EKS-TEN-00184
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00184
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR541.43.7E-163435711277
StatusUnreviewed
Ensembl ProteinENSTNIP00000022035
UniProt AccessionH3DND6;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1 (1 of 2)
Gene Synonyms/Alias FGFR1 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000018850ENSTNIP00000022035ENSTNIT00000022271
OrganismTetraodon nigroviridis
Functional Description
Protein Length776
Protein Sequence
(FASTA)
PSAATEAPVE MFTLYSGERL DLSCAASDAT QAVNWTKDQA LVVDGEHTRI HNGHLEIESV 60
ELSDSGLYAC TTFGNHSGFF NISASEDDEE DEESSSEEAK LLGSQKELPM APQWAHPEKM 120
AKKLHAVPAS KTVKFRCQAS GNPIPTLKWY KNGKEFKREH RIGGFKVRDH MWTIIMEAVV 180
PSDKGNYTCV VENQYGSINH TYQLDVVERS PHRPILQAGL PANRTAVVGS DVEFECKVFS 240
DPQPHIQWLK HIEVNGSRLG PDGLPYVRIL KTAGFNTTDK EMEVLQLRNV SFEDAGKYTC 300
LAGNSIGFSY HSAWLTVFEA VPHYPPANHT YLEVVIYCVG FFFIAVMITI AIMVKIRTSS 360
KKSDFSSQVA VHKLAKSIPL HRQVTVSVDS GSSVHSGAML VRPSRLSSSG SPMLSGVSEY 420
ELPDPRWELP PGDRLVLGKP LGEGCFGQVV MGEAMGLDRD RPNWVTKVAV KMLKADATEK 480
DLSDLISEME MMKIIGKHKN IINLLGACTQ DGPLYVIVEY ASKGNLREYL RARRPPGMEY 540
CYNPYQVPVE NMSIKDLVSC AFQVARGMEY LASKKCIHRD LAARNVLVTE DNVMKIADFG 600
LARDIHHIDY YKKTTNGRLP VKWMAPEALF DRIYTHQSDV WSFGVLLWEI FTLGGSPYPG 660
VPVEELFKLL KEGHRMDKPS TCTHQLYMMM RDCWHAVPAQ RPTFKQLVED LDRCLAVASN 720
QEYLELTTPL DQCYPDTRSS TCSSGEDSVF SHDAGAEEPC LPQLPPHANG AAVKKR 776
Nucleotide Sequence
(FASTA)
CCCTCAGCAG CGACGGAGGC TCCTGTGGAA ATGTTCACGC TCTACTCTGG AGAACGTCTG 60
GACCTGAGCT GCGCCGCCAG CGACGCCACG CAAGCCGTCA ACTGGACCAA AGACCAGGCG 120
TTGGTGGTGG ACGGCGAGCA CACGCGCATC CACAACGGCC ACCTGGAGAT CGAGAGCGTG 180
GAGCTGAGCG ACTCCGGCCT GTACGCCTGC ACCACCTTCG GGAACCACAG CGGCTTCTTC 240
AACATCTCCG CATCGGAGGA CGATGAAGAA GACGAGGAGT CTTCATCGGA GGAGGCCAAG 300
CTGCTGGGCA GCCAGAAGGA GCTGCCCATG GCGCCGCAGT GGGCTCATCC GGAGAAAATG 360
GCCAAAAAGC TCCACGCCGT TCCGGCTAGC AAGACGGTCA AGTTCCGCTG CCAGGCCAGC 420
GGAAACCCCA TCCCCACCCT GAAGTGGTAC AAGAACGGCA AGGAGTTCAA GCGGGAACAC 480
CGCATCGGAG GCTTCAAGGT CCGTGACCAC ATGTGGACCA TCATCATGGA GGCCGTGGTC 540
CCCTCCGACA AGGGCAACTA CACCTGCGTG GTGGAGAACC AGTACGGCAG CATCAACCAC 600
ACCTACCAGC TGGACGTCGT GGAGCGCTCC CCCCACAGGC CCATCCTGCA GGCGGGCCTG 660
CCGGCCAACC GCACCGCCGT GGTGGGCAGC GACGTGGAGT TCGAGTGCAA GGTGTTCAGC 720
GACCCGCAGC CGCACATCCA GTGGCTGAAG CACATCGAGG TCAACGGCAG CCGGCTGGGC 780
CCCGACGGCC TGCCCTACGT CCGCATCCTC AAGACGGCCG GCTTTAACAC CACCGACAAG 840
GAAATGGAGG TCCTGCAGCT GAGAAACGTG TCTTTTGAAG ACGCGGGGAA GTATACCTGC 900
TTGGCGGGCA ATTCTATCGG CTTCTCTTAT CACTCTGCAT GGTTGACCGT CTTTGAAGCC 960
GTGCCCCACT ACCCTCCGGC CAACCACACC TACCTGGAGG TGGTCATCTA CTGCGTGGGC 1020
TTCTTCTTCA TCGCCGTGAT GATCACCATC GCCATCATGG TGAAGATCCG CACCTCGTCC 1080
AAGAAGAGCG ACTTCAGCAG CCAGGTGGCC GTGCACAAGC TGGCCAAGAG CATCCCCCTG 1140
CACCGACAGG TAACAGTGTC GGTGGACTCG GGCTCCTCCG TCCACTCCGG CGCCATGCTG 1200
GTGCGGCCGT CCCGCCTGTC CTCCAGCGGC TCCCCGATGC TCTCGGGGGT GTCGGAGTAC 1260
GAGCTGCCTG ACCCCCGCTG GGAGCTGCCC CCGGGGGACA GGCTGGTCCT GGGGAAGCCG 1320
CTGGGCGAAG GCTGCTTCGG CCAGGTGGTG ATGGGCGAGG CCATGGGCCT GGACAGGGAC 1380
CGGCCCAACT GGGTCACCAA GGTGGCCGTC AAAATGCTGA AAGCCGACGC CACCGAGAAA 1440
GACCTGTCAG ACCTGATATC AGAGATGGAG ATGATGAAGA TCATCGGCAA GCACAAGAAC 1500
ATCATTAATC TGCTGGGAGC GTGCACGCAA GATGGTCCTC TCTACGTCAT CGTGGAATAC 1560
GCGTCCAAGG GCAACCTGCG GGAATACCTG CGAGCGCGGC GCCCCCCGGG GATGGAGTAC 1620
TGCTACAACC CCTACCAGGT GCCGGTGGAG AACATGTCCA TCAAGGACCT GGTGTCCTGC 1680
GCCTTCCAGG TGGCTCGAGG GATGGAGTAC CTGGCCTCCA AAAAGTGCAT CCACAGAGAC 1740
CTGGCCGCCC GCAACGTCCT GGTGACGGAG GACAACGTGA TGAAGATCGC AGACTTCGGC 1800
CTGGCCAGGG ACATCCACCA CATCGACTAC TACAAGAAGA CCACCAACGG CCGTCTGCCG 1860
GTGAAGTGGA TGGCTCCGGA GGCGCTCTTC GACCGCATCT ACACCCACCA GAGCGACGTG 1920
TGGTCGTTCG GCGTCCTGCT GTGGGAGATC TTCACCCTGG GCGGGTCCCC GTACCCCGGC 1980
GTCCCCGTGG AGGAGCTCTT CAAGCTGCTG AAGGAAGGAC ACCGCATGGA CAAACCCTCC 2040
ACCTGCACCC ACCAGCTGTA CATGATGATG CGGGACTGCT GGCACGCCGT CCCCGCCCAA 2100
AGACCCACCT TCAAGCAGCT GGTGGAGGAC CTGGACCGCT GCCTGGCCGT GGCCTCCAAC 2160
CAGGAGTACC TGGAGCTGAC CACGCCCCTG GACCAGTGCT ACCCGGACAC CCGCAGCTCC 2220
ACCTGCTCCT CCGGCGAGGA CTCCGTCTTC TCCCACGACG CCGGCGCCGA GGAGCCCTGC 2280
CTGCCGCAGT TGCCCCCCCA CGCCAACGGC GCCGCCGTCA AGAAACGCTG A 2331
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqvv+ ea+gld+d+++  ++vavkmlk dat+kdl+dl+seme++k+
Q: 435   LVLGKPLGEGCFGQVVMGEAMGLDRDRPNWVTKVAVKMLKADATEKDLSDLISEMEMMKI  494
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+++++ +++ e+++ 
Q: 495   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYCYNPYQVPVENMSI  554
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+a+qvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt
Q: 555   KDLVSCAFQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  614
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 615   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  674
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct++ly++mr+cwha++++rptfkqlvedl
Q: 675   RMDKPSTCTHQLYMMMRDCWHAVPAQRPTFKQLVEDL  711
         ***********************************97
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVVMGEA MGLDRDRPNW VTKVAVKMLK ADATEKDLSD LISEMEMMKI 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYCYNP YQVPVENMSI 120
KDLVSCAFQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMDKPSTCTH QLYMMMRDCW HAVPAQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00140
EKS-BOT-00147
EKS-CAJ-00152
EKS-CAF-00156
EKS-CAP-00148
EKS-DAR-00434
EKS-EQC-00147
EKS-FEC-00138
EKS-GAM-00076
EKS-GAG-00126
EKS-GAA-00173
EKS-GOG-00148
EKS-HOS-00154
EKS-ICT-00142
EKS-LAC-00157
EKS-LOA-00147
EKS-MAM-00145
EKS-MUM-00153
EKS-MUP-00152
EKS-MYL-00157
EKS-NOL-00142
EKS-ORN-00183
EKS-ORA-00126
EKS-ORC-00139
EKS-ORL-00171
EKS-OTG-00153
EKS-PAT-00139
EKS-POA-00144
EKS-RAN-00147
EKS-SAH-00143
EKS-SUS-00129
EKS-TAG-00177
EKS-TAR-00192
EKS-XET-00136
EKS-XIM-00177
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0060249; P:anatomical structure homeostasis
GO:0048738; P:cardiac muscle tissue development
GO:0009953; P:dorsal/ventral pattern formation
GO:0031101; P:fin regeneration
GO:0001889; P:liver development
GO:0042664; P:negative regulation of endodermal cell fate specification
GO:0008284; P:positive regulation of cell proliferation
GO:0048916; P:posterior lateral line development
GO:0043589; P:skin morphogenesis
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR013106; Ig_V-set.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
PF07686; V-set; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013