EKS-TEN-00616

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00616

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	349.3	1.2E-104	18	273	256

Status

Unreviewed

Ensembl Protein

ENSTNIP00000021194

UniProt Accession

H3DKZ6;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000018028	ENSTNIP00000021194	ENSTNIT00000021428

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

889

Protein Sequence
(FASTA)

MGPLRDAQLG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTVIH PRLCHYVDIS 60

RGKHERLIVV AEHYESNLSD FQKQGKAVSP EKVLRIAYEV LEGLEFMNKH GLVHRALGAH 120

NVLMDCKGNV KLAKFGLYHM TDHGADVDFP IGYPSYLAPE VIAQGCFHPS DSSHDEAPLP 180

SGPKTDVWSL GVLLFELCAG RRLLQNIDLS DRLKFILNLG CMDDIVTVLA EEHGCLDTIK 240

ELPPNVLELL RKCLTFLPPK RLTPAELLRD PVFSSVSCLY TPFLKPVSLF SSSLRCAHLE 300

LPDDINDLCK VDDDEDYLSE RAINEVYHLW CLAGGDLEKE LINKDIIQSK PPICTLPNFV 360

LEDGESFGQG RDRSFLLDDT TVTLSLCQLR NRLRDVSGEA YYPLLEDEQS SLPQSNSSNE 420

LSATVTLPLI IRERDTEYQL NRIVLFDRLL KAYPYKKNLV WKEARVDIPP LVRGLTWAAL 480

LGIEGDIQSK YESIDKDTPI PTDRQIEVDI PRCHQYDELL SSPQGHVKFR RVLKAWVVSH 540

PDLVYWQGLD SLCAPFLYLN FNNEALAYAC MSAFIPKYLY NFFLKDNSHV IQEYLTVFSQ 600

MIAFHDPELS NHLNEIGFIP DLYAIPWFLT MFTHVFPLHK IFHLWDTLLL GNSSFPFCIG 660

VAILQQLRDR LLANGFNECI LLFSDLPEID IERCVRESIS LFCWTPKSTT YRQHAQPPRA 720

PAENGFGKTA TYYSSEYQDT PKTDLSREPL ALSDLKAEVS PRISADDLID LCELSSAGLA 780

KRTRAGKPKI IAVDIRPVED FNRGHITGSV SVPFSTAFSP DGELLQCPTS GILHNYKGRV 840

IVVISHAMKT AATFAAHLVK VAFPRVCILD GGINKLKPTG LLTVPSPQI 889

Nucleotide Sequence
(FASTA)

ATGGGCCCCC TCAGGGACGC ACAGCTGGGG GCCTTCACCT TCTTTGCCTC AGCTCTCCCT 60

CATGACGTCT GTGGCAGTAA TGGCCTCCCC CTCACCCCCA ACTCCATCAA AATCCTGGGA 120

CGATTCCAGA TCCTCAAGAC TGTTATACAC CCCAGACTTT GTCACTATGT TGACATCTCC 180

AGAGGCAAAC ACGAACGGCT GATCGTTGTT GCCGAACACT ATGAAAGCAA TTTAAGTGAT 240

TTCCAGAAGC AGGGAAAGGC AGTCAGCCCA GAAAAGGTGC TGCGAATCGC CTATGAGGTC 300

CTCGAGGGTC TGGAGTTCAT GAACAAGCAC GGTCTGGTTC ACCGAGCGCT CGGCGCTCAC 360

AACGTTCTCA TGGACTGCAA GGGAAATGTC AAGCTGGCAA AGTTCGGCCT TTATCACATG 420

ACCGATCATG GAGCTGACGT AGACTTCCCC ATTGGGTACC CATCATACCT TGCTCCAGAG 480

GTCATCGCTC AGGGCTGCTT TCACCCCAGT GACTCTTCCC ACGATGAAGC TCCTCTTCCC 540

TCCGGACCCA AGACTGATGT CTGGTCTCTC GGCGTTCTGC TCTTTGAATT ATGCGCAGGC 600

AGGCGACTGC TGCAGAATAT CGATTTAAGC GACAGGTTGA AATTCATTCT GAACCTGGGC 660

TGCATGGATG ACATTGTCAC TGTCCTTGCT GAGGAACACG GTTGCCTGGA TACCATTAAG 720

GAGCTGCCTC CAAATGTTCT CGAGTTATTG AGGAAGTGTT TGACTTTTCT TCCACCCAAA 780

AGGCTGACCC CTGCAGAGCT GCTGCGAGAC CCCGTCTTCA GCAGCGTCTC CTGCCTCTAC 840

ACACCCTTCC TGAAACCCGT GAGCCTCTTC TCCTCCTCGC TGCGCTGTGC ACATCTGGAG 900

CTACCGGACG ACATCAACGA CCTCTGCAAA GTAGATGATG ATGAAGATTA CCTGTCTGAG 960

CGCGCCATAA ACGAGGTGTA CCACCTGTGG TGCTTGGCTG GAGGAGACCT GGAGAAGGAG 1020

CTGATCAACA AGGATATCAT CCAGTCAAAA CCTCCCATCT GCACCCTGCC CAATTTTGTC 1080

CTGGAAGACG GGGAGTCGTT CGGTCAGGGA CGGGATCGAA GTTTCTTACT CGACGACACA 1140

ACAGTGACGC TCTCGCTCTG CCAACTCAGA AACAGACTGA GGGATGTATC AGGGGAAGCC 1200

TATTACCCTC TACTGGAGGA CGAGCAGTCA AGTCTCCCCC AGTCCAACAG CAGCAACGAA 1260

CTGTCGGCCA CCGTCACGCT GCCCCTCATC ATCCGGGAGA GAGACACCGA GTACCAACTG 1320

AACCGCATCG TCCTCTTTGA CAGGCTGCTC AAGGCGTATC CTTACAAGAA GAACCTGGTC 1380

TGGAAAGAGG CCAGAGTGGA CATCCCTCCT CTGGTTCGGG GGCTGACTTG GGCTGCGCTG 1440

CTTGGCATTG AGGGAGACAT TCAATCCAAA TATGAAAGCA TTGACAAGGA CACTCCCATA 1500

CCCACAGACA GACAGATCGA GGTGGACATC CCCCGCTGCC ACCAGTACGA TGAGCTGCTG 1560

TCGTCCCCCC AGGGTCATGT CAAGTTTAGG CGCGTTCTAA AAGCCTGGGT GGTCTCCCAT 1620

CCCGACCTAG TCTACTGGCA GGGCTTGGAT TCACTTTGCG CCCCGTTCCT CTACTTGAAT 1680

TTCAACAACG AAGCTCTAGC ATACGCATGC ATGTCTGCCT TCATCCCCAA ATACTTGTAC 1740

AATTTCTTCC TGAAGGACAA CTCTCACGTC ATCCAAGAGT ACTTGACTGT CTTCTCCCAG 1800

ATGATTGCCT TCCATGACCC GGAGCTCAGC AACCATCTGA ATGAGATTGG CTTCATCCCA 1860

GATCTTTATG CCATTCCTTG GTTCCTGACT ATGTTCACAC ATGTGTTTCC ACTACACAAG 1920

ATCTTCCACC TGTGGGACAC GCTGCTGTTG GGTAACTCCT CTTTCCCCTT CTGCATCGGC 1980

GTGGCCATCC TGCAGCAGCT CAGAGATCGC CTCTTGGCTA ACGGCTTCAA CGAGTGCATC 2040

CTGCTCTTCT CAGACCTGCC TGAAATTGAC ATCGAGCGAT GTGTTCGGGA ATCCATCAGT 2100

CTGTTCTGCT GGACTCCGAA GAGCACCACG TACCGACAAC ACGCTCAACC GCCAAGGGCA 2160

CCCGCCGAAA ACGGCTTTGG CAAAACAGCG ACGTACTACA GCTCTGAATA CCAGGACACA 2220

CCCAAGACCG ACTTGTCACG GGAGCCGCTG GCGCTCTCTG ACCTGAAAGC AGAAGTGTCT 2280

CCCAGAATCT CGGCGGACGA CTTAATCGAC CTCTGCGAGC TGTCCTCAGC CGGCCTGGCG 2340

AAGAGAACCA GAGCTGGCAA GCCCAAAATC ATCGCTGTCG ACATCCGCCC CGTAGAGGAC 2400

TTCAACAGAG GCCACATCAC TGGTAGCGTC AGCGTTCCGT TCAGCACAGC GTTCAGCCCT 2460

GACGGCGAGC TCCTGCAGTG CCCCACCTCG GGAATCCTTC ACAACTACAA AGGCCGCGTC 2520

ATTGTGGTCA TTAGCCACGC CATGAAGACC GCGGCTACGT TTGCAGCACA CCTGGTTAAA 2580

GTGGCCTTTC CACGGGTTTG CATCCTGGAC GGAGGCATCA ACAAGCTGAA GCCCACGGGC 2640

CTCCTCACTG TCCCTTCCCC CCAGATCTGA 2670

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk++ h+rLc Y+disrgkher+ivvaeh+e +

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTVIHPRLCHYVDISRGKHERLIVVAEHYESN  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         L D+ k++k vs  +vlriayevl+gl+++nkh++vhral  +++l+d kg+ vkLak+G

Q: 78    LSDFQKQGKAVSPEKVLRIAYEVLEGLEFMNKHGLVHRALGAHNVLMDCKGN-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+t++G+dvdfpigy+sylaPe+i+q+         ++ +l++++k DvWsLg++l+e

Q: 137   LYHMTDHGADVDFPIGYPSYLAPEVIAQGcfhpsdsshDEAPLPSGPKTDVWSLGVLLFE  196

         ************************************9999********************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l+ g++L +++dls+rlk++l+l++ d+ + +laee++cld ik+l+ ++ +ll+kCLt+

Q: 197   LCAGRRLLQNIDLSDRLKFILNLGCMDDIVTVLAEEHGCLDTIKELPPNVLELLRKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         lp kR +p ell+++vf

Q: 257   LPPKRLTPAELLRDPVF  273

         **************997

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT VIHPRLCHYV DISRGKHERL IVVAEHYESN 60

LSDFQKQGKA VSPEKVLRIA YEVLEGLEFM NKHGLVHRAL GAHNVLMDCK GNVKLAKFGL 120

YHMTDHGADV DFPIGYPSYL APEVIAQGCF HPSDSSHDEA PLPSGPKTDV WSLGVLLFEL 180

CAGRRLLQNI DLSDRLKFIL NLGCMDDIVT VLAEEHGCLD TIKELPPNVL ELLRKCLTFL 240

PPKRLTPAEL LRDPVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013