EKS-TAR-00190

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00190

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	556.0	2.7E-167	398	673	276

Status

Unreviewed

Ensembl Protein

ENSTRUP00000008590

UniProt Accession

H2S861;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000003670	ENSTRUP00000008591	ENSTRUT00000008642
ENSTRUG00000003670	ENSTRUP00000008592	ENSTRUT00000008643
ENSTRUG00000003670	ENSTRUP00000008583	ENSTRUT00000008634
ENSTRUG00000003670	ENSTRUP00000008584	ENSTRUT00000008635
ENSTRUG00000003670	ENSTRUP00000008590	ENSTRUT00000008641
ENSTRUG00000003670	ENSTRUP00000008585	ENSTRUT00000008636
ENSTRUG00000003670	ENSTRUP00000008586	ENSTRUT00000008637
ENSTRUG00000003670	ENSTRUP00000008587	ENSTRUT00000008638
ENSTRUG00000003670	ENSTRUP00000008588	ENSTRUT00000008639
ENSTRUG00000003670	ENSTRUP00000008589	ENSTRUT00000008640

Organism

Takifugu rubripes

Functional Description

Protein Length

738

Protein Sequence
(FASTA)

EDYVLGVGDT LEMTCDMEDH AEPIVWFKDG AVLASSNRTR VGQRILRIIN VSYEDSGVYS 60

CRLARSNVLL SNYTIRVTGA PYWTRPDRMD KKLLAIPAAN TVKFRCAASG NPTPTIHWLK 120

NGKEFKGEQR MGGIKLRHQQ WSLVMESAVP SDRGNYTCVV QNKYGSISHT YQLDVLERSP 180

HRPILQAGLA NQTVEVGSNV EFHCKVYSDA QPHIQWLKHM EVNGSRYGPD GAPYVHILKT 240

ADINTTDKEL EVLLLPNVSF EDAGEYTCLA GNSIGYAFHS AWLTVLPGTE VSPEKDDFYA 300

DILIYVTGCV LFILAVVIIV LCRMRMTTQK TLPTPPVQKL SKFPLKRQVS LDSNSSMNSN 360

TPLVRIARLS SSDGPMLANV SELELPPDPK WEFPRTRLTL GKPLGEGCFG QVVMADAVGI 420

DKEKPNKPLT VAVKMLKDDA TDKDLSDLVS EMEMMKMIGK HKNIINLLGA CTQDGPLYVL 480

VEYASKGNLR EYLRARRPPG MDYSFDTCKI PDEQLTFKDL VSCAYQVARG MEYLASQKCI 540

HRDLAARNVL VTDDNVMKIA DFGLARDVHN IDYYKKTTNG RLPVKWMAPE ALFDRVYTHQ 600

SDVWSYGVLM WEIFTLGGSP YPGIPVEELF KLLKEGHRMD KPTNCTHELY MIMRECWHAV 660

PSQRPTFRQL VEDHDRVLSM TSTDEYLDLA VPFEQYSPTC QDSNSTCSSG DDSVFAHDSL 720

PDEPCLPKQP PSNGVIRT 738

Nucleotide Sequence
(FASTA)

GAGGACTATG TCCTGGGCGT GGGGGACACC CTGGAAATGA CCTGTGACAT GGAGGACCAC 60

GCCGAGCCCA TCGTCTGGTT CAAAGACGGC GCCGTGTTGG CCTCCAGCAA CCGCACGCGG 120

GTGGGCCAGA GGATCCTGCG CATCATCAAC GTGTCGTACG AGGACTCGGG CGTCTACTCG 180

TGTCGGCTGG CTCGCAGCAA CGTGCTGCTG AGTAACTACA CCATCAGGGT GACAGGAGCG 240

CCGTACTGGA CCCGGCCCGA TCGGATGGAC AAGAAACTCT TGGCCATCCC GGCTGCCAAC 300

ACCGTCAAGT TCCGCTGTGC TGCGTCGGGC AACCCAACGC CAACCATCCA CTGGCTGAAG 360

AACGGCAAAG AGTTCAAGGG GGAGCAGCGG ATGGGCGGCA TCAAGTTGCG GCACCAGCAG 420

TGGAGCCTGG TGATGGAGAG CGCCGTCCCG TCCGACCGGG GGAACTACAC CTGCGTGGTG 480

CAGAACAAGT ACGGCTCCAT CTCCCACACC TACCAGCTGG ACGTCCTGGA GCGTTCCCCC 540

CACAGGCCCA TCCTCCAGGC GGGGCTGGCC AATCAGACGG TTGAGGTGGG CAGTAATGTG 600

GAGTTCCATT GTAAGGTTTA CAGCGACGCG CAGCCGCACA TCCAGTGGCT GAAACACATG 660

GAGGTGAACG GCAGCCGCTA CGGGCCCGAC GGCGCCCCCT ACGTCCACAT CCTGAAGACA 720

GCTGATATTA ACACCACAGA TAAGGAGCTT GAGGTTCTCC TCTTGCCCAA TGTGTCTTTT 780

GAGGATGCGG GCGAGTACAC TTGCCTGGCG GGGAACTCTA TCGGCTATGC TTTCCACTCT 840

GCCTGGCTGA CGGTGCTTCC AGGGACAGAA GTGAGCCCGG AGAAGGACGA CTTCTATGCC 900

GACATCCTGA TTTATGTGAC GGGCTGCGTG CTCTTCATCC TCGCCGTTGT CATCATCGTA 960

CTCTGCCGCA TGAGGATGAC CACGCAGAAG ACGTTGCCCA CGCCGCCCGT GCAAAAGCTG 1020

TCCAAGTTTC CCCTCAAGAG ACAGGTGTCC TTGGATTCCA ACTCTTCCAT GAACTCCAAC 1080

ACGCCGCTGG TGAGAATCGC CCGCCTGTCG TCGAGTGACG GGCCAATGCT CGCCAACGTC 1140

TCTGAGCTGG AACTGCCACC TGACCCCAAA TGGGAGTTTC CTCGTACACG GCTGACTCTG 1200

GGTAAACCTC TGGGTGAGGG CTGCTTCGGC CAGGTGGTCA TGGCCGACGC CGTCGGGATT 1260

GACAAGGAGA AGCCCAACAA GCCGCTGACC GTCGCTGTGA AGATGCTCAA AGACGATGCC 1320

ACAGACAAAG ACCTGTCGGA CTTGGTGTCA GAAATGGAGA TGATGAAGAT GATTGGAAAG 1380

CACAAAAACA TCATCAACCT GCTGGGAGCG TGCACGCAGG ACGGTCCTCT GTATGTCCTG 1440

GTGGAATACG CCTCCAAGGG TAACCTGAGG GAGTACCTGC GAGCCCGCCG GCCGCCCGGC 1500

ATGGATTACT CCTTCGACAC GTGCAAGATC CCAGACGAGC AGCTCACGTT CAAAGACCTG 1560

GTGTCGTGTG CCTACCAGGT GGCCCGGGGG ATGGAGTACC TGGCCTCGCA GAAGTGTATC 1620

CACAGAGACC TGGCGGCCAG AAATGTTCTG GTGACGGACG ACAACGTTAT GAAGATCGCC 1680

GACTTCGGCC TGGCCAGAGA CGTGCACAAC ATAGACTACT ACAAGAAGAC CACCAACGGT 1740

CGTCTGCCCG TGAAATGGAT GGCCCCGGAG GCTCTGTTTG ACCGGGTCTA CACACACCAG 1800

AGCGACGTGT GGTCCTACGG GGTCCTGATG TGGGAGATCT TCACGCTGGG AGGGTCTCCG 1860

TACCCAGGGA TCCCGGTGGA GGAGCTCTTC AAGCTGCTGA AGGAGGGACA CCGAATGGAC 1920

AAACCCACCA ACTGCACACA TGAACTGTAC ATGATCATGA GGGAGTGCTG GCACGCCGTG 1980

CCGTCGCAGA GGCCCACCTT CCGACAGCTG GTGGAGGATC ACGACCGGGT GCTGTCCATG 2040

ACTTCCACAG ATGAGTACCT GGACCTGGCC GTGCCCTTTG AGCAGTACTC CCCCACCTGT 2100

CAGGACTCCA ACAGCACCTG CTCCTCAGGA GACGACTCGG TCTTCGCCCA CGACTCGCTG 2160

CCCGACGAGC CCTGTCTTCC CAAGCAGCCC CCCAGTAACG GGGTGATTCG GACATAA 2217

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+a+a+g+dk+k++k  tvavkmlk+datdkdl+dlvseme++k+

Q: 398   LTLGKPLGEGCFGQVVMADAVGIDKEKPNKPLTVAVKMLKDDATDKDLSDLVSEMEMMKM  457

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyv+veya+kGnlre+lrarrp+g+++s d++k+++eqlt+

Q: 458   IGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKIPDEQLTF  517

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvt+dnv+kiadfGlardvh+idyykkt

Q: 518   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDVHNIDYYKKT  577

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvws+Gvl+wei+tlGgspypgi+veelfkllkeGh

Q: 578   TNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  637

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlved  276

         rm+kp++ct+ely++mrecwha++s+rptf+qlved

Q: 638   RMDKPTNCTHELYMIMRECWHAVPSQRPTFRQLVED  673

         **********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMADA VGIDKEKPNK PLTVAVKMLK DDATDKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVLVEYASKG NLREYLRARR PPGMDYSFDT CKIPDEQLTF 120

KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTDDNVM KIADFGLARD VHNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSYG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPTNCTH ELYMIMRECW HAVPSQRPTF RQLVED 276

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013