EKS-TEN-00091

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00091

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	350.6	6.7E-105	9	295	287

Status

Unreviewed

Ensembl Protein

ENSTNIP00000021406

UniProt Accession

H3C1K9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK4

Gene Synonyms/Alias

CDK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000018240	ENSTNIP00000002125	ENSTNIT00000002180
ENSTNIG00000018240	ENSTNIP00000021406	ENSTNIT00000021641

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

297

Protein Sequence
(FASTA)

MAHGTSVQYE PVAEIGGGAY GTVYKARDTE SGKFVALKSV RVQTDQNGLP VSTVREVALL 60

RRLEQFDHPN VVRLMDVCAT QRSEQETKVT LVFEHVDQDL KTYLEKAPAP GLPPGRIKDL 120

MRQLLCGLAF LHSNRVMHRD LKPENILVTS QGQVKLADFG LARMYSCHMP LTPVVVTLWY 180

RPPEVLLQSG YATPVDIWST GCIFAEMFRR KPLFCGESEV DQLTKIIKVL GLPSEEEWPT 240

DVTLSRKNFP SVSPSPITDF VPEISESGAQ LLLKMLTFDP AKRISALNAL EHPYFQN 297

Nucleotide Sequence
(FASTA)

ATGGCCCACG GCACCAGTGT CCAGTACGAG CCAGTGGCGG AGATCGGAGG CGGAGCTTAC 60

GGGACGGTTT ACAAGGCCCG GGATACGGAG AGCGGGAAGT TCGTGGCGCT GAAGAGCGTA 120

CGCGTCCAGA CGGATCAAAA TGGCCTCCCG GTCTCCACGG TCCGAGAAGT GGCTCTGCTG 180

CGGAGGCTGG AGCAGTTCGA CCACCCCAAC GTGGTTCGGC TCATGGATGT GTGCGCCACC 240

CAGAGGTCGG AACAGGAGAC CAAAGTCACC CTGGTTTTTG AGCACGTGGA CCAGGACCTG 300

AAGACGTACC TAGAGAAAGC CCCCGCGCCC GGATTACCCC CCGGTCGCAT CAAAGACCTG 360

ATGCGACAGC TGCTGTGCGG TCTCGCCTTC CTCCACTCCA ATCGGGTGAT GCATCGAGAC 420

TTGAAGCCGG AGAACATCCT GGTGACCAGC CAGGGCCAGG TGAAGCTGGC CGACTTCGGC 480

CTGGCCAGGA TGTACAGCTG CCACATGCCG CTCACCCCCG TGGTGGTGAC CTTGTGGTAC 540

CGGCCACCGG AGGTGCTGCT GCAGTCCGGT TACGCCACAC CTGTAGACAT ATGGAGCACC 600

GGCTGCATCT TTGCCGAGAT GTTCCGACGC AAACCTTTAT TCTGCGGAGA ATCCGAAGTG 660

GACCAACTTA CGAAGATTAT CAAGGTCCTC GGCTTGCCTT CAGAGGAGGA GTGGCCAACC 720

GATGTTACGC TGTCCAGAAA AAACTTCCCG TCGGTCTCTC CCAGCCCCAT CACCGACTTC 780

GTTCCAGAGA TCAGCGAGTC CGGAGCTCAG CTGTTGTTGA AAATGCTGAC CTTTGACCCC 840

GCCAAACGAA TCTCGGCCCT GAACGCGCTA GAGCACCCGT ACTTTCAGAA CTAG 894

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkel...kh  57

         ye +++ig G+yg+vyka+d+e+g++vAlK++r++++++g+p++++rE++ll++l   +h

Q: 9     YEPVAEIGGGAYGTVYKARDTESGKFVALKSVRVQTDQNGLPVSTVREVALLRRLeqfDH  68

         88899************************************************998889*

S: 58    knivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl  113

         +n+v+L++v+a    ++++k++Lvfe+++qdLk++l+k ++ +l++ ++k l++qll gl

Q: 69    PNVVRLMDVCAtqrsEQETKVTLVFEHVDQDLKTYLEKAPAPGLPPGRIKDLMRQLLCGL  128

         ***********99877789*****************************************

S: 114   aylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLl  173

         a+lHsn+++HRDlKp+N+L++++g++klaDfGlar +s ++  +t++vvTlwYr+Pe+Ll

Q: 129   AFLHSNRVMHRDLKPENILVTSQGQVKLADFGLARMYSCHMP-LTPVVVTLWYRPPEVLL  187

         *************************************99887.*****************

S: 174   gakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpe  233

         ++  Y t vDiWs gci+ae+++rkplf g+se+dql++i+k+lg pse++wp+  +l++

Q: 188   QS-GYATPVDIWSTGCIFAEMFRRKPLFCGESEVDQLTKIIKVLGLPSEEEWPTDVTLSR  246

         88.5*************************************************9999998

S: 234   ykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

            +fp+ +++ +++ v++++e++ +ll k+l++dp+kRisa +al+h+yf

Q: 247   K--NFPSVSPSPITDFVPEISESGAQLLLKMLTFDPAKRISALNALEHPYF  295

         5..6**********************************************9

Domain Sequence
(FASTA)

YEPVAEIGGG AYGTVYKARD TESGKFVALK SVRVQTDQNG LPVSTVREVA LLRRLEQFDH 60

PNVVRLMDVC ATQRSEQETK VTLVFEHVDQ DLKTYLEKAP APGLPPGRIK DLMRQLLCGL 120

AFLHSNRVMH RDLKPENILV TSQGQVKLAD FGLARMYSCH MPLTPVVVTL WYRPPEVLLQ 180

SGYATPVDIW STGCIFAEMF RRKPLFCGES EVDQLTKIIK VLGLPSEEEW PTDVTLSRKN 240

FPSVSPSPIT DFVPEISESG AQLLLKMLTF DPAKRISALN ALEHPYF 287

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013