EKS-TAR-00496

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00496

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	357.3	1.4E-106	626	882	257

Status

Unreviewed

Ensembl Protein

ENSTRUP00000002506

UniProt Accession

H2RQT9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K5

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000001070	ENSTRUP00000002505	ENSTRUT00000002517
ENSTRUG00000001070	ENSTRUP00000002506	ENSTRUT00000002518

Organism

Takifugu rubripes

Functional Description

Protein Length

1319

Protein Sequence
(FASTA)

PAAGTFWQDS VVGGAGLSPT IGSSPGDGGG LLSTGKTCKS RPVTVAYVVN GETSQQSNAE 60

SLALQCLRDA CDMVGSRLET VNFGQLDFGE TTVLDTFYNA DIAVVEMTDA FRQLSLFYHL 120

GVRESFSMAN NIILYCDTNS DSLQSLQTCS ANYAFIPYMV TPHNKVYCCE GSLMKGLTEL 180

MQPSFEMLLG PICMPLLDRF IQLLKVSQAN SHQYFREMIL NEIRKARELY SGTELAAELS 240

RIQHRLDNVE CLSVDIVINL LLTYRDIQDY ESIVKLVETL EKLPTFDPMA HPHVKFHYAF 300

ALNRRNLPGD RQKALDIMLP LVEAEEQVAS DIYCLVGRIY KDMFLESHFT DTQSRDSGTH 360

WFKRGFESEP TLHSGINYAV LLLAAGHQFD TSFELRKVGV KLSSLLGKKG SLDKLQSYWD 420

VGFFLGASIL AGDNIRVIQA SEKLFKLKAP IWYLRSLVET ILIYQQFHRP GAEQPSPKQE 480

LVDFWMDFLV EATKRDVSSV RFPVLILEPT KIYQPSYLSI NKDVDDNTVS IWHVAPDDKN 540

KGIHEWNFSA TSVRGVSISK FDERSAFLYV LHNAEDFQIY FCTEIHCRRF CDLVNSITEE 600

AWKGPEEGDC DHETLEYDYE YDEHGERVVL GKGTFGVVYA GRDLSNQVRL AIKEIPERDS 660

RYSQPLHEEI ALHKHLKHKN IVQYLGSISE NGFIKIFMEQ VPGGSLSALL RSKWGPLKNN 720

ESTIGFYTRQ ILEGLKYLHD NQIAHRDIKG DNVLINTYSG VLKISDFGTS KRLAGINPCT 780

ETFTGTLQYM APEIIDKGPR GYGKPADIWS LGCTIIEMAT GKPPFYELGE PQAAMFKVGM 840

FKIHPEIPES MSLEAKAFIL RCFEPDPDRR ATALDLLTDE FLTVTSRKKK SKGSFTALSP 900

GSEYLRSISL PVPVVVEDTS SSSEYGSVSP DNDLNANPFI FKPSLKCYSE RDVKGTRSLF 960

LSIPVENFED HSAPPSPEEK DSGFFMLRKD SERRATLHHI LTEDRDKVVA NLREAFMQGT 1020

EEMKLKPQHI STLVVSLADF VRMADRKIIA STLSQLKLEL DFDSGAISQL QVVLFGFQDA 1080

VNKVLRNHNI KPHWMFALDN IIRKAVQTAI TILVPELRPH FSLASESDPA DQDDMEDDAE 1140

PQRHSTHQSH VHPPAVNDDT VATSGVSTLS STVSHESHGE QRPASMELGR MKLETNRLLH 1200

QLLEKEREYQ SILQQVLKER EQEIKLLRLR SESAEAPTSS HCPQEETSPP CPRREDPDLV 1260

RWLQLHGADQ ESIDRILSEE YALNDILNDV TRDDLKSLRL RGGVLCKLWK AITEYRQKP 1319

Nucleotide Sequence
(FASTA)

CCTGCAGCCG GGACCTTCTG GCAGGACTCC GTGGTCGGGG GCGCGGGGCT CAGTCCGACC 60

ATCGGGAGCA GCCCGGGGGA CGGCGGGGGG CTGCTGTCCA CCGGGAAGAC GTGCAAGAGC 120

AGGCCTGTGA CTGTGGCCTA CGTGGTGAAC GGGGAGACGA GTCAGCAGAG CAACGCGGAG 180

AGCCTGGCCC TGCAGTGCCT GAGGGACGCG TGTGACATGG TGGGCAGCCG GCTGGAGACC 240

GTGAACTTCG GCCAACTGGA CTTTGGGGAG ACCACGGTGC TGGACACCTT CTACAACGCT 300

GATATAGCGG TGGTGGAGAT GACCGATGCC TTCCGCCAGC TCTCGCTCTT CTATCACCTG 360

GGAGTCCGCG AGAGCTTCAG CATGGCCAAC AACATCATCC TGTACTGCGA CACTAACTCG 420

GACTCGCTCC AGTCTCTGCA GACGTGTTCG GCCAACTACG CCTTCATCCC GTACATGGTG 480

ACGCCGCACA ACAAGGTGTA CTGCTGCGAG GGCAGCCTGA TGAAGGGCCT GACGGAGCTG 540

ATGCAGCCCA GCTTCGAGAT GCTGCTGGGG CCCATCTGCA TGCCGCTGCT CGACCGCTTC 600

ATCCAGCTGC TGAAGGTGTC GCAGGCCAAC TCGCATCAGT ACTTCCGGGA GATGATTCTG 660

AACGAGATCC GGAAGGCCCG GGAGCTGTAC TCCGGCACGG AGCTGGCGGC CGAGCTGAGC 720

CGCATCCAGC ACCGGCTGGA CAACGTGGAG TGCCTTTCCG TGGACATCGT CATCAACCTG 780

CTGCTGACGT ACCGGGACAT TCAGGATTAC GAGTCCATCG TGAAGCTGGT GGAGACGCTG 840

GAGAAGCTTC CCACCTTCGA CCCCATGGCT CACCCACACG TCAAGTTCCA CTACGCCTTT 900

GCACTGAACC GGAGGAACCT GCCCGGGGAC AGACAGAAGG CTCTGGACAT CATGCTGCCC 960

CTGGTGGAGG CAGAAGAGCA GGTGGCCTCA GACATCTACT GCCTGGTGGG ACGAATCTAC 1020

AAGGACATGT TCCTGGAGTC CCACTTCACC GACACGCAGA GCAGAGACAG CGGCACACAC 1080

TGGTTTAAAC GGGGCTTTGA GTCCGAGCCA ACGCTGCACT CCGGGATCAA CTACGCCGTC 1140

CTCCTGCTGG CAGCCGGACA CCAGTTTGAC ACGTCCTTTG AGCTTCGTAA AGTGGGAGTG 1200

AAGCTGAGCA GCCTGTTGGG CAAGAAAGGC AGCCTGGACA AGCTGCAGAG CTACTGGGAT 1260

GTGGGCTTCT TCCTGGGCGC CAGCATCCTG GCGGGCGATA ATATCAGGGT GATCCAGGCC 1320

TCCGAGAAGC TCTTCAAACT CAAAGCTCCC ATCTGGTATC TGCGCTCGCT GGTGGAGACC 1380

ATTCTGATCT ACCAGCAGTT CCACAGACCC GGCGCCGAGC AGCCGTCGCC CAAACAGGAG 1440

CTGGTGGACT TCTGGATGGA CTTTCTGGTG GAGGCCACCA AGAGGGACGT CTCCTCGGTC 1500

CGATTCCCTG TTTTGATTTT AGAACCCACC AAAATTTACC AGCCGTCGTA CCTGTCCATC 1560

AACAAAGACG TGGACGACAA CACCGTCTCC ATCTGGCACG TCGCCCCTGA CGATAAGAAT 1620

AAAGGCATCC ACGAGTGGAA CTTCAGCGCG ACCTCGGTGC GAGGTGTCAG CATCTCCAAG 1680

TTTGACGAGC GCAGCGCTTT CCTGTACGTC CTTCACAACG CCGAGGACTT CCAGATCTAC 1740

TTCTGCACAG AGATTCACTG CAGAAGGTTC TGCGATCTGG TCAACAGTAT AACTGAGGAA 1800

GCCTGGAAGG GTCCCGAGGA GGGAGACTGT GACCACGAAA CCTTAGAGTA TGATTATGAG 1860

TACGATGAGC ACGGAGAGAG GGTGGTTCTG GGAAAAGGCA CCTTCGGGGT CGTGTATGCC 1920

GGCCGAGATC TCAGCAACCA GGTCCGTCTG GCTATCAAAG AAATCCCTGA ACGGGACAGC 1980

AGGTACTCTC AGCCGCTCCA CGAGGAGATC GCGCTCCACA AACACCTGAA GCACAAGAAC 2040

ATCGTTCAGT ACCTGGGATC CATCAGCGAG AACGGCTTCA TCAAGATCTT CATGGAGCAG 2100

GTGCCCGGAG GAAGTCTTTC AGCGTTACTC CGGTCCAAGT GGGGCCCCCT GAAAAACAAC 2160

GAGTCCACCA TCGGCTTCTA CACCCGGCAG ATCCTGGAGG GCCTGAAGTA CCTGCACGAC 2220

AACCAGATAG CCCACAGGGA CATCAAGGGT GATAATGTTC TCATCAACAC CTACAGTGGC 2280

GTCTTAAAGA TATCGGATTT CGGCACATCC AAGAGGCTGG CTGGGATCAA TCCCTGCACC 2340

GAGACGTTCA CAGGCACACT ACAGTACATG GCCCCTGAAA TCATCGACAA GGGTCCTCGA 2400

GGATACGGCA AACCGGCGGA CATCTGGTCT CTGGGCTGCA CCATCATAGA AATGGCAACA 2460

GGAAAACCGC CTTTCTATGA ACTGGGAGAG CCGCAAGCTG CGATGTTCAA GGTGGGCATG 2520

TTCAAGATCC ACCCCGAGAT CCCCGAGTCC ATGTCACTGG AGGCCAAAGC CTTCATCCTG 2580

CGCTGCTTCG AGCCCGATCC CGACCGCCGC GCCACCGCTT TGGACCTGCT CACCGACGAG 2640

TTCCTGACCG TCACCAGCCG CAAGAAGAAG AGCAAAGGGA GCTTCACAGC TCTCTCGCCA 2700

GGTTCAGAAT ATCTGCGCAG CATCTCTCTG CCAGTGCCGG TTGTTGTGGA GGACACCAGC 2760

AGCAGCAGCG AGTACGGCTC CGTCTCCCCC GACAACGATC TCAACGCCAA CCCTTTCATC 2820

TTCAAGCCCA GCCTCAAGTG CTACAGCGAG AGGGATGTCA AGGGGACCCG ATCGCTGTTC 2880

CTCAGCATTC CAGTGGAGAA TTTTGAAGAT CACAGTGCAC CCCCGTCCCC GGAAGAGAAA 2940

GATTCGGGCT TCTTTATGCT TCGGAAGGAC AGCGAGCGAA GAGCCACTCT GCATCACATC 3000

CTGACAGAGG ACCGGGACAA GGTGGTGGCC AACCTGAGGG AGGCGTTCAT GCAGGGCACT 3060

GAAGAGATGA AGCTGAAGCC TCAGCACATC TCCACTCTCG TGGTCAGCCT GGCGGATTTC 3120

GTTCGCATGG CGGACAGGAA GATCATCGCC AGCACGCTGT CTCAGCTCAA GCTGGAGCTG 3180

GACTTTGACA GCGGCGCCAT CAGCCAACTG CAGGTTGTGC TGTTCGGATT CCAGGATGCC 3240

GTGAACAAAG TTCTGCGTAA CCACAACATC AAACCTCACT GGATGTTTGC TTTGGACAAT 3300

ATCATCCGCA AAGCTGTGCA GACGGCCATC ACAATCCTAG TGCCAGAGCT GAGGCCTCAC 3360

TTCAGCCTGG CCTCAGAGAG CGACCCCGCT GATCAGGACG ACATGGAGGA CGACGCTGAG 3420

CCACAGCGAC ATTCCACCCA CCAGAGCCAC GTGCACCCTC CTGCCGTCAA CGACGACACC 3480

GTGGCCACCT CTGGGGTCAG CACGCTCAGC TCCACGGTGT CACACGAGTC CCACGGCGAA 3540

CAGCGGCCCG CCAGCATGGA GCTGGGCAGG ATGAAGCTCG AGACCAACAG GCTGCTTCAC 3600

CAGCTGTTGG AGAAGGAGAG AGAGTACCAG AGCATCTTGC AACAAGTGCT GAAGGAGAGG 3660

GAGCAGGAGA TTAAACTACT GAGGCTGAGA TCTGAGTCTG CAGAGGCTCC CACATCATCC 3720

CACTGTCCAC AGGAAGAGAC AAGTCCACCG TGTCCAAGAC GTGAGGACCC AGATCTGGTC 3780

AGGTGGCTGC AGCTTCATGG TGCTGACCAG GAATCCATAG ACAGAATCCT GAGCGAAGAG 3840

TACGCGTTGA ACGACATCCT CAATGATGTA ACAAGAGATG ATCTGAAGAG TCTAAGACTG 3900

AGAGGTGGGG TCCTGTGCAA GCTGTGGAAG GCCATCACAG AATACAGGCA GAAGCCG 3957

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG+fg vya++d++++ +la+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n

Q: 626   ERVVLGKGTFGVVYAGRDLSNQVRLAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  680

         6889**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  es+i +yt+qilegl+yLH+

Q: 681   IVQYLGSISENGFIKIFMEQVPGGSLSALLRsKWGPLKnnESTIGFYTRQILEGLKYLHD  740

         *******************************9*****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++i HRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k

Q: 741   NQIAHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  797

         ***************************************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg+ aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s e+k+

Q: 798   GPRGYGKPADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKIHPEIPESMSLEAKA  857

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         f+ +c+e dp++r++a +LL++efl

Q: 858   FILRCFEPDPDRRATALDLLTDEFL  882

         **********************996

Domain Sequence
(FASTA)

ERVVLGKGTF GVVYAGRDLS NQVRLAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60

GSISENGFIK IFMEQVPGGS LSALLRSKWG PLKNNESTIG FYTRQILEGL KYLHDNQIAH 120

RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKP 180

ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKIHP EIPESMSLEA KAFILRCFEP 240

DPDRRATALD LLTDEFL 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013