EKS-TAR-00211
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00211
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb386.99.8E-116403658256
StatusUnreviewed
Ensembl ProteinENSTRUP00000001343
UniProt AccessionH2RMH8;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000000567ENSTRUP00000001345ENSTRUT00000001351
ENSTRUG00000000567ENSTRUP00000001341ENSTRUT00000001347
ENSTRUG00000000567ENSTRUP00000001342ENSTRUT00000001348
ENSTRUG00000000567ENSTRUP00000001343ENSTRUT00000001349
ENSTRUG00000000567ENSTRUP00000001344ENSTRUT00000001350
OrganismTakifugu rubripes
Functional Description
Protein Length724
Protein Sequence
(FASTA)
DSSDDSDGKT NEKPCTVKHQ ITNGHTEKVG MENFELLKVL GTGAYGKVFL VRKNSGHDVG 60
QLYAMKVLKK AAIVQKAKTT EHTRTERQVL ENIRQSPFLV TLHYAFQTQS KLHLILDYVS 120
GGEMFTHLYQ RDHFPEEAVQ IYIGEIILAL EHLHKQLGIV YRDIKLENIL LDSEGHIVLT 180
DFGLSKEFLE EEKERTYSFC GTIEYMAPEI IRGKAGHGKS VDWWSLGILM FELLTGASPF 240
TLEGERNSQR RILRCDPPFP SMIGHTAQDL LKKLLVKDPH KRLGSGPRGA EDIKAHPFFK 300
GLNWDDLAQK KVPSPFKPEL KSELDVGNFA EEFTGMDPVY SPASTPPSTG RLFKGYSFIA 360
PSILFNKNAV MTRQTANLYQ RHTVHFHESQ FFNHYELCLS GPPLGAGSFS VCRKCQHKQS 420
GRDYAVKIVS RRMEANTKRE IAALRHLSHP NIVKLHEVYT DQYHTYLVME LLRGGELLER 480
IKKKKLFGEA EASQLLQSLV SAVSFMHEAG VVHRDLKPEN VLFADEGEDS NLKVIDFGFA 540
RLCPAGSAPL QTPCFTLQYA APELFESAGY DKACDLWSLG VILYTMLSGQ VPFQSEQRGM 600
TSSYAADIMH KIKEGDFSLD GECWKGVSDD AKELVKGLLT VDPENRLKLS DLKENSWLQG 660
GASMSTTPLC TPDVLESSGP TVRTYVNATY KAFNRGKREG FFLKSVDNAP LAKRRKQKMT 720
STGV 724
Nucleotide Sequence
(FASTA)
GATAGTAGTG ATGACTCTGA TGGAAAAACA AATGAAAAGC CCTGCACCGT CAAACATCAG 60
ATCACGAATG GTCACACCGA GAAGGTCGGC ATGGAAAACT TTGAGCTGCT CAAAGTCCTT 120
GGAACTGGAG CTTATGGAAA AGTGTTTCTG GTGAGGAAGA ACAGTGGTCA TGATGTGGGC 180
CAGCTGTATG CTATGAAGGT GTTGAAGAAA GCAGCAATAG TTCAAAAGGC AAAGACGACG 240
GAACACACTC GAACTGAGCG GCAGGTGCTG GAGAACATCC GCCAGTCTCC GTTCCTGGTC 300
ACGCTGCACT ACGCCTTTCA GACCCAGAGC AAGCTGCATC TCATCCTGGA CTACGTGAGC 360
GGCGGGGAGA TGTTCACTCA CTTGTATCAG CGCGACCACT TTCCTGAGGA GGCGGTGCAG 420
ATTTATATCG GGGAAATAAT CTTAGCTCTG GAACACCTAC ACAAGCAGCT CGGGATCGTT 480
TACCGAGACA TCAAATTGGA AAACATTCTC CTGGACAGCG AAGGACACAT AGTTTTGACA 540
GACTTCGGGC TCAGTAAGGA GTTTCTGGAA GAGGAGAAGG AACGGACATA CTCGTTCTGT 600
GGCACCATTG AGTACATGGC CCCTGAAATC ATCAGAGGGA AAGCTGGACA CGGCAAGTCT 660
GTAGATTGGT GGAGTCTGGG GATCCTGATG TTTGAACTGC TGACGGGAGC GTCTCCGTTT 720
ACCTTGGAGG GAGAGAGGAA CTCCCAGAGG CGGATTTTGC GCTGCGATCC ACCCTTCCCC 780
TCCATGATTG GACACACTGC TCAGGACCTG TTGAAGAAGC TATTGGTGAA AGACCCCCAC 840
AAGAGGCTGG GTTCTGGACC ACGGGGGGCC GAAGACATTA AAGCTCACCC TTTCTTCAAG 900
GGCCTCAACT GGGATGACCT AGCACAGAAG AAGGTACCCA GTCCATTTAA ACCAGAGCTC 960
AAGAGTGAAC TTGATGTTGG GAACTTTGCC GAGGAGTTCA CTGGGATGGA TCCAGTCTAT 1020
TCTCCGGCGA GCACTCCCCC CAGCACTGGG CGTTTGTTCA AAGGTTACTC CTTCATCGCC 1080
CCGTCCATCC TTTTTAATAA AAACGCAGTC ATGACGAGGC AGACTGCAAA TCTCTATCAG 1140
CGACATACAG TACATTTCCA CGAATCCCAG TTTTTTAACC ACTATGAGCT GTGTCTCAGC 1200
GGACCTCCTC TGGGCGCGGG CAGTTTCTCT GTGTGCAGGA AATGCCAACA CAAGCAAAGT 1260
GGGCGTGACT ACGCTGTCAA GATCGTCAGC CGCAGAATGG AGGCAAACAC AAAGAGGGAG 1320
ATCGCTGCGT TGAGACATTT GTCTCACCCA AATATTGTCA AGCTGCACGA AGTTTATACT 1380
GACCAGTACC ACACATATTT AGTGATGGAG CTTCTGAGGG GAGGAGAGTT ACTGGAGAGG 1440
ATCAAGAAGA AGAAGCTGTT TGGTGAGGCA GAGGCGAGCC AGCTGCTGCA AAGCCTGGTG 1500
TCAGCTGTCA GCTTCATGCA CGAAGCAGGA GTCGTGCACA GAGACCTAAA ACCCGAGAAT 1560
GTGCTGTTTG CAGATGAGGG GGAGGACTCC AACCTGAAGG TAATAGACTT TGGCTTTGCC 1620
CGCCTGTGCC CTGCCGGGAG CGCTCCCCTG CAGACGCCCT GCTTCACGCT GCAGTACGCT 1680
GCCCCCGAAC TGTTTGAGAG CGCAGGGTAC GACAAAGCCT GCGACCTCTG GAGTCTCGGG 1740
GTCATCTTGT ACACCATGCT GTCAGGCCAG GTGCCGTTCC AGAGTGAACA GCGTGGGATG 1800
ACCTCATCAT ACGCTGCCGA CATCATGCAC AAAATCAAAG AGGGCGACTT CTCATTGGAC 1860
GGGGAATGTT GGAAGGGTGT TTCAGACGAT GCCAAAGAGC TCGTCAAAGG TTTACTCACA 1920
GTAGACCCAG AGAATCGTCT GAAACTGTCT GATCTGAAGG AGAATAGCTG GCTGCAGGGT 1980
GGAGCCTCCA TGTCCACCAC TCCTCTGTGT ACCCCAGACG TGCTCGAGTC CAGCGGGCCT 2040
ACAGTCCGTA CCTACGTCAA TGCCACCTAC AAGGCTTTTA ACCGCGGAAA GAGAGAAGGC 2100
TTCTTTCTAA AGAGCGTCGA CAACGCCCCC CTGGCAAAGA GACGGAAGCA GAAGATGACG 2160
AGCACGGGCG TG 2172
Domain Profile
S: 6     dlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvydd  64
         +lG Gs+svc++c hk++++++avki++++ +++t++ei++l++  +hpniv+l++vy d
Q: 403   PLGAGSFSVCRKCQHKQSGRDYAVKIVSRRmEANTKREIAALRH-LSHPNIVKLHEVYTD  461
         69****************************9**********976.58*************
S: 65    gkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkpeni  124
         + ++ylv+ell+GGell+rikkkk f e eas++l++lv+av+++he Gvvhrdlkpen+
Q: 462   QYHTYLVMELLRGGELLERIKKKKLFGEAEASQLLQSLVSAVSFMHEAGVVHRDLKPENV  521
         ************************************************************
S: 125   lyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlwslG  184
         l++de ++++ +k+idfGfa+l +a + +l+tpc+tl+++ape+++  Gyd+acdlwslG
Q: 522   LFADEGEDSN-LKVIDFGFARLCPAGSAPLQTPCFTLQYAAPELFESAGYDKACDLWSLG  580
         *******999.*************************************************
S: 185   vllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         v+lytml+G+vpf    +  +++ a++i+ kikeG+fsl+Ge w++vs++ak+lv++llt
Q: 581   VILYTMLSGQVPFqseqRGMTSSYAADIMHKIKEGDFSLDGECWKGVSDDAKELVKGLLT  640
         *************877555678899***********************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rlkl++l+++swl
Q: 641   VDPENRLKLSDLKENSWL  658
         *****************7
Domain Sequence
(FASTA)
PLGAGSFSVC RKCQHKQSGR DYAVKIVSRR MEANTKREIA ALRHLSHPNI VKLHEVYTDQ 60
YHTYLVMELL RGGELLERIK KKKLFGEAEA SQLLQSLVSA VSFMHEAGVV HRDLKPENVL 120
FADEGEDSNL KVIDFGFARL CPAGSAPLQT PCFTLQYAAP ELFESAGYDK ACDLWSLGVI 180
LYTMLSGQVP FQSEQRGMTS SYAADIMHKI KEGDFSLDGE CWKGVSDDAK ELVKGLLTVD 240
PENRLKLSDL KENSWL 256
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAE-00125
EKS-CAF-00171
EKS-CAP-00163
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00453
EKS-DRM-00077
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-LAC-00165
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-ORN-00204
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SUS-00141
EKS-TEN-00204
EKS-XET-00153
EKS-XIM-00199
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013