EKS-TAR-00129

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00129

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	344.8	1.3E-102	2716	3035	320

Status

Unreviewed

Ensembl Protein

ENSTRUP00000007953

UniProt Accession

H2S6D1;

Protein Name

Protein Synonyms/Alias

Gene Name

ATM

Gene Synonyms/Alias

ATM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000003394	ENSTRUP00000007954	ENSTRUT00000008002
ENSTRUG00000003394	ENSTRUP00000007953	ENSTRUT00000008001

Organism

Takifugu rubripes

Functional Description

Protein Length

3077

Protein Sequence
(FASTA)

MSLPLSNLLL CCRGLENDRA TERKKAADQF RRLIRSPEVM QELDRTSGCK TKGSNQLTWD 60

AVFRFLQRYI QRETESMQSS KSNVTASTLT TRQKKMAEMC SLIKYFIRCA NKRGPCLKCS 120

ELLKHMTEVM QSSYSCAAYG EDYSSLLVKD ILSVRKYWCD IAPRQWHNLL ELYCHLFVSP 180

SKPVNLVLVS RVIHMLVQGC CMQTEGFHNT LFSFFSKVLL AKQEKHLTVL EHLVSALNIF 240

VRSVAMNHRM RVCYLGELLV PALLCIWADM RPSLALKEGI LEFFNLQICA HHPKGARTQE 300

TGAYAEDWSR WRSLLYSLYD ALIGEISQIG SRGKYVTGSR HIAVKENLIQ LTAHICHQLF 360

SDSSDPRGLE VTQGSCRGSA SKRRRIELGW EVLREHLQPQ HSDFDLIPWL QITAVLTSTH 420

PSMLPGRELL LLLASLYQLL AEQKRGERGP YVLRCLKGLA RCQTNYPNKA QIHRSELSRL 480

WARVCALALR GVSSPQSEAL SLDLLRVVVH GGLISVDREL WMLFSGSVCK PSLAAALCLA 540

QALVKCPLPK SIASPSDCRY VGLTDRIASP NLKETLIAWL LMTDQSDEME ENSKPHPIIC 600

RDFPYDLIAN ILVSLTMKDT GTVLRFLMGS DEQEQHSPDG KTNLEEMELL FLQFSFNTLP 660

TTVGGTHEKE PLVSSGGQFT AAPHLRNKLE ELMLLVADNL LLFYVPDAPS TPPECLVRCV 720

GLLTGVLAAY ISTGVMSEKE ACCSQIFSKA KVLLQELSSF VFAAKMKMTE KGSMNPLRSV 780

MKLCTQSSSR NEKDKVFLVS SRLFVLLLPA SLLSDLADIT KLLVSEQQSS SVSGKVTVTD 840

DNDCMREDWD LSRTQNEKID LFDEGIDKMD NSDSMCGPAG AKSLLSEDHL AQQDLLFLAV 900

LDFLCECGSV QPIHGLLFKP QEVRQRLLLL LKQVDFSKAL HLSMYLVLLK KLPTEHSLAP 960

EEFDALLHPL ADLCSDYHQD QDICAAVLLG LLPSIRSLGE SHHPPEEMRH VQGSLLQVVS 1020

GFCYLSQTGK CVAAVRVALV QCLVALLEAD PRCNWAILSL KDHDGTENDI PVSAILSSHL 1080

ADAHHQVRML VATSVERLFL EVQPNDPDQR RMLPLKRQQE AFESIYLKAQ EGMKFLTNCS 1140

SEDQQDESFN RKAALLKSLS VVLCCSPVCE KQALFALFQS YKENNIEEQL IKKILGSVCR 1200

VLGYSSVKSL VTSHLYYLVA EWLAQRLSDD RYTLGSFPYT VLDQETVRDF YRSSYQVLIP 1260

HLVFLDDFEQ VKSIGRCLER DWKDLLADCF PKIMVNILPY FALCGQDALV AQQREKAHRV 1320

YDLLKDSSYL GKQEMDNLIH SNLADIVVEL LMTLYEGGGP EGSTGDLKQF VGELDPAPNP 1380

PFFSSYVIKA TLDYLSKCHS ANHKSLVAIL SKTPISIQRI LLAVCDRAAE TTNRYERHRI 1440

LLVYHLFVNL LLIEVKDGLG GAWAFVLRDV IYTLIHHINS NPLHSDEVSN RSICLCCDLL 1500

TSVCRAALQF CDDAVDCHLQ VIVGTLVVQV TSRPPPISQQ MLRLLQFLIV ENQQKLKEVI 1560

SRLEPFPNLP VFTELRSVQN QLKYSTGTFT LTQEVDHFLS VTSCSSLLLT RLEGLKQLTR 1620

QLHGNKGQIK ELLRECHSTI PTIVLVKLVL SLLQLCKLAI RQPGGADILE AVGSCLGELG 1680

PVDFSTIALL HSRDPLYEKS VSLFTSTELQ QFYIIFNCMN DALTQPGIEV RKAAALCVKN 1740

ILAAQSGVNF WEQHKQNRDP MLTYLNPFRK AKKKVEIVSV EESSEARKKL ENPTLWFAEA 1800

GSHGSWLKAL STVLLDSGGV KSEALLLSRP LCMVWVDCCQ RLLPLIIHSI LQQDSDGSWR 1860

ELLSSHIQEF FRCCCRAQAS NRSTAGVPPN CDAAESDAAS QSLPDQNSLR TMLAVIDYLR 1920

HQQYPVSNGS RSPGTVCDSN FWLELNYLEV AKAAQSCSAH FTALLYTEIY VDKLKANMED 1980

HYSSKSRATR RLTFDDTSQA FTISNLTKKS VEDTNISMQE LLFEVYRSIG EPDSLYGCGG 2040

EMMTSPLTRI RTYEHEALWG KALTSYDLHT SLPEVTRQVG LVEQQGLQKF GLNSILTTYM 2100

KGLESEGVEY GSELRELRFQ AAWRNTQWDC ELPERNKTQA GFHESVFCSL QALRDKEFSV 2160

FDKTMQKART TLVEELCTGS LEAVSSFYPA LRNLQTIQQL ENIKQLFSKP FSDVHLLDVC 2220

TQWRQQSQLL SDSDFTLVEP IMAALSVALH TLMTKVEDPD SKQYLSSVLT DHLMDLCQLA 2280

RKAGNTKLAE RAVFQMKEQC SGRSCVLTPV SSWQLEEAQV FWAKGEQEVA LGLLRRMINN 2340

MEEVVDINPV VVPVYTESLR LCGNWLAETC LESPGVILEN YLERAVEVIT KESRSPQDTR 2400

LLNQRTEAFL ALARFSDMQY QIIDKYMNSS EFENKQALLK KAKEEVDLIR EHKFVRNRYT 2460

TKVQKELELD EKALSNLQAD KQRFLCKAVE NYIQCLEEGE EHDTWVFRLA SLWLENGDVN 2520

AVNAIMKNGV KKIPSHKFLP LMYQLAARMG TKMVSGMAKD MGFHSVLYNL MCRVCTEHPH 2580

HTLFIIFALV NANKDKVFCT TTVSKGVPWQ SSPLDLERSE KAQMIINAVK KKRSQLVQGI 2640

ERLCDAYITL AYMDASRHKT EKRAIPIPAD QPIMQIKDLD QVVIPTMELK VDPSGHYDNL 2700

VTVRSFMPHY HLAGGVNLPK IIDCVGSDGK SRRQLVKGKD DLRQDAVMQQ VFSMCSMLLQ 2760

RNTDTRKRKL NIRRYKVVPF SQRSGVLEWC SGTVPIGQFL VDPDNGAHKR FRPQDWTNLN 2820

CRRKMAVAAN QGFDEKLQAY SEVCKNFRPV FRYFCMERFL DPAVWMEKRL AYTRSVATSS 2880

IVGYIVGLGD RHIQNILIDE QTAELVHIDL GVAFEQGKTL PTPETVPFRL SRDIVDGMGI 2940

TGVEGVFRRC CEKTLEVMRN SQEALLTIVE VLLYDPLFDW TMNPLKAFYL QRDEQQELNA 3000

TLGSTMGGEN MDNQRKFSDS QSFNKVAERV LLRLQEKLKG VEEGTVLSIG GQVNLLIQQA 3060

MDPRNLSRLF PGWQAWV 3077

Nucleotide Sequence
(FASTA)

ATGAGCCTCC CTCTTTCAAA TCTCCTGCTG TGCTGCAGAG GGCTGGAGAA TGACAGAGCA 60

ACAGAGAGGA AGAAAGCAGC TGATCAGTTT CGAAGGCTGA TTCGATCTCC AGAGGTCATG 120

CAGGAGTTGG ATCGTACCTC TGGATGCAAA ACAAAAGGTT CCAATCAGCT CACATGGGAT 180

GCTGTTTTCA GATTTCTGCA GCGTTACATC CAGAGAGAGA CAGAAAGCAT GCAGTCCAGT 240

AAATCCAACG TGACGGCATC TACGCTGACC ACGCGGCAGA AAAAGATGGC CGAAATGTGC 300

AGCTTAATTA AATACTTCAT TCGATGTGCT AACAAACGTG GGCCATGTTT AAAGTGCAGT 360

GAGCTGCTGA AACACATGAC GGAGGTCATG CAGAGTTCAT ACAGCTGTGC AGCTTATGGA 420

GAAGACTACA GCAGTTTGCT TGTGAAGGAC ATCCTGTCTG TACGCAAATA CTGGTGTGAC 480

ATAGCTCCAC GACAGTGGCA CAATCTCTTG GAATTATATT GTCACTTATT CGTCTCTCCA 540

TCCAAGCCTG TTAACCTTGT TTTGGTGAGC AGAGTCATTC ACATGCTGGT GCAAGGCTGC 600

TGCATGCAAA CTGAAGGATT CCACAACACA CTGTTCAGCT TCTTCTCTAA AGTCCTGCTG 660

GCCAAGCAGG AGAAACATTT AACTGTTTTG GAACATCTGG TCTCTGCTCT GAATATCTTT 720

GTAAGATCGG TGGCCATGAA CCATCGGATG AGGGTGTGTT ACTTGGGAGA GTTGCTGGTG 780

CCAGCTTTGT TATGTATCTG GGCAGATATG AGACCCAGTC TGGCTCTGAA AGAGGGCATT 840

TTGGAGTTTT TTAACCTGCA GATTTGTGCT CACCATCCCA AAGGGGCCAG GACACAGGAG 900

ACAGGTGCTT ATGCTGAGGA CTGGAGCAGG TGGAGGAGTC TGCTGTACAG CCTGTACGAT 960

GCTTTAATAG GAGAAATCAG CCAGATAGGC AGCCGAGGGA AATACGTCAC AGGAAGCAGA 1020

CACATAGCTG TGAAGGAGAA TCTTATCCAG CTCACAGCTC ACATCTGTCA TCAGCTGTTC 1080

AGTGACAGTA GTGACCCCCG GGGGTTAGAG GTGACCCAGG GATCCTGCAG AGGATCAGCC 1140

AGCAAACGCC GGCGCATTGA ACTGGGCTGG GAGGTCCTCC GGGAACACCT GCAGCCTCAG 1200

CATAGTGACT TTGATCTAAT TCCATGGCTG CAGATCACAG CAGTCTTGAC CTCCACACAT 1260

CCTTCTATGT TACCTGGTCG GGAGCTGCTC CTCCTGTTGG CGTCACTTTA CCAGCTGCTG 1320

GCAGAACAAA AGAGGGGTGA GAGGGGGCCG TATGTGCTGC GCTGTTTGAA GGGGTTGGCC 1380

CGATGTCAGA CCAACTATCC CAACAAAGCC CAAATCCACA GGAGCGAGCT GAGCAGGCTG 1440

TGGGCTCGGG TATGTGCATT GGCCCTGAGA GGGGTCAGCT CACCTCAGAG CGAAGCCCTC 1500

AGCCTGGATC TTCTGAGAGT TGTTGTCCAC GGTGGTCTAA TCAGTGTGGA CAGGGAACTG 1560

TGGATGCTGT TTTCTGGATC AGTGTGTAAA CCATCACTAG CTGCTGCTCT CTGTCTTGCC 1620

CAAGCCCTTG TAAAGTGTCC ACTCCCTAAA AGCATTGCTT CACCGTCAGA CTGCAGATAT 1680

GTGGGCCTCA CTGATAGAAT TGCATCTCCT AACCTGAAGG AGACTCTCAT AGCCTGGCTG 1740

CTGATGACGG ATCAGAGTGA TGAGATGGAG GAGAACTCCA AACCGCATCC CATCATCTGC 1800

AGGGACTTTC CTTATGATCT GATTGCAAAC ATCCTGGTGT CCCTGACTAT GAAGGACACA 1860

GGAACCGTCC TCAGGTTTCT GATGGGTTCC GACGAACAAG AGCAACATTC CCCTGATGGC 1920

AAAACCAACT TGGAAGAGAT GGAGTTGTTG TTCCTGCAGT TCAGCTTCAA CACACTGCCC 1980

ACCACTGTGG GAGGGACTCA TGAGAAGGAG CCACTGGTTT CATCTGGAGG CCAGTTCACA 2040

GCTGCTCCTC ACCTCAGAAA CAAGCTGGAG GAATTGATGC TTTTAGTTGC TGATAACCTG 2100

CTGCTCTTCT ACGTTCCTGA TGCTCCTTCC ACCCCTCCTG AGTGTCTGGT ACGCTGTGTT 2160

GGTCTTCTAA CAGGTGTTCT TGCAGCTTAC ATTTCCACTG GGGTTATGAG TGAGAAGGAA 2220

GCCTGCTGCT CTCAGATCTT CAGTAAAGCC AAGGTGCTTC TGCAGGAACT GAGCAGTTTT 2280

GTTTTTGCTG CTAAAATGAA GATGACAGAA AAAGGAAGCA TGAATCCGCT GAGATCTGTC 2340

ATGAAGCTGT GCACTCAGTC ATCCAGCAGG AATGAGAAGG ACAAAGTTTT TCTCGTCTCC 2400

TCCCGTTTGT TTGTTCTGCT CCTGCCAGCT AGTCTCCTCA GTGATCTGGC TGATATCACC 2460

AAACTCCTTG TGAGTGAGCA ACAGTCAAGC AGTGTTTCTG GGAAAGTTAC TGTCACGGAT 2520

GACAACGATT GTATGAGGGA AGACTGGGAC TTGTCCAGAA CACAAAATGA AAAGATTGAT 2580

CTGTTTGATG AGGGGATTGA CAAAATGGAC AACAGCGACA GCATGTGTGG CCCAGCAGGT 2640

GCCAAAAGTC TGTTGTCAGA GGACCATTTG GCCCAACAGG ACCTGCTTTT CCTGGCAGTT 2700

TTGGACTTCC TGTGTGAATG TGGTTCTGTC CAGCCCATCC ATGGTTTGCT TTTCAAACCG 2760

CAGGAGGTGC GGCAGAGGCT GTTGCTTCTG TTGAAGCAGG TGGACTTCAG CAAAGCTCTC 2820

CATCTCAGCA TGTATCTCGT CCTGCTGAAG AAGCTTCCCA CTGAACACTC TCTGGCACCA 2880

GAAGAATTTG ACGCATTACT TCATCCTCTT GCTGACCTGT GTTCTGACTA CCATCAGGAT 2940

CAGGACATCT GTGCTGCTGT GCTGCTGGGT TTGTTACCAT CCATCAGGAG TCTTGGGGAA 3000

TCCCATCACC CTCCCGAAGA AATGAGACAT GTGCAAGGGT CGCTGCTTCA AGTAGTGTCT 3060

GGATTCTGCT ACCTGAGCCA AACTGGGAAG TGTGTGGCAG CCGTACGTGT GGCGTTAGTG 3120

CAATGTCTGG TGGCTCTGCT GGAGGCAGAC CCGAGGTGTA ATTGGGCCAT TCTGAGCCTG 3180

AAGGACCATG ATGGCACAGA AAATGACATT CCAGTGTCAG CCATCCTATC ATCTCACCTT 3240

GCAGATGCCC ACCATCAGGT CCGCATGCTG GTAGCCACAT CAGTGGAGCG GTTATTCCTG 3300

GAGGTTCAGC CCAATGATCC AGATCAGAGG AGGATGCTGC CACTTAAAAG GCAGCAGGAA 3360

GCCTTTGAAA GTATTTACCT GAAGGCTCAG GAAGGGATGA AGTTCCTGAC AAACTGCTCC 3420

TCTGAGGACC AGCAGGATGA GTCCTTTAAC CGCAAAGCTG CCTTGTTGAA GAGCCTGTCT 3480

GTTGTGCTGT GCTGTAGTCC AGTCTGTGAA AAACAGGCTC TCTTTGCCCT GTTCCAGTCC 3540

TACAAGGAGA ACAACATCGA AGAGCAGCTT ATTAAAAAGA TACTGGGCAG TGTGTGTAGA 3600

GTGTTGGGCT ACAGCAGCGT GAAATCATTG GTCACCTCTC ATCTCTACTA CTTGGTAGCT 3660

GAATGGCTTG CGCAGAGACT GTCAGATGAC CGCTACACTC TGGGATCTTT TCCTTACACT 3720

GTCCTTGACC AGGAAACAGT CAGAGACTTC TACAGGTCTT CGTACCAGGT CCTCATACCT 3780

CACCTGGTCT TTCTGGATGA CTTTGAGCAG GTTAAGTCTA TCGGCAGGTG TCTAGAGAGG 3840

GACTGGAAAG ATTTACTGGC TGACTGTTTC CCCAAAATCA TGGTGAACAT ACTGCCGTAC 3900

TTCGCCCTGT GTGGCCAGGA TGCATTGGTT GCACAGCAGC GAGAGAAGGC CCACAGAGTG 3960

TACGATCTGC TGAAAGATAG CAGCTATTTG GGAAAACAGG AAATGGACAA CCTGATCCAC 4020

AGTAACTTGG CAGATATTGT GGTGGAACTG TTAATGACTC TGTATGAAGG AGGTGGACCT 4080

GAAGGTTCCA CAGGAGATCT GAAACAATTC GTAGGGGAAT TAGACCCAGC ACCAAATCCA 4140

CCATTTTTTA GCTCCTATGT GATCAAGGCA ACCCTGGACT ACCTCAGCAA ATGTCACAGC 4200

GCCAATCACA AGTCCCTGGT AGCCATTCTC TCCAAAACTC CGATCTCTAT CCAGAGGATC 4260

CTGCTGGCTG TGTGTGATAG AGCGGCAGAA ACCACCAACC GCTACGAACG CCATCGCATC 4320

CTCCTGGTGT ATCACCTGTT TGTTAACTTG CTGCTCATAG AGGTGAAGGA CGGCCTGGGA 4380

GGAGCCTGGG CCTTCGTCCT GAGAGACGTC ATTTACACAC TCATTCACCA CATCAACAGC 4440

AACCCGCTTC ACTCTGATGA GGTTTCCAAC AGAAGTATCT GTCTGTGCTG TGACCTGTTG 4500

ACCTCTGTGT GCCGTGCAGC ACTGCAGTTC TGTGATGATG CTGTAGACTG TCACCTACAG 4560

GTCATTGTGG GGACTCTGGT GGTTCAGGTG ACCAGCCGGC CCCCTCCCAT CTCACAGCAG 4620

ATGCTCCGTC TGCTGCAGTT CCTCATCGTA GAAAATCAAC AGAAGCTGAA GGAGGTCATC 4680

AGCAGGTTGG AGCCTTTTCC AAACCTCCCT GTGTTCACAG AGCTGCGATC TGTACAGAAC 4740

CAGCTCAAAT ACAGCACAGG GACCTTTACG CTGACGCAGG AGGTGGACCA CTTCCTGTCA 4800

GTCACCTCCT GTAGTTCATT ACTTCTGACC AGACTGGAGG GCCTGAAGCA GCTGACCAGG 4860

CAGCTCCATG GCAACAAGGG GCAGATCAAA GAGCTTCTCA GAGAATGCCA CAGTACGATT 4920

CCAACCATCG TGCTGGTGAA GCTTGTGCTC AGCCTACTGC AGCTCTGTAA ATTGGCCATC 4980

CGCCAGCCTG GAGGAGCTGA CATTCTCGAG GCGGTGGGCA GCTGTCTGGG AGAACTGGGA 5040

CCTGTGGATT TCTCAACCAT TGCCCTGCTT CATAGCAGAG ACCCCCTCTA TGAGAAGTCT 5100

GTCAGTCTCT TCACCTCCAC CGAGCTGCAG CAGTTTTATA TCATCTTCAA TTGCATGAAT 5160

GATGCACTCA CACAGCCTGG CATTGAAGTG AGGAAGGCTG CTGCTCTGTG TGTGAAGAAC 5220

ATCCTCGCTG CTCAATCTGG AGTCAATTTC TGGGAGCAGC ACAAACAGAA CCGAGACCCC 5280

ATGCTGACCT ACCTTAATCC CTTTAGAAAG GCCAAGAAGA AGGTGGAAAT AGTCAGTGTC 5340

GAGGAGAGCT CGGAGGCCAG GAAGAAGCTG GAGAATCCCA CGTTATGGTT CGCTGAGGCA 5400

GGCAGCCACG GATCCTGGCT GAAAGCTCTG AGCACTGTCC TGCTGGACAG TGGGGGGGTC 5460

AAGAGTGAAG CTCTGCTGCT GTCACGGCCA TTGTGTATGG TGTGGGTGGA CTGCTGTCAG 5520

AGGCTGTTGC CCCTTATCAT TCACTCCATC CTTCAGCAGG ATTCTGATGG TTCCTGGAGA 5580

GAGTTGCTCT CTTCTCACAT TCAGGAGTTC TTCCGTTGTT GTTGCCGTGC TCAGGCCTCC 5640

AATCGCTCCA CTGCTGGAGT GCCTCCCAAC TGTGACGCTG CAGAGTCGGA TGCTGCCAGT 5700

CAGAGCCTGC CGGACCAGAA CTCTCTACGC ACAATGTTGG CTGTTATTGA CTATCTGAGA 5760

CACCAGCAGT ACCCAGTGTC CAATGGTAGC AGGTCCCCTG GAACTGTGTG TGATTCCAAC 5820

TTCTGGTTGG AGCTGAACTA TCTGGAGGTG GCCAAAGCTG CTCAGTCGTG CTCGGCACAT 5880

TTCACCGCCC TGCTGTACAC GGAAATCTAT GTGGACAAGC TCAAAGCTAA CATGGAGGAC 5940

CATTACAGCT CCAAGTCGAG AGCAACACGC AGACTCACTT TTGATGACAC CAGTCAGGCC 6000

TTCACCATCT CCAACCTGAC TAAGAAGAGT GTGGAAGACA CCAACATTAG CATGCAGGAA 6060

CTGCTGTTCG AGGTCTATCG GAGCATTGGA GAACCTGATA GCTTGTACGG GTGCGGTGGC 6120

GAGATGATGA CCAGTCCACT GACCAGGATT AGGACCTATG AACATGAGGC TTTGTGGGGG 6180

AAGGCTCTGA CGTCCTACGA CCTTCACACC TCACTGCCCG AGGTCACCCG GCAAGTCGGG 6240

CTTGTAGAGC AACAGGGCCT GCAGAAATTT GGCCTGAACA GCATCCTAAC CACCTACATG 6300

AAAGGTCTGG AAAGTGAAGG GGTGGAATAT GGATCAGAGC TGAGAGAGCT CCGCTTCCAG 6360

GCTGCCTGGA GGAACACTCA GTGGGACTGT GAGCTGCCAG AGAGGAACAA AACCCAGGCC 6420

GGCTTCCACG AATCAGTCTT CTGTTCCCTG CAAGCTCTGA GGGACAAAGA GTTTAGTGTG 6480

TTTGATAAAA CCATGCAGAA GGCTAGGACT ACGCTGGTGG AGGAACTGTG TACAGGAAGT 6540

CTTGAGGCAG TGTCCTCCTT CTACCCTGCT CTCAGGAACC TTCAGACCAT CCAGCAGCTG 6600

GAGAACATCA AACAGCTCTT TTCCAAGCCC TTCTCAGATG TGCATCTGCT AGACGTTTGC 6660

ACCCAGTGGC GGCAGCAGTC CCAGCTGCTG AGTGACAGCG ACTTTACACT AGTGGAGCCC 6720

ATCATGGCTG CACTCTCTGT GGCCCTACAC ACCCTGATGA CCAAGGTGGA AGACCCTGAC 6780

AGCAAGCAGT ACCTCAGCTC CGTGCTCACT GACCATCTCA TGGACCTCTG TCAGCTGGCT 6840

CGCAAAGCTG GGAACACAAA GCTGGCAGAG CGTGCAGTCT TCCAGATGAA AGAGCAGTGT 6900

TCAGGGAGAT CTTGTGTGTT AACTCCTGTG TCCTCATGGC AACTAGAGGA AGCCCAAGTA 6960

TTCTGGGCCA AGGGTGAGCA GGAAGTGGCT CTGGGTCTGC TGAGACGGAT GATAAATAAC 7020

ATGGAGGAAG TGGTGGACAT AAATCCTGTG GTGGTGCCAG TCTACACCGA GAGCCTCCGG 7080

CTGTGTGGTA ATTGGCTGGC AGAGACATGC CTGGAAAGTC CTGGAGTAAT CCTGGAAAAC 7140

TACCTGGAGA GGGCTGTGGA AGTGATCACG AAGGAATCAA GATCTCCTCA GGACACCAGA 7200

CTGCTGAACC AACGAACCGA GGCCTTCCTG GCTCTGGCAC GCTTCTCTGA CATGCAGTAC 7260

CAGATCATTG ACAAGTACAT GAACTCCTCA GAGTTTGAAA ACAAGCAGGC ACTGCTGAAG 7320

AAGGCCAAAG AGGAAGTGGA CTTGATACGG GAGCATAAAT TTGTCAGAAA CAGGTACACC 7380

ACAAAGGTGC AGAAAGAGCT GGAGCTCGAT GAGAAGGCAT TGTCCAACCT GCAGGCAGAC 7440

AAACAGCGCT TCCTCTGTAA GGCAGTGGAG AACTACATCC AGTGTCTGGA AGAGGGAGAA 7500

GAACATGACA CCTGGGTTTT CCGCCTTGCT TCGCTCTGGC TGGAGAACGG CGACGTCAAC 7560

GCTGTAAATG CCATAATGAA GAATGGTGTG AAGAAGATCC CCTCCCACAA GTTTCTGCCT 7620

CTGATGTATC AGCTAGCCGC TAGGATGGGG ACGAAGATGG TGTCTGGGAT GGCCAAGGAC 7680

ATGGGCTTTC ACAGTGTTCT CTACAATCTG ATGTGTAGAG TGTGTACGGA GCACCCTCAC 7740

CACACACTCT TCATCATCTT TGCCTTGGTG AATGCCAACA AAGACAAGGT CTTCTGCACG 7800

ACAACTGTGT CGAAGGGTGT CCCCTGGCAG TCATCTCCAC TCGACCTGGA GCGCTCGGAA 7860

AAAGCACAGA TGATCATCAA TGCGGTCAAG AAGAAGAGAA GCCAGCTGGT CCAAGGAATT 7920

GAGCGTCTGT GTGATGCCTA CATCACTCTG GCCTACATGG ATGCCAGCAG GCACAAAACT 7980

GAGAAGAGGG CGATTCCCAT CCCTGCTGAT CAGCCAATCA TGCAGATTAA AGACCTGGAC 8040

CAGGTCGTCA TCCCCACAAT GGAGCTGAAG GTGGATCCAT CTGGTCACTA TGACAACTTG 8100

GTAACGGTCA GGTCATTCAT GCCTCACTAT CACCTGGCTG GGGGAGTCAA CCTGCCGAAG 8160

ATCATCGACT GTGTGGGCTC TGACGGTAAA AGCAGGAGAC AGCTGGTGAA GGGGAAGGAT 8220

GACTTGCGGC AGGATGCGGT GATGCAGCAG GTCTTCAGCA TGTGCTCCAT GCTGCTCCAG 8280

CGCAACACAG ACACTCGCAA GAGGAAGCTG AACATCAGGC GATACAAGGT GGTGCCGTTC 8340

TCACAGAGGA GCGGTGTTTT GGAGTGGTGT TCTGGAACGG TGCCCATTGG GCAGTTCCTG 8400

GTGGACCCAG ATAATGGAGC CCATAAGCGT TTCAGACCTC AGGACTGGAC CAACCTCAAC 8460

TGCCGGCGGA AGATGGCGGT AGCTGCAAAT CAGGGATTTG ATGAGAAGCT CCAGGCCTAC 8520

AGTGAGGTGT GTAAGAACTT CAGGCCCGTC TTCAGGTACT TCTGCATGGA ACGCTTCCTG 8580

GACCCCGCAG TATGGATGGA AAAACGGCTG GCCTACACTC GCAGCGTAGC CACCTCCTCT 8640

ATAGTTGGCT ATATTGTGGG TCTGGGTGAC AGACACATCC AGAACATTCT GATCGACGAG 8700

CAGACCGCTG AACTGGTACA CATTGATTTA GGTGTGGCCT TTGAGCAGGG GAAGACCCTC 8760

CCCACCCCTG AGACCGTCCC CTTCAGACTG TCCAGAGACA TCGTTGACGG CATGGGCATC 8820

ACCGGCGTTG AGGGCGTTTT CAGGAGATGT TGTGAGAAGA CATTGGAGGT GATGCGGAAT 8880

TCTCAGGAAG CTCTGCTGAC AATTGTGGAG GTGCTGCTCT ATGACCCTCT ATTCGACTGG 8940

ACCATGAACC CCCTGAAGGC CTTCTACCTG CAGCGCGATG AACAGCAGGA GCTCAACGCA 9000

ACCCTCGGCT CCACAATGGG GGGTGAAAAC ATGGACAACC AGCGTAAATT CAGCGACAGT 9060

CAGAGCTTCA ACAAAGTGGC GGAGAGGGTT CTGCTGAGGC TGCAGGAGAA GCTGAAGGGA 9120

GTGGAGGAAG GCACGGTGCT GAGCATCGGG GGGCAGGTCA ACCTGCTGAT CCAACAGGCC 9180

ATGGACCCCA GGAACCTCAG CAGATTGTTC CCAGGCTGGC AGGCCTGGGT GTAG 9234

Domain Profile

S: 14    kqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdketsrrkLkirty  73

          + pk +   Gsdgk++++Lvkgk+Dlrqd++++q+fs++  lL++++ t++rkL+ir+y

Q: 2716  VNLPKIIDCVGSDGKSRRQLVKGKDDLRQDAVMQQVFSMCSMLLQRNTDTRKRKLNIRRY  2775

         567999999***************************************************

S: 74    kVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdlstvqarkpklkhl  133

         kVvp s+rsg++ew+ +tv+++++l   v+  +++++   + r++d+ +  +r +++ +

Q: 2776  KVVPFSQRSGVLEWCSGTVPIGQFL---VDPDNGAHK---RFRPQDWTNLNCRRKMAVAA  2829

         *************************...688899998...99***********9888777

S: 134   kls....levfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvislvgyiLg  189

          +     l+ ++ev++n+ p  +++++++e f++p++w e+r aytrs+A++s+vgyi+g

Q: 2830  NQGfdekLQAYSEVCKNFRP--VFRYFCMERFLDPAVWMEKRLAYTRSVATSSIVGYIVG  2887

         7667788*************..9*************************************

S: 190   LgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnalgvtgveGv  249

         Lgdrh +n+lid++t+e+vhid+gvafe++kt l++pe+vPFRL r+iv+++g+tgveGv

Q: 2888  LGDRHIQNILIDEQTAELVHIDLGVAFEQGKT-LPTPETVPFRLSRDIVDGMGITGVEGV  2946

         ********************************.***************************

S: 250   frasceavlrvlreskeklltiLevflydplvdwkk........kkktsketeeelaeka  301

         fr++ce++l+v+r+s+e llti+ev+lydpl+dw++        ++ +++e + +l ++

Q: 2947  FRRCCEKTLEVMRNSQEALLTIVEVLLYDPLFDWTMnplkafylQRDEQQELNATLGSTM  3006

         **************************************9998665556666666777888

S: 302   kaealkikkllskvekaenavatrdlllle  331

           e+++ +++ s+ ++++n+va+r+ll+l+

Q: 3007  GGENMDNQRKFSD-SQSFNKVAERVLLRLQ  3035

         8889998888866.6789999999888776

Domain Sequence
(FASTA)

VNLPKIIDCV GSDGKSRRQL VKGKDDLRQD AVMQQVFSMC SMLLQRNTDT RKRKLNIRRY 60

KVVPFSQRSG VLEWCSGTVP IGQFLVDPDN GAHKRFRPQD WTNLNCRRKM AVAANQGFDE 120

KLQAYSEVCK NFRPVFRYFC MERFLDPAVW MEKRLAYTRS VATSSIVGYI VGLGDRHIQN 180

ILIDEQTAEL VHIDLGVAFE QGKTLPTPET VPFRLSRDIV DGMGITGVEG VFRRCCEKTL 240

EVMRNSQEAL LTIVEVLLYD PLFDWTMNPL KAFYLQRDEQ QELNATLGST MGGENMDNQR 300

KFSDSQSFNK VAERVLLRLQ 320

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0016572	; P:histone phosphorylation
GO:0090399	; P:replicative senescence
GO:0010212	; P:response to ionizing radiation
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013