EKS-TAR-00512
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00512
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR468.24.5E-140553892340
StatusReviewed
Ensembl ProteinENSTRUP00000006675
UniProt AccessionQ8UVR8;
Protein NameMacrophage colony-stimulating factor 1 receptor 2
Protein Synonyms/Alias CSF-1-R 2;
Gene Namecsf1r2
Gene Synonyms/Alias csf1r2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000002871ENSTRUP00000006679ENSTRUT00000006723
ENSTRUG00000002871ENSTRUP00000006678ENSTRUT00000006722
ENSTRUG00000002871ENSTRUP00000006677ENSTRUT00000006721
ENSTRUG00000002871ENSTRUP00000006676ENSTRUT00000006720
ENSTRUG00000002871ENSTRUP00000006675ENSTRUT00000006719
ENSTRUG00000002871ENSTRUP00000006674ENSTRUT00000006718
ENSTRUG00000002871ENSTRUP00000006673ENSTRUT00000006717
ENSTRUG00000002871ENSTRUP00000006672ENSTRUT00000006716
ENSTRUG00000002871ENSTRUP00000006680ENSTRUT00000006724
ENSTRUG00000002871ENSTRUP00000006671ENSTRUT00000006715
OrganismTakifugu rubripes
Functional DescriptionTyrosine-protein kinase that acts as cell-surfacereceptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Activates several signaling pathways in response to ligand binding (By similarity).
Protein Length926
Protein Sequence
(FASTA)
PNQAEAILTA GTPFTLRCTG ASSVHWSSSA FCLLYHGRLV DPIDVQRADP RHTGTYCCGY 60
TNQSLEHLST WIHLYVKDPA DPSTVFVTPR NSPRVKEGQD FLYRCLLTDP SVTNLTFQPE 120
DNIQGSGQHL PVGMNVTVDP QRGALIQDVQ RSFSGQYVCS GWKDGRHFIS RSFHLLVAPR 180
LPPPSVAIHQ NKAVRLEGEK FEVTCVSSST THLFNVTWTH LTKKNFDVAV TREYRNSHMY 240
ISSTLMIAAV SQEDRGTYTC AAASEDGVTT ATTHLIVLDS RFMTTYLKTS TTVEAYEGLD 300
VILTFVTESY PPLSNQSWTK PTKVNNNNNV TMYQENYSIN DTRSEASLLL RRVRQEDHGS 360
YTFHFSNSFF SGSQNIDLRI YRSPSAIISV EKNTLTCSSS GYPVPTIAWY SCPGILKTCG 420
NLTTTESSEA DPTSEHDEEN VRKLLNLPLS TGGDVTAECI ASNQVGAFRK VFHLRMLSEN 480
TTRVYFRPTL IGAGSTAAIL FLLLLVVFYK WRQKPKYEIR WKIIESTEGN HYTFVDPTLL 540
PYNYKWEFPR DKLRLGRAVL GSGAFGKVVE ATAYGLGTDD VTRVAVKMLK PRALSEEREA 600
LMSELKILSH LGYHDNIVNL LGACTQGGPM LMITEYCSYG DLLNFLRARA QDFMASILSA 660
DEMEGDPFYK NMATLYGRLR SDSGISCCSD YQEMQPILGS AEKQQVCLSV CLSVCLSVCL 720
SVCLSGVQMG GLSFGDLLSF SHQVAQGLDF LSTRNCIHRD VAARNVLLTD HRVAKICDFG 780
LARDIQNDDS YIVQGNARLP VKWMAPESIF QCVYTVQSDV WSYGVLLWEI FSLGKSPYPN 840
VAVDTHFYKM IKDGRHMTQP DFAPVEMYQL MTHCWSLEPT DRPTFKMICQ LIDRLLQSND 900
DTNHQSYSNI NETKKEHHEN DASRQA 926
Nucleotide Sequence
(FASTA)
CCAAACCAAG CCGAGGCAAT CCTGACAGCC GGGACTCCAT TTACCCTCAG ATGTACTGGT 60
GCAAGTTCAG TCCACTGGTC TAGCTCTGCT TTCTGCCTGC TGTACCACGG CAGGCTGGTT 120
GACCCCATAG ATGTTCAGAG GGCAGATCCC AGACACACTG GTACATACTG TTGTGGGTAC 180
ACCAACCAGA GCTTGGAGCA CTTGAGCACC TGGATCCACC TTTATGTCAA AGATCCGGCT 240
GACCCCTCCA CTGTGTTTGT CACCCCTCGC AATAGCCCCC GTGTGAAGGA AGGTCAGGAT 300
TTCTTATACA GGTGTCTGCT GACTGACCCA TCAGTCACTA ACCTCACCTT CCAACCTGAG 360
GACAACATCC AAGGAAGTGG GCAGCATCTA CCCGTTGGCA TGAACGTGAC TGTTGACCCT 420
CAGCGCGGAG CCCTGATCCA GGATGTGCAG CGCTCATTTA GTGGACAATA TGTCTGTTCA 480
GGCTGGAAGG ACGGACGCCA TTTCATATCC AGATCTTTCC ACTTGTTGGT GGCCCCCAGG 540
CTGCCTCCTC CCTCAGTGGC CATCCACCAG AACAAGGCAG TTCGACTCGA AGGTGAGAAG 600
TTTGAGGTCA CCTGTGTGAG CAGTAGCACC ACCCACCTCT TCAACGTCAC CTGGACGCAC 660
CTCACTAAAA AGAATTTTGA TGTTGCTGTC ACGCGTGAAT ATCGCAACAG CCACATGTAC 720
ATCAGCAGCA CACTGATGAT AGCTGCTGTC AGTCAGGAAG ACAGAGGAAC TTACACCTGT 780
GCGGCTGCCA GTGAGGACGG AGTCACCACA GCAACCACAC ACCTCATCGT TCTTGATTCG 840
CGCTTTATGA CGACTTACTT GAAGACCAGT ACGACGGTGG AAGCATACGA AGGACTCGAT 900
GTGATACTGA CCTTTGTGAC GGAGTCGTAT CCTCCACTCA GCAACCAAAG CTGGACAAAA 960
CCAACAAAGG TCAATAACAA CAATAACGTC ACCATGTACC AGGAGAACTA CTCCATTAAT 1020
GATACCAGAT CAGAGGCGAG TTTGCTGCTG CGGCGAGTTC GTCAGGAGGA CCACGGCAGT 1080
TACACATTCC ATTTCTCCAA CTCATTCTTC AGCGGTTCTC AGAACATTGA TTTACGAATT 1140
TATCGTTCTC CTAGTGCCAT TATCAGTGTG GAGAAAAACA CGCTGACCTG CAGCAGCTCT 1200
GGATACCCAG TACCCACAAT CGCCTGGTAC AGCTGCCCTG GAATCCTAAA GACGTGTGGA 1260
AATCTGACCA CCACTGAGTC TTCTGAAGCT GACCCCACCT CGGAGCATGA TGAAGAGAAT 1320
GTTAGAAAAC TCCTAAACCT CCCTCTATCC ACCGGTGGTG ATGTCACAGC AGAATGCATC 1380
GCCAGCAATC AAGTCGGAGC GTTTCGCAAA GTCTTCCACC TTCGTATGTT GTCCGAGAAC 1440
ACAACAAGAG TTTATTTTCG GCCAACTCTG ATTGGAGCTG GCAGCACTGC TGCCATCCTG 1500
TTCCTGCTCT TATTGGTGGT CTTCTACAAG TGGAGACAGA AACCCAAATA TGAAATTCGT 1560
TGGAAGATAA TCGAGAGCAC CGAGGGAAAT CACTACACCT TTGTTGACCC CACCCTGCTG 1620
CCATACAACT ACAAGTGGGA GTTTCCAAGG GACAAGCTGA GACTGGGTCG TGCGGTCTTG 1680
GGTTCTGGGG CCTTTGGGAA GGTTGTAGAG GCCACAGCAT ATGGTCTGGG AACTGATGAT 1740
GTCACTCGTG TTGCTGTCAA GATGCTGAAA CCGAGAGCTC TGTCTGAGGA ACGTGAAGCT 1800
CTGATGTCAG AGTTGAAGAT TCTAAGTCAC CTTGGGTACC ATGACAACAT TGTGAATCTT 1860
CTGGGCGCAT GCACTCAAGG AGGTCCCATG TTGATGATCA CGGAGTACTG CAGCTACGGC 1920
GACCTGCTCA ACTTCTTGCG GGCTCGCGCT CAAGATTTCA TGGCCTCCAT TTTGAGTGCA 1980
GATGAAATGG AGGGTGATCC CTTTTACAAG AACATGGCGA CCCTGTACGG TAGGCTCAGG 2040
AGTGACAGTG GGATCTCATG TTGTTCCGAC TATCAAGAGA TGCAGCCAAT TCTGGGTTCT 2100
GCAGAAAAAC AGCAGGTCTG TCTGTCTGTC TGTCTGTCTG TCTGTCTGTC TGTCTGTCTG 2160
TCTGTCTGTC TGTCAGGTGT GCAGATGGGC GGCCTCTCTT TTGGTGACCT CTTGAGCTTT 2220
TCCCACCAGG TAGCTCAAGG TCTGGACTTC CTGTCAACCA GGAATTGTAT CCACCGAGAC 2280
GTTGCAGCGA GGAACGTCCT GCTGACGGAT CATCGCGTGG CGAAGATCTG TGACTTTGGC 2340
TTGGCCCGAG ACATCCAAAA CGACGACAGT TACATCGTCC AGGGGAATGC CCGCCTTCCT 2400
GTGAAGTGGA TGGCTCCGGA GAGCATCTTT CAGTGCGTTT ACACAGTCCA GAGTGATGTC 2460
TGGTCCTATG GAGTTTTACT ATGGGAAATC TTTTCTCTGG GTAAAAGTCC CTACCCAAAT 2520
GTTGCCGTGG ACACCCACTT CTACAAGATG ATCAAAGATG GCCGCCACAT GACACAGCCC 2580
GACTTCGCCC CTGTTGAAAT GTATCAGCTG ATGACGCACT GCTGGAGTTT GGAGCCCACA 2640
GACAGACCAA CCTTCAAAAT GATTTGCCAG CTCATCGACA GGCTGCTCCA GTCCAATGAT 2700
GACACGAACC ATCAGTCATA CAGTAACATC AATGAAACCA AAAAAGAGCA CCACGAGAAT 2760
GATGCCAGCC GACAGGCG 2778
Domain Profile
S: 1     lelGk.vlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshl  59
         l+lG+ vlGsGafGkvveatayGl+ +d+  +vavkmlk++a s+e+ealmselkilshl
Q: 553   LRLGRaVLGSGAFGKVVEATAYGLGTDDV-TRVAVKMLKPRALSEEREALMSELKILSHL  611
         56787579****************98775.69****************************
S: 60    GehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldsk  119
         G h+nivnllGact+gGp+++iteyc yGdlln+lr +++ f+ + l+   e e +  +k
Q: 612   GYHDNIVNLLGACTQGGPMLMITEYCSYGDLLNFLRARAQDFMASILSA-DEMEGDPFYK  670
         *******************************************998888.6667777777
S: 120   al.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaalee  178
         ++ +    lrs+s +s    ++y ++++ + + ++  ++   s   +  l       l+ 
Q: 671   NMaTLYGRLRSDSGIS--CCSDYQEMQPILGSAEK--QQVCLSVCLSVCLSVCLSVCLSG  726
         7735555666666666..677899***95554433..33344555455556666667888
S: 179   edsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardim  238
          +  +l++ dllsfs+qva+G++fl+++nc+hrd+aarnvllt+ +v+kicdfGlardi+
Q: 727   VQMGGLSFGDLLSFSHQVAQGLDFLSTRNCIHRDVAARNVLLTDHRVAKICDFGLARDIQ  786
         8999********************************************************
S: 239   kdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdsk  298
         +d +y+v+Gnarlpvkwmapesif+++ytv+sdvwsyG+llweifslG +pyp++ vd++
Q: 787   NDDSYIVQGNARLPVKWMAPESIFQCVYTVQSDVWSYGVLLWEIFSLGKSPYPNVAVDTH  846
         ************************************************************
S: 299   fyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         fyk+ik+G +m+qp++a+ e+y++m +cw  ep+ rp+fk +++l+
Q: 847   FYKMIKDGRHMTQPDFAPVEMYQLMTHCWSLEPTDRPTFKMICQLI  892
         *******************************************996
Domain Sequence
(FASTA)
LRLGRAVLGS GAFGKVVEAT AYGLGTDDVT RVAVKMLKPR ALSEEREALM SELKILSHLG 60
YHDNIVNLLG ACTQGGPMLM ITEYCSYGDL LNFLRARAQD FMASILSADE MEGDPFYKNM 120
ATLYGRLRSD SGISCCSDYQ EMQPILGSAE KQQVCLSVCL SVCLSVCLSV CLSGVQMGGL 180
SFGDLLSFSH QVAQGLDFLS TRNCIHRDVA ARNVLLTDHR VAKICDFGLA RDIQNDDSYI 240
VQGNARLPVK WMAPESIFQC VYTVQSDVWS YGVLLWEIFS LGKSPYPNVA VDTHFYKMIK 300
DGRHMTQPDF APVEMYQLMT HCWSLEPTDR PTFKMICQLI 340
KeywordATP-binding; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Inflammatory response; Innate immunity; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAA-00516
EKS-ORN-00517
EKS-TEN-00514
EKS-XIM-00531
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006954; P:inflammatory response
GO:0045087; P:innate immune response
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013