EKS-TEN-00311
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00311
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CAMKL315.13.3E-9411263253
StatusUnreviewed
Ensembl ProteinENSTNIP00000020975
UniProt AccessionH3BW05;
Protein Name
Protein Synonyms/Alias
Gene NameMELK
Gene Synonyms/Alias MELK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000017819ENSTNIP00000020975ENSTNIT00000021208
ENSTNIG00000017819ENSTNIP00000000167ENSTNIT00000003195
OrganismTetraodon nigroviridis
Functional Description
Protein Length651
Protein Sequence
(FASTA)
FRGADELYKY YELYETIGSG GFAKVKLGRH ILTGEKVAIK IMNKRDLGDD LPRVKVEIEA 60
MKNLSHQHIC RLYHVIETST QIFMVMEYCT GGELFDYIIA KDRLSEEETR VFFRQIVSAM 120
AYVHSQGYAH RDLKPENLLI DEDHNLKLID FGLCAITKGG LGYELMTCCG SPAYAAPELI 180
QGKAYIGSEA DVWSMGVLLF ALLCGYLPFD DDNCMILYRK ITRGKYDNPR WLSPGSILLL 240
NQMMQVDPKR RLTVEQLLGH PWVIKDYNSP VEWHSQQPLG HIDVDCITEM AVNMKKTRES 300
ATALVQEWRY DQTTATYLLL LSKKQRGKPV RLRPELSVCE DSCSPLHQGI QTGDGLHFSE 360
DEDIVLVRSL DFVSDYIDDC PWLSRETPKK LVSESPSKKS ASSRTPERGR TTPQHRQERR 420
DRDRERTAEN KENVAAQDRD VDLFALPPPR TPASSRKNAR QKNALTSPNH NASGAKVSLR 480
CLSDSSPHTK AFELTSVSNA VGPERRSRSL DMAVTGDSGK KKRGGKVFGS LERGLDKMIN 540
MLTPSKRRAL RDGPRKIRPQ YNVTLTSQTN PDQVLNQILS ILPEKNVDFT QKGYTLKCRT 600
KGDFGKVTMA FELEVCLLQR PEVVGVRRQR LKGDAWVYKH LVEDILSTSR I 651
Nucleotide Sequence
(FASTA)
TTTCGTGGAG CCGACGAGCT CTACAAATAC TACGAGCTTT ATGAGACGAT CGGATCGGGG 60
GGCTTTGCTA AGGTCAAGCT GGGTCGTCAC ATCCTGACAG GAGAGAAAGT TGCAATCAAA 120
ATCATGAACA AGAGGGATTT AGGAGATGAT TTACCCCGGG TCAAGGTGGA GATCGAGGCT 180
ATGAAGAATT TGAGCCACCA GCACATCTGT CGCCTGTATC ACGTCATTGA GACGTCTACC 240
CAGATCTTCA TGGTGATGGA GTACTGTACA GGCGGGGAGC TCTTTGACTA CATCATAGCG 300
AAGGACCGCC TGTCGGAAGA GGAGACCAGG GTGTTCTTCA GGCAGATCGT GTCAGCGATG 360
GCCTACGTGC ACAGCCAGGG TTATGCGCAC AGGGACCTTA AGCCGGAGAA CCTACTGATC 420
GATGAAGATC ATAATTTGAA GCTAATAGAT TTTGGATTGT GCGCAATAAC CAAAGGAGGT 480
TTGGGTTACG AGCTCATGAC GTGTTGCGGA AGTCCCGCCT ACGCTGCTCC CGAGCTCATC 540
CAGGGAAAAG CCTACATCGG CTCGGAGGCT GATGTGTGGA GTATGGGGGT GTTGCTCTTC 600
GCTCTGCTCT GCGGATATCT GCCCTTTGAT GATGACAACT GCATGATTCT CTACAGGAAG 660
ATTACAAGAG GTAAATATGA CAACCCCCGG TGGCTTTCTC CTGGGAGTAT CCTCCTCCTC 720
AACCAAATGA TGCAGGTGGA CCCAAAGCGG CGTCTGACAG TGGAGCAGCT CCTAGGCCAC 780
CCTTGGGTCA TCAAAGACTA CAACAGCCCG GTGGAGTGGC ATAGCCAGCA GCCGCTCGGC 840
CACATTGATG TGGACTGCAT CACTGAAATG GCGGTCAACA TGAAGAAAAC GAGGGAGAGC 900
GCCACAGCGC TGGTTCAGGA GTGGCGCTAC GACCAGACGA CAGCCACCTA CCTTCTGCTG 960
CTGTCAAAGA AGCAGAGGGG CAAACCCGTC CGTCTGCGCC CCGAACTAAG CGTCTGCGAG 1020
GACTCCTGCT CTCCGCTGCA TCAGGGAATT CAGACTGGGG ACGGCCTGCA CTTCAGTGAA 1080
GATGAGGACA TCGTCCTCGT GAGGTCTCTA GATTTCGTCT CGGACTACAT AGACGATTGC 1140
CCCTGGTTGT CACGGGAGAC GCCCAAGAAA CTCGTATCCG AATCTCCGTC CAAAAAAAGC 1200
GCTTCCAGTC GGACTCCGGA GAGGGGCCGA ACGACCCCCC AGCACCGCCA GGAGCGCAGG 1260
GACAGAGACA GGGAGCGAAC GGCGGAGAAC AAGGAGAACG TGGCGGCGCA GGACAGAGAC 1320
GTGGACCTGT TTGCGTTGCC TCCTCCGCGC ACGCCGGCAT CCAGCAGGAA GAACGCGCGG 1380
CAGAAGAACG CGCTCACCTC GCCCAATCAC AACGCCAGCG GCGCTAAAGT TTCCCTCCGG 1440
TGTCTGTCAG ACTCGTCTCC GCACACCAAA GCTTTCGAGT TGACTTCAGT GTCAAACGCA 1500
GTCGGTCCTG AGAGAAGGTC TCGCTCCCTG GACATGGCTG TGACCGGAGA CAGCGGGAAG 1560
AAGAAACGAG GAGGGAAGGT CTTCGGCTCT CTGGAGAGAG GCCTGGACAA GATGATCAAC 1620
ATGCTCACTC CCAGCAAGAG ACGAGCTCTG CGCGACGGCC CGCGCAAGAT CAGGCCACAG 1680
TACAATGTGA CTCTGACCAG TCAGACCAAC CCAGACCAGG TCCTGAACCA GATCCTCTCC 1740
ATCCTACCGG AGAAAAACGT GGATTTCACA CAGAAGGGGT ACACCCTCAA GTGTCGGACC 1800
AAGGGCGACT TCGGGAAGGT AACCATGGCG TTCGAGCTGG AGGTGTGCCT GCTGCAGAGG 1860
CCAGAGGTCG TCGGAGTCCG CAGGCAGAGG CTGAAGGGCG ACGCCTGGGT CTACAAACAC 1920
CTGGTGGAAG ACATCCTCTC CACATCTCGC ATTTAA 1956
Domain Profile
S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60
         y+l +t+G+g f+kVkl +h +t+ekva+Ki++k+ l ++ l ++k Eie++k+l+h++i
Q: 11    YELYETIGSGGFAKVKLGRHILTGEKVAIKIMNKRDLGDD-LPRVKVEIEAMKNLSHQHI  69
         999*******************************999755.89*****************
S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120
         ++l++viet++++++v+ey++ggeLfdyi +k rl+e+e+r +f+q+vsa+ Y+hs+g +
Q: 70    CRLYHVIETSTQIFMVMEYCTGGELFDYIIAKDRLSEEETRVFFRQIVSAMAYVHSQGYA  129
         ************************************************************
S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178
         HrDlKpeNll+d+++n+k++DFGl++++k g    l t+cGsp+YaaPel++gk Y g++
Q: 130   HRDLKPENLLIDEDHNLKLIDFGLCAITKGGlgYELMTCCGSPAYAAPELIQGKAYIGSE  189
         **************************999988899*************************
S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238
         +DvWs+Gv+L+al++g lPfd++n+  l++ki++gk++ p +ls+  + Ll+++++vdp+
Q: 190   ADVWSMGVLLFALLCGYLPFDDDNCMILYRKITRGKYDNPRWLSPGSILLLNQMMQVDPK  249
         ************************************************************
S: 239   kRatieeilkhewl  252
         +R+t+e++l h+w+
Q: 250   RRLTVEQLLGHPWV  263
         *************7
Domain Sequence
(FASTA)
YELYETIGSG GFAKVKLGRH ILTGEKVAIK IMNKRDLGDD LPRVKVEIEA MKNLSHQHIC 60
RLYHVIETST QIFMVMEYCT GGELFDYIIA KDRLSEEETR VFFRQIVSAM AYVHSQGYAH 120
RDLKPENLLI DEDHNLKLID FGLCAITKGG LGYELMTCCG SPAYAAPELI QGKAYIGSEA 180
DVWSMGVLLF ALLCGYLPFD DDNCMILYRK ITRGKYDNPR WLSPGSILLL NQMMQVDPKR 240
RLTVEQLLGH PWV 253
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00232
EKS-ANC-00242
EKS-BOT-00247
EKS-CAE-00220
EKS-CAJ-00256
EKS-CAF-00258
EKS-CAP-00276
EKS-CII-00148
EKS-CIS-00025
EKS-DAR-00571
EKS-EQC-00244
EKS-FEC-00234
EKS-GAG-00208
EKS-GAA-00309
EKS-GOG-00250
EKS-HOS-00261
EKS-ICT-00236
EKS-LAC-00262
EKS-MAM-00250
EKS-MEG-00190
EKS-MOD-00249
EKS-MUM-00259
EKS-MYL-00249
EKS-NOL-00231
EKS-ORN-00325
EKS-ORA-00215
EKS-ORC-00223
EKS-ORL-00312
EKS-OTG-00257
EKS-PAT-00239
EKS-PES-00221
EKS-PEM-00133
EKS-POA-00246
EKS-PTV-00021
EKS-RAN-00248
EKS-SAH-00236
EKS-SUS-00214
EKS-TAG-00265
EKS-TAR-00318
EKS-TAS-00013
EKS-XET-00329
EKS-XIM-00316
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0048821; P:erythrocyte development
GO:0008016; P:regulation of heart contraction
KEGG
InterPros
IPR001772; Kinase-assoc_KA1.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF02149; KA1; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50032; KA1; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013