EKS-TAR-00481

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00481

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	342.4	3.8E-102	92	349	258

Status

Unreviewed

Ensembl Protein

ENSTRUP00000009191

UniProt Accession

H2S9W5;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000003898	ENSTRUP00000009191	ENSTRUT00000009246

Organism

Takifugu rubripes

Functional Description

Protein Length

973

Protein Sequence
(FASTA)

LWTAAYDYDA SGEDELSLRR GDVVEVLSKD AAISGDEGWW TGKIHHRVGI FPSNYVTYQP 60

AIYRLPTTTG SVGVAERVPG SPVQIPFSEL VLEEIIGVGG FGKVYRGTWT DQEVAVKAAR 120

QDPDEDITAT ASSVKQEAKL FSMLQHPNII KLEGVCLEEP NLCLVMEYAR GGTLNRALTG 180

RRIPPHILVN WAVQIARGMQ YLHEEAVVSI IHRDLKSSNI LLLEKIENDD IGRKTLKITD 240

FGLAREWHKT TKMSAAGTYS WMAPEVIKSS LFSKGSDIWG YGVLLWELLT GEVPYRGIDG 300

LAVAYGVAVN KLTLPIPSTC PEPFAKLMEE CWDQDPHVRP SFSCILEQLS AIEEAVMATM 360

PQDSFHSMQD DWRVEIQEMF DELRTKEKEL RSREEELTRA ALQQKSQEEL LKRREQQLAE 420

REIDVLEREL NILIFQLNKD KPNVKKRKGK FKRSRLKLKD GNRISLPSDF QHKITVQASP 480

SMDKRRSLHS NSSSPPSSPT LIPRLRAIQL TQDESNRTWG RSSLYRPEEF DDVKKGIKKK 540

GRTWGPSSVQ TKERPAAVER VRPLSDGSNP WSTSLVKSQK SVPLAALFAE QASAGKDETV 600

SQESPDSSSK PKQLKFPNQV YIDLPLWRDE PQSPGGAGDC GVGAGASSTS TTPQHTPTNS 660

LKRTSARRKT DSVLYGCGSL LASVVLGYDI REALKNPITP GDDCESPREE KEKKKKEGLF 720

QRATRFRRST SPPGGRSRKD EASSNHQGSA QPVNLISMSA IIECNSTKCL LQSEACLSDN 780

GPGMVSPVVL SQHTEPVRVG SEPVRRTQLQ DNHRCHKDHN ANPKSDAGAD QPQHRNTPAQ 840

EEIPQQFCGI LTLWHLFPAN GQPTPATQKK QDKDRAPDKV SGGEGLSRPR PVSFRAKPHA 900

WALLRGRNKS YSLGHYSGER TAQNLSMVLS SEGCSLLDMD TEGQKRDCTV PLCRIQSSPA 960

RPSVFELEKE FLS 973

Nucleotide Sequence
(FASTA)

CTCTGGACAG CCGCGTATGA CTACGACGCA AGCGGCGAGG ACGAGCTCAG CCTTAGACGC 60

GGGGACGTGG TGGAGGTCCT CTCCAAGGAT GCAGCGATCT CCGGCGACGA GGGATGGTGG 120

ACAGGTAAAA TTCACCACCG AGTTGGGATT TTCCCCTCCA ACTATGTCAC CTACCAGCCC 180

GCTATATACC GCCTCCCCAC GACCACTGGC TCGGTGGGTG TTGCGGAGCG GGTCCCGGGC 240

TCGCCCGTCC AGATCCCTTT CAGTGAACTG GTGCTAGAGG AAATCATCGG CGTGGGGGGA 300

TTTGGCAAAG TTTACAGGGG CACGTGGACA GACCAAGAGG TCGCCGTTAA GGCGGCCAGA 360

CAGGATCCAG ACGAGGACAT AACGGCCACC GCCAGCAGTG TTAAACAAGA AGCTAAACTT 420

TTCTCCATGT TGCAACACCC CAATATCATC AAACTGGAAG GTGTGTGTTT GGAAGAGCCC 480

AACCTGTGCC TAGTTATGGA GTACGCACGA GGCGGGACCC TGAATCGGGC GTTGACCGGA 540

AGGCGCATAC CTCCACACAT CCTGGTCAAC TGGGCCGTGC AGATCGCAAG AGGGATGCAG 600

TACCTGCACG AGGAGGCGGT GGTATCCATC ATCCACCGCG ACCTGAAGTC TAGCAACATT 660

TTGTTACTTG AAAAGATTGA GAATGACGAC ATTGGCAGGA AGACCTTGAA GATCACAGAT 720

TTTGGGCTGG CCAGGGAGTG GCACAAAACC ACCAAAATGT CAGCTGCAGG CACCTACTCC 780

TGGATGGCTC CTGAAGTCAT CAAGTCATCT CTCTTCTCCA AAGGCAGCGA CATCTGGGGC 840

TATGGTGTCC TGCTGTGGGA GTTGCTAACT GGGGAGGTGC CGTATCGTGG GATAGACGGT 900

CTGGCTGTAG CTTATGGTGT GGCTGTCAAT AAATTAACCC TACCAATCCC CTCCACCTGC 960

CCCGAACCTT TTGCCAAGCT CATGGAGGAG TGTTGGGACC AGGACCCCCA TGTGCGTCCA 1020

TCTTTTTCCT GCATCCTGGA GCAGTTGTCA GCCATTGAGG AGGCGGTGAT GGCCACCATG 1080

CCCCAGGACT CTTTCCACAG CATGCAGGAC GACTGGCGTG TGGAGATCCA GGAAATGTTT 1140

GACGAGCTCA GGACCAAAGA GAAGGAGCTT CGTTCCAGAG AAGAGGAGCT GACGCGCGCT 1200

GCCCTGCAGC AGAAGTCACA GGAGGAGCTG CTGAAGCGGC GGGAGCAGCA GCTGGCTGAG 1260

CGCGAGATCG ACGTGCTGGA GCGGGAGCTC AACATCCTCA TTTTTCAGCT CAACAAAGAC 1320

AAGCCTAACG TGAAGAAGAG GAAAGGCAAA TTCAAACGTT CGCGACTTAA ACTCAAGGAT 1380

GGAAACCGCA TCAGCCTGCC CTCCGACTTC CAGCATAAGA TCACAGTTCA GGCTTCACCC 1440

TCCATGGACA AGAGACGAAG CCTCCACAGC AACAGCTCCT CTCCTCCCAG CAGTCCCACC 1500

CTCATTCCCC GCCTGAGAGC CATCCAGCTC ACTCAGGACG AGAGCAACCG CACGTGGGGC 1560

CGCAGCTCCC TCTACAGGCC AGAGGAGTTT GACGACGTGA AGAAAGGAAT AAAGAAGAAG 1620

GGAAGGACCT GGGGACCCAG TTCAGTGCAG ACTAAAGAGA GGCCCGCTGC TGTAGAGAGA 1680

GTTCGTCCTC TGTCGGACGG CAGTAACCCC TGGTCCACCA GCCTGGTAAA GTCACAGAAA 1740

TCTGTTCCCC TCGCTGCCCT GTTTGCAGAA CAAGCAAGTG CCGGTAAAGA TGAGACTGTG 1800

TCCCAGGAAA GTCCTGACAG CAGCTCCAAG CCAAAGCAGC TCAAGTTCCC CAACCAGGTG 1860

TACATCGATC TACCTCTGTG GAGGGACGAG CCTCAGAGCC CCGGGGGAGC GGGAGACTGC 1920

GGGGTCGGCG CAGGAGCCTC ATCGACCTCC ACCACACCTC AGCACACCCC CACCAACAGC 1980

CTGAAGCGGA CGTCGGCTCG ACGGAAGACC GACTCGGTGC TGTACGGCTG CGGCTCTCTG 2040

CTGGCTTCAG TGGTGCTCGG GTACGACATC AGAGAGGCTC TGAAAAACCC AATCACCCCT 2100

GGAGACGACT GTGAGTCACC ACGCGAGGAG AAAGAGAAGA AGAAGAAAGA AGGCCTGTTT 2160

CAGCGCGCCA CTCGATTCCG CCGCAGCACC TCGCCGCCAG GCGGTCGCTC CCGCAAAGAC 2220

GAGGCGTCGT CAAACCACCA GGGCTCCGCC CAGCCCGTTA ATCTGATCTC CATGTCAGCC 2280

ATCATAGAGT GTAACTCCAC CAAGTGTCTC CTACAGTCTG AAGCCTGTCT TTCAGACAAC 2340

GGCCCTGGGA TGGTCAGCCC AGTCGTCCTC AGTCAACACA CGGAGCCGGT CAGGGTCGGC 2400

TCAGAGCCTG TACGGAGGAC TCAGCTCCAA GACAACCATC GATGCCACAA GGACCACAAT 2460

GCAAACCCAA AGTCAGATGC AGGAGCTGAC CAACCACAAC ACAGGAACAC GCCTGCGCAG 2520

GAAGAAATAC CACAACAGTT TTGTGGTATT TTAACACTTT GGCACCTGTT TCCAGCCAAT 2580

GGTCAGCCCA CTCCAGCCAC ACAGAAGAAG CAGGACAAGG ACAGAGCACC AGACAAGGTC 2640

TCAGGCGGGG AGGGGTTGTC CAGACCACGA CCAGTGTCAT TCCGGGCCAA GCCCCACGCC 2700

TGGGCCCTGT TGAGAGGTCG CAACAAGAGC TACTCGCTGG GCCACTACTC TGGAGAGAGA 2760

ACGGCACAAA ACCTGAGTAT GGTTCTGTCC TCGGAGGGCT GCTCCCTCCT GGACATGGAC 2820

ACAGAGGGCC AGAAACGGGA CTGCACGGTG CCACTCTGTC GCATTCAGAG TTCTCCTGCA 2880

CGACCGTCAG TGTTTGAGCT GGAGAAGGAG TTCTTGTCTT GA 2922

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60

         lee+ig g fgkvy+++w+++evavK++r++  e  ++++ ++++eakl+s+l+hpnii+

Q: 92    LEEIIGVGGFGKVYRGTWTDQEVAVKAARQDPDEdiTATASSVKQEAKLFSMLQHPNIIK  151

         589****************************999888999********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         l Gvcleepnl+lvmey++gg L+++l +   r+i+++ lv+wa+qiArGm+YLh+ea++

Q: 152   LEGVCLEEPNLCLVMEYARGGTLNRALTG---RRIPPHILVNWAVQIARGMQYLHEEAVV  208

         *****************************...9***************************

S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173

         +iihrdLks+n+Ll       +   ktlki+dFG are++k+tkmsaagt+ wmaPEv+k

Q: 209   SIIHRDLKSSNILLlekiendDIGRKTLKITDFGLAREWHKTTKMSAAGTYSWMAPEVIK  268

         **************9**99988889***********************************

S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233

         ++ +s+ sD+w ygv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe+++kLm

Q: 269   SSLFSKGSDIWGYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLM  328

         ************************************************************

S: 234   kecwnedpekRpsfseivksl  254

         +ecw++dp+ Rpsfs i+++l

Q: 329   EECWDQDPHVRPSFSCILEQL  349

         *****************9986

Domain Sequence
(FASTA)

LEEIIGVGGF GKVYRGTWTD QEVAVKAARQ DPDEDITATA SSVKQEAKLF SMLQHPNIIK 60

LEGVCLEEPN LCLVMEYARG GTLNRALTGR RIPPHILVNW AVQIARGMQY LHEEAVVSII 120

HRDLKSSNIL LLEKIENDDI GRKTLKITDF GLAREWHKTT KMSAAGTYSW MAPEVIKSSL 180

FSKGSDIWGY GVLLWELLTG EVPYRGIDGL AVAYGVAVNK LTLPIPSTCP EPFAKLMEEC 240

WDQDPHVRPS FSCILEQL 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50002	; SH3; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013