EKS-TEN-00246

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00246

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	378.8	1.5E-113	52	298	247

Status

Unreviewed

Ensembl Protein

ENSTNIP00000022244

UniProt Accession

H3DNZ5;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK1 (1 of 2)

Gene Synonyms/Alias

TESK1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000019052	ENSTNIP00000022244	ENSTNIT00000022483

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

634

Protein Sequence
(FASTA)

LERPGWRWSR SRARDAEPPL HSVHGPNRIR PSSYRALRSA VSSLARLDDF SREKIGAGFF 60

SEVFKVQHRV SGQVMALKMN ILPSNRANML REVQLMNRLS HPNILRFIGV CVHEGQLHAL 120

TEYINGGNLE QLLGSEVYLS WRVRLSLALD IARGLRYLHS KGFFHRDLTS KNCLIRWEGC 180

MCSAIVGDFG LAEKIPDCSE EEEQTPLAIV GPYWMAPEML RGEVYDEKVD VFAYGIILCE 240

IIARIQADPD ILPRTEDFGL DVKSFQQMVG DCPADFLKLA ISCCCLNVKV RPSFSVIVVE 300

LEKRRAEKTQ KGDPEVKGER SDKHGFLVSS FPKAECPAVD AFRRHSLCLT SDPGLADERP 360

SDAPSGAHPA APARVNPFSL REDLKGGKIK LFDTPSKSVI SLTFTLPPPP DCSDPSDVDC 420

EDWPRRHRRC HSLPCTPPPH ITPLSLGRER DGEEEEPMDC SSSPDTQETA SSPCSKLSVP 480

PSDASTPLQP STPPFQNGWR SDISNGPPSF PRLPPLDNNN TVAGGPLGWD PTTTSAPTRT 540

KNNGYGSPAS DPAGPSPFGS GSGHSLEQEE VISCPGCCLA GFRFPSVCLR APRRRNPYKN 600

LNGDHGASRG LLCPGPKDLS PAPTPATVTP STEP 634

Nucleotide Sequence
(FASTA)

CTGGAGAGGC CGGGATGGAG ATGGAGTCGG AGCAGAGCGA GAGACGCGGA GCCGCCCCTG 60

CACAGCGTCC ACGGACCCAA CCGGATCCGG CCGTCGTCGT ACCGGGCCCT GCGCAGCGCC 120

GTCTCCAGCC TGGCTCGCCT GGACGACTTC AGCCGGGAGA AGATCGGAGC GGGCTTCTTC 180

TCCGAGGTGT TCAAGGTGCA GCATCGCGTG TCGGGTCAGG TCATGGCTCT GAAGATGAAC 240

ATCCTGCCCA GTAACAGAGC CAACATGCTC AGGGAGGTCC AGCTCATGAA CCGACTCTCG 300

CACCCAAACA TACTCAGGTT CATCGGCGTG TGTGTTCACG AGGGGCAGCT CCACGCGCTC 360

ACAGAGTACA TCAACGGCGG TAACCTGGAG CAGCTGTTGG GCAGCGAGGT GTACCTGTCG 420

TGGCGCGTGC GCCTGAGCCT GGCGTTGGAC ATCGCCCGGG GACTCCGCTA CCTGCACAGC 480

AAGGGCTTCT TCCACAGAGA CCTCACCTCC AAGAACTGCC TGATTCGCTG GGAAGGCTGC 540

ATGTGCTCGG CCATCGTGGG AGACTTTGGT CTGGCAGAGA AAATTCCAGA TTGCAGTGAG 600

GAAGAGGAAC AGACCCCGCT GGCTATCGTT GGTCCCTACT GGATGGCCCC AGAGATGCTG 660

AGAGGGGAGG TGTACGATGA GAAGGTGGAT GTGTTTGCGT ACGGGATCAT CCTGTGCGAG 720

ATCATCGCGA GGATACAGGC CGACCCCGAC ATCCTGCCAC GCACTGAGGA CTTTGGTCTG 780

GATGTGAAGA GCTTTCAGCA AATGGTCGGA GACTGTCCTG CAGACTTCCT GAAACTGGCC 840

ATCTCCTGCT GTTGTTTGAA TGTGAAGGTC CGTCCGTCCT TCTCCGTGAT TGTAGTGGAG 900

CTGGAAAAGC GGAGAGCTGA GAAGACGCAG AAGGGCGACC CAGAGGTCAA AGGTGAGAGG 960

TCGGATAAAC ACGGATTCCT CGTTTCTTCC TTCCCCAAAG CCGAATGCCC GGCTGTAGAC 1020

GCTTTCCGGA GACATTCCCT CTGCCTCACG TCGGACCCGG GACTGGCGGA CGAGCGGCCC 1080

TCGGACGCGC CCTCTGGCGC CCACCCGGCG GCTCCCGCGC GGGTCAACCC CTTCTCCCTG 1140

AGGGAGGACC TCAAGGGCGG CAAGATCAAG CTGTTCGACA CGCCCAGCAA GTCGGTGATC 1200

TCCCTGACCT TCACCCTGCC GCCTCCGCCC GACTGCAGCG ACCCCTCCGA CGTGGACTGT 1260

GAGGACTGGC CCCGGAGGCA CCGGCGCTGC CACTCGCTGC CCTGCACGCC GCCGCCTCAC 1320

ATTACGCCCC TGTCGCTGGG CCGAGAGAGA GACGGCGAAG AGGAGGAGCC GATGGACTGC 1380

TCCAGCTCCC CGGACACGCA GGAAACGGCC TCGTCGCCCT GCTCCAAGCT CTCCGTTCCT 1440

CCCTCTGACG CCTCCACCCC CCTCCAACCG TCCACCCCTC CCTTCCAAAA CGGCTGGCGG 1500

TCGGACATTT CCAACGGGCC TCCCAGCTTC CCTCGGCTGC CCCCGCTGGA CAACAACAAC 1560

ACGGTGGCCG GTGGTCCCCT GGGCTGGGAC CCCACCACCA CCAGCGCTCC CACCAGGACC 1620

AAAAACAACG GCTACGGCTC CCCGGCCTCC GACCCCGCCG GGCCGTCCCC GTTCGGCTCC 1680

GGCAGCGGCC ACTCTCTGGA GCAGGAGGAG GTGATCTCCT GCCCGGGCTG CTGCCTGGCC 1740

GGCTTCCGCT TCCCATCAGT GTGTCTCAGA GCTCCACGGC GCAGGAACCC CTACAAGAAC 1800

CTGAACGGGG ACCACGGAGC CTCTCGGGGA CTTCTCTGCC CCGGACCCAA GGATCTGTCC 1860

CCAGCGCCTA CCCCCGCCAC TGTGACCCCC AGCACGGAGC CG 1902

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          ek+G+Gffsevfkv+hr sG+vm+lk  ++ + +nr+n+l+ev+l+++l+hpn+l+fiG

Q: 52    REKIGAGFFSEVFKVQHRVSGQVMALK--MNILPSNRANMLREVQLMNRLSHPNILRFIG  109

         69*************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi+gG+l++ll s+  l+w +r++la dia+Gl+ylhskg +hrdl+

Q: 110   VCVHEGQLHALTEYINGGNLEQLLGSEVYLSWRVRLSLALDIARGLRYLHSKGFFHRDLT  169

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl+r      s++v+dfGla          ek+++ ++++ +  l++vG PywmaPe

Q: 170   SKNCLIRWegcMCSAIVGDFGLA----------EKIPDCSEEEEQTPLAIVG-PYWMAPE  218

         *******9777789*********..........9*****************9.*******

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         +l+g+ ydekvdvf++Gi+lceiiar++adPd+lPrtedfgldvk+f++ +v+ dcP +f

Q: 219   MLRGEVYDEKVDVFAYGIILCEIIARIQADPDILPRTEDFGLDVKSFQQ-MVG-DCPADF  276

         ************************************************9.999.******

S: 241   lklavvccdldpesrpsfeele  262

         lkla+ cc l+ + rpsf+ +

Q: 277   LKLAISCCCLNVKVRPSFSVIV  298

         ******************9875

Domain Sequence
(FASTA)

REKIGAGFFS EVFKVQHRVS GQVMALKMNI LPSNRANMLR EVQLMNRLSH PNILRFIGVC 60

VHEGQLHALT EYINGGNLEQ LLGSEVYLSW RVRLSLALDI ARGLRYLHSK GFFHRDLTSK 120

NCLIRWEGCM CSAIVGDFGL AEKIPDCSEE EEQTPLAIVG PYWMAPEMLR GEVYDEKVDV 180

FAYGIILCEI IARIQADPDI LPRTEDFGLD VKSFQQMVGD CPADFLKLAI SCCCLNVKVR 240

PSFSVIV 247

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013