EKS-TAR-00111

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00111

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	417.5	6.3E-125	56	341	286

Status

Unreviewed

Ensembl Protein

ENSTRUP00000005296

UniProt Accession

H2RYS5;

Protein Name

Protein Synonyms/Alias

Gene Name

GSK3B

Gene Synonyms/Alias

GSK3B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000002302	ENSTRUP00000005296	ENSTRUT00000005329

Organism

Takifugu rubripes

Functional Description

Protein Length

421

Protein Sequence
(FASTA)

MSGRPRTTSF AESCKPVPQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60

VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKDSELNI LNIVHYLWTK KRLRYFFYSS 120

GDKKDEVYLN LVLDYVPETV YRVARHYSRA KQTLPMVYVK LYMYQLFRSL AYIHSFGICH 180

RDIKPQNLLL DPETAVLKLC DFGSAKQLVR GEPNVSYICS RYYRAPELIF GATDYTSSID 240

VWSAGCVLAE LLLGQPIFPG DSGVDQLVEI IKVLGTPTRE QIREMNPNYT EFKFPQIKAH 300

PWTKVFRPRT PPEAIALCSR LLEYTPTARL TPLEACAHSF FDELRDPNIK LPNGREKPSL 360

FNFTTQELSS NPSLASILIP AHARSQAAAS TPTNPSSTTD GSTERGPSTT TASASASNAT 420

S 421

Nucleotide Sequence
(FASTA)

ATGTCGGGGC GGCCCAGGAC CACATCCTTC GCGGAGAGCT GCAAACCAGT GCCGCAGCCA 60

TCGGCATTCG GCAGCATGAA AGTCAGCAGG GATAAAGATG GCAGCAAAGT AACAACAGTC 120

GTGGCCACTC CGGGCCAGGG TCCTGACCGA CCACAGGAGG TCAGCTACAC AGACACCAAG 180

GTCATCGGAA ACGGCTCGTT CGGCGTCGTG TACCAGGCTA AACTGTGTGA CTCTGGAGAG 240

CTGGTGGCCA TCAAGAAGGT CCTTCAGGAT AAAAGGTTCA AGGACTCTGA GCTTAACATC 300

TTAAACATCG TTCATTATCT CTGGACTAAA AAACGTCTGC GGTACTTCTT CTACTCCAGC 360

GGAGACAAGA AAGATGAAGT GTATCTGAAC TTGGTTCTGG ATTACGTTCC TGAGACGGTG 420

TACAGAGTGG CGAGACACTA CAGCCGAGCC AAGCAGACCC TGCCCATGGT TTATGTCAAG 480

TTGTACATGT ACCAGCTGTT CAGGAGTCTG GCCTACATCC ATTCGTTTGG GATCTGCCAT 540

CGAGACATCA AGCCCCAAAA TCTGCTGCTG GATCCAGAGA CGGCTGTTCT GAAACTCTGC 600

GACTTTGGCA GTGCTAAGCA GCTGGTCCGT GGGGAGCCGA ACGTGTCCTA CATCTGCTCT 660

CGCTACTATC GAGCCCCTGA GCTCATCTTC GGTGCCACCG ACTACACCTC CAGCATAGAC 720

GTGTGGTCGG CCGGCTGCGT GCTGGCAGAA CTTTTATTAG GACAGCCAAT CTTTCCTGGT 780

GACAGTGGAG TGGATCAGTT GGTTGAAATC ATCAAGGTTC TGGGCACACC GACCCGGGAG 840

CAGATCAGAG AGATGAACCC CAACTACACC GAGTTCAAGT TTCCTCAAAT CAAGGCACAC 900

CCTTGGACTA AGGTATTCCG ACCACGTACA CCCCCCGAGG CCATTGCCCT GTGCTCTCGC 960

CTGCTCGAGT ACACACCCAC AGCCCGCCTC ACGCCCTTAG AGGCCTGTGC ACACTCATTC 1020

TTTGACGAGC TGCGTGACCC CAACATCAAA CTGCCCAATG GGAGAGAGAA GCCATCGCTT 1080

TTCAATTTCA CCACCCAGGA GTTATCCAGT AATCCATCTT TGGCCTCCAT ACTCATCCCT 1140

GCCCACGCCC GCAGCCAGGC CGCAGCTTCT ACTCCGACCA ATCCATCTTC CACCACAGAT 1200

GGCAGCACAG AGCGTGGTCC CAGCACCACC ACCGCCTCTG CCTCGGCCTC CAACGCCACC 1260

TCCTGA 1266

Domain Profile

S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHk.nivrLl  59

         ++++k+ig+GsFg+Vyqa+l+++ e  vaiKkvlqdk++k+ El+il+ ++      rL+

Q: 56    YTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKDSELNILNIVHYLwTKKRLR  114

         5789**********************.********************98876514568**

S: 60    yffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylh  119

         yff++s +kkd+vylnlvl+y+Pet+++v+r+++++k++l++++vkly+yQlfr+lay+h

Q: 115   YFFYSSGDKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIH  174

         ************************************************************

S: 120   sleivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgake  179

         s++i+HrDiKPqNll+d+et+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++

Q: 175   SFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATD  234

         ************************************************************

S: 180   yttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkf  239

         yt++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf

Q: 235   YTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKF  294

         ************************************************************

S: 240   kkikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         ++ik+++++kv++ ++++ea++l++++l+y+p++Rl++le++ah+ff

Q: 295   PQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF  341

         **********************************************9

Domain Sequence
(FASTA)

YTDTKVIGNG SFGVVYQAKL CDSGELVAIK KVLQDKRFKD SELNILNIVH YLWTKKRLRY 60

FFYSSGDKKD EVYLNLVLDY VPETVYRVAR HYSRAKQTLP MVYVKLYMYQ LFRSLAYIHS 120

FGICHRDIKP QNLLLDPETA VLKLCDFGSA KQLVRGEPNV SYICSRYYRA PELIFGATDY 180

TSSIDVWSAG CVLAELLLGQ PIFPGDSGVD QLVEIIKVLG TPTREQIREM NPNYTEFKFP 240

QIKAHPWTKV FRPRTPPEAI ALCSRLLEYT PTARLTPLEA CAHSFF 286

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013