q: 638   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRENFLNPKAEK--NNKKELDIFG  695

         ******************************************988887..7888999999

S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163

         + +ad+s rs+++ls+es+++y+d+k++                +sd++ s++d++ s+k

Q: 696   InPADESSRSYVILSFESKGDYMDMKQAdntqyvpmlersntskYSDLQGSNYDHPPSQK  755

         999************************99***************************9998

S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223

           s  + e+ + l+++ +e+l+ +dllsf+yqvakGmeflaskncvhrdlaarnvll++G

Q: 756   -GSNADGEMDELLSDNVNEGLTTKDLLSFTYQVAKGMEFLASKNCVHRDLAARNVLLSQG  814

         .8889999****************************************************

S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283

         k+vkicdfGlardim+d nyv+kG+++lpvkwmapesifd+lyt  sdvwsyGillweif

Q: 815   KIVKICDFGLARDIMHDNNYVSKGSTFLPVKWMAPESIFDNLYTSLSDVWSYGILLWEIF  874

         ************************************************************

S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlv  341

         slG+tpypg++vds fy++ik+Gyrm++p++a++++y++m +cw++epekrpsf  l+

Q: 875   SLGGTPYPGMIVDSSFYNKIKSGYRMSKPEHAPQDVYDMMMRCWNSEPEKRPSFLGLS  932

         ******************************************************8776

Domain Sequence
(FASTA)

LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60

PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNREN FLNPKAEKNN KKELDIFGIN 120

PADESSRSYV ILSFESKGDY MDMKQADNTQ YVPMLERSNT SKYSDLQGSN YDHPPSQKGS 180

NADGEMDELL SDNVNEGLTT KDLLSFTYQV AKGMEFLASK NCVHRDLAAR NVLLSQGKIV 240

KICDFGLARD IMHDNNYVSK GSTFLPVKWM APESIFDNLY TSLSDVWSYG ILLWEIFSLG 300

GTPYPGMIVD SSFYNKIKSG YRMSKPEHAP QDVYDMMMRC WNSEPEKRPS FLGLS 355

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084	; P:vascular endothelial growth factor signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR01832

; VEGFRECEPTOR.

Created Date

20-Feb-2013