EKS-TEN-00027
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TEN-00027
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR518.24.2E-1569991264266
StatusUnreviewed
Ensembl ProteinENSTNIP00000022427
UniProt AccessionH3DPH8;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameIGF1R (2 of 2)
Gene Synonyms/Alias IGF1R (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTNIG00000019227ENSTNIP00000022427ENSTNIT00000022666
OrganismTetraodon nigroviridis
Functional Description
Protein Length1410
Protein Sequence
(FASTA)
MIRGAPMGSP TLFWALTLSA FTICILSACG EICGPVIDIR NDISEFNLLE KCTVVEGVLK 60
IVLMNDKTKN INQELFRSLS FPKLTIITDY LLLFRVSGLE SLSTLFPNLA VIRGRNLLFN 120
YALVIYEMPH LKDIGLYNLR NITRGALRIE KNSELCYLNS VDWSLIMNAE TNVISLNKKP 180
EECDNVCPGI MVKDEPLCQR TSFNDNHDAR CWTSNHCQKV CPERCKLACT DQGECCHSQC 240
LGSCTEPNND MACSACLHYH HEGRCVQDCP PGTYKFEGWR CITMDACSQV HLLGDTQFVI 300
HEGECMLECP SGFKRNETNQ MFCSACNGPC DKSCRSSMID SVDAAQSLKG CTVIDGNLHI 360
NIRNGNNITS ELESFMGLIQ TVKGYVKIRH SHALISLSFL KSLRFINGHE LDNMYAFSSI 420
DNQNLQNLWD WNHHNLTILR GRLFFRQNPK LCMSEIHKMW EKTGRTEKPE EGDFSNNGAR 480
ASCKSHILKF KSNATTSHTI GLTWENYRPP EYEGLISFIV YYKESPFQNI TEFDGQDGCG 540
SNSWHMVDVD LSHDQKIDPE VTLLHLKPWT QYAIFVKVIT LQVGDKHIKG AKSAIIYIRT 600
RPSLPSMPKD PRAYANSSTQ LIVKWSPPVF PNGNLTYYLV RWQRQPEDRE LYQHNYCSKK 660
LKIPIRISAT GLMDMEENTK PTKSDLDGAG NIQCCTCPKT PEMKDREKAD RVFFKRFENF 720
LHNSIFTPRP PDRRRRDVFG VANNTLFLEG GSRGNTTFGT GDNATESIPP VKHYPFSEGK 780
STVEFLEIHN LQPFTVYRID LHACNEEVGH CSVGAFVYSR TKPAVGADDI PGKVTYERSE 840
TVGGCVLLHW LEPVMPNGLI LMYEVKFRLG NEPEKHKCVS RQHYLEHRGA RLTNLGPGNY 900
SAQVRATSLA GNSSWTESMF FYVPPPKRDD GVTFYLVIII PIIATLLIAS LITILFFVNK 960
KRKSDRLGNG VLYASVNPEY FSAAEMYVPD EWEVAREKIT MHKELGQGSF GMVYEGIAKG 1020
VVKDEPEIRV AIKTVNESAS MRERIEFLNE ASVMKEFNCH HVVRLLGVVS QGQPTLVIME 1080
LMTRGDLKSY LRSLRKENST SEVLPPLKKM IQMAGEIADG MSYLNANKFV HRDLAARNCM 1140
VAEDFTVKIG DFGMTRDIYE TDYYRKGGKG LLPVRWMSPE SLKDGVFTTM SDVWSFGVVL 1200
WEIATLAEQP YQGMSNEQVL RFVMEGGLLD KPDNCPDMLF ELMRMCWQYN PKMRPSFLEI 1260
ISSIKEELDP SFREVSFFYS EENKPPDTEE LDMEVENMEN IPLDPASARQ GSPLSGCTGG 1320
CTPPPSAQQL SPIQGPGTPL LGPVSPSSLG LVAPSLASPG QALDKHSGHV SANGPVVVLR 1380
PNFEEMQPYA HMNGGRKNER ALPLPQSSAC 1410
Nucleotide Sequence
(FASTA)
ATGATCCGTG GCGCACCGAT GGGCAGCCCG ACCTTGTTTT GGGCTCTGAC GCTGTCTGCC 60
TTCACCATCT GCATCCTCTC CGCGTGTGGG GAAATTTGTG GTCCGGTCAT CGACATCCGA 120
AACGACATCA GTGAGTTCAA CCTGCTGGAG AAATGTACGG TGGTGGAGGG CGTCCTGAAG 180
ATCGTCCTCA TGAATGACAA GACCAAGAAC ATTAACCAGG AGCTCTTCCG CTCACTCAGC 240
TTCCCGAAGC TGACCATCAT CACCGACTAC CTGCTGCTGT TTCGCGTCTC GGGCCTGGAG 300
AGCCTAAGCA CGCTTTTCCC CAACCTGGCC GTCATCCGAG GGCGTAACCT CCTCTTCAAC 360
TATGCCCTGG TGATCTACGA GATGCCCCAC CTGAAGGACA TCGGCCTGTA CAACCTGAGG 420
AACATCACCC GAGGAGCCCT GCGGATCGAG AAGAACTCTG AGCTCTGCTA CCTGAACTCG 480
GTGGACTGGT CGCTCATTAT GAATGCCGAA ACTAACGTCA TCAGTTTAAA CAAGAAGCCA 540
GAGGAGTGCG ATAATGTTTG CCCAGGAATA ATGGTTAAGG ATGAGCCTCT TTGTCAGAGG 600
ACGTCGTTCA ATGACAACCA CGACGCCCGA TGCTGGACCT CGAACCACTG CCAGAAAGTA 660
TGTCCTGAAC GCTGCAAACT TGCCTGCACA GACCAGGGCG AGTGTTGCCA CAGCCAGTGC 720
CTGGGCAGCT GCACCGAACC CAACAACGAC ATGGCGTGCT CCGCCTGCCT CCACTACCAC 780
CACGAGGGCC GCTGCGTGCA AGACTGTCCC CCGGGAACCT ACAAGTTTGA GGGCTGGCGC 840
TGCATCACCA TGGACGCGTG CTCTCAAGTG CACCTACTTG GCGACACTCA GTTTGTCATC 900
CACGAGGGAG AGTGCATGCT CGAATGCCCC TCCGGCTTTA AACGCAACGA GACGAATCAA 960
ATGTTTTGCA GCGCCTGCAA CGGGCCCTGT GACAAATCGT GCCGTTCGTC CATGATTGAC 1020
TCGGTGGATG CTGCTCAGAG CCTGAAGGGC TGCACCGTCA TCGACGGCAA TCTGCACATT 1080
AACATTCGCA ACGGAAATAA CATCACATCG GAGCTGGAGA GCTTCATGGG ATTGATCCAG 1140
ACAGTGAAGG GCTACGTGAA GATCCGACAC TCCCACGCAC TCATCTCGCT GTCCTTCCTC 1200
AAAAGCCTGC GCTTCATCAA CGGGCACGAG CTCGATAACA TGTACGCATT CTCCTCCATC 1260
GACAACCAGA ACCTGCAGAA TCTGTGGGAC TGGAACCATC ACAACCTGAC AATTCTGCGC 1320
GGACGACTCT TCTTTCGCCA GAACCCCAAG CTGTGCATGT CGGAGATCCA CAAGATGTGG 1380
GAAAAAACGG GCAGGACTGA GAAGCCGGAG GAGGGAGACT TCAGTAACAA TGGCGCTAGA 1440
GCCAGCTGTA AAAGTCACAT CTTGAAGTTC AAGTCCAATG CCACAACAAG CCATACCATC 1500
GGGCTGACGT GGGAAAACTA CCGACCTCCG GAATACGAAG GCCTGATTAG CTTCATCGTC 1560
TACTACAAGG AATCTCCGTT CCAGAACATC ACAGAGTTTG ACGGCCAGGA CGGCTGTGGA 1620
TCAAACAGTT GGCACATGGT GGACGTGGAT CTCTCCCATG ACCAGAAGAT CGACCCGGAA 1680
GTCACTCTTC TGCACCTCAA GCCCTGGACC CAGTATGCTA TATTTGTGAA AGTCATCACC 1740
CTGCAGGTGG GGGACAAACA CATCAAAGGG GCCAAAAGCG CCATAATATA CATCCGCACA 1800
CGCCCATCAT TGCCGTCTAT GCCCAAGGAC CCTCGTGCGT ATGCCAACTC CTCTACCCAG 1860
CTGATAGTGA AGTGGTCACC TCCGGTCTTT CCCAACGGCA ATCTGACATA CTACTTGGTC 1920
CGCTGGCAGC GGCAGCCGGA GGACAGAGAG CTCTACCAAC ACAACTACTG CTCCAAAAAA 1980
CTTAAGATCC CAATCCGAAT CTCAGCCACG GGCCTTATGG ACATGGAGGA GAACACCAAG 2040
CCCACGAAAT CTGACCTAGA TGGGGCAGGT AACATCCAGT GCTGCACCTG CCCGAAGACG 2100
CCTGAAATGA AGGACCGGGA GAAGGCAGAT CGTGTGTTTT TCAAGAGATT CGAGAACTTC 2160
CTCCACAACT CCATCTTTAC GCCAAGGCCT CCGGATCGTC GCCGCAGAGA TGTCTTTGGT 2220
GTGGCTAACA ATACACTGTT TCTGGAGGGT GGCAGCAGGG GAAACACCAC ATTCGGCACG 2280
GGGGATAACG CCACGGAGAG CATCCCTCCT GTCAAGCATT ACCCCTTCTC CGAGGGCAAG 2340
AGCACAGTGG AATTTTTAGA GATCCACAAC CTGCAACCCT TTACCGTGTA CCGCATTGAC 2400
CTCCACGCCT GCAACGAGGA GGTGGGACAC TGCAGCGTCG GGGCCTTCGT CTACTCCAGG 2460
ACCAAACCCG CAGTTGGAGC AGACGACATC CCTGGGAAGG TGACCTATGA AAGGAGCGAG 2520
ACAGTTGGGG GTTGTGTGTT GCTGCATTGG CTGGAGCCTG TCATGCCCAA TGGTCTCATC 2580
CTGATGTACG AGGTCAAGTT CCGCCTGGGA AATGAGCCCG AGAAGCACAA GTGTGTGTCG 2640
CGGCAGCACT ACCTCGAGCA CAGGGGAGCC CGGCTGACCA ACCTTGGACC TGGGAATTAC 2700
TCTGCTCAAG TGCGCGCCAC TTCTCTGGCA GGGAACAGCT CCTGGACCGA GAGCATGTTT 2760
TTCTACGTGC CACCGCCCAA ACGAGACGAT GGTGTTACCT TCTACCTGGT CATCATAATT 2820
CCCATCATCG CGACCCTTTT GATCGCCAGC CTCATAACAA TTCTGTTTTT TGTGAACAAA 2880
AAAAGGAAAA GTGACAGGCT GGGAAATGGG GTTCTTTACG CATCCGTCAA TCCAGAATAC 2940
TTCAGTGCCG CAGAGATGTA CGTTCCGGAT GAGTGGGAGG TGGCCAGGGA GAAGATCACA 3000
ATGCACAAGG AGCTGGGCCA GGGCTCCTTC GGCATGGTGT ACGAGGGCAT CGCCAAGGGT 3060
GTGGTCAAGG ACGAACCCGA GATACGAGTG GCCATCAAGA CAGTCAACGA ATCGGCCAGC 3120
ATGAGGGAGC GAATTGAGTT TCTGAACGAG GCCTCTGTCA TGAAGGAGTT CAACTGCCAC 3180
CACGTGGTGC GGCTGCTGGG CGTGGTGTCT CAGGGGCAGC CGACATTGGT GATCATGGAG 3240
CTGATGACCC GTGGAGATCT CAAGAGCTAC TTGCGCTCTT TGCGCAAAGA AAATTCCACC 3300
AGTGAGGTCC TGCCCCCACT TAAAAAGATG ATCCAGATGG CAGGGGAAAT CGCCGATGGC 3360
ATGTCGTACC TCAATGCCAA CAAATTTGTC CACAGAGATC TGGCTGCCAG GAACTGCATG 3420
GTAGCCGAGG ACTTCACTGT GAAGATTGGA GATTTTGGCA TGACAAGAGA CATTTATGAG 3480
ACTGATTACT ACAGAAAAGG AGGGAAAGGC CTGCTGCCTG TCCGCTGGAT GTCTCCAGAG 3540
TCACTGAAAG ATGGCGTGTT CACTACAATG TCTGATGTCT GGTCATTCGG TGTGGTGCTG 3600
TGGGAGATCG CCACCTTGGC AGAACAGCCG TACCAGGGCA TGTCTAACGA ACAAGTGCTG 3660
CGCTTCGTCA TGGAGGGAGG ACTCCTGGAC AAACCCGACA ACTGCCCCGA CATGCTGTTC 3720
GAGCTGATGA GGATGTGCTG GCAGTATAAC CCCAAGATGC GTCCGTCCTT CCTGGAGATC 3780
ATCAGCAGCA TCAAAGAGGA ACTGGATCCT TCTTTCAGGG AGGTGAGCTT CTTCTACAGC 3840
GAGGAGAACA AGCCGCCAGA CACGGAAGAG CTGGACATGG AGGTGGAGAA CATGGAGAAC 3900
ATTCCACTGG ACCCTGCATC TGCCAGACAG GGTTCCCCGT TGTCGGGCTG TACCGGAGGT 3960
TGCACACCTC CTCCCTCCGC CCAGCAGTTA TCCCCCATAC AAGGCCCAGG TACTCCGCTG 4020
CTGGGGCCCG TGTCTCCCTC CTCCCTGGGC CTGGTGGCCC CATCTTTGGC ATCACCGGGT 4080
CAAGCCTTGG ACAAGCACTC AGGACATGTT TCTGCCAACG GGCCTGTGGT AGTTCTTCGG 4140
CCCAACTTTG AAGAGATGCA ACCCTATGCA CACATGAACG GAGGCAGAAA GAATGAACGG 4200
GCGTTACCGC TGCCCCAGTC GTCGGCCTGC TGA 4233
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i++ +elGqGsfGmvyeG+ak+vvk+e e rvaiktvne+as+reriefl+easvmkef+
Q: 999   ITMHKELGQGSFGMVYEGIAKGVVKDEPEIRVAIKTVNESASMRERIEFLNEASVMKEFN  1058
         7899********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslr+e+    +l+p  l+k+iqma+e
Q: 1059  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRKENSTSEVLPP--LKKMIQMAGE  1116
         *************************************99876655544..7*********
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGm+yl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw
Q: 1117  IADGMSYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1176
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         mspeslkdGvft+ sdvwsfGvvlwei+tlaeqpyqG+sneqvl+fv++gg+l+kp+ncp
Q: 1177  MSPESLKDGVFTTMSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPDNCP  1236
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
         ++l+elmr+cwqynpk+rpsflei++++
Q: 1237  DMLFELMRMCWQYNPKMRPSFLEIISSI  1264
         *************************976
Domain Sequence
(FASTA)
ITMHKELGQG SFGMVYEGIA KGVVKDEPEI RVAIKTVNES ASMRERIEFL NEASVMKEFN 60
CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRKEN STSEVLPPLK KMIQMAGEIA 120
DGMSYLNANK FVHRDLAARN CMVAEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS 180
PESLKDGVFT TMSDVWSFGV VLWEIATLAE QPYQGMSNEQ VLRFVMEGGL LDKPDNCPDM 240
LFELMRMCWQ YNPKMRPSFL EIISSI 266
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00013
EKS-DAR-00020
EKS-DRM-00003
EKS-GAG-00015
EKS-GAA-00024
EKS-MOD-00014
EKS-MYL-00017
EKS-ORN-00027
EKS-ORL-00022
EKS-PES-00016
EKS-SAH-00013
EKS-TAG-00014
EKS-TAR-00025
EKS-XET-00015
EKS-XIM-00025
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0031076; P:embryonic camera-type eye development
GO:0031101; P:fin regeneration
GO:0008354; P:germ cell migration
GO:0003007; P:heart morphogenesis
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0048752; P:semicircular canal morphogenesis
GO:0021522; P:spinal cord motor neuron differentiation
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013