EKS-TAR-00014
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00014
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph476.14.5E-143620876257
StatusUnreviewed
Ensembl ProteinENSTRUP00000002557
UniProt AccessionH2RQZ2;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2 (1 of 2)
Gene Synonyms/Alias EPHA2 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000001093ENSTRUP00000002556ENSTRUT00000002568
ENSTRUG00000001093ENSTRUP00000002558ENSTRUT00000002570
ENSTRUG00000001093ENSTRUP00000002557ENSTRUT00000002569
ENSTRUG00000001093ENSTRUP00000002559ENSTRUT00000002571
OrganismTakifugu rubripes
Functional Description
Protein Length983
Protein Sequence
(FASTA)
MDFFAGFRPL LFSYVLINGI LITLQTKEEV LLDMNAIGGE LGWLTWPLDQ GDRPGWEVVQ 60
KTLNGSQLYT YSVCNVGERE QDNWLRTTFI QRRPSASRVF VELKFIVRDC NSFDSSSLTC 120
KETFNLFTSE SDADVGTTFR KGQFKKIATI APDEISKNEL RINTDTRVVE NLSRKGFYLA 180
FQDIGACIAL LSVRVYYKTC SATVKSLASF PETIAGGENQ ALREVNGVCV KNSISEEQPR 240
IHCTVDGEWV VPVGQCQCKP GYEEVKDSCQ ECQAGFFKTE ASGEKCQPCP ANTQRLNSGA 300
LYCPCMEGFY RAPTDLLTGP CSGLPSAPRD LLATHSAGKL LLSWSPPQDT GGRTDITYNI 360
ECQRCEGLVC QSCGEKIHYE PANVGLTDTK VLVSDLDAHL NYTFSVEAQS GVSLFIRPAS 420
TSSLTTSLLY TDPPKITTMR LAERTSTSLS LSWDVSPRPR AHSPPIRYEL KYCKKDDNLD 480
VTTYTVLILE KNSVQIHKLA PGTAYLFRVQ ALSSDDSSGG SSMEEQFETL IEERSQSNIA 540
VILGAVVGGA AMLLIVVVVL LVRRRKRNPH IRQGAEDTYF SSSEPTEQLK PLKTYVDPHT 600
YEDPNTAVMK FATEIHPSHI TKEKVIGAGE FGEVYRGNLK VPGRKESAVA IKTLKPGYTE 660
KQRQDFLSEA SIMGQFSHQN IIRLEGVVTK FKHAMIVTEY MENGALDRYL RDHDGEFTSF 720
QLVGMLRGIA AGMKYLSDMS YVHRDLAARN ILVNNTLECK VSDFGLSRVL EDDPEGTYTT 780
SGGKIPIRWT APEAIAYRKF TSASDVWSFG IVMWEVMAFG ERPYWDMSNH EVMKAINEAF 840
RLPAPMDCPS AVYQLMLQCW LHDRSKRPRF GDIVNLLDKL LRSPDSLKTI ADFDPRVSIR 900
LPSTSGSDGS PFRSVSEWLE SIKMSQYGEN FSRAGVVTMD QVLQMKNEDI KNIGVRLPGH 960
LKRIAYSILG LKDQTSTLSV FAV 983
Nucleotide Sequence
(FASTA)
ATGGATTTCT TTGCTGGATT TAGACCTTTA TTATTTTCTT ATGTGCTCAT AAATGGTATA 60
TTAATTACAC TCCAGACTAA AGAAGAGGTG CTGTTGGATA TGAATGCAAT AGGAGGTGAA 120
CTGGGCTGGT TGACATGGCC TTTAGATCAG GGAGACAGGC CTGGGTGGGA GGTTGTCCAG 180
AAGACCCTGA ATGGCTCTCA GCTCTACACG TATTCTGTTT GTAATGTCGG TGAACGTGAG 240
CAAGACAACT GGCTGCGCAC CACTTTCATC CAGCGACGCC CGTCGGCATC GCGGGTTTTC 300
GTTGAGCTCA AGTTTATCGT ACGTGACTGC AATTCTTTCG ACAGTTCCTC GCTGACCTGC 360
AAAGAAACCT TCAACCTCTT CACGTCTGAG TCAGACGCAG ATGTGGGCAC CACCTTTCGC 420
AAGGGACAGT TTAAGAAAAT TGCCACCATA GCACCTGATG AGATCAGCAA AAACGAACTG 480
CGCATCAACA CTGACACCAG AGTGGTGGAA AACCTGTCCC GAAAAGGCTT CTACCTGGCT 540
TTCCAAGACA TCGGTGCTTG CATTGCACTT CTCTCTGTGA GGGTGTACTA TAAAACCTGC 600
TCAGCCACTG TCAAGAGCCT TGCATCATTC CCTGAGACCA TCGCTGGAGG TGAGAATCAG 660
GCACTGAGGG AAGTGAATGG AGTGTGCGTG AAAAACTCCA TCAGCGAAGA GCAGCCACGC 720
ATCCATTGCA CAGTAGATGG CGAGTGGGTT GTACCAGTGG GACAGTGCCA GTGCAAACCA 780
GGCTACGAAG AAGTGAAAGA CTCATGTCAA GAATGTCAGG CGGGCTTTTT CAAAACAGAA 840
GCATCCGGTG AGAAGTGCCA GCCGTGTCCT GCTAACACCC AGAGGCTAAA CTCCGGGGCT 900
TTGTATTGTC CCTGCATGGA GGGATTCTAC CGGGCCCCAA CAGACCTACT GACTGGACCC 960
TGTTCAGGGC TCCCCTCTGC ACCACGAGAC CTCTTGGCCA CCCACAGTGC AGGAAAACTC 1020
CTTCTCTCCT GGAGTCCGCC TCAGGACACA GGTGGTCGAA CGGACATCAC CTATAACATT 1080
GAATGCCAGC GCTGCGAGGG GCTCGTGTGC CAGTCCTGCG GTGAAAAAAT CCACTATGAG 1140
CCAGCCAACG TGGGCCTGAC GGACACCAAA GTTTTGGTGA GCGACCTGGA TGCTCACCTG 1200
AACTACACCT TCAGCGTAGA GGCTCAAAGC GGCGTATCCC TCTTCATCAG ACCAGCGTCT 1260
ACCAGCTCTC TGACAACATC TCTGCTCTAC ACAGACCCCC CCAAGATTAC CACCATGCGA 1320
CTGGCTGAGA GGACCTCCAC GAGTTTGTCC CTTTCTTGGG ATGTATCACC CCGACCACGA 1380
GCCCACTCCC CACCCATCCG CTATGAGTTA AAATACTGCA AGAAGGATGA TAATCTGGAC 1440
GTGACTACCT ACACGGTGCT GATACTTGAG AAGAACTCTG TACAGATCCA TAAGCTGGCC 1500
CCTGGGACAG CCTACCTCTT CAGGGTGCAG GCCCTCAGCA GTGACGACAG CTCTGGAGGC 1560
TCCAGCATGG AGGAACAGTT TGAGACCTTG ATTGAAGAGC GTTCTCAAAG CAACATCGCA 1620
GTCATTCTCG GTGCAGTGGT TGGTGGAGCA GCCATGCTAC TCATCGTGGT AGTGGTTCTG 1680
TTAGTACGCA GAAGGAAAAG AAATCCTCAC ATCCGGCAAG GAGCGGAGGA CACCTACTTT 1740
TCCAGCTCAG AACCCACAGA GCAATTAAAG CCTTTGAAAA CATACGTGGA TCCGCATACA 1800
TATGAGGACC CCAACACTGC AGTCATGAAG TTTGCCACAG AAATCCACCC CAGCCACATA 1860
ACCAAAGAAA AAGTCATTGG AGCTGGGGAG TTTGGGGAGG TGTACCGTGG TAATCTCAAG 1920
GTGCCAGGGA GGAAGGAGTC TGCCGTGGCA ATCAAGACAC TGAAGCCGGG CTACACGGAA 1980
AAGCAGCGGC AGGACTTTCT GAGCGAGGCG TCCATCATGG GCCAGTTCTC TCATCAGAAC 2040
ATCATCCGCC TGGAGGGAGT GGTCACCAAA TTCAAACACG CCATGATCGT CACCGAATAC 2100
ATGGAGAACG GTGCCTTGGA CAGGTATCTT CGGGATCACG ACGGAGAGTT CACCTCCTTC 2160
CAGCTGGTGG GCATGCTGCG AGGCATTGCT GCGGGCATGA AGTACCTCTC TGACATGAGC 2220
TATGTCCACC GCGACCTGGC TGCCAGGAAC ATCCTCGTTA ACAACACCCT GGAGTGTAAA 2280
GTTTCTGACT TCGGCCTGTC ACGGGTGTTG GAGGACGATC CTGAGGGGAC GTACACCACA 2340
AGTGGAGGAA AGATCCCCAT TCGTTGGACA GCTCCAGAAG CAATAGCATA CCGAAAGTTT 2400
ACTTCAGCCA GTGATGTGTG GAGTTTCGGT ATCGTCATGT GGGAAGTCAT GGCTTTTGGT 2460
GAGAGGCCGT ACTGGGACAT GAGCAACCAC GAGGTGATGA AAGCTATCAA TGAGGCTTTT 2520
CGATTGCCGG CTCCGATGGA CTGCCCCTCA GCCGTGTATC AGCTCATGTT GCAGTGCTGG 2580
CTCCACGATC GCTCTAAAAG GCCACGCTTC GGAGACATCG TTAACCTGCT AGACAAACTG 2640
CTGCGGAGCC CAGACTCCCT GAAGACCATT GCAGATTTTG ACCCACGCGT CTCCATACGC 2700
CTTCCCAGCA CCAGTGGCTC CGATGGTTCC CCCTTCAGGT CCGTGTCAGA GTGGCTGGAG 2760
TCCATTAAAA TGAGTCAGTA CGGCGAGAAC TTCAGCCGCG CCGGGGTTGT CACTATGGAC 2820
CAGGTCCTTC AGATGAAGAA TGAGGACATT AAAAACATCG GGGTGAGGCT GCCTGGCCAT 2880
TTGAAAAGAA TTGCCTACAG CATCTTGGGT TTAAAGGACC AGACCAGCAC CCTGAGTGTG 2940
TTTGCAGTGT GA 2952
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++ ekviGaGefGev++G+lk+pg++e+avaiktlk g+tekqr+dflseasi+Gqf+h+
Q: 620   ITKEKVIGAGEFGEVYRGNLKVPGRKESAVAIKTLKPGYTEKQRQDFLSEASIMGQFSHQ  679
         5679********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtk k  mivteymengald +lr +dg+ft+ qlvgmlrGia+gmkylsdm
Q: 680   NIIRLEGVVTKFKHAMIVTEYMENGALDRYLRDHDGEFTSFQLVGMLRGIAAGMKYLSDM  739
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvn+ l ckvsdfGlsrvledd+e +yttsggkipirwtapeaiayrk
Q: 740   SYVHRDLAARNILVNNTLECKVSDFGLSRVLEDDPEGTYTTSGGKIPIRWTAPEAIAYRK  799
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvws+Giv+wev+++Gerpywdmsn++v+kai+e +rlp+pmdcp+a+yqlml+c
Q: 800   FTSASDVWSFGIVMWEVMAFGERPYWDMSNHEVMKAINEAFRLPAPMDCPSAVYQLMLQC  859
         ************************************************************
S: 241   wqkdraerpkfeqivsi  257
         w +dr++rp+f +iv++
Q: 860   WLHDRSKRPRFGDIVNL  876
         **************987
Domain Sequence
(FASTA)
ITKEKVIGAG EFGEVYRGNL KVPGRKESAV AIKTLKPGYT EKQRQDFLSE ASIMGQFSHQ 60
NIIRLEGVVT KFKHAMIVTE YMENGALDRY LRDHDGEFTS FQLVGMLRGI AAGMKYLSDM 120
SYVHRDLAAR NILVNNTLEC KVSDFGLSRV LEDDPEGTYT TSGGKIPIRW TAPEAIAYRK 180
FTSASDVWSF GIVMWEVMAF GERPYWDMSN HEVMKAINEA FRLPAPMDCP SAVYQLMLQC 240
WLHDRSKRPR FGDIVNL 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00009
EKS-ANC-00009
EKS-BOT-00008
EKS-CAF-00010
EKS-CAP-00007
EKS-DAR-00015
EKS-EQC-00010
EKS-FEC-00007
EKS-GAA-00015
EKS-HOS-00011
EKS-ICT-00009
EKS-LAC-00010
EKS-LOA-00010
EKS-MAM-00009
EKS-MAE-00001
EKS-MUM-00010
EKS-MUP-00010
EKS-MYL-00011
EKS-NOL-00009
EKS-OCP-00002
EKS-ORN-00018
EKS-ORA-00008
EKS-ORC-00009
EKS-ORL-00015
EKS-OTG-00010
EKS-PAT-00012
EKS-PES-00008
EKS-POA-00010
EKS-RAN-00009
EKS-SAH-00008
EKS-SUS-00007
EKS-TEN-00014
EKS-XIM-00015
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013