EKS-TAR-00398
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00398
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/Alpha189.31.8E-5513101528219
StatusUnreviewed
Ensembl ProteinENSTRUP00000003121
UniProt AccessionH2RSK3;
Protein Name
Protein Synonyms/Alias
Gene NameTRPM6
Gene Synonyms/Alias TRPM6;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000001357ENSTRUP00000003123ENSTRUT00000003141
ENSTRUG00000001357ENSTRUP00000003120ENSTRUT00000003138
ENSTRUG00000001357ENSTRUP00000003122ENSTRUT00000003140
ENSTRUG00000001357ENSTRUP00000003119ENSTRUT00000003137
ENSTRUG00000001357ENSTRUP00000003121ENSTRUT00000003139
OrganismTakifugu rubripes
Functional Description
Protein Length1533
Protein Sequence
(FASTA)
GVSKYVGEAV RTFGSHSLRS RNTVGITPWG VIHSNTDLIG RDVFKPYQPL ANPLSKRACL 60
NGFHSHFLLV DDGTVGKHGC QQGLRKSLEK HIQQQKIHPR LKLGVPVVCV VVEGGPNIVS 120
AVLDCVQSVP PVPVFVFEGS GKAADLLAFL HKHTATDRQL HADFTHDLLI RVQSAFGVES 180
SEASELCGLL QQCMDHRQSI TVYDSESEDL GLPDAAILTS ALKGTTAGPA EQLSMTLAWN 240
RADLAQKHIL VSGQHWKVGS LEQALLDALV MDRVGFVKLL IDNGMTMSRF LTVNRLEELY 300
NTPQSGGQTD RFLRHLVEDV KQTSLPEGYR LSIIDVGLVM EYLMGGAYCS TYTRKPFRAV 360
YSRLQKKKGR RESWTAVSKQ RHGLVLDSSR SHLHFFRTAQ PYKPQQQAFP TVSRRQNTTS 420
TGPCEAPPLV AFNFNDLFVW AVLQQRQQMA LFLWPRGEEA LARATAACQL YRSMAFEARR 480
SSMDDSTAER LRTCSLEFGQ LAVDLLDVAF HQNEQMAMKL LTSEMEAWSH FTCLQMAVSS 540
CHRPFVSHSC TQTLLTDLWS GPLNMRKNSS LKIILSLILP PAILLLEFKS KAEMCHVPQS 600
YETMLFGLDP AKSESSPERA DQMVTHQGRD HTHTHTRTHA RAHTRTRAHT RTHTHTHTRT 660
HTHTHWFYLM FYLGFLMLFS YVVLVKMEEQ PSAQEWLLIS YMVSTALEKT REVLMSEPRK 720
LSHKLKVWFS EYWNVSDFLA ILLFLAGLAL RWHPEPYRTA GRISYCLDLI FWFIRSMDLL 780
AVNQHAGPYL TIITKMTRNM FFIVVMMAIV LLSFGVSRKA ILSPYSEPSW SLARDVVFQP 840
YWMIYGEVYA SEMDVCDGVQ HCPPAAFLSP LLQAVYMFLQ YIIMVNILIA FVNNIYFDMA 900
ATSNKLWKYN RYRYIMTYQD RPWLPPPMVL LSHVVLLLRT ICRRKRRQQK ANYTTELFLG 960
CEDRKLLHEF EEKCVEAYFQ EKSNDASSNQ MNRIRTTAER VEEMNVMVEE VSEKVNFIQD 1020
SLLELDSQLG HLQDLSALAV DTLTMLSASD SQLQEEVRLS QCQPPAVPWC AGMKLVRKPP 1080
VFKPPVSPGT CPPGTRTHRM QNYGHPEEIS MEEEEEEEDE DGLTHERLTN VEGCAGAVLS 1140
TPCGGSGNPA FVPEDNAARC HSRISSQWRQ AGTLSNTQSP KRTFRDEASL QCSRSRGMNT 1200
SVCRSTPVFH LNSSLVKADR KLIKLFKIKN NENLDAPADL EPLDIMQKTA FSHQSSETLY 1260
PHYSAVERNN LMRLATSIPF TPVSILGGEE VSIYSLEELP SDGDVGSTSI SSWASRGLSA 1320
ILQPLSSAEG SLDGGLRQGC RVLCTWAEQD VLRPGLVYVV KAFRPEVLGV WQQYFHGSTS 1380
LQLCLREIQQ QRAAQKLMQV FNRIRPRDLC PSPSFLDVSL LLCPSSGHWF TIERNMCGEF 1440
RKYNNNSGEE IAPCCSLEEL LLAFSHWTFE YSHRELLVLD IQGVGEALTD PTVIMAQEKR 1500
GEMLFGPDNL GDVAIKGFLQ RHCCRTSCSR LGL 1533
Nucleotide Sequence
(FASTA)
GGTGTCTCCA AATATGTGGG TGAGGCAGTA AGAACCTTTG GCAGCCACAG CCTGAGGAGC 60
AGGAACACCG TTGGCATCAC ACCGTGGGGA GTCATCCACA GTAACACCGA CCTTATCGGA 120
AGAGATGTAT TCAAGCCCTA CCAACCACTT GCTAACCCCC TGAGCAAGAG GGCCTGTCTG 180
AATGGCTTCC ACTCCCACTT CCTGTTGGTG GACGATGGAA CAGTGGGAAA ACATGGATGC 240
CAACAAGGCC TCAGGAAGAG CCTGGAGAAG CACATCCAGC AGCAGAAGAT ACACCCACGG 300
CTGAAGCTGG GGGTGCCAGT GGTGTGTGTG GTGGTGGAGG GGGGACCTAA CATCGTGTCT 360
GCGGTGCTGG ACTGTGTTCA GAGTGTTCCC CCAGTTCCTG TGTTTGTGTT TGAGGGGTCC 420
GGCAAGGCGG CTGACCTGCT CGCTTTCTTA CACAAACACA CGGCTACAGA CAGGCAGCTA 480
CATGCAGACT TCACACATGA CCTCCTCATC AGGGTCCAAA GTGCTTTTGG TGTGGAGAGC 540
TCAGAAGCCT CTGAGCTGTG TGGTCTCCTG CAGCAGTGTA TGGATCACAG GCAGTCGATA 600
ACTGTCTATG ACTCTGAATC AGAGGACCTG GGTTTGCCTG ATGCAGCTAT TCTGACAAGT 660
GCTCTGAAGG GCACCACAGC TGGTCCTGCA GAACAGCTGA GCATGACGCT GGCCTGGAAC 720
CGAGCCGATC TCGCTCAGAA ACACATCCTG GTGTCTGGAC AGCACTGGAA GGTTGGTTCT 780
TTGGAGCAGG CTCTGCTGGA CGCTCTGGTG ATGGACCGGG TCGGTTTTGT GAAGCTGCTG 840
ATTGATAACG GCATGACCAT GAGCCGTTTC CTGACTGTCA ATCGTCTCGA GGAGCTTTAT 900
AACACTCCCC AGTCGGGGGG GCAGACGGAC CGCTTCCTCC GCCACCTCGT TGAAGATGTG 960
AAACAGACGT CTCTGCCTGA AGGGTACCGT CTGTCCATCA TCGATGTGGG CCTGGTGATG 1020
GAGTACCTGA TGGGAGGAGC CTACTGCAGC ACCTACACAC GGAAGCCCTT CAGGGCCGTT 1080
TACAGCCGCC TGCAGAAGAA GAAGGGGAGA CGGGAAAGCT GGACTGCTGT GTCAAAGCAG 1140
CGACACGGAT TGGTTCTGGA CTCCAGCAGG AGTCACCTGC ATTTCTTTAG GACGGCACAG 1200
CCCTACAAAC CCCAGCAACA AGCCTTCCCA ACGGTCAGCA GACGTCAGAA CACGACGAGC 1260
ACTGGCCCCT GCGAGGCCCC CCCGCTGGTC GCCTTCAATT TCAACGACCT GTTTGTGTGG 1320
GCCGTGCTCC AGCAGCGCCA GCAGATGGCG CTGTTCTTGT GGCCACGCGG TGAAGAGGCA 1380
CTCGCCCGAG CCACAGCAGC CTGTCAACTC TACCGCTCCA TGGCCTTTGA AGCCCGGCGG 1440
AGCAGCATGG ACGACAGCAC CGCGGAGCGA CTCAGGACGT GCTCCCTTGA GTTTGGACAG 1500
CTGGCCGTGG ACCTGCTGGA TGTGGCCTTC CACCAGAACG AGCAGATGGC CATGAAGCTG 1560
TTGACCTCCG AGATGGAGGC GTGGAGCCAC TTCACGTGTC TGCAGATGGC CGTCTCCTCG 1620
TGCCACCGGC CGTTCGTCTC ACACTCCTGC ACCCAGACCC TGCTCACGGA CCTGTGGTCG 1680
GGTCCACTCA ACATGAGGAA GAACTCTTCT CTGAAGATCA TCCTCAGCCT CATCCTGCCT 1740
CCTGCCATCC TGCTGCTGGA GTTTAAGAGC AAGGCTGAGA TGTGTCACGT GCCCCAGTCC 1800
TACGAGACAA TGCTGTTTGG ACTTGACCCG GCCAAGTCAG AATCATCCCC GGAGCGAGCG 1860
GATCAGATGG TAACGCACCA GGGCCGAGAT CACACACACA CGCACACACG CACACACGCA 1920
CGCGCACACA CACGCACACG CGCGCACACG CGCACACACA CGCACACACA CACACGCACA 1980
CACACACACA CACACTGGTT TTATTTGATG TTCTACCTGG GTTTCCTGAT GCTCTTCTCC 2040
TATGTGGTGC TGGTAAAGAT GGAGGAGCAG CCAAGTGCTC AGGAATGGCT GCTTATATCG 2100
TACATGGTGT CCACAGCGCT GGAGAAGACC AGAGAGGTTC TAATGTCTGA GCCGAGGAAA 2160
CTGAGCCACA AGCTGAAGGT TTGGTTCTCT GAGTATTGGA ACGTTTCAGA CTTCCTGGCC 2220
ATCCTTCTCT TTCTGGCTGG ACTGGCCTTG CGCTGGCATC CCGAGCCCTA CCGGACAGCA 2280
GGGCGGATCA GCTACTGTCT GGATCTCATC TTCTGGTTCA TCAGGTCCAT GGATCTGTTG 2340
GCTGTCAACC AGCATGCTGG GCCTTACCTC ACCATCATCA CAAAGATGAC CCGTAACATG 2400
TTCTTCATCG TGGTGATGAT GGCCATAGTG CTGCTGAGCT TTGGCGTGTC CAGAAAGGCC 2460
ATCCTGTCCC CGTACTCAGA GCCCTCCTGG AGTCTGGCTC GGGACGTGGT CTTCCAGCCT 2520
TACTGGATGA TTTATGGTGA GGTCTATGCC TCAGAGATGG ACGTGTGTGA CGGTGTGCAA 2580
CACTGCCCCC CAGCGGCCTT CCTCTCCCCT CTCCTTCAGG CTGTCTATAT GTTTCTTCAG 2640
TACATCATCA TGGTCAATAT TCTGATTGCA TTTGTCAACA ACATCTACTT TGACATGGCC 2700
GCTACATCCA ACAAGCTGTG GAAGTACAAC CGCTACCGCT ACATCATGAC CTACCAGGAC 2760
CGGCCCTGGC TGCCTCCTCC CATGGTCCTC CTCAGCCACG TGGTCCTGCT ACTGAGAACC 2820
ATCTGCAGGA GAAAGAGGCG TCAACAGAAA GCAAACTACA CAACAGAGCT GTTTCTGGGG 2880
TGTGAAGATC GAAAACTGCT GCACGAGTTT GAGGAGAAAT GTGTTGAAGC GTACTTCCAG 2940
GAGAAGAGCA ACGACGCTAG CAGCAACCAG ATGAACAGGA TCAGAACCAC AGCCGAGAGG 3000
GTTGAAGAGA TGAATGTGAT GGTGGAGGAG GTCTCGGAGA AGGTCAACTT CATTCAGGAC 3060
AGTTTGTTAG AGTTAGATTC TCAGCTGGGC CACCTCCAAG ACCTGTCAGC CCTGGCTGTG 3120
GACACCCTGA CCATGCTGTC TGCATCGGAC AGTCAGCTCC AGGAAGAGGT CCGTCTTTCC 3180
CAGTGTCAGC CTCCTGCAGT GCCCTGGTGT GCTGGAATGA AGCTCGTACG CAAACCTCCT 3240
GTTTTTAAAC CTCCTGTGAG CCCTGGGACC TGTCCTCCTG GAACCAGGAC TCATCGCATG 3300
CAAAACTATG GACATCCGGA AGAAATATCA ATGGAAGAAG AGGAGGAGGA GGAGGATGAG 3360
GATGGCTTGA CACACGAGCG GCTAACTAAT GTTGAAGGAT GCGCTGGTGC TGTCCTGTCC 3420
ACACCTTGTG GTGGTTCTGG AAATCCAGCC TTTGTTCCAG AGGATAATGC AGCACGTTGT 3480
CACTCCAGAA TTTCCAGCCA ATGGAGACAA GCGGGGACGT TATCCAACAC ACAGAGTCCA 3540
AAGAGGACTT TCAGAGATGA AGCATCTCTC CAGTGCAGCA GGAGCAGAGG TATGAACACT 3600
TCCGTGTGCA GGTCCACACC AGTTTTCCAC TTGAACTCCT CTCTTGTCAA AGCTGATAGA 3660
AAGCTGATTA AATTATTTAA GATAAAGAAT AATGAAAATC TTGATGCTCC TGCAGATCTT 3720
GAGCCACTGG ACATCATGCA GAAAACAGCG TTTTCTCATC AGTCTTCGGA GACCCTGTAC 3780
CCACACTATT CAGCTGTGGA GCGAAACAAC CTGATGAGAC TGGCCACCAG CATCCCCTTC 3840
ACTCCCGTCT CCATCCTCGG AGGTGAAGAG GTAAGCATCT ACTCGCTAGA GGAGCTTCCC 3900
TCTGATGGTG ATGTGGGATC CACCAGCATC TCCTCGTGGG CCTCGCGGGG CCTGTCGGCC 3960
ATACTGCAGC CCCTCTCGAG TGCGGAGGGC TCTCTCGACG GGGGTCTGAG GCAGGGCTGC 4020
AGGGTGCTGT GCACATGGGC GGAGCAGGAT GTGCTCCGGC CTGGTCTGGT CTACGTGGTC 4080
AAAGCCTTCA GGCCGGAGGT GCTTGGTGTC TGGCAGCAGT ACTTCCATGG CAGCACGTCA 4140
CTGCAGCTGT GTTTGAGGGA GATCCAGCAG CAACGAGCGG CCCAGAAACT GATGCAAGTG 4200
TTCAACCGGA TCAGGCCCAG AGACCTGTGC CCCTCCCCCA GCTTCCTGGA CGTGTCCCTG 4260
CTCCTGTGCC CGTCCTCCGG TCACTGGTTC ACCATTGAGA GGAACATGTG TGGGGAGTTC 4320
CGGAAGTACA ACAACAACAG CGGAGAGGAG ATCGCCCCCT GCTGCTCACT GGAGGAACTG 4380
CTGCTGGCGT TCTCTCACTG GACCTTTGAG TACTCCCACC GAGAGCTTCT GGTCCTGGAT 4440
ATCCAAGGAG TAGGTGAAGC ACTGACCGAC CCCACTGTCA TCATGGCCCA GGAGAAAAGG 4500
GGGGAGATGC TCTTCGGTCC CGATAACCTG GGAGATGTTG CCATCAAGGG CTTCCTGCAG 4560
AGACACTGCT GTCGCACCTC CTGCTCCAGA CTGGGACTC 4599
Domain Profile
S: 2     sesWsqqetivlikvlskeek..kGalRkalrv..........kkgslflvkeelkevvr  49
          +sW+ +++ ++++ ls  e+  +G+lR+  rv          ++g +++vk + +ev  
Q: 1310  ISSWASRGLSAILQPLSSAEGslDGGLRQGCRVlctwaeqdvlRPGLVYVVKAFRPEVLG  1369
         689*************99875348************************************
S: 50    yvakiykeqkvlhlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknql  109
          +++ ++ ++ l+l+lr++++qraaqkl++ fn+ +P+ +  +p+++ v L  ++s + +
Q: 1370  VWQQYFHGSTSLQLCLREIQQQRAAQKLMQVFNRIRPRDLCPSPSFLDVSLLLCPSSGHW  1429
         ************************************************************
S: 110   ltvEeyllGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklT  169
         +t+E+ + Gef+Kynnn+g+ei +   leel lafsH+t+ey++ ellV+D+qGvge lT
Q: 1430  FTIERNMCGEFRKYNNNSGEEIAPCCSLEELLLAFSHWTFEYSHRELLVLDIQGVGEALT  1489
         ************************************************************
S: 170   Dpqiat...ksrgtkfgkanlgeraiknFfakhhCNeiC  205
         Dp ++    k  ++ fg+ nlg  aik F ++h C   C
Q: 1490  DPTVIMaqeKRGEMLFGPDNLGDVAIKGFLQRHCCRTSC  1528
         ****98876677899********************9988
Domain Sequence
(FASTA)
ISSWASRGLS AILQPLSSAE GSLDGGLRQG CRVLCTWAEQ DVLRPGLVYV VKAFRPEVLG 60
VWQQYFHGST SLQLCLREIQ QQRAAQKLMQ VFNRIRPRDL CPSPSFLDVS LLLCPSSGHW 120
FTIERNMCGE FRKYNNNSGE EIAPCCSLEE LLLAFSHWTF EYSHRELLVL DIQGVGEALT 180
DPTVIMAQEK RGEMLFGPDN LGDVAIKGFL QRHCCRTSC 219
KeywordComplete proteome; Ion transport; Ionic channel; Membrane; Reference proteome; Transmembrane; Transport.
Sequence SourceEnsembl
Orthology
Ortholog group
Ciona savignyi"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-CIS-00078
EKS-GAA-00378
EKS-ORN-00396
EKS-ORL-00366
EKS-TEN-00394
EKS-XIM-00386
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005216; F:ion channel activity
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR005821; Ion_trans_dom.
IPR011009; Kinase-like_dom.
IPR004166; MHCK_EF2_kinase.
Pfam
PF02816; Alpha_kinase; 1.
PF00520; Ion_trans; 1.
SMARTs
SM00811; Alpha_kinase; 1.
Prosites
PS51158; ALPHA_KINASE; 1.
Prints
Created Date20-Feb-2013