EKS-TEN-00053

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00053

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	288.3	7.3E-86	678	946	269

Status

Unreviewed

Ensembl Protein

ENSTNIP00000021743

UniProt Accession

H3DMJ5;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000018569	ENSTNIP00000021743	ENSTNIT00000021978

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

957

Protein Sequence
(FASTA)

NESLGMALLH MSHQALQTWL HTSSVLCFSL SYLDCIPKCF AKHIAKDNFL TKVRIQRMFA 60

DSVRTFQEHT VDKGRLGMQK TMFKYISTLE RLVPSFGVES FYVSHLNLRE AWEESGSLHT 120

HAPCEDRAAA THEIMVNGNK GIWWRISIQT EQAATQPHKD TPHKWNVFCD FPEITHIVIS 180

EANVCISTQD NHCMEVQMSS SQEARSFISL LDGYYRLTAD AHHYLCHDVA PPRVLLNKAN 240

GLHGPMHIYF ALQKLKKEAA EDKAFLICWS PVNYDRLILV ALNKSHCFVQ NGQAQDHKQF 300

QIQHKDSKFC LDGWNREFSS VKELTDSLKS LVLISGSESL TIKKCCLPRH GELSNLLVLR 360

APLQPLSNKT QVQVRHIKET EIVQGRHLGC GTKTNIHKGS LQVRSTEDGD QENEFNNNSS 420

GLDIPVVLKI PHQNLEVSLA FIETVGIMGQ LSHSHLVRVH GLSVLKHIMV EEWVKFGPLD 480

VFLHREKASV SAHWKLIVAM QLASALRYLF DLSGVLNQQC SCRIRFNILD QVTTRFSQQL 540

PQFQGIGAFS PTERLERIPW IAPECIDGGV SIRSNPDQWS FGATFLEICY NGNLPMSTIT 600

LSEKERFYQQ KGRLPVLSSK TVSNFINTCL AYDPTERPSF RIVLRELSEF MKTITAPDLS 660

PSETLPYTGH RIFHKRFLKM QQVLGEGNFG KVILYRYDPA NDDTGELVAV KTLKRENGNT 720

EGWIKEINVL KSLDHRNIVK YKGCCSEGGG QGLLLIMEFL PLGSLLKYLP KNKLNLSQLM 780

IFAQQICEGM EYLHSKRYIH RDLAARNVLL DRDRLVKIGD FGLTKHIPTG ELYYRVSENG 840

ENPVFWFAVE CLKENKFSFA SDVWSFGVTL YEILTHCDPK QSPRKKFEEM LEPKSLINQV 900

PLIELLEKKM RLPCPKNCPQ EVRIIMEQCW AAEPKQRPSF RSLIEKFQEM CHGEKFS 957

Nucleotide Sequence
(FASTA)

AACGAGAGCC TGGGAATGGC TCTGCTCCAC ATGTCACACC AGGCATTACA AACATGGCTG 60

CACACTTCAA GCGTGTTGTG TTTTTCTTTA AGCTATTTAG ACTGCATCCC AAAGTGTTTC 120

GCCAAACACA TTGCCAAAGA CAACTTCCTT ACAAAAGTAA GGATTCAGCG GATGTTTGCA 180

GATTCTGTGC GGACTTTTCA GGAGCACACT GTGGACAAAG GGCGACTCGG TATGCAAAAG 240

ACCATGTTTA AGTACATCTC TACCCTTGAA CGTTTGGTGC CAAGTTTTGG TGTGGAGAGC 300

TTCTATGTTT CGCACCTAAA TCTGAGAGAG GCATGGGAGG AAAGTGGCTC TTTGCACACG 360

CATGCACCGT GTGAAGACAG AGCAGCTGCT ACACATGAAA TAATGGTGAA CGGCAACAAG 420

GGCATCTGGT GGAGAATATC CATTCAAACG GAACAAGCAG CAACACAACC ACACAAAGAC 480

ACTCCCCATA AATGGAATGT CTTCTGTGAC TTCCCAGAAA TAACCCATAT AGTCATTAGT 540

GAGGCTAATG TGTGTATTAG CACTCAGGAC AATCACTGCA TGGAGGTTCA AATGAGCTCC 600

AGCCAAGAGG CCCGTTCCTT TATCTCCCTT CTAGATGGAT ACTATCGGCT GACTGCAGAC 660

GCCCACCACT ATCTTTGTCA TGATGTGGCT CCCCCAAGGG TGCTGCTGAA CAAAGCAAAT 720

GGACTGCATG GACCTATGCA TATTTATTTT GCACTTCAAA AGCTGAAAAA GGAAGCAGCT 780

GAGGATAAGG CTTTCCTCAT ATGTTGGAGT CCTGTGAATT ATGACCGCCT TATACTGGTT 840

GCCCTTAATA AAAGTCATTG TTTTGTACAG AATGGCCAAG CACAGGACCA CAAACAGTTT 900

CAGATTCAGC ACAAAGATTC AAAGTTCTGT CTGGATGGTT GGAACCGAGA GTTCTCCAGT 960

GTGAAGGAGC TCACAGACAG TCTCAAGAGT TTGGTGCTCA TCTCTGGTTC AGAAAGCTTA 1020

ACTATCAAGA AATGCTGCTT GCCACGACAT GGAGAGCTAT CCAATCTATT GGTTTTGAGG 1080

GCTCCCTTAC AACCTTTATC GAACAAGACC CAGGTACAGG TACGCCACAT CAAGGAGACA 1140

GAGATTGTGC AGGGACGGCA TTTGGGCTGT GGGACAAAGA CAAACATCCA TAAAGGGTCT 1200

CTGCAAGTTC GCAGCACAGA AGATGGTGAT CAAGAGAATG AATTCAACAA CAACTCAAGT 1260

GGCCTTGACA TCCCGGTGGT TCTTAAGATT CCACATCAAA ACCTTGAAGT TTCACTTGCA 1320

TTTATTGAAA CTGTAGGAAT CATGGGCCAG CTGTCCCACA GTCATTTGGT GCGCGTTCAT 1380

GGTCTGTCAG TACTGAAACA TATCATGGTG GAAGAATGGG TGAAATTTGG GCCTCTTGAT 1440

GTCTTCCTCC ATCGTGAAAA AGCCTCAGTA TCTGCTCATT GGAAACTCAT TGTTGCGATG 1500

CAACTTGCCA GTGCTTTAAG ATACCTGTTT GATCTATCTG GTGTGTTAAA TCAACAGTGT 1560

AGTTGTCGAA TCAGGTTTAA TATACTTGAT CAAGTAACTA CCCGTTTTAG CCAGCAATTG 1620

CCACAATTTC AGGGCATTGG AGCTTTTAGT CCAACAGAAC GTCTGGAGCG CATCCCATGG 1680

ATTGCCCCAG AGTGTATTGA CGGTGGTGTA TCCATCAGGA GTAATCCTGA TCAGTGGAGT 1740

TTTGGAGCAA CTTTCCTTGA AATATGCTAT AATGGAAATC TTCCAATGAG TACCATCACA 1800

TTATCTGAGA AAGAGCGTTT TTACCAGCAA AAGGGACGGC TGCCTGTCCT CTCCTCCAAG 1860

ACAGTGTCCA ACTTTATCAA CACGTGCTTG GCTTATGACC CAACGGAGAG GCCTTCCTTT 1920

CGCATTGTGC TCAGAGAACT CTCAGAGTTC ATGAAAACAA TCACAGCTCC TGATTTATCA 1980

CCAAGTGAAA CCCTTCCATA CACGGGCCAT AGAATATTCC ATAAACGCTT TCTAAAAATG 2040

CAGCAAGTCT TAGGAGAGGG TAACTTTGGA AAGGTGATTC TCTACAGGTA CGACCCAGCC 2100

AATGATGATA CTGGGGAGCT TGTAGCAGTA AAGACATTGA AACGAGAAAA TGGCAACACT 2160

GAGGGCTGGA TAAAGGAAAT AAATGTTCTT AAGTCGCTTG ATCATCGCAA CATTGTGAAG 2220

TACAAGGGCT GTTGTTCTGA AGGAGGTGGA CAAGGGCTGC TGCTAATAAT GGAGTTCCTT 2280

CCACTTGGGA GTCTGCTGAA GTACCTTCCC AAGAACAAGC TGAACTTGTC CCAGTTGATG 2340

ATATTTGCTC AGCAAATCTG TGAGGGTATG GAGTACCTAC ATTCCAAGCG ATACATCCAT 2400

CGAGACCTCG CTGCCCGAAA TGTTTTGTTG GACAGAGACA GACTGGTCAA GATTGGAGAT 2460

TTTGGCCTCA CAAAACACAT CCCCACTGGA GAGTTGTATT ACCGTGTCAG TGAGAATGGG 2520

GAGAATCCAG TCTTCTGGTT TGCTGTTGAG TGTTTAAAGG AGAACAAATT TTCCTTTGCT 2580

TCTGATGTTT GGTCCTTTGG GGTCACGTTA TATGAAATCT TGACTCACTG TGACCCCAAG 2640

CAGAGTCCTC GAAAGAAATT TGAAGAAATG CTGGAACCAA AATCTCTAAT AAACCAAGTG 2700

CCACTCATTG AACTTTTGGA GAAGAAAATG CGACTCCCTT GTCCCAAAAA CTGCCCGCAA 2760

GAGGTGAGGA TAATAATGGA GCAATGTTGG GCCGCTGAAC CAAAACAACG GCCATCATTC 2820

AGGTCCCTCA TTGAAAAGTT TCAGGAAATG TGCCATGGGG AAAAGTTTTC TTAA 2874

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60

         lk+++ Lg+g+f+kv ++r+d+ +d+t+e va+k Lk + + + +++ +e+++l++l+h+

Q: 678   LKMQQVLGEGNFGKVILYRYDPANDDTGELVAVKTLK-RENGNTEGWIKEINVLKSLDHR  736

         689999*******************************.888899****************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kg+c ++g +   l+me+++ GsL +yL+k+  +l+ls+l+ +a+q++++meYL+

Q: 737   NIVKYKGCCSEGGGQglLLIMEFLPLGSLLKYLPKN--KLNLSQLMIFAQQICEGMEYLH  794

         ***************99*****************99..9*********************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +k+++hrd+aarnvL++r++       vk++d+gl+k ++++ +Yy v e+++++++w a

Q: 795   SKRYIHRDLAARNVLLDRDRL------VKIGDFGLTKHIPTGeLYYRVSENGENPVFWFA  848

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp.......lrsesle...rklelle  226

         +ecl+e+k +s asdvWsFgvtlye+lt c+ ++sp       l+ +sl+    ++elle

Q: 849   VECLKENK-FSFASDVWSFGVTLYEILThCDPKQSPrkkfeemLEPKSLInqvPLIELLE  907

         ********.***************************88886665555555777789****

S: 227   ekerlpkpk.cpaelaelmtnclsyepsqrpsFrailed  264

         +k rlp+pk cp+e+  +m++c+++ep+qrpsFr ++e+

Q: 908   KKMRLPCPKnCPQEVRIIMEQCWAAEPKQRPSFRSLIEK  946

         ***********************************9986

Domain Sequence
(FASTA)

LKMQQVLGEG NFGKVILYRY DPANDDTGEL VAVKTLKREN GNTEGWIKEI NVLKSLDHRN 60

IVKYKGCCSE GGGQGLLLIM EFLPLGSLLK YLPKNKLNLS QLMIFAQQIC EGMEYLHSKR 120

YIHRDLAARN VLLDRDRLVK IGDFGLTKHI PTGELYYRVS ENGENPVFWF AVECLKENKF 180

SFASDVWSFG VTLYEILTHC DPKQSPRKKF EEMLEPKSLI NQVPLIELLE KKMRLPCPKN 240

CPQEVRIIME QCWAAEPKQR PSFRSLIEK 269

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Danio rerio"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.

Pfam

PF07714

; Pkinase_Tyr; 3.

SMARTs

SM00252	; SH2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013