EKS-TAR-00347

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00347

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	427.4	8.3E-128	102	398	297

Status

Unreviewed

Ensembl Protein

ENSTRUP00000003716

UniProt Accession

H2RU99;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK4

Gene Synonyms/Alias

DYRK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000001609	ENSTRUP00000003716	ENSTRUT00000003736

Organism

Takifugu rubripes

Functional Description

Protein Length

409

Protein Sequence
(FASTA)

SPASSLQCVS VQRWIKSPSP GTAKVSVKKQ KKTIPVAEAL KNFQDRLTRF EQEEITDYSE 60

IWFMGLSSHK IAGSQGTPQN CGYDDEHGSY IRVLHDHIAY RFEVLEVIGK GSFGQVLKCL 120

DHKNNELVAI KMIRNKKRFH HQALVELKIL DVIKRKDKDN LHNVIHMKEY FYFRNHLCIS 180

FELLGVNLYE LIKKNNFQGF SIALIRRFTH ALLRCLQMLH REKIIHCDLK PENILLSQRG 240

PGNIKVVDFG SSCYEQQRVY TYIQSRFYRS PEVILGHPYS MAIDMWSLGC ILAELYTGYP 300

LFPGESEVEQ IACIMEVLGM PPNDFAQSAS RRRLFFDSKG NPRNVTNSKG KKRIPNSNEL 360

STALKTTDPL FLDFIKRCLT WDPTKRMTPN EGLQHEWILE GNFNKVRPR 409

Nucleotide Sequence
(FASTA)

AGCCCAGCCA GCAGTTTGCA ATGCGTTTCG GTACAGCGAT GGATAAAGTC TCCATCTCCC 60

GGAACAGCAA AGGTTTCAGT AAAAAAACAG AAAAAGACAA TTCCGGTTGC AGAAGCACTC 120

AAGAACTTCC AGGACCGACT GACGAGGTTT GAACAGGAGG AAATCACGGA TTATTCAGAG 180

ATCTGGTTCA TGGGTCTGAG CTCTCACAAG ATCGCGGGAT CTCAAGGCAC CCCGCAGAAC 240

TGCGGCTATG ATGACGAGCA TGGGAGCTAT ATAAGGGTGC TGCATGACCA CATTGCCTAC 300

AGGTTTGAAG TCCTTGAAGT TATTGGAAAA GGCTCATTTG GGCAGGTCCT GAAATGTCTG 360

GACCACAAGA ATAACGAGCT TGTAGCCATT AAGATGATAC GCAACAAGAA AAGGTTTCAT 420

CACCAGGCTC TGGTTGAGCT GAAGATCCTG GATGTAATAA AGAGGAAAGA CAAAGACAAC 480

CTGCACAATG TCATTCACAT GAAGGAGTAC TTCTATTTCC GCAACCACCT GTGCATCTCA 540

TTTGAACTGC TCGGGGTCAA CTTATATGAA CTCATTAAAA AAAACAACTT CCAGGGCTTC 600

AGTATTGCTC TCATTCGTCG CTTCACCCAT GCTCTTCTCC GGTGCCTGCA GATGCTTCAC 660

AGAGAGAAGA TTATCCACTG TGACCTTAAA CCGGAAAACA TACTTTTGTC TCAGAGAGGT 720

CCAGGAAACA TCAAGGTCGT TGACTTTGGG TCAAGCTGTT ATGAACAACA AAGGGTTTAC 780

ACCTACATCC AGAGTCGTTT CTATCGCTCT CCTGAAGTCA TCCTGGGTCA CCCCTACAGC 840

ATGGCCATTG ATATGTGGAG TCTGGGCTGC ATCCTTGCTG AACTCTACAC AGGATATCCC 900

CTCTTCCCAG GAGAGAGTGA AGTAGAGCAA ATAGCTTGCA TAATGGAGGT TCTTGGAATG 960

CCTCCCAATG ACTTTGCTCA GTCAGCATCA AGGAGGAGAC TGTTTTTTGA CTCTAAAGGA 1020

AATCCCAGAA ATGTCACCAA TAGCAAGGGG AAGAAACGGA TACCCAATTC CAACGAACTG 1080

TCTACGGCTT TAAAAACAAC AGATCCACTG TTCCTAGACT TCATTAAACG GTGCCTCACT 1140

TGGGATCCAA CCAAGCGCAT GACACCTAAT GAGGGACTCC AACATGAATG GATCCTGGAA 1200

GGGAACTTTA ACAAAGTCCG ACCAAGA 1227

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         +evlevigkGsfgqV+k+ld+k++e vaik+i+nkkrf++qa  E++iL+ +++kdk++

Q: 102   FEVLEVIGKGSFGQVLKCLDHKNNELVAIKMIRNKKRFHHQALVELKILDVIKRKDKDNL  161

         69**********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv++++e+f+frnhlc+ fell +nLyel+kkn+f+g+s+ l+r++++ +l++L++L++

Q: 162   HNVIHMKEYFYFRNHLCISFELLGVNLYELIKKNNFQGFSIALIRRFTHALLRCLQMLHR  221

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill +++  ++kv+DFGss++++q+ +ytyiqsrfYr+PE+ilg++y+

Q: 222   EKIIHCDLKPENILLSQRGPGNIKVVDFGSSCYEQQR-VYTYIQSRFYRSPEVILGHPYS  280

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         +aiDmWSlGc+laEl+tG+pLfpGe+ev+q+a+i+evlg+pp+ + ++a++++ ff++k+

Q: 281   MAIDMWSLGCILAELYTGYPLFPGESEVEQIACIMEVLGMPPNDFAQSASRRRLFFDSKG  340

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+ ++                +++ k+++p+s+el++alk+++  lf d++kr+l++dp

Q: 341   NPRNVT----------------NSKGKKRIPNSNELSTALKTTD-PLFLDFIKRCLTWDP  383

         **9665................3344567888889998888765.55*************

S: 301   akRitpkealkhpfv  315

         +kR+tp+e l+h+++

Q: 384   TKRMTPNEGLQHEWI  398

         **************7

Domain Sequence
(FASTA)

FEVLEVIGKG SFGQVLKCLD HKNNELVAIK MIRNKKRFHH QALVELKILD VIKRKDKDNL 60

HNVIHMKEYF YFRNHLCISF ELLGVNLYEL IKKNNFQGFS IALIRRFTHA LLRCLQMLHR 120

EKIIHCDLKP ENILLSQRGP GNIKVVDFGS SCYEQQRVYT YIQSRFYRSP EVILGHPYSM 180

AIDMWSLGCI LAELYTGYPL FPGESEVEQI ACIMEVLGMP PNDFAQSASR RRLFFDSKGN 240

PRNVTNSKGK KRIPNSNELS TALKTTDPLF LDFIKRCLTW DPTKRMTPNE GLQHEWI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013