EKS-TAR-00222

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00222

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	464.5	2.4E-139	211	471	261

Status

Unreviewed

Ensembl Protein

ENSTRUP00000000783

UniProt Accession

H2RKW9;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCE (1 of 2)

Gene Synonyms/Alias

PRKCE (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000000339	ENSTRUP00000000783	ENSTRUT00000000786
ENSTRUG00000000339	ENSTRUP00000000782	ENSTRUT00000000785

Organism

Takifugu rubripes

Functional Description

Protein Length

540

Protein Sequence
(FASTA)

RRRQGAVRRR VHQVNGHKFM ATYLRQPTYC SHCRDFIWGV LGKQGYQCQV CTCVVHKRCH 60

ELIITKCAGM KKQEDTPEEV GSQRFSVNMP HKFSIHNYKV PTFCDHCGSL LWGLMRQGLQ 120

CKVCKMNVHR RCEKNVAPNC GVDARGIAKV LSDLGVTPDK ISNTAQRRRK AALSLDQQGP 180

QHSSSSSTTS SSSSSAGRED GQVQRRTLKD FNFIKVLGKG SFGKVMLAEL KGSEDVYAVK 240

VLKKDVILQD DDVDCTMTEK RILALARRHP YLTQLHCCFQ TRDRLFFVME YVNGGDLMFQ 300

IQRSRKFDEP RSRFYAAEVT SALMFLHRNG VIYRDLKLDN ILLDAEGHCK LADFGMCKEG 360

IMNGVTTTTF CGTPDYIAPE ILQELEYGAS VDWWALGVLM YEMMAGQPPF EADNEDDLFE 420

SILHDDVLYP VWLSKEAVSI LRAFMTKNPA KRLGCVVTQG CEEAIKTHAF FREIDWVLLE 480

QRKVKPPFKP RIKTKRDVNN FDQDFTKEDP VLTPTDEAII RQINQEEFKD FSYCAPEETH 540

Nucleotide Sequence
(FASTA)

CGGCGCCGGC AGGGAGCCGT CCGGAGACGC GTCCATCAGG TCAACGGACA CAAGTTCATG 60

GCCACCTACC TGAGACAGCC CACCTACTGC TCACACTGCA GGGACTTCAT CTGGGGCGTG 120

CTGGGGAAGC AGGGCTACCA GTGCCAGGTG TGTACTTGTG TTGTTCACAA GCGCTGCCAT 180

GAACTCATCA TCACCAAGTG TGCTGGGATG AAGAAACAGG AGGACACACC CGAAGAGGTG 240

GGCTCACAGA GGTTCAGTGT TAACATGCCG CACAAGTTCA GTATTCACAA CTACAAGGTG 300

CCCACCTTCT GCGACCACTG TGGCTCCCTG CTGTGGGGCC TGATGAGGCA GGGTCTGCAG 360

TGCAAAGTGT GTAAGATGAA CGTGCACCGA AGGTGTGAGA AGAACGTGGC TCCTAACTGT 420

GGCGTGGACG CCCGAGGAAT CGCCAAGGTC CTGTCCGACC TGGGCGTCAC CCCCGACAAG 480

ATCTCCAACA CCGCACAGCG CCGGAGGAAG GCGGCGCTGT CCCTGGATCA GCAGGGACCC 540

CAACACTCCT CCTCCTCGTC CACCACCTCC TCCTCTTCGT CCTCGGCGGG CAGGGAGGAC 600

GGCCAGGTCC AGAGGAGGAC GCTGAAGGAC TTCAACTTCA TCAAAGTTCT GGGCAAAGGC 660

AGCTTCGGCA AGGTGATGCT GGCAGAGCTG AAGGGGTCAG AGGACGTTTA TGCCGTCAAG 720

GTCCTGAAGA AGGACGTGAT CCTGCAGGAC GACGATGTCG ACTGCACCAT GACGGAGAAG 780

CGCATCCTGG CCCTGGCCCG CCGACACCCC TACCTCACCC AGCTGCACTG CTGCTTCCAG 840

ACACGGGATC GTCTGTTCTT CGTCATGGAA TACGTGAACG GAGGAGACCT GATGTTCCAG 900

ATCCAGCGCT CCAGGAAGTT CGACGAGCCG CGCTCCCGCT TCTACGCCGC CGAGGTCACC 960

TCGGCGCTCA TGTTCCTGCA CCGCAACGGC GTCATCTACA GGGATCTGAA GCTGGACAAC 1020

ATCCTGCTGG ACGCAGAGGG ACACTGCAAG CTGGCCGACT TCGGCATGTG CAAAGAGGGC 1080

ATCATGAACG GCGTGACCAC CACCACCTTC TGTGGCACAC CTGACTACAT CGCCCCCGAG 1140

ATCCTGCAGG AGCTGGAGTA CGGCGCCTCG GTGGACTGGT GGGCGCTCGG GGTTCTGATG 1200

TACGAGATGA TGGCCGGACA GCCGCCGTTC GAGGCCGATA ACGAAGACGA TTTGTTCGAG 1260

TCCATCCTCC ACGACGACGT CCTCTACCCC GTCTGGCTCA GCAAAGAAGC CGTTTCTATC 1320

CTCCGAGCGT TCATGACCAA GAACCCGGCC AAGCGGCTGG GCTGCGTGGT GACCCAGGGC 1380

TGCGAGGAGG CCATCAAGAC CCACGCCTTC TTCAGGGAGA TCGACTGGGT CCTGCTGGAG 1440

CAGAGGAAAG TGAAGCCGCC CTTTAAACCC CGAATCAAAA CCAAACGTGA TGTGAATAAC 1500

TTTGACCAGG ACTTCACTAA GGAGGACCCG GTGCTGACGC CCACCGACGA GGCCATCATC 1560

CGTCAGATCA ACCAGGAGGA GTTCAAAGAC TTCTCTTACT GCGCCCCCGA GGAGACGCAC 1620

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+++kvlGkGsfgkv+laelk+++++ya+kvlkkdv+lqdddv++t++ekr+lala+++p

Q: 211   FNFIKVLGKGSFGKVMLAELKGSEDVYAVKVLKKDVILQDDDVDCTMTEKRILALARRHP  270

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         +l+ql++cfqt+drlffv+eyvnGGdlmf+iq++rk++e+r+rfyaae+++al+flh++g

Q: 271   YLTQLHCCFQTRDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHRNG  330

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         +iyrdlkldn+lldaeGh+kladfG+cke+i++g tt+tfcGtPdyiaPeil+e eyg+s

Q: 331   VIYRDLKLDNILLDAEGHCKLADFGMCKEGIMNGVTTTTFCGTPDYIAPEILQELEYGAS  390

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwalGvl+yem+agq+Pfe+++ed+lfesil+++vlyP++lskeav+il++++tk+p+

Q: 391   VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILRAFMTKNPA  450

         ************************************************************

S: 241   krlGv..keegeedikehaff  259

         krlG+  ++  ee+ik+haff

Q: 451   KRLGCvvTQGCEEAIKTHAFF  471

         *****544778999******9

Domain Sequence
(FASTA)

FNFIKVLGKG SFGKVMLAEL KGSEDVYAVK VLKKDVILQD DDVDCTMTEK RILALARRHP 60

YLTQLHCCFQ TRDRLFFVME YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHRNG 120

VIYRDLKLDN ILLDAEGHCK LADFGMCKEG IMNGVTTTTF CGTPDYIAPE ILQELEYGAS 180

VDWWALGVLM YEMMAGQPPF EADNEDDLFE SILHDDVLYP VWLSKEAVSI LRAFMTKNPA 240

KRLGCVVTQG CEEAIKTHAF F 261

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013