EKS-TAR-00180

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00180

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	499.2	5.9E-150	147	404	258

Status

Unreviewed

Ensembl Protein

ENSTRUP00000001808

UniProt Accession

H2RNU5;

Protein Name

Protein Synonyms/Alias

Gene Name

AKT3 (1 of 2)

Gene Synonyms/Alias

AKT3 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000000753	ENSTRUP00000001808	ENSTRUT00000001816

Organism

Takifugu rubripes

Functional Description

Protein Length

478

Protein Sequence
(FASTA)

IYASSHLKSS SLGEYIKNWR PRYFLLKTDG SFIGYKEKPQ DADLPYPLNN FSVAKCQLMK 60

TERPKPNTFI IRCLQWTTVI ERTFHVDSPD ERDEWTEAIQ MVADKLQRQE EERIQCSPTS 120

NIDNMVEEEM DISTTHHKRK VTTMSDFDYL KLLGKGTFGK VILVREKASG KYYAMKILKK 180

EVIIAKDEVA HTLTESRVLK NTRHPFLTSL KYSFQTKDRL CFVMEYVNGG ELFFHLSRER 240

VFSEERTRFY GAEIVSALDY LHSAKIVYRD LKLENLMLDK DGHMKITDFG LCKEGITDAA 300

TMKTFCGTPE YLAPEVLEDN DYGRAVDWWG LGVVTYEMMC GRLPFYNQDH EKLFELILME 360

DIKFPRTLSS DAKSLLSGLL IKDPNKRLGG GPDDAKEIMR HSFFSGIDWQ DVYDKKLVPP 420

FKPQVTSETD TRYFDEEFTA QTITITPPEK FDEDGMDCLD NERRPHFPQF SYSASGRE 478

Nucleotide Sequence
(FASTA)

ATTTATGCAT CCAGTCATCT GAAATCTTCT TCTTTAGGTG AATACATAAA GAACTGGCGG 60

CCACGATACT TCCTGTTGAA GACAGACGGC TCTTTCATCG GCTACAAAGA GAAACCTCAG 120

GACGCAGATC TGCCCTACCC TCTAAACAAC TTCTCCGTAG CAAAATGTCA GCTGATGAAG 180

ACAGAGAGGC CGAAGCCAAA CACCTTCATC ATCCGCTGCC TCCAGTGGAC CACTGTCATA 240

GAGAGGACCT TCCACGTGGA CTCACCTGAT GAAAGAGATG AGTGGACGGA GGCTATCCAG 300

ATGGTGGCTG ACAAGCTTCA GAGGCAGGAG GAAGAAAGGA TCCAGTGCAG CCCCACCTCC 360

AACATTGACA ACATGGTGGA GGAGGAGATG GACATCTCCA CCACGCACCA CAAACGCAAG 420

GTAACAACAA TGAGCGACTT TGACTACCTG AAGCTTCTGG GAAAGGGAAC CTTTGGGAAG 480

GTGATTCTTG TCCGAGAGAA GGCCAGTGGC AAATACTACG CCATGAAAAT TCTTAAAAAA 540

GAAGTCATCA TAGCCAAGGA CGAAGTTGCT CACACGCTCA CGGAGAGCAG AGTTCTGAAG 600

AACACCAGAC ACCCCTTCCT CACCTCACTG AAGTATTCAT TCCAGACGAA AGACCGCCTG 660

TGTTTTGTCA TGGAGTATGT GAATGGAGGA GAGCTGTTTT TCCATTTGTC CAGAGAGCGC 720

GTGTTCTCAG AGGAACGCAC ACGCTTCTAC GGCGCCGAAA TCGTTTCTGC TCTCGACTAC 780

TTGCATTCAG CCAAAATTGT GTACCGGGAC CTGAAGTTGG AGAATCTGAT GCTGGACAAA 840

GACGGACATA TGAAAATCAC AGACTTTGGC CTGTGCAAGG AGGGCATCAC CGACGCCGCC 900

ACCATGAAGA CCTTCTGTGG CACCCCAGAA TACCTGGCAC CAGAGGTCCT GGAGGACAAT 960

GACTACGGCC GGGCGGTGGA CTGGTGGGGT CTGGGTGTGG TGACGTACGA GATGATGTGT 1020

GGACGCCTGC CATTCTACAA CCAGGACCAC GAGAAGCTGT TTGAACTCAT ACTCATGGAG 1080

GACATCAAGT TCCCGCGCAC GCTGTCCTCT GACGCCAAGT CGCTGCTGTC CGGCCTGCTC 1140

ATCAAAGACC CCAACAAACG CCTTGGTGGG GGACCAGACG ACGCTAAAGA AATAATGAGG 1200

CACAGTTTTT TCTCGGGTAT CGACTGGCAG GACGTCTACG ATAAAAAGTT GGTTCCTCCC 1260

TTCAAGCCTC AGGTGACGTC GGAGACAGAC ACCAGATACT TTGACGAGGA GTTCACGGCC 1320

CAGACCATCA CCATCACTCC TCCGGAGAAA TTTGACGAGG ACGGGATGGA CTGTCTCGAC 1380

AACGAGAGAA GACCGCACTT CCCACAATTC TCCTACTCTG CCAGTGGCCG GGAATGA 1437

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 147   FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  206

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGelffhls+ervfse+r+rfygaeivsaldylhs ++

Q: 207   LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEERTRFYGAEIVSALDYLHSAKI  266

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGh+kitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 267   VYRDLKLENLMLDKDGHMKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  326

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv yem+cGrlpfyn+dheklfelil+e++kfpr+ls++aksllsGll kdp+k

Q: 327   DWWGLGVVTYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNK  386

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 387   RLGGGPDDAKEIMRHSFF  404

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEER TRFYGAEIVS ALDYLHSAKI 120

VYRDLKLENL MLDKDGHMKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVTY EMMCGRLPFY NQDHEKLFEL ILMEDIKFPR TLSSDAKSLL SGLLIKDPNK 240

RLGGGPDDAK EIMRHSFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013