EKS-TEN-00386
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00386
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR469.33.3E-141717972256
StatusUnreviewed
Ensembl ProteinENSTNIP00000002830
UniProt AccessionH3DNM0;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000018932ENSTNIP00000002830ENSTNIT00000001827
ENSTNIG00000018932ENSTNIP00000022119ENSTNIT00000022356
ENSTNIG00000018932ENSTNIP00000003640ENSTNIT00000003458
OrganismTetraodon nigroviridis
Functional Description
Protein Length1031
Protein Sequence
(FASTA)
MKVRTRLRCG YTLTFSLLTV SSGSAQSACM GTDMKLSLPS SLENHHEMLR LLYTGCQVVH 60
GNLEITHLHG TPDLSFLQGI VEVQGYVLVA HVSVSLLPLD NLRIIRGSQL YNSSYALAVL 120
DNTLDGRGLR TLHLRSLTEI LFGSVYVWGN PQLCFPDPQS INWRDILDQQ NTDTRHRLQP 180
RAQNCAGPNC SSQCLTSCWG EAAQDCQTFK VTRSNCASGC QRCKGFLPND CCHKQCAAGC 240
TGPKDSDCLA CRHFNDSGVC KENCPPPTTY DPATFQSKPN PDRKFSFGAT CVKTCPYNYL 300
AMDVACTLNY PKPNPKDVVP QPCGNDTQKC EKCEGDCPKG MDDHGAVDSS GSTMVTAANV 360
GQFNKCTKIF GSLAFHSQSF SRDPVTNASG LSPEQLSVFR NLEEITGYLY IEAWPQEWMN 420
LNVFDNLKVI RGRMLYKGVF SLAIQNLQIT SLGLRSLRSI SGGLVLLHNN SQLCYTSSLP 480
WESIVHPTQG PHRIVSKNLD PQICEKQGHV CHRLCKGGCW GPGPGQCASC ETFQRGTECV 540
EHCDIYQGSV REYASESLCV ACHPECQPLN GSASCHGPGA EHCVECRKFQ DGDFCVDHCP 600
SGVKEDHQTV WKYSNATGHC LPCNTNCTLS CTVKDERGCP VDTRAGLGTT IAAAVGGVVL 660
FFILLGLLFF YLRRQKKLKR KETMARILQE HELVEPLAPS GASPNQAQMR ILKETELKKL 720
KVLGAGAFGT VYKGVWAPDG ENVKIPVAIK VLRENTSPKA NKEILDEAYV MAGVASPYVC 780
RLLGICLTST VQVTQLMSYG CLLEYVRKNK DHIGSQLLLN WCVQIAKGMS YLEEVRLVHR 840
DLAARNVLVK NPNHVKITDF GLARLLDIDE TEYHADGGKV PIKWMALESI LQRKFTHQSD 900
VWSYGVTVWE LMTFGAKPYD MIPARDIPEV LEGGERLPQP PICTIDVYMI MVKCWMIDPD 960
YRPRFKDLVK EFTTMARDPP RYVVIQNEEQ MGTPSPVDNQ FFRLLVEEEG NNLRELLDAE 1020
EYLVPQPNHF P 1031
Nucleotide Sequence
(FASTA)
ATGAAAGTCA GAACCAGACT GAGGTGTGGC TACACACTGA CTTTCAGTCT GCTCACAGTC 60
TCAAGCGGCA GCGCTCAGTC AGCCTGCATG GGTACTGACA TGAAGCTGTC CCTGCCCTCC 120
AGTCTGGAAA ATCACCATGA AATGCTCAGG CTGTTGTACA CAGGCTGCCA GGTTGTTCAT 180
GGCAACCTGG AAATTACGCA CCTTCACGGA ACGCCCGACC TCTCCTTCCT GCAGGGGATC 240
GTGGAGGTGC AGGGATATGT GCTGGTGGCC CACGTGTCCG TGAGTCTGCT GCCTTTGGAC 300
AACCTGCGGA TCATCCGAGG CAGCCAGCTT TATAACTCCA GCTACGCTCT GGCTGTGCTG 360
GATAACACCC TGGATGGACG AGGGCTCCGG ACTCTTCATC TCCGCAGTCT GACAGAGATC 420
CTCTTTGGCA GCGTGTATGT GTGGGGGAAC CCCCAGCTGT GCTTCCCTGA CCCACAGAGC 480
ATCAACTGGA GGGACATTTT GGATCAGCAG AACACTGACA CCCGACACCG ACTGCAGCCT 540
CGCGCACAGA ACTGTGCAGG CCCCAACTGT TCCTCGCAGT GTTTGACAAG CTGCTGGGGA 600
GAAGCTGCGC AGGACTGCCA GACCTTTAAA GTGACCCGCA GTAACTGTGC GTCGGGCTGC 660
CAGCGGTGCA AAGGCTTCCT GCCCAATGAC TGCTGCCACA AGCAGTGTGC CGCTGGATGC 720
ACCGGCCCTA AAGACTCCGA CTGTCTGGCT TGTCGTCACT TCAACGACAG CGGTGTGTGT 780
AAGGAGAACT GCCCTCCTCC TACGACCTAC GACCCTGCCA CCTTCCAGTC CAAACCGAAC 840
CCTGACAGAA AGTTCAGCTT CGGAGCCACC TGTGTGAAGA CGTGTCCTTA TAACTATCTG 900
GCCATGGACG TGGCTTGTAC GCTGAACTAC CCCAAACCCA ACCCTAAGGA CGTCGTGCCC 960
CAGCCCTGTG GAAATGACAC GCAGAAGTGT GAAAAGTGTG AGGGGGACTG TCCCAAAGGT 1020
ATGGACGACC ACGGAGCCGT GGACAGCAGC GGCAGCACCA TGGTAACGGC TGCCAACGTG 1080
GGGCAATTCA ACAAATGCAC AAAGATTTTT GGTAGCCTGG CCTTCCACTC GCAAAGCTTC 1140
AGCAGGGACC CTGTGACTAA TGCGTCAGGC CTGAGCCCAG AGCAGCTCAG TGTCTTCAGA 1200
AATCTGGAGG AGATCACAGG TTATTTGTAC ATTGAGGCCT GGCCACAGGA ATGGATGAAT 1260
CTGAACGTGT TTGACAATCT GAAGGTGATC CGAGGGAGGA TGCTATACAA GGGTGTGTTT 1320
TCACTGGCCA TCCAGAACCT GCAGATCACG TCTTTGGGGC TGCGCTCACT GCGCAGCATC 1380
AGTGGAGGTT TGGTCCTGTT GCATAACAAT TCCCAGCTCT GCTACACCAG CTCGCTGCCG 1440
TGGGAGAGTA TTGTCCACCC CACCCAGGGA CCCCACCGCA TTGTCAGCAA AAATCTGGAC 1500
CCCCAGATCT GTGAGAAACA GGGGCATGTT TGTCACCGGC TGTGCAAGGG CGGCTGCTGG 1560
GGCCCGGGGC CCGGCCAGTG TGCGTCCTGC GAGACTTTCC AGCGTGGCAC CGAGTGTGTC 1620
GAGCACTGTG ATATCTATCA GGGGTCCGTC CGGGAATATG CCAGTGAGTC TCTGTGTGTT 1680
GCCTGTCACC CCGAGTGCCA GCCACTCAAC GGTTCTGCTT CTTGTCACGG CCCAGGAGCA 1740
GAGCATTGTG TGGAGTGCAG GAAGTTCCAG GACGGAGATT TCTGCGTGGA TCACTGCCCC 1800
AGTGGTGTGA AGGAAGACCA CCAGACTGTG TGGAAATACA GCAATGCTAC AGGACACTGT 1860
CTGCCATGCA ACACCAACTG CACACTGTCC TGCACTGTGA AGGATGAGAG AGGCTGTCCC 1920
GTGGACACGA GGGCAGGCCT GGGAACAACC ATCGCTGCTG CAGTAGGCGG GGTGGTGCTC 1980
TTCTTCATCC TGCTGGGTCT ACTTTTCTTT TACCTGAGAA GACAGAAGAA GCTGAAGAGG 2040
AAGGAAACGA TGGCGAGGAT CCTGCAGGAA CATGAGCTGG TGGAACCTCT GGCCCCCAGC 2100
GGTGCATCAC CCAATCAGGC TCAGATGCGC ATCCTGAAAG AGACGGAGTT AAAGAAGCTG 2160
AAAGTGTTGG GTGCCGGGGC GTTTGGCACT GTCTACAAGG GAGTGTGGGC CCCCGATGGG 2220
GAAAATGTGA AAATACCGGT AGCCATTAAA GTGTTGCGGG AGAACACTTC ACCAAAGGCC 2280
AACAAAGAAA TCCTTGATGA GGCCTATGTC ATGGCGGGCG TGGCCAGCCC CTACGTGTGC 2340
CGTCTGCTGG GGATCTGCTT GACCTCCACC GTGCAGGTCA CCCAGCTGAT GTCGTACGGC 2400
TGCCTCCTTG AATACGTCAG GAAGAACAAG GATCACATCG GTTCCCAGTT GCTCCTCAAC 2460
TGGTGTGTCC AGATTGCTAA GGGAATGAGT TACCTGGAGG AAGTTCGTCT GGTGCACAGA 2520
GATCTAGCAG CCCGCAATGT CCTGGTAAAG AATCCAAACC ACGTGAAGAT CACGGACTTC 2580
GGTCTGGCCC GTCTGCTGGA TATAGACGAG ACGGAATATC ACGCCGACGG GGGGAAGGTG 2640
CCGATCAAAT GGATGGCCCT GGAGTCAATT CTGCAAAGGA AGTTCACTCA TCAGAGTGAT 2700
GTGTGGAGCT ACGGGGTGAC CGTCTGGGAG TTGATGACAT TTGGTGCCAA ACCGTACGAC 2760
ATGATCCCGG CCAGGGACAT CCCTGAGGTT CTGGAGGGGG GAGAACGGCT TCCCCAGCCT 2820
CCGATCTGCA CCATCGATGT CTACATGATC ATGGTCAAAT GTTGGATGAT TGACCCAGAC 2880
TACAGGCCCA GGTTCAAGGA TTTGGTCAAG GAATTTACCA CAATGGCCAG AGATCCTCCT 2940
CGTTATGTTG TCATTCAGAA CGAGGAGCAA ATGGGCACAC CCAGCCCGGT GGACAACCAG 3000
TTCTTCCGGT TGCTTGTAGA GGAAGAGGGC AATAACTTGA GGGAATTGCT GGATGCTGAG 3060
GAGTACCTGG TGCCTCAACC AAACCACTTC CCC 3093
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkklkvlG+GafGtvykG+w p+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 717   LKKLKVLGAGAFGTVYKGVWAPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVAS  776
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+q vtql+ +Gcll+yvr++kd++Gsq llnwcvqiakGmsylee 
Q: 777   PYVCRLLGICLTSTVQ-VTQLMSYGCLLEYVRKNKDHIGSQLLLNWCVQIAKGMSYLEEV  835
         ***************9.7******************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+pnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+rk+
Q: 836   RLVHRDLAARNVLVKNPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILQRKF  895
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpyd ipa++ip++le Gerl+qppictidvym++vkcw
Q: 896   THQSDVWSYGVTVWELMTFGAKPYDMIPARDIPEVLEGGERLPQPPICTIDVYMIMVKCW  955
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid++ rp+fk+l++ef
Q: 956   MIDPDYRPRFKDLVKEF  972
         ****************9
Domain Sequence
(FASTA)
LKKLKVLGAG AFGTVYKGVW APDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVAS 60
PYVCRLLGIC LTSTVQVTQL MSYGCLLEYV RKNKDHIGSQ LLLNWCVQIA KGMSYLEEVR 120
LVHRDLAARN VLVKNPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILQRKFT 180
HQSDVWSYGV TVWELMTFGA KPYDMIPARD IPEVLEGGER LPQPPICTID VYMIMVKCWM 240
IDPDYRPRFK DLVKEF 256
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007413; P:axonal fasciculation
GO:0001837; P:epithelial to mesenchymal transition
GO:0031101; P:fin regeneration
GO:0048914; P:myelination of anterior lateral line nerve axons
GO:0048932; P:myelination of posterior lateral line nerve axons
GO:0001755; P:neural crest cell migration
GO:0032285; P:non-myelinated axon ensheathment
GO:0048919; P:posterior lateral line neuromast development
GO:0014044; P:Schwann cell development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013