EKS-TEN-00212
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00212
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC471.68.3E-142271529259
StatusUnreviewed
Ensembl ProteinENSTNIP00000021149
UniProt AccessionH3DKV1;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCA (2 of 2)
Gene Synonyms/Alias PRKCA (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000017985ENSTNIP00000021149ENSTNIT00000021382
OrganismTetraodon nigroviridis
Functional Description
Protein Length603
Protein Sequence
(FASTA)
VCCFVVHKRC HEFVTFCCPG ADKGPDTDDP RSKHKFKIHT YGSPTFCDHC GSLLYGLIHQ 60
GMKCDTCDMN VHKQCVVNVP SLCGTDHTER RGRLFLKIEV KLDRLHVTVG EARNLIPMDP 120
NGLSDPYVKL KITPDPKNET KQKTKTIRSS LNPCWNESFT FKLKASDKDR RLSVEVWDWD 180
RTTRNDFMGS MSFGVSELIK APHCGWYKLL SQEEGEYYNV PIPEVDDVNL ELRQKFEKAK 240
LGQGKKMITP SDHRRFSLPS GNMDRVRLSD FNFLALLGKG SFGKVMLAEM KSTEELYAIK 300
ILKKDVVIQD DDVECTMVEK RVLAQRDKPP FLTQLHSCFQ TVDRLYFVME YINGGDLMYH 360
IQRMGKFKEP QAVFYAAEIA VGLFFLHRKG IIYRDLKLDN VMLDSEGHIK IADFGMCKEN 420
MYEGITTRTF CGTPDYIAPE IIAYQPYGKS VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ 480
SIMEHNVSYP KSMSKEAVSI CKGLMTKHPS KRLGCGPEGE MDIREQVFFR RIDWDRLANR 540
EIQPPFKPKV GGKGAENFDK FFTRTQPVTP PDQLVIANID QSEFEGFSYV NPQFVPASLH 600
SVV 603
Nucleotide Sequence
(FASTA)
GTCTGCTGTT TTGTGGTCCA CAAGCGGTGC CATGAATTCG TCACCTTCTG CTGTCCCGGA 60
GCCGACAAGG GTCCTGACAC AGATGACCCC AGGAGCAAAC ACAAGTTCAA GATCCACACG 120
TACGGGAGCC CCACCTTCTG TGACCACTGT GGATCTCTGC TGTACGGCCT CATCCACCAG 180
GGGATGAAAT GTGACACCTG CGACATGAAC GTGCACAAGC AGTGTGTGGT CAACGTGCCC 240
AGCCTGTGCG GCACCGACCA CACGGAGCGC CGCGGCCGCC TCTTCCTGAA GATCGAGGTG 300
AAGCTGGACA GGCTACACGT CACAGTGGGA GAAGCCAGGA ACCTGATCCC CATGGACCCC 360
AACGGCTTAT CAGACCCCTA CGTCAAACTC AAAATCACCC CCGACCCCAA AAACGAGACC 420
AAGCAGAAGA CCAAGACCAT CCGCTCGTCC CTCAACCCCT GCTGGAACGA GTCCTTCACC 480
TTCAAGCTGA AAGCGTCGGA CAAGGACCGC CGTCTGTCTG TGGAGGTGTG GGACTGGGAC 540
CGGACCACCA GGAACGACTT CATGGGCTCC ATGTCCTTCG GCGTGTCGGA GCTGATCAAG 600
GCGCCTCACT GCGGATGGTA CAAGCTGCTC AGCCAGGAGG AGGGGGAGTA CTACAACGTT 660
CCCATCCCCG AGGTGGACGA CGTGAACCTG GAGCTGCGGC AGAAGTTCGA GAAGGCCAAA 720
CTGGGCCAGG GCAAGAAGAT GATCACGCCA TCGGACCACC GGCGCTTCAG CCTGCCCTCG 780
GGGAACATGG ACCGGGTCCG GCTGAGCGAC TTCAACTTCC TGGCCCTGCT GGGAAAGGGC 840
AGCTTCGGCA AGGTCATGCT GGCGGAGATG AAGTCGACGG AGGAGCTGTA CGCCATCAAG 900
ATCCTGAAGA AGGACGTGGT CATCCAGGAC GACGACGTGG AATGCACCAT GGTGGAGAAG 960
AGGGTGCTGG CGCAGCGGGA CAAGCCTCCG TTCCTCACGC AGCTGCACTC CTGCTTCCAG 1020
ACTGTGGATC GCCTCTACTT TGTGATGGAG TACATCAACG GCGGAGACCT GATGTACCAC 1080
ATCCAGCGGA TGGGCAAATT CAAGGAGCCG CAGGCGGTGT TCTACGCCGC CGAGATCGCC 1140
GTGGGTTTGT TCTTCTTGCA CCGAAAGGGA ATCATCTACA GGGACCTGAA GCTGGACAAC 1200
GTGATGCTGG ACTCCGAGGG CCACATCAAG ATCGCCGACT TCGGCATGTG TAAGGAGAAC 1260
ATGTACGAGG GCATCACCAC GCGCACCTTC TGCGGGACCC CCGACTACAT CGCACCAGAG 1320
ATTATAGCGT ACCAGCCCTA CGGGAAGTCA GTGGACTGGT GGGCCTATGG GGTCCTGCTC 1380
TACGAGATGC TGGCTGGACA GCCTCCGTTT GACGGGGAGG ATGAAGACGA GCTCTTCCAG 1440
TCAATCATGG AGCACAACGT GTCCTACCCC AAGTCCATGT CCAAAGAGGC CGTGTCCATC 1500
TGCAAAGGAC TGATGACCAA GCATCCGTCC AAGCGTCTCG GCTGTGGTCC AGAGGGCGAG 1560
ATGGACATCA GGGAGCAGGT CTTCTTCCGG CGCATCGACT GGGATCGGCT GGCGAACCGG 1620
GAGATCCAAC CGCCGTTTAA ACCAAAAGTG GGTGGCAAAG GAGCAGAGAA CTTCGACAAG 1680
TTCTTCACGC GCACGCAGCC GGTGACGCCT CCCGACCAGC TGGTCATCGC CAACATCGAC 1740
CAGAGCGAGT TCGAAGGGTT CTCCTACGTG AACCCTCAGT TCGTCCCTGC GTCCCTGCAC 1800
AGCGTGGTAT GA 1812
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l +lGkGsfgkv+lae+k+t+elyaik+lkkdvv+qdddve+t+vekrvla+ +k+p
Q: 271   FNFLALLGKGSFGKVMLAEMKSTEELYAIKILKKDVVIQDDDVECTMVEKRVLAQRDKPP  330
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt drl+fv+ey+nGGdlm+hiq+++k+ke++a+fyaaei+++l+flh+kg
Q: 331   FLTQLHSCFQTVDRLYFVMEYINGGDLMYHIQRMGKFKEPQAVFYAAEIAVGLFFLHRKG  390
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke+++eg tt+tfcGtPdyiaPei+++++ygks
Q: 391   IIYRDLKLDNVMLDSEGHIKIADFGMCKENMYEGITTRTFCGTPDYIAPEIIAYQPYGKS  450
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPks+skeav+i+kgl+tk+p+
Q: 451   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSMSKEAVSICKGLMTKHPS  510
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+di+e+ ff
Q: 511   KRLGCGPEGEMDIREQVFF  529
         *****************98
Domain Sequence
(FASTA)
FNFLALLGKG SFGKVMLAEM KSTEELYAIK ILKKDVVIQD DDVECTMVEK RVLAQRDKPP 60
FLTQLHSCFQ TVDRLYFVME YINGGDLMYH IQRMGKFKEP QAVFYAAEIA VGLFFLHRKG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEN MYEGITTRTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSMSKEAVSI CKGLMTKHPS 240
KRLGCGPEGE MDIREQVFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00165
EKS-BOT-00169
EKS-CAJ-00173
EKS-CAF-00176
EKS-CAP-00169
EKS-DAR-00460
EKS-EQC-00167
EKS-FEC-00159
EKS-GAM-00089
EKS-GAA-00203
EKS-GOG-00167
EKS-ICT-00164
EKS-LAC-00179
EKS-MEG-00134
EKS-MYL-00178
EKS-NOL-00162
EKS-ORN-00213
EKS-ORA-00149
EKS-ORC-00155
EKS-ORL-00198
EKS-PES-00149
EKS-PRC-00045
EKS-SAH-00163
EKS-TAG-00197
EKS-TAR-00221
EKS-XIM-00209
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013