EKS-TAR-00517

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00517

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Trk	528.8	5.6E-159	449	717	269

Status

Unreviewed

Ensembl Protein

ENSTRUP00000001475

UniProt Accession

H2RMV8;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

NTRK2 (1 of 2)

Gene Synonyms/Alias

NTRK2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000000615	ENSTRUP00000001475	ENSTRUT00000001482
ENSTRUG00000000615	ENSTRUP00000001476	ENSTRUT00000001483
ENSTRUG00000000615	ENSTRUP00000001473	ENSTRUT00000001480
ENSTRUG00000000615	ENSTRUP00000001474	ENSTRUT00000001481
ENSTRUG00000000615	ENSTRUP00000001471	ENSTRUT00000001478
ENSTRUG00000000615	ENSTRUP00000001472	ENSTRUT00000001479
ENSTRUG00000000615	ENSTRUP00000001470	ENSTRUT00000001477
ENSTRUG00000000615	ENSTRUP00000001469	ENSTRUT00000001476

Organism

Takifugu rubripes

Functional Description

Protein Length

735

Protein Sequence
(FASTA)

MENITEIFIS NQNRLFDITD SSLRHYINLR NLTVMKTRLT SISPDAFYNN TRLQYVNLRN 60

NNLSTLSWRT FQNFNSSYPL LLSGNPLVCI CENLWIKLRL LEEPDGQDLT CTDDRGVSQA 120

FITLTPPDCV VPKVVVSPNM VTEMQGSDVK AVCQATGSPP PEIQWNLDMI VTHKENSDRV 180

LTLISKVGIG LTLSDLSPDD NGRVIVCSAE NMVGQNEATL QLDIHFAPSV QQLLEPERDH 240

HWCIPFSVKG NPKPDLQWYH ENLPLQEQDY IRTRIHESTE SEYHGCLQLV NPTHIHNGVY 300

RLVAKNQYGQ DEKTVSAQFI EPPNFNHTDP PLPPLDDSVA VSAPDFVYFF VYVVVGIAGI 360

ALTGCVLMVI ILKYGRNSKF GIKGSSSVIS NDDDSASPLH HVSNGNNTPS SSEMGPDAVI 420

IGMTKIPVIE NPQYFRNSII VQHIKRHNIV LKRELGEGAF GKVFLAECYN LTPDQEKLHV 480

AVKTLKEANE SSRADFYREA ELLTNLQHEH IVTFYGVCVE SDPLIMVFEY MKHGDLNKFL 540

RSHGPDALLI VDGQHSIPVE LTQSQMLHIA QQIAAGMVYL ASQHFVHRDL ATRNCLVGEN 600

LLVKIGDFGM SRDVYSTDYY RVGGHTMLPI RWMPPESIMY RRFTTESDVW SLGVVLWEIF 660

TYGKQPWYQL SNNEVIECIT QGRVLQRPRT CPKEVYDLML GCWHREPYMR LNIKEIYGML 720

QSLAKASPVY LDILG 735

Nucleotide Sequence
(FASTA)

ATGGAAAACA TCACCGAGAT ATTCATTTCC AATCAAAACA GACTCTTTGA CATTACTGAC 60

AGCAGCTTGA GGCACTACAT AAACCTCAGA AACCTAACAG TGATGAAGAC TAGGCTGACG 120

TCCATATCGC CGGATGCTTT CTATAATAAC ACAAGACTTC AATATGTAAA TTTACGAAAC 180

AATAACCTGT CAACACTGTC ATGGAGAACG TTTCAGAACT TCAACTCATC ATACCCGCTC 240

CTCCTGTCTG GAAACCCTCT GGTCTGCATC TGTGAGAACT TGTGGATCAA GCTGAGGCTC 300

CTGGAAGAAC CCGACGGTCA AGATCTGACG TGCACGGATG ACAGAGGGGT GTCCCAGGCC 360

TTCATCACCC TCACCCCACC TGACTGTGTG GTTCCCAAAG TGGTGGTGTC CCCAAACATG 420

GTGACTGAGA TGCAGGGGAG CGACGTTAAA GCTGTGTGCC AGGCAACGGG ATCCCCTCCT 480

CCGGAGATCC AGTGGAATCT TGATATGATC GTTACCCACA AGGAGAATAG TGACAGAGTT 540

CTTACGTTAA TTTCAAAAGT GGGGATCGGC CTCACCCTGT CGGACCTCTC TCCTGACGAT 600

AATGGCAGGG TGATCGTATG CAGCGCCGAG AACATGGTGG GCCAGAACGA GGCCACCCTC 660

CAGCTGGATA TTCACTTTGC CCCCAGTGTC CAGCAGCTGC TGGAGCCAGA GCGGGACCAC 720

CACTGGTGCA TCCCCTTCAG CGTGAAGGGG AACCCCAAAC CTGATCTGCA GTGGTACCAC 780

GAGAACCTTC CCCTCCAGGA GCAGGACTAC ATCCGCACCA GGATCCACGA GTCCACCGAG 840

AGCGAGTACC ACGGCTGCCT GCAGCTGGTC AACCCCACCC ACATCCACAA TGGCGTCTAC 900

AGGCTGGTGG CGAAGAACCA GTACGGCCAG GATGAGAAGA CGGTGTCGGC CCAGTTCATC 960

GAGCCGCCTA ACTTCAACCA CACAGATCCG CCACTCCCTC CTCTGGATGA CAGCGTTGCA 1020

GTAAGCGCTC CTGACTTTGT TTACTTCTTC GTGTACGTAG TTGTGGGAAT CGCAGGCATC 1080

GCCCTGACTG GCTGCGTTCT CATGGTCATC ATTCTGAAAT ATGGAAGAAA TTCCAAGTTT 1140

GGAATTAAAG GCTCCTCCTC AGTCATCAGC AACGACGACG ACTCTGCCAG CCCCCTTCAT 1200

CACGTCTCCA ATGGCAACAA CACCCCGTCG TCCTCGGAGA TGGGTCCAGA CGCAGTGATC 1260

ATTGGGATGA CAAAGATTCC CGTCATCGAG AACCCGCAGT ACTTCCGTAA CTCCATCATC 1320

GTGCAGCACA TCAAGAGACA CAACATCGTG CTGAAGCGGG AGCTGGGAGA AGGAGCCTTT 1380

GGGAAGGTGT TTCTGGCAGA GTGCTACAAC CTGACCCCAG ACCAGGAGAA GCTCCACGTG 1440

GCGGTCAAGA CCCTGAAAGA AGCCAACGAG AGCAGCCGTG CGGACTTCTA CAGGGAGGCC 1500

GAGCTCCTCA CCAACCTGCA GCACGAGCAC ATCGTCACCT TCTACGGCGT GTGCGTGGAG 1560

AGCGACCCGC TCATCATGGT GTTTGAGTAT ATGAAACACG GAGACCTGAA CAAGTTCCTC 1620

AGGTCCCACG GTCCCGACGC GCTGCTCATC GTGGACGGCC AACACAGCAT CCCGGTGGAG 1680

CTGACCCAGT CCCAGATGCT ACACATCGCC CAGCAGATCG CCGCCGGCAT GGTCTATCTG 1740

GCCTCCCAGC ACTTTGTCCA CAGAGACCTG GCGACCAGGA ACTGCCTGGT CGGGGAAAAC 1800

CTACTTGTCA AGATCGGAGA TTTCGGCATG TCCCGGGATG TCTACAGCAC AGACTACTAC 1860

AGAGTTGGTG GTCATACGAT GCTGCCCATC CGCTGGATGC CCCCAGAGAG CATCATGTAC 1920

CGGCGGTTCA CCACAGAGAG CGACGTGTGG AGCCTCGGCG TGGTGCTGTG GGAGATCTTC 1980

ACCTACGGGA AGCAGCCCTG GTACCAGCTC TCCAACAACG AGGTGATCGA GTGCATCACG 2040

CAGGGCCGCG TGCTGCAGCG ACCCCGTACC TGCCCTAAAG AGGTCTACGA CCTGATGCTG 2100

GGCTGCTGGC ACCGGGAGCC TTACATGAGG CTGAACATCA AGGAGATCTA CGGCATGCTC 2160

CAGAGCCTCG CCAAGGCCTC GCCCGTGTAC CTGGACATAC TGGGCTGA 2208

Domain Profile

S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60

         ivlkrelgegafgkvflaecynl+p+++kl vavk+lk+a+e++r df reaelltnlqh

Q: 449   IVLKRELGEGAFGKVFLAECYNLTPDQEKLHVAVKTLKEANESSRADFYREAELLTNLQH  508

         89**********************************************************

S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep..kgelglsqlla  118

         ehiv +yGvc+e+dpl++vfeymkhGdlnkflr+hgpda l+v+g+   + el++sq+l+

Q: 509   EHIVTFYGVCVESDPLIMVFEYMKHGDLNKFLRSHGPDALLIVDGQHsiPVELTQSQMLH  568

         **********************************************98999*********

S: 119   iakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtml  178

         ia+qiaaG+vylasqhfvhrdlatrnclvge+llvkigdfgmsrdvystdyyrvgg+tml

Q: 569   IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTML  628

         ************************************************************

S: 179   pirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerp  238

         pirw+ppesi+yr+fttesdvwslGvvlwei+tyGkqp+yqlsn+eviecitqGrvl+rp

Q: 629   PIRWMPPESIMYRRFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRP  688

         ************************************************************

S: 239   racpkevydlmlgcwqrepqkrlnikeiy  267

         r+cpkevydlmlgcw+rep +rlnikeiy

Q: 689   RTCPKEVYDLMLGCWHREPYMRLNIKEIY  717

         ****************************8

Domain Sequence
(FASTA)

IVLKRELGEG AFGKVFLAEC YNLTPDQEKL HVAVKTLKEA NESSRADFYR EAELLTNLQH 60

EHIVTFYGVC VESDPLIMVF EYMKHGDLNK FLRSHGPDAL LIVDGQHSIP VELTQSQMLH 120

IAQQIAAGMV YLASQHFVHR DLATRNCLVG ENLLVKIGDF GMSRDVYSTD YYRVGGHTML 180

PIRWMPPESI MYRRFTTESD VWSLGVVLWE IFTYGKQPWY QLSNNEVIEC ITQGRVLQRP 240

RTCPKEVYDL MLGCWHREPY MRLNIKEIY 269

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005030	; F:neurotrophin receptor activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000372	; LRR-contain_N.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020455	; Tyr_kin_neurotrophic_rcpt_2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR020777	; Tyr_kinase_NGF_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00013	; LRRNT; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR01939	; NTKRECEPTOR.
PR01941	; NTKRECEPTOR2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013