EKS-TEN-00333

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00333

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	462.6	7.9E-139	154	467	314

Status

Unreviewed

Ensembl Protein

ENSTNIP00000021896

UniProt Accession

H3DMZ8;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK2

Gene Synonyms/Alias

DYRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000018717	ENSTNIP00000021896	ENSTNIT00000022132

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

542

Protein Sequence
(FASTA)

PSALPPQGGA KAAMTDPVQL SHSQVQITQL FEDKRPVPAP QLNGQARPGL PPPEHHPLAA 60

ESPHRGRQGS GASARSTDSK AKAAFVSPEQ AMKQFMSKLS TFEHHEVFSY PEIYFVGPNA 120

KKRVGIMGGA NNGGYDDDQG SYIQVPHDHI AYRYEVLKVI GKGSFGQVVK AYDHKCQTHV 180

ALKMVRNEKR FHRQAAEEIR ILEHLRKQDK DCSMNVIHML ENFTFRNHIC MTFELLSMNL 240

YELIKKNKFQ GFTLPLVRKF AYSILQCLDA LHRNRIIHCD LKPENILLKQ QGRSGIKVID 300

FGSSCYEHQR VYTYIQSRFY RAPEVILGSR YGMPIDMWSL GCILAELLTG YPLLPGEDEG 360

DQLACTMELL GMPSQKLLDA SKRSKNFVSS KGFPRYCTVT TLPDGTSVLN GGRSRRGKAR 420

GPPCSKDWSA ALKGCDDQLF LDFLKQCLEW DPALRMTPSQ ALRHPWLKKR LPKPPGGTGT 480

TDKASRRIGT AAADGALTSI SKIATTSSTA VSSSSKTRTN LASITDANGN IQPRTVLPKL 540

VS 542

Nucleotide Sequence
(FASTA)

CCTTCTGCGC TTCCTCCACA GGGGGGCGCT AAAGCAGCCA TGACGGATCC CGTCCAGCTG 60

TCCCACTCGC AGGTCCAAAT CACCCAGCTG TTTGAGGACA AGCGTCCTGT CCCGGCCCCC 120

CAGCTCAACG GCCAGGCCCG GCCCGGGTTG CCGCCGCCGG AGCACCACCC CCTCGCCGCC 180

GAGTCCCCCC ACCGCGGCCG CCAGGGCAGC GGCGCCTCGG CCAGGTCGAC GGACAGCAAG 240

GCCAAGGCGG CGTTCGTGAG CCCGGAGCAG GCCATGAAGC AGTTCATGTC CAAGCTGTCC 300

ACCTTCGAGC ACCACGAGGT CTTCAGCTAC CCCGAGATCT ACTTTGTCGG TCCCAACGCC 360

AAGAAGCGGG TGGGGATAAT GGGCGGGGCC AACAACGGCG GCTACGACGA CGACCAAGGC 420

TCGTACATCC AGGTTCCGCA CGACCACATC GCCTACCGCT ACGAGGTGCT CAAGGTCATC 480

GGCAAGGGCA GTTTCGGACA GGTGGTGAAG GCCTATGACC ACAAGTGTCA GACCCACGTG 540

GCGCTGAAGA TGGTGCGCAA CGAGAAGCGC TTCCACCGGC AGGCGGCGGA GGAGATCCGC 600

ATCCTGGAGC ACCTGAGGAA GCAGGACAAA GACTGCAGCA TGAACGTCAT CCACATGCTG 660

GAGAACTTCA CCTTCCGCAA CCACATCTGC ATGACCTTCG AGCTGCTCAG CATGAACCTG 720

TACGAGCTCA TCAAGAAGAA CAAGTTCCAG GGCTTCACTC TGCCGCTGGT GCGCAAGTTC 780

GCCTACTCCA TCCTGCAGTG TCTGGACGCG CTGCACCGCA ACCGCATCAT CCACTGCGAC 840

CTGAAGCCCG AAAACATCCT GCTGAAGCAG CAGGGCCGCA GCGGCATCAA GGTGATCGAC 900

TTCGGCTCCA GCTGCTACGA GCACCAGAGG GTCTACACCT ACATCCAGTC CAGGTTTTAC 960

CGAGCGCCGG AGGTCATCTT AGGTTCCCGG TACGGGATGC CCATCGACAT GTGGTCCCTG 1020

GGCTGCATCC TGGCCGAGCT GCTGACGGGC TACCCGCTGC TGCCGGGCGA GGACGAGGGC 1080

GACCAGCTGG CCTGCACCAT GGAGCTGCTG GGCATGCCCA GCCAGAAGCT GCTGGACGCC 1140

TCCAAGAGGT CCAAGAACTT CGTGTCCTCC AAAGGGTTCC CCCGCTACTG CACCGTCACC 1200

ACGCTGCCCG ACGGCACCAG CGTGCTGAAC GGCGGGCGCT CGCGGCGGGG CAAGGCACGC 1260

GGCCCGCCGT GCAGCAAGGA CTGGAGCGCG GCGCTGAAGG GCTGCGACGA CCAGCTCTTC 1320

CTGGACTTCC TCAAGCAGTG TCTGGAGTGG GACCCCGCCC TCAGGATGAC CCCCAGCCAG 1380

GCGCTGCGCC ACCCGTGGCT GAAGAAGCGG CTGCCCAAGC CGCCGGGCGG GACCGGCACC 1440

ACGGACAAGG CCTCCAGGCG GATCGGCACC GCCGCCGCCG ATGGCGCCCT CACCTCCATC 1500

TCCAAGATCG CCACCACCTC CTCCACCGCC GTGTCCTCCT CCTCCAAAAC CAGGACTAAC 1560

CTGGCGTCCA TCACCGACGC TAACGGGAAC ATCCAGCCCA GGACGGTGCT GCCCAAGCTG 1620

GTCAGCTGA 1629

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka+d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 154   YEVLKVIGKGSFGQVVKAYDHKCQTHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDCS  213

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g++l lvrk+a +il++L++L++

Q: 214   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFTLPLVRKFAYSILQCLDALHR  273

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg +y

Q: 274   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGSRYG  332

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+ +e+lg+p++kll+++k++k+f+++k+

Q: 333   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACTMELLGMPSQKLLDASKRSKNFVSSKG  392

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+  d + +l+ ++++++k r +p sk+++ alk ++d+lf d+lk++le+dp

Q: 393   FPRYCTVTTLPDGTSVLNGGRSRRGKARGPPCSKDWSAALKGCDDQLFLDFLKQCLEWDP  452

         ************************************************************

S: 301   akRitpkealkhpfv  315

         a R+tp++al+hp++

Q: 453   ALRMTPSQALRHPWL  467

         **************6

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAYD HKCQTHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDCS 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFT LPLVRKFAYS ILQCLDALHR 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGSRYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACTMELLGMP SQKLLDASKR SKNFVSSKGF 240

PRYCTVTTLP DGTSVLNGGR SRRGKARGPP CSKDWSAALK GCDDQLFLDF LKQCLEWDPA 300

LRMTPSQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013