EKS-TAR-00468

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00468

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	444.9	1.7E-133	285	534	250

Status

Unreviewed

Ensembl Protein

ENSTRUP00000007128

UniProt Accession

H2S406;

Protein Name

Protein Synonyms/Alias

Gene Name

YES1 (1 of 2)

Gene Synonyms/Alias

YES1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000003054	ENSTRUP00000007128	ENSTRUT00000007173

Organism

Takifugu rubripes

Functional Description

Protein Length

551

Protein Sequence
(FASTA)

MGCIKSKEEK GPTMKYRPEN SMMADPNATA ASQTGHYGPD PTQLQQNQVP SSSSGNVGVN 60

FNHSITPFGG SSSAMTPFGG VSSSFTGPVS NSFSGAVSSG VTFFVALYDY EARTSDDLSF 120

TKGDRFQIIN NTEGDWWEAR SITTGRTGYI PSNYVAPADS IQAEEWYFGK MGRKDAERLL 180

LIPGNHRGTF LVRESETTKG AYSLSIRDWE EAKGDNVKHY KIRKLDSGGY YITTRVQFDA 240

LQKLVKHYTE HADGLCHRLT TVCPTVKPQT QGLAKDAWEI PRESLRLEIK LGQGCFGEVW 300

MGTWNGTTKV AIKTLKTGTM SPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEYMA 360

KGSLLDFLKE GDGKFLKLPL LVDMAAQIAD GMAFIERMNY IHRDLRAANI LVGDNLVCKI 420

ADFGLARLIE DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILL TELVTKGRVP 480

YPGMVNREVL EQVERGYRMP CPQGCPESLH EMMKLCWKKD PDERPTFEYL QSFLEDYFTA 540

TEPQYQPGEN L 551

Nucleotide Sequence
(FASTA)

ATGGGATGCA TAAAGAGCAA GGAGGAAAAA GGCCCCACTA TGAAGTACCG TCCAGAGAAC 60

TCCATGATGG CAGACCCCAA CGCCACCGCC GCCTCTCAGA CGGGTCATTA CGGGCCGGAT 120

CCCACTCAGC TGCAGCAGAA CCAGGTCCCC TCGTCCTCGT CGGGAAACGT GGGCGTGAAC 180

TTCAACCACT CAATCACGCC ATTTGGGGGA TCTTCATCTG CCATGACTCC CTTCGGAGGG 240

GTGTCATCGT CCTTCACCGG TCCAGTGTCC AACTCCTTCT CCGGGGCTGT TTCAAGTGGG 300

GTTACCTTCT TCGTGGCTTT ATATGACTAC GAAGCTCGGA CCTCGGACGA TCTGTCCTTT 360

ACAAAAGGAG ACCGCTTTCA GATCATCAAC AACACAGAGG GAGATTGGTG GGAGGCCCGC 420

TCCATCACCA CAGGGAGGAC AGGCTACATC CCCAGCAATT ACGTGGCCCC TGCCGACTCC 480

ATCCAGGCTG AAGAGTGGTA TTTTGGTAAA ATGGGGCGCA AAGATGCTGA GAGATTGCTG 540

CTGATCCCAG GGAACCATCG AGGAACTTTC CTGGTGCGGG AAAGCGAAAC CACTAAAGGA 600

GCTTATTCCC TGTCCATCAG AGACTGGGAG GAGGCCAAAG GAGACAACGT GAAACACTAC 660

AAGATCCGCA AGCTGGACAG CGGCGGCTAC TACATCACCA CCAGGGTGCA GTTCGACGCG 720

TTACAGAAGC TCGTCAAACA CTACACGGAG CACGCCGACG GGCTCTGCCA CAGGCTGACC 780

ACGGTGTGCC CCACGGTGAA GCCTCAGACC CAGGGACTGG CTAAGGATGC CTGGGAGATT 840

CCCCGGGAGT CCCTGCGACT GGAGATCAAA CTGGGCCAGG GCTGCTTCGG CGAGGTGTGG 900

ATGGGCACGT GGAACGGTAC CACTAAGGTG GCCATCAAGA CCCTGAAGAC GGGCACCATG 960

TCGCCCGAGG CCTTCCTCCA GGAGGCTCAG ATCATGAAGA AGCTCAGACA CGACAAGCTG 1020

GTGCCTCTTT ACGCCGTGGT GTCTGAGGAG CCCATCTACA TCGTCACAGA GTACATGGCC 1080

AAAGGAAGTT TGCTCGACTT CCTCAAAGAG GGTGATGGCA AATTCCTGAA GCTCCCTCTG 1140

TTGGTGGACA TGGCTGCGCA GATCGCTGAC GGCATGGCGT TCATCGAGAG GATGAACTAC 1200

ATCCACAGGG ACCTGCGAGC CGCCAACATC CTCGTGGGAG ACAACCTTGT ATGCAAGATT 1260

GCTGACTTCG GTCTGGCCAG GTTGATTGAG GACAACGAGT ACACGGCGAG GCAAGGAGCC 1320

AAATTCCCCA TTAAATGGAC AGCGCCTGAG GCTGCTCTGT ATGGACGCTT CACCATCAAG 1380

TCAGACGTCT GGTCCTTTGG GATCTTACTC ACCGAGCTTG TGACCAAAGG AAGGGTGCCG 1440

TATCCAGGCA TGGTTAACCG TGAGGTGCTG GAGCAGGTGG AGCGAGGCTA CCGTATGCCC 1500

TGCCCCCAGG GGTGCCCCGA GTCCCTGCAC GAGATGATGA AGCTCTGCTG GAAGAAAGAC 1560

CCGGACGAAA GGCCCACGTT CGAGTACCTG CAGTCCTTCC TAGAGGACTA TTTCACAGCC 1620

ACGGAGCCAC AATACCAACC TGGAGAAAAC CTATAG 1656

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt+speafl+eaqi+kklrh+klv ly

Q: 285   LRLEIKLGQGCFGEVWMGTWNGTTKVAIKTLKTGTMSPEAFLQEAQIMKKLRHDKLVPLY  344

         57899*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+makGslldflke +gk lklp lvd+aaq+a+Gma++e++n+ihr

Q: 345   AVVSE-EPIYIVTEYMAKGSLLDFLKEGDGKFLKLPLLVDMAAQIADGMAFIERMNYIHR  403

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvg++lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 404   DLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  463

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l+e+++ cwkkdp+e

Q: 464   WSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHEMMKLCWKKDPDE  523

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 524   RPTFEYLQSFL  534

         ********986

Domain Sequence
(FASTA)

LRLEIKLGQG CFGEVWMGTW NGTTKVAIKT LKTGTMSPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEYMAKGSL LDFLKEGDGK FLKLPLLVDM AAQIADGMAF IERMNYIHRD 120

LRAANILVGD NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHEMMK LCWKKDPDER 240

PTFEYLQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013