EKS-TAR-00474
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00474
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src430.35.0E-129184434251
StatusUnreviewed
Ensembl ProteinENSTRUP00000003758
UniProt AccessionH2RUE1;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000001630ENSTRUP00000003758ENSTRUT00000003778
OrganismTakifugu rubripes
Functional Description
Protein Length446
Protein Sequence
(FASTA)
LAPGEMVAVA LYDYEAIHDG DLTFKKGDRL KILEESGEWW RAKLTSTGDE GYIPCNYVAK 60
DTLETEEWFF KGISRKDAER QLSAPGNVLG SFMIRDSETT KGSYSLSVRD SPTGDTVKHY 120
KIRTLDNGGF YISPRITFGT LQELVSHYKQ SSDGLCQTLT KACLNPKPEK PWEKDAWEIP 180
RSSLKLEKKL GAGQFGEVWM ATYNKHTKVA VKTMKPGSMS VEAFMAEANL MKSLQHDKLV 240
RLNAVVTKEE PIYIITEFME KGSLLDFLKS DEGNRVQLPK LIDFSAQTAE GMAYIEQRNY 300
IHRDLRAANI LVNKALVCKI ADFGLARIIE DNEYTAREGA KFPIKWTAPE AINYGSFTIK 360
SDVWSFGILL TEIISYGRTP YPGMTNPEVI RALEKGYRMQ KLDSCPPELY KIMMECWKNK 420
PEDRPTFDYL QSVLEDFFTA TESQYQ 446
Nucleotide Sequence
(FASTA)
CTTGCACCAG GTGAGATGGT TGCCGTGGCG CTGTACGACT ATGAGGCCAT TCATGATGGT 60
GACCTCACCT TCAAGAAGGG GGATCGTCTT AAAATCCTGG AGGAGTCTGG AGAGTGGTGG 120
AGAGCCAAGC TGACCAGCAC CGGTGACGAA GGTTATATCC CCTGCAACTA TGTGGCCAAA 180
GACACCCTGG AGACAGAGGA ATGGTTCTTT AAGGGCATCA GCAGGAAAGA TGCAGAAAGG 240
CAGCTGTCAG CTCCTGGGAA CGTTCTAGGT TCCTTCATGA TCCGAGACAG TGAGACCACA 300
AAGGGAAGCT ACTCCCTGTC CGTCAGAGAC AGTCCGACCG GAGACACCGT CAAACACTAC 360
AAGATCCGAA CGCTGGACAA CGGAGGATTC TACATCTCTC CTCGGATCAC CTTCGGCACG 420
CTGCAGGAGC TGGTCAGCCA TTACAAACAG AGCTCCGATG GTCTGTGTCA GACTCTGACC 480
AAAGCGTGTC TGAACCCCAA ACCTGAGAAA CCATGGGAGA AAGATGCCTG GGAGATCCCC 540
AGATCATCGC TGAAACTGGA AAAGAAGCTG GGAGCAGGCC AGTTTGGAGA AGTCTGGATG 600
GCTACGTACA ATAAGCACAC AAAGGTGGCG GTGAAGACCA TGAAGCCTGG CAGCATGTCT 660
GTGGAGGCCT TCATGGCTGA AGCCAACCTG ATGAAGAGCC TCCAGCACGA CAAACTGGTG 720
CGCCTCAATG CTGTGGTCAC CAAGGAGGAG CCCATCTATA TTATCACTGA GTTCATGGAG 780
AAAGGAAGTT TATTGGACTT CTTAAAGAGT GACGAAGGAA ATCGTGTCCA GCTTCCAAAA 840
CTCATCGATT TCTCTGCCCA GACTGCAGAG GGGATGGCCT ACATTGAGCA GAGGAACTAC 900
ATCCACAGAG ACCTGAGAGC CGCCAACATC CTGGTCAACA AAGCTCTGGT CTGCAAGATC 960
GCCGACTTCG GCCTCGCTCG CATCATCGAA GATAACGAGT ACACGGCCAG AGAAGGAGCC 1020
AAATTCCCTA TCAAATGGAC GGCCCCTGAA GCCATCAACT ACGGCTCGTT CACCATCAAG 1080
TCCGATGTGT GGTCCTTTGG AATCCTGCTG ACTGAGATCA TCAGCTATGG ACGCACACCC 1140
TACCCTGGGA TGACCAACCC AGAAGTGATC CGGGCCCTGG AGAAAGGCTA CCGCATGCAG 1200
AAGCTGGACA GTTGTCCTCC AGAACTCTAT AAAATCATGA TGGAGTGCTG GAAGAACAAA 1260
CCTGAGGATC GTCCCACCTT TGATTACCTG CAGAGCGTCT TGGAGGACTT CTTCACAGCC 1320
ACAGAGAGCC AGTATCAG 1338
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eaf++ea+++k+l+h+klv+l 
Q: 184   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFMAEANLMKSLQHDKLVRLN  243
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++eePiyi+te+m+kGslldflk++eg++++lpkl+d++aq aeGmay+e++n+ihr
Q: 244   AVVTKEEPIYIITEFMEKGSLLDFLKSDEGNRVQLPKLIDFSAQTAEGMAYIEQRNYIHR  303
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv++ lv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 304   DLRAANILVNKALVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDV  363
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGilltei+++G++PypGmtn ev++++e+gyr+ + ++cp ely++++ecwk++pe+
Q: 364   WSFGILLTEIISYGRTPYPGMTNPEVIRALEKGYRMQKLDSCPPELYKIMMECWKNKPED  423
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++lq+vl
Q: 424   RPTFDYLQSVL  434
         ********986
Domain Sequence
(FASTA)
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FMAEANLMKS LQHDKLVRLN 60
AVVTKEEPIY IITEFMEKGS LLDFLKSDEG NRVQLPKLID FSAQTAEGMA YIEQRNYIHR 120
DLRAANILVN KALVCKIADF GLARIIEDNE YTAREGAKFP IKWTAPEAIN YGSFTIKSDV 180
WSFGILLTEI ISYGRTPYPG MTNPEVIRAL EKGYRMQKLD SCPPELYKIM MECWKNKPED 240
RPTFDYLQSV L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LAC-00384
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORA-00322
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PES-00327
EKS-PEM-00194
EKS-POA-00358
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAS-00040
EKS-XIM-00467
Gene Ontology
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013