EKS-TEN-00369

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TEN-00369

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	338.1	4.7E-101	200	498	299

Status

Unreviewed

Ensembl Protein

ENSTNIP00000022591

UniProt Accession

H3DPZ2;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTNIG00000019387	ENSTNIP00000022591	ENSTNIT00000022830

Organism

Tetraodon nigroviridis

Functional Description

Protein Length

531

Protein Sequence
(FASTA)

LCRWCEASSP ACLDDVCFSN CSLSSFCSLA EEICIAIWRK TNETTTVHTT CHNPALPLEG 60

ISPALLLNFT SRECHMTSQP AEGATLMVCG CRGEHECNDK LIFDQGASFS KLQNKDLVPV 120

VLVSLVPPLL VAVAATLAFY FYRTRQVDKP DSPGRPDWPP KRSTELYLAS DLPCGAVPGG 180

EGGCAGDVTG SGEVTELLPI KLEVLVGKGR FAEVWLGRLL QAEKAEGTVH DPVAVKVFPA 240

VEYESWRNEC SILSDPKMEH GNIVRFLAAE DRGPPGHALR QYWLVLAYHS LGNLQDFLAA 300

NLLSWDELVA MAGSIAKGLA HLHSDTTPGG LPKVPVAHRD LKSSNIVMKS RSECALCDFG 360

LALRLDLSLT VDDYANSGQV GTARYMAPEV LESRVNLEDL EAFKQMDVYS MALVLWEMAS 420

RCRANGEVRS YEPAFGSQVC EQPCVDSMRD LVLRDRGRPD IPATWSRHKG LSIFCSTIME 480

CWDHDPEARL TAHCVVERFT ALQEDQEELS AVGRSCIWTE LEMDGAAVGR S 531

Nucleotide Sequence
(FASTA)

CTGTGCCGGT GGTGCGAGGC CTCCAGCCCC GCCTGTCTGG ACGACGTCTG CTTCTCCAAC 60

TGCTCGCTGT CGTCCTTCTG CAGCCTCGCC GAGGAGATCT GCATCGCCAT CTGGAGGAAG 120

ACCAACGAGA CCACCACCGT CCACACCACG TGTCACAACC CAGCTCTGCC ACTAGAGGGC 180

ATTAGCCCTG CTCTCCTGCT CAATTTCACC TCCAGGGAGT GTCACATGAC CTCCCAGCCT 240

GCGGAGGGCG CCACCCTGAT GGTGTGTGGT TGCCGGGGCG AACACGAGTG TAACGACAAG 300

CTCATCTTTG ACCAGGGGGC CAGCTTCTCT AAGCTCCAGA ACAAAGACCT GGTCCCGGTG 360

GTTCTGGTCA GCCTGGTTCC TCCTCTCCTG GTTGCTGTTG CCGCCACTCT GGCCTTCTAC 420

TTCTACCGGA CCCGTCAAGT GGACAAGCCG GACTCGCCCG GGCGGCCTGA CTGGCCTCCT 480

AAACGGAGCA CTGAGCTGTA CCTGGCCTCA GACCTGCCCT GTGGGGCTGT CCCTGGTGGA 540

GAGGGCGGAT GTGCAGGAGA CGTGACGGGT TCAGGGGAGG TGACGGAGCT GCTGCCCATC 600

AAGCTGGAGG TGCTGGTGGG TAAAGGGCGC TTTGCAGAGG TGTGGCTGGG ACGTCTGCTG 660

CAGGCGGAGA AGGCAGAAGG TACCGTGCAC GACCCCGTGG CGGTGAAGGT GTTTCCGGCT 720

GTTGAGTATG AATCCTGGAG AAACGAGTGT TCCATCCTGT CCGACCCAAA GATGGAGCAC 780

GGCAACATTG TTCGCTTCCT CGCAGCCGAG GACAGAGGGC CACCTGGCCA CGCCCTCCGC 840

CAGTACTGGC TGGTCCTGGC CTATCACAGC CTCGGGAATC TGCAGGACTT CCTCGCAGCT 900

AACCTTTTGA GCTGGGACGA GCTTGTTGCC ATGGCAGGAA GCATTGCAAA GGGGCTAGCG 960

CATCTCCATA GCGACACAAC ACCCGGCGGG CTGCCAAAGG TGCCTGTTGC CCACCGAGAC 1020

CTGAAGAGCA GCAACATCGT GATGAAGAGC AGGTCCGAGT GTGCCCTCTG TGACTTTGGT 1080

CTGGCGCTGC GGTTGGACTT GTCCCTCACC GTGGATGACT ACGCCAACAG TGGACAGGTG 1140

GGGACTGCTC GCTACATGGC TCCTGAGGTG CTGGAGTCGA GGGTGAACCT AGAAGACCTG 1200

GAAGCCTTCA AGCAGATGGA TGTTTACTCC ATGGCTCTGG TCCTGTGGGA GATGGCGTCA 1260

CGTTGCCGTG CCAACGGAGA GGTGAGGAGC TACGAGCCAG CCTTCGGCTC CCAGGTGTGT 1320

GAGCAGCCCT GCGTGGACAG TATGAGGGAC CTGGTGCTGC GGGACCGAGG ACGCCCGGAC 1380

ATCCCTGCAA CCTGGAGCCG ACACAAGGGC CTGAGCATCT TCTGCTCCAC CATCATGGAG 1440

TGCTGGGATC ACGACCCAGA GGCCCGGCTG ACCGCTCACT GCGTGGTGGA GCGCTTCACG 1500

GCCCTGCAGG AGGACCAGGA GGAGCTGAGT GCAGTTGGAC GGAGCTGCAT TTGGACGGAG 1560

CTGGAGATGG ACGGAGCTGC AGTTGGACGG AGC 1593

Domain Profile

S: 1     lklleligkGrygeVwkaklrg.........eevAvKifstedeaswkrEkeiyqtvllr  51

         +kl  l+gkGr++eVw ++l +         + vAvK+f++ + +sw++E  i + ++++

Q: 200   IKLEVLVGKGRFAEVWLGRLLQaekaegtvhDPVAVKVFPAVEYESWRNECSILSDPKME  259

         567789*************99989999999999***************************

S: 52    henilqfiaadk..keedsltelllvteyhekgsLsdyLkretldveellrlalslasGl  109

         h ni++f+aa+      + l +++lv++yh  g+L+d+L ++ l+++el+ +a s+a+Gl

Q: 260   HGNIVRFLAAEDrgPPGHALRQYWLVLAYHSLGNLQDFLAANLLSWDELVAMAGSIAKGL  319

         **********99544567899***************************************

S: 110   ahLHeeivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaans  169

         ahLH++ ++  g  K  +aHRDlks Ni++k+   c+++D+GLal+l+ + ++ d a++

Q: 320   AHLHSD-TTPGGLPKVPVAHRDLKSSNIVMKSRSECALCDFGLALRLDLSLTVDDYANSG  378

         ******.566689***********************************************

S: 170   qvGtkRYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfee  229

         qvGt RYmaPEvle+++nl+d+eafk++DvYs++LvlWE+asRc++ ++ev  y+++f +

Q: 379   QVGTARYMAPEVLESRVNLEDLEAFKQMDVYSMALVLWEMASRCRA-NGEVRSYEPAFGS  437

         **********************************************.*************

S: 230   vvgsdPsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkk  289

         +v ++P++++m+++v++++ rP ip +w++++ l+ +++++ ecWd+dpeaRlta++v +

Q: 438   QVCEQPCVDSMRDLVLRDRGRPDIPATWSRHKGLSIFCSTIMECWDHDPEARLTAHCVVE  497

         **********************************************************88

S: 290   r  290

Q: 498   R  498

Domain Sequence
(FASTA)

IKLEVLVGKG RFAEVWLGRL LQAEKAEGTV HDPVAVKVFP AVEYESWRNE CSILSDPKME 60

HGNIVRFLAA EDRGPPGHAL RQYWLVLAYH SLGNLQDFLA ANLLSWDELV AMAGSIAKGL 120

AHLHSDTTPG GLPKVPVAHR DLKSSNIVMK SRSECALCDF GLALRLDLSL TVDDYANSGQ 180

VGTARYMAPE VLESRVNLED LEAFKQMDVY SMALVLWEMA SRCRANGEVR SYEPAFGSQV 240

CEQPCVDSMR DLVLRDRGRP DIPATWSRHK GLSIFCSTIM ECWDHDPEAR LTAHCVVER 299

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013