EKS-TEN-00496

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00496

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	320.2	1.4E-95	640	900	261

Status

Unreviewed

Ensembl Protein

ENSTNIP00000022322

UniProt Accession

H3DP73;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K5

Gene Synonyms/Alias

MAP3K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000019125	ENSTNIP00000022322	ENSTNIT00000022561
ENSTNIG00000019125	ENSTNIP00000000643	ENSTNIT00000004037

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

1342

Protein Sequence
(FASTA)

PRVTPLPPPP PTPPSFWQDP AVGGAGLSPS SPVEGGGGLL PTGKPCHGRP VSVAYVVNGE 60

SSPPSSAESR ALRCLRDACD AVGSRETLNF GKLDFGETAV LDAFYNADIA VVEMTDAFRQ 120

LSLFYHLGVR ESFSMANNII LYCDTNSDSL QSLQEIIGQK NTTCSANYTF IPYMVTPHNK 180

VYCCEGSLMK GLTELMQPGL EALLGPICMP LHDRFVQLLK VSQANSHQYF REMILNEIRK 240

ARDLYSGAEL AGELSRIQQR LDNVECLSVD IVINLLLTYR DIQDYESIVK LVETLEKLPT 300

FDPMANPHVK FHYAFALNRR NLPGDRRKAL DIMLPLVEAE GQVASDIYCL VGRIYKDMFL 360

ESHFTDTQSR DSGTQFKRGF ESEPTLHSGI NYAVLLLAAG HQFDSSFELR KVGVKLSSLL 420

GKKGSLDKLQ SYWDVGFFLG ASILAGDNIR VIQASEKLFK LKAPTWYLRS LVETILIYQQ 480

FHKPGPEQPA PKQELVDFWM DFLVEATKSD VSSVRFPVLI LEPTKIYQPS YLSINKDVED 540

NTVSIWHVAP DDKNKGIHEW NFSATSVRGV SISKFDERSA FLYVLHNAED FQIYFCTEVH 600

CRRFCDLVNS ITEEAWRGPE EGDCDSETLE YDYEYDEHGE RVVLGKGTFG VVYAGRDLSN 660

QVRLAIKEIP ERDSRYSQPL HEEIALHKHL KHKNIVQYLG SISENGFIKI FMEQVPGGSL 720

SALLRSKWGP LKNNEPTIGF YTRQEFLEME LKVGPARLTM IAHRDIKGDN VLINTYSGVL 780

KISDFGTSKR LAGINPCTET FTGTLQYMAP EIIDKGPRGY GKPADIWSLG CTIIEMATGK 840

PPFYELGEPQ AAMFKVGMFK IHPEIPESMS PEAKAFILRC FEPDPDRRAT ALDLLTDEFL 900

TVTSRKKKSK AALISLRTCC VSEYLRSISL PVPVVVEDTS SSSEYGSVSP DNDLNANPFI 960

FKPSVKCYSE RDVKGTRTLF LSIPVENFED HSAPPSPEEK DTGFFMLRKD SERRATLHRI 1020

LTEDRDKVVA NLTEAFTQGT EEMRLKPQHI STLVVSLADF VRMADRKIVA STLSQLKLEL 1080

DFDSAAISQL QVVLFGFQDA VNKVLRNHNI KPHWMFALDN IIRKAVQTAI TILVPGSELR 1140

PHFSLASESD PADQDDMDEE AEPRQHSTHQ SHTHPPAVND DTVATSGVST LSSTVSHESP 1200

SEQRPASMEL GRMKLETNRL LQQLMAKERE YQSILQQVLK EREQEITLLR TRSAGLLDAP 1260

SSSRRPHEKT SPASPRCEDP ELIGWLRLHG ADQEAVDRIL DEEYTLSDIL HDVTRDDLKS 1320

LSLRGGVLCK LWKAITEYRQ KP 1342

Nucleotide Sequence
(FASTA)

CCGCGCGTAA CGCCGCTTCC CCCGCCGCCC CCCACCCCTC CATCTTTCTG GCAGGACCCG 60

GCGGTCGGAG GCGCGGGGCT GAGTCCCAGC AGCCCGGTGG AGGGCGGCGG GGGGCTGCTC 120

CCCACCGGGA AGCCGTGCCA CGGCAGGCCG GTGAGCGTGG CCTACGTGGT GAACGGAGAG 180

AGCAGCCCGC CGAGCAGCGC CGAGAGCCGG GCGCTGCGGT GCCTGCGGGA CGCCTGCGAC 240

GCGGTGGGCA GCCGCGAGAC CCTCAACTTC GGCAAGCTGG ACTTCGGGGA GACCGCCGTG 300

CTGGACGCCT TCTACAACGC TGACATAGCC GTGGTGGAGA TGACGGACGC CTTCCGCCAG 360

CTCTCGCTCT TCTACCACCT GGGGGTCCGG GAGAGCTTCA GCATGGCCAA CAACATCATC 420

CTGTACTGCG ACACCAACTC AGACTCCCTC CAGTCGCTGC AGGAGATAAT TGGCCAGAAA 480

AACACTACGT GTTCGGCCAA CTACACCTTC ATCCCGTACA TGGTGACGCC GCACAACAAG 540

GTGTACTGCT GCGAGGGCAG CCTGATGAAG GGCCTGACGG AGCTGATGCA GCCCGGCTTG 600

GAGGCGCTGC TGGGGCCCAT CTGCATGCCG CTGCACGACC GCTTCGTCCA GCTGCTGAAG 660

GTGTCGCAGG CCAACTCGCA TCAGTACTTC CGGGAGATGA TCCTGAACGA GATCCGGAAG 720

GCCCGGGACC TGTACTCCGG TGCCGAGCTG GCCGGCGAGC TGAGCCGCAT CCAGCAGCGG 780

CTGGACAACG TGGAGTGCCT CTCGGTGGAC ATCGTCATCA ACCTGCTGCT GACCTACAGG 840

GACATCCAGG ATTACGAGTC CATCGTGAAG CTGGTGGAGA CGCTGGAGAA GCTCCCCACC 900

TTCGACCCCA TGGCTAACCC GCACGTCAAG TTCCACTACG CCTTTGCCCT CAACCGGCGG 960

AACCTGCCCG GGGACCGTCG GAAGGCCCTG GACATCATGC TGCCCCTGGT GGAGGCAGAA 1020

GGGCAGGTGG CCTCGGACAT CTACTGCCTG GTGGGGCGGA TCTACAAGGA CATGTTCCTG 1080

GAGTCCCACT TCACAGACAC GCAGAGCAGA GACAGCGGGA CGCAGTTCAA ACGGGGCTTC 1140

GAGTCAGAGC CGACGCTGCA CTCGGGGATC AACTACGCCG TCCTGCTGCT GGCCGCCGGA 1200

CACCAGTTCG ACTCCTCCTT TGAGCTGCGG AAAGTGGGAG TGAAGCTGAG CAGCCTGTTG 1260

GGCAAAAAAG GCAGCCTGGA CAAGCTGCAG AGCTACTGGG ACGTGGGCTT CTTCCTGGGC 1320

GCCAGCATCC TGGCGGGCGA CAATATCCGG GTGATCCAGG CCTCCGAGAA GCTCTTCAAA 1380

CTCAAAGCTC CCACCTGGTA CCTGCGCTCG CTGGTGGAGA CCATCCTGAT CTACCAGCAG 1440

TTCCACAAAC CCGGCCCGGA GCAGCCGGCG CCCAAGCAGG AGCTGGTGGA CTTCTGGATG 1500

GACTTCCTGG TGGAGGCCAC CAAGAGTGAC GTGTCCTCGG TCCGATTCCC TGTGCTGATT 1560

CTGGAACCCA CCAAGATCTA CCAGCCGTCC TATCTGTCCA TCAACAAGGA CGTGGAGGAC 1620

AACACCGTCT CCATCTGGCA CGTTGCCCCC GACGATAAGA ATAAAGGGAT TCACGAGTGG 1680

AACTTCAGCG CCACCTCGGT GCGCGGAGTC AGCATCTCCA AGTTTGACGA GCGCAGCGCC 1740

TTCTTGTACG TCCTCCACAA CGCCGAGGAC TTCCAGATCT ACTTCTGCAC CGAGGTTCAC 1800

TGCCGAAGGT TCTGCGATCT GGTCAACAGC ATCACCGAGG AGGCCTGGAG GGGTCCGGAG 1860

GAGGGAGACT GCGACAGCGA GACCCTGGAG TACGACTACG AGTACGACGA GCACGGAGAG 1920

AGGGTGGTGC TGGGCAAGGG CACCTTCGGG GTGGTGTACG CAGGCCGGGA TCTCAGCAAC 1980

CAGGTCCGCT TGGCCATCAA GGAGATCCCC GAACGGGACA GCAGGTACTC CCAGCCGCTT 2040

CACGAGGAGA TTGCGCTCCA CAAACACCTG AAGCACAAGA ACATCGTCCA GTACCTAGGA 2100

TCCATCAGCG AGAACGGCTT CATCAAGATC TTCATGGAGC AGGTGCCCGG AGGGAGTCTT 2160

TCGGCGCTGC TCAGGTCCAA GTGGGGCCCC CTCAAAAACA ACGAGCCCAC CATCGGCTTC 2220

TACACCCGGC AGGAATTCCT GGAGATGGAG CTGAAAGTCG GACCTGCACG ACTAACCATG 2280

ATCGCACACC GGGACATCAA GGGCGATAAT GTTCTCATCA ACACCTACAG CGGCGTCTTG 2340

AAGATCTCGG ATTTTGGCAC GTCCAAGAGG CTGGCTGGGA TTAATCCCTG CACCGAGACC 2400

TTCACAGGCA CACTACAGTA CATGGCTCCT GAGATCATAG ACAAGGGTCC TCGGGGATAC 2460

GGCAAGCCGG CGGACATTTG GTCTCTGGGC TGCACCATCA TAGAAATGGC GACAGGGAAG 2520

CCGCCCTTCT ACGAGCTGGG AGAGCCGCAA GCTGCCATGT TTAAGGTGGG CATGTTCAAG 2580

ATCCACCCCG AGATCCCCGA GTCCATGTCC CCGGAGGCCA AAGCCTTCAT CCTGCGCTGC 2640

TTCGAGCCCG ACCCGGACCG CCGCGCCACC GCTCTGGACC TGCTCACCGA CGAGTTCCTG 2700

ACCGTCACCA GCCGCAAGAA GAAGAGCAAG GCAGCTCTTA TTTCCCTCCG AACCTGCTGT 2760

GTTTCAGAGT ATCTCCGCAG CATCTCCCTG CCGGTGCCGG TGGTTGTGGA GGACACCAGC 2820

AGCAGCAGCG AGTACGGCTC CGTCTCCCCC GACAACGATC TCAACGCCAA CCCTTTCATC 2880

TTCAAGCCCA GCGTCAAGTG CTACAGCGAG AGGGATGTCA AGGGGACCAG AACGCTCTTC 2940

CTCAGCATTC CCGTGGAGAA CTTTGAGGAC CACAGCGCCC CTCCGTCTCC GGAAGAGAAA 3000

GACACGGGCT TCTTTATGCT GCGGAAGGAC AGCGAGAGAC GAGCCACTCT GCATCGCATC 3060

CTGACGGAGG ACCGGGACAA GGTGGTGGCC AACCTGACGG AGGCCTTCAC GCAGGGCACC 3120

GAGGAGATGA GGCTGAAGCC CCAGCACATC TCCACCCTCG TGGTCAGTCT GGCGGACTTT 3180

GTTCGCATGG CGGACAGGAA GATCGTCGCC AGCACGCTGT CCCAGCTCAA GCTGGAGCTG 3240

GACTTTGACA GCGCCGCCAT CAGCCAGCTC CAGGTGGTGC TGTTTGGCTT CCAGGATGCT 3300

GTGAACAAAG TGCTGCGAAA CCACAACATC AAACCTCACT GGATGTTCGC TTTGGACAAC 3360

ATCATCCGCA AAGCTGTGCA GACGGCCATC ACCATCCTGG TGCCAGGATC AGAGCTGAGG 3420

CCTCACTTCA GCCTGGCCTC GGAGAGCGAC CCCGCCGACC AGGACGACAT GGACGAGGAG 3480

GCTGAGCCGC GGCAACATTC CACCCACCAG AGCCACACGC ACCCTCCGGC GGTCAACGAC 3540

GACACGGTGG CCACCTCCGG GGTCAGCACC CTCAGCTCCA CCGTGTCCCA CGAGTCCCCC 3600

AGCGAGCAGC GGCCCGCCAG CATGGAGCTG GGCAGGATGA AGCTGGAGAC CAACAGGCTG 3660

CTTCAGCAGC TGATGGCCAA GGAGAGGGAG TACCAGAGCA TCCTGCAACA AGTGCTGAAG 3720

GAGAGGGAGC AGGAGATTAC GCTGCTGAGG ACCAGATCCG CAGGTCTGTT AGATGCTCCC 3780

TCATCCTCAC GCCGTCCACA CGAGAAGACC AGCCCGGCTT CTCCCAGGTG CGAGGACCCA 3840

GAGCTGATCG GCTGGCTGCG TCTCCATGGC GCCGACCAGG AGGCCGTGGA CAGGATACTG 3900

GACGAAGAGT ACACGTTGAG CGATATCCTC CACGATGTAA CCAGAGACGA TCTGAAAAGT 3960

TTGAGCCTGA GAGGTGGGGT CCTGTGCAAA CTGTGGAAGG CCATCACAGA GTACAGGCAG 4020

AAGCCG 4026

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG+fg vya++d++++ +la+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n

Q: 640   ERVVLGKGTFGVVYAGRDLSNQVRLAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  694

         6889**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglay...  116

         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e +i +yt+q    ++

Q: 695   IVQYLGSISENGFIKIFMEQVPGGSLSALLRsKWGPLKnnEPTIGFYTRQEFLEMELkvg  754

         *******************************9*****98899*******96554443112

S: 117   .LHekkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPE  174

             ++i HRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE

Q: 755   pARLTMIAHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPE  811

         245689*************************************...8*************

S: 175   vikkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklse  234

         +i+k+ +gyg+ aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+

Q: 812   IIDKGPRGYGKPADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKIHPEIPESMSP  871

         ************************************************************

S: 235   egkdflekcleldpkkrpsaeeLLkhefl  263

         e+k+f+ +c+e dp++r++a +LL++efl

Q: 872   EAKAFILRCFEPDPDRRATALDLLTDEFL  900

         **************************996

Domain Sequence
(FASTA)

ERVVLGKGTF GVVYAGRDLS NQVRLAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60

GSISENGFIK IFMEQVPGGS LSALLRSKWG PLKNNEPTIG FYTRQEFLEM ELKVGPARLT 120

MIAHRDIKGD NVLINTYSGV LKISDFGTSK RLAGINPCTE TFTGTLQYMA PEIIDKGPRG 180

YGKPADIWSL GCTIIEMATG KPPFYELGEP QAAMFKVGMF KIHPEIPESM SPEAKAFILR 240

CFEPDPDRRA TALDLLTDEF L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013