EKS-TEN-00202

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00202

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	425.5	7.9E-128	375	633	259

Status

Unreviewed

Ensembl Protein

ENSTNIP00000000310

UniProt Accession

H3DPN8;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA5

Gene Synonyms/Alias

RPS6KA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000019285	ENSTNIP00000000310	ENSTNIT00000004048
ENSTNIG00000019285	ENSTNIP00000000880	ENSTNIT00000004227
ENSTNIG00000019285	ENSTNIP00000022487	ENSTNIT00000022726

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

701

Protein Sequence
(FASTA)

ERVGIENFEL LKVLGTGAYG KVFLVRKVSG HDAGKLYAMK VLKKATIVQK AKTAEHTRTE 60

RQVLEHIRQS PFLVTLHYAF QTDTKLHLIL DYVNGGELFT HLVQRVRFKE QEVALYSGEI 120

VLALEHLHKL GIVYRDLKLE NILLDSIGHI VLTDFGLSKE FDQVERAFSV CGTIEYMAPE 180

IVEGGESGHD KAVDWWSLGV LMYELLTGGS PFTVDGDNNS HTDIAKRILK KDPPFPKDMG 240

PLAKDIIQRL LVKDPKKRLG SGPNGAENVK KHPFYQKISW EELAAKKVPA PFKPVIRDEL 300

DVSNFAEEFT EMDPTYSPAA LPQNCDRIFQ GYSFMAPSIL FKRNVAGGPR SPVHAIIVRL 360

QDSPFYMSYE MDLRDSVLGE GSFSICRRCT HKKTGQKYAV KIVSKRMEAQ TQREIAALKL 420

CDGHPNIVKL HEIYHDQLHT YLVLELLGGG ELLERIRRKQ HFSETEASRI MRKLVSAVSH 480

MHDVGVVHRD LKPENLLFTD ESENSEIKII DFGFARLKPP DNQLLKTPCF TLQYAAPEIL 540

KYDGYDESCD LWSLGVILYT MLSGQVPFQC REKSLMHTSA EEIMKKIKQG DFSFEGEAWR 600

NVSQQAKDLI QELLTVDPNK RIKMCGLRYN AWLQDDSQLS SNPLMTPDIL GSSTASVHTC 660

VKATFNAFNK CKREGFRLQT VDKAPLAKRR KMKKTSTSTE T 701

Nucleotide Sequence
(FASTA)

GAGAGGGTTG GCATTGAAAA CTTTGAGCTT CTAAAGGTGC TTGGAACAGG AGCATACGGA 60

AAGGTGTTCC TGGTGAGGAA GGTGAGTGGC CACGATGCAG GAAAGCTGTA CGCCATGAAG 120

GTTTTGAAAA AGGCCACTAT TGTGCAGAAG GCAAAGACTG CTGAACACAC GCGCACTGAA 180

AGGCAAGTGC TGGAGCACAT CCGCCAGTCC CCATTCCTCG TCACACTTCA CTACGCCTTC 240

CAGACGGACA CCAAGCTGCA CCTCATTCTC GATTATGTCA ACGGCGGAGA GCTCTTCACA 300

CATTTGGTGC AAAGGGTGCG CTTTAAGGAG CAGGAGGTAG CGCTGTACAG CGGAGAGATT 360

GTGCTGGCGC TGGAGCATCT ACACAAGCTC GGGATCGTCT ACCGAGACCT AAAACTGGAA 420

AATATTCTCC TGGATTCCAT CGGTCATATA GTTCTGACGG ACTTTGGCCT GAGTAAAGAG 480

TTTGACCAGG TGGAAAGGGC CTTTTCTGTG TGCGGCACTA TCGAATACAT GGCTCCGGAA 540

ATCGTAGAAG GTGGCGAGTC GGGGCATGAC AAGGCGGTGG ACTGGTGGAG CCTCGGCGTT 600

TTGATGTATG AGCTCTTGAC CGGCGGATCT CCCTTCACCG TGGACGGAGA CAACAACTCA 660

CACACGGACA TCGCCAAGAG GATATTAAAA AAAGATCCTC CTTTCCCCAA AGATATGGGG 720

CCGCTGGCCA AAGACATCAT CCAGCGGCTC CTCGTCAAAG ATCCAAAGAA AAGACTGGGC 780

TCAGGTCCCA ATGGAGCGGA GAACGTGAAG AAGCACCCGT TCTACCAGAA AATCAGCTGG 840

GAGGAGCTGG CAGCGAAGAA GGTGCCTGCC CCGTTCAAGC CCGTGATCCG GGACGAGCTG 900

GATGTCAGCA ACTTTGCCGA AGAGTTCACG GAGATGGACC CCACCTACTC CCCTGCGGCG 960

CTGCCTCAGA ACTGCGACCG CATCTTCCAG GGCTACTCTT TCATGGCTCC TTCTATCCTC 1020

TTCAAGCGGA ACGTGGCAGG AGGCCCTCGC TCCCCTGTCC ACGCCATTAT TGTTCGGCTG 1080

CAGGACTCGC CTTTCTATAT GAGTTATGAG ATGGACCTGA GGGACAGCGT TTTGGGAGAA 1140

GGGAGCTTTT CCATCTGCAG ACGCTGCACA CACAAGAAGA CCGGGCAGAA ATACGCCGTT 1200

AAAATTGTCA GCAAGAGGAT GGAGGCACAG ACGCAGCGGG AAATAGCTGC CCTGAAGCTC 1260

TGCGACGGCC ACCCCAACAT CGTCAAGTTG CACGAAATCT ACCACGATCA GCTTCACACC 1320

TACCTGGTTC TGGAGCTGCT GGGCGGAGGA GAACTGCTGG AGAGGATTCG CAGAAAACAA 1380

CATTTCAGCG AAACAGAGGC CAGCCGCATC ATGCGAAAGC TGGTGTCGGC CGTCAGTCAC 1440

ATGCACGATG TAGGAGTTGT ACACAGAGAC CTTAAACCGG AGAACCTGCT CTTTACAGAT 1500

GAGAGCGAGA ACTCCGAGAT AAAAATCATA GATTTCGGCT TCGCTCGCCT GAAACCACCA 1560

GACAATCAGC TTCTGAAGAC TCCCTGCTTC ACGCTGCAGT ACGCCGCACC AGAGATACTC 1620

AAATACGACG GCTACGACGA GTCCTGTGAC CTGTGGAGTC TGGGGGTCAT TCTGTACACC 1680

ATGCTGTCCG GCCAGGTGCC TTTTCAGTGT CGGGAGAAGA GCCTGATGCA CACGAGTGCT 1740

GAAGAGATCA TGAAGAAAAT CAAACAGGGT GACTTTTCAT TTGAAGGAGA GGCCTGGAGA 1800

AATGTGTCTC AGCAGGCCAA AGACCTCATA CAGGAGCTGC TGACGGTTGA CCCAAACAAG 1860

AGGATTAAGA TGTGTGGCCT GCGTTACAAC GCCTGGCTGC AGGACGACAG CCAGCTGTCC 1920

TCCAACCCTC TCATGACCCC AGATATCCTC GGCTCATCCA CCGCCTCCGT CCACACTTGC 1980

GTCAAAGCCA CCTTTAATGC ATTCAACAAA TGTAAGCGTG AAGGTTTCCG GCTGCAGACG 2040

GTGGACAAAG CCCCACTGGC GAAGAGAAGA AAGATGAAGA AGACCAGTAC CAGCACAGAG 2100

ACC 2103

Domain Profile

S: 4     kedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvy  62

         +  lG+Gs+s+c+rc hk+t+q++avki++k+ +++t++ei++l+++++hpniv+l+++y

Q: 375   DSVLGEGSFSICRRCTHKKTGQKYAVKIVSKRmEAQTQREIAALKLCDGHPNIVKLHEIY  434

         6779****************************9***************************

S: 63    ddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkpe  122

         +d++++ylvlell GGell+ri++k++fse+eas i+r+lv+av+++h++Gvvhrdlkpe

Q: 435   HDQLHTYLVLELLGGGELLERIRRKQHFSETEASRIMRKLVSAVSHMHDVGVVHRDLKPE  494

         ************************************************************

S: 123   nilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlws  182

         n+l++des+n+e ikiidfGfa+lk+++n+llktpc+tl+++ape+lk +Gyde+cdlws

Q: 495   NLLFTDESENSE-IKIIDFGFARLKPPDNQLLKTPCFTLQYAAPEILKYDGYDESCDLWS  553

         ************.***********************************************

S: 183   lGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvskl  238

         lGv+lytml+G+vpf    +++ +++aeei++kik+G+fs++Geaw++vs++akdl+++l

Q: 554   LGVILYTMLSGQVPFqcreKSLMHTSAEEIMKKIKQGDFSFEGEAWRNVSQQAKDLIQEL  613

         ***************998888999************************************

S: 239   ltvdpakrlkleqllkhswl  258

         ltvdp+kr+k+ +l+++ wl

Q: 614   LTVDPNKRIKMCGLRYNAWL  633

         *******************7

Domain Sequence
(FASTA)

DSVLGEGSFS ICRRCTHKKT GQKYAVKIVS KRMEAQTQRE IAALKLCDGH PNIVKLHEIY 60

HDQLHTYLVL ELLGGGELLE RIRRKQHFSE TEASRIMRKL VSAVSHMHDV GVVHRDLKPE 120

NLLFTDESEN SEIKIIDFGF ARLKPPDNQL LKTPCFTLQY AAPEILKYDG YDESCDLWSL 180

GVILYTMLSG QVPFQCREKS LMHTSAEEIM KKIKQGDFSF EGEAWRNVSQ QAKDLIQELL 240

TVDPNKRIKM CGLRYNAWL 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013