EKS-TEN-00354

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00354

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	465.6	6.8E-140	202	488	287

Status

Unreviewed

Ensembl Protein

ENSTNIP00000022139

UniProt Accession

H3DNP0;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1 (2 of 2)

Gene Synonyms/Alias

TGFBR1 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000018951	ENSTNIP00000022139	ENSTNIT00000022376

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

ANAGRARASA AGVALAACSA LLLSLSPGLQ CYCDRCSANS SCVTDGVCFV AIRRSGSHQT 60

TEQRQCVHKK ELIPWDRPFI CAPSVKDDTG VYPMCCTSDY CNKEHKLPVS PPEVRPLGPV 120

ALAAVIAGPV CVLCLLLVLA FYICHNHRGH HHRVPNEEDP SMDHPFITVG TTLKDLIYDM 180

TTSGSGSGLP LLVQRTIART IILQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR 240

EAEIYQTVML RHENILGFIA ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK 300

LSLSTASGLA HLHMEIVGTQ GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT 360

IDIAPNHRVG TKRYMAPEVL DDSINMKHFE SFKRADIYAM GLVFWEVANR CSMGGIHEDY 420

QLPYYDLVQS DPSVEEMRKV VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANSAARLT 480

ALRIKKTLSQ LSQQEGIKM 499

Nucleotide Sequence
(FASTA)

GCAAACGCAG GACGCGCCAG AGCTTCCGCA GCCGGCGTCG CGCTAGCAGC TTGTTCTGCT 60

CTCCTCCTCT CTCTCTCCCC AGGCCTCCAG TGCTACTGCG ACCGCTGCAG TGCCAACTCC 120

AGCTGCGTCA CCGATGGCGT GTGTTTTGTG GCCATCCGCA GGTCAGGTAG CCACCAGACC 180

ACCGAGCAGC GCCAGTGCGT CCACAAGAAG GAGCTGATCC CTTGGGATCG CCCCTTCATC 240

TGCGCCCCTT CGGTCAAGGA CGACACGGGC GTCTACCCCA TGTGCTGCAC CAGCGACTAC 300

TGCAACAAGG AACACAAGCT CCCAGTCTCC CCACCCGAGG TCCGGCCCCT GGGCCCCGTG 360

GCCCTGGCAG CAGTGATCGC CGGGCCCGTC TGCGTGCTCT GCCTGCTCCT GGTCTTGGCC 420

TTCTACATCT GCCACAACCA CAGAGGCCAT CACCACCGGG TGCCTAACGA GGAAGACCCC 480

TCTATGGATC ACCCCTTCAT CACTGTTGGA ACAACGCTGA AGGACCTCAT CTACGACATG 540

ACCACTTCTG GCTCTGGCTC AGGACTGCCG CTGCTCGTCC AGAGGACCAT CGCCAGGACC 600

ATCATCCTCC AGGAGAGCAT AGGGAAGGGC AGATTCGGGG AGGTTTGGCG GGGTAAGTGG 660

CGTGGGGAGG AGGTGGCCGT CAAGATCTTC TCCTCGCGGG AGGAGCGCTC CTGGTTCCGC 720

GAGGCCGAGA TCTACCAGAC TGTGATGCTG AGACACGAGA ACATCCTGGG CTTCATCGCC 780

GCCGACAACA AGGACAACGG GACCTGGACT CAGCTGTGGC TGGTGTCGGA TTACCACGAG 840

CACGGGTCGC TCTTCGACTA CCTGAACCGC TACACGGTCA CCGTGGAGGG CATGATCAAG 900

CTGTCCCTGT CCACAGCCAG CGGCCTGGCC CACCTGCACA TGGAGATCGT GGGCACTCAA 960

GGCAAACCAG CCATCGCTCA CCGAGACCTG AAGTCCAAGA ACATCCTGGT GAAGAAAAAC 1020

GGGACCTGCT GCATCGCAGA CCTGGGTCTG GCCGTACGCC ACGACTCCGC CACCGACACC 1080

ATCGATATCG CTCCCAACCA CCGAGTGGGA ACCAAGAGGT ACATGGCTCC AGAGGTCCTC 1140

GACGACTCCA TAAACATGAA GCACTTCGAG TCCTTCAAGC GGGCGGACAT TTACGCCATG 1200

GGCCTGGTCT TCTGGGAGGT GGCCAACCGC TGCTCCATGG GAGGGATCCA CGAGGACTAC 1260

CAGCTGCCCT ACTACGACCT GGTCCAGTCC GACCCATCCG TGGAGGAGAT GAGGAAGGTG 1320

GTTTGTGAGC AGAAGCTCCG CCCCAACATT CCCAACCGCT GGCAGAGCTG TGAGGCCTTA 1380

CGGGTGATGG CAAAGATAAT GAGGGAGTGC TGGTATGCCA ACAGCGCCGC GCGCCTGACT 1440

GCTCTCCGGA TCAAAAAGAC GCTGTCCCAG CTCAGCCAGC AGGAGGGGAT CAAGATGTAG 1500

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61

          l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fiaa

Q: 202   ILQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAA  261

         58899*******************************************************

S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121

         d+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++l ls+asGlahLH+eivgt+g

Q: 262   DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQG  321

         ************************************************************

S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181

           KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPEv

Q: 322   --KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEV  379

         ..**********************************************************

S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241

         l++++n+k+fe+fkraD+Y++gLv+WEva Rc++ ++++e+y+lp+++ v+sdPs+eem+

Q: 380   LDDSINMKHFESFKRADIYAMGLVFWEVANRCSM-GGIHEDYQLPYYDLVQSDPSVEEMR  438

         **********************************.*************************

S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 439   KVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANSAARLTALRIKKTL  488

         ************************************************97

Domain Sequence
(FASTA)

ILQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR HENILGFIAA 60

DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMIKL SLSTASGLAH LHMEIVGTQG 120

KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI DIAPNHRVGT KRYMAPEVLD 180

DSINMKHFES FKRADIYAMG LVFWEVANRC SMGGIHEDYQ LPYYDLVQSD PSVEEMRKVV 240

CEQKLRPNIP NRWQSCEALR VMAKIMRECW YANSAARLTA LRIKKTL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013