EKS-TAR-00047
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00047
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak318.77.5E-95206478273
StatusUnreviewed
Ensembl ProteinENSTRUP00000009733
UniProt AccessionH2SBF2;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK2 (1 of 2)
Gene Synonyms/Alias JAK2 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000004107ENSTRUP00000009732ENSTRUT00000009787
ENSTRUG00000004107ENSTRUP00000009733ENSTRUT00000009788
ENSTRUG00000004107ENSTRUP00000009730ENSTRUT00000009785
ENSTRUG00000004107ENSTRUP00000009731ENSTRUT00000009786
OrganismTakifugu rubripes
Functional Description
Protein Length495
Protein Sequence
(FASTA)
RVNITWKLEV AKQLSWAMHY LEDKNLIHGK VCAKNVILIR EEDRTTGSLP FIKLSDPGIS 60
VGVLPREILV DHIPWVPPEC IDNPQNLSLA ADKWSFGTTL WEICSSGDKP LSTLDSSKKR 120
LFYEDRHQLP APKWTELANL INSCMDYEPS HRPSFRAIIR DLNSLFTPDY ELLVESDMVP 180
NRTKGSGFPW ASENQEPTQF EERHLIFIKQ LGKGNFGSVE MCRYDPLQDS TGEVVAVKKL 240
QHSTAEHLRD FEREIEILKS LHHENIVKYK GVCYSAGRRN LRLIMEYLPY GSLRDYLIKH 300
RERFQPAKLL LYASQICKGM DYLAGKRYIH RDLATRNILV ESEMRVKIGD FGLTKVLPQD 360
KEYYTVREPG ESPIFWYAPE SLTESKFSVA SDVWSFGVVL YELFTYSDKT CSPPAVFMEK 420
MGKEKQGQMI VYHLIDLLKQ GYRLPAPDSC PAEIHTIMME CWSSNLGLRP SFNSLMHRVE 480
AVRGSLDSNT DFPPF 495
Nucleotide Sequence
(FASTA)
CGTGTGAACA TCACCTGGAA GCTGGAGGTG GCCAAGCAGC TGTCCTGGGC CATGCACTAC 60
CTGGAGGACA AGAACCTCAT TCACGGGAAG GTTTGTGCCA AGAACGTCAT CCTGATCCGA 120
GAGGAGGATC GGACAACGGG GAGCCTGCCC TTCATCAAGC TGAGTGACCC GGGCATCAGC 180
GTGGGCGTGC TGCCCCGAGA AATTCTAGTG GACCACATCC CCTGGGTGCC CCCCGAGTGC 240
ATCGACAACC CCCAGAACCT GAGCCTGGCC GCGGACAAGT GGAGCTTCGG GACCACGCTG 300
TGGGAGATCT GCAGCAGCGG AGACAAGCCG CTCAGCACGT TGGACAGCTC CAAGAAGCGC 360
TTGTTTTATG AGGACCGGCA CCAGCTGCCG GCTCCTAAAT GGACCGAGCT GGCCAACCTG 420
ATCAACAGCT GCATGGACTA CGAGCCGTCG CACCGGCCCT CCTTCAGAGC CATCATCAGA 480
GACCTCAACA GCCTCTTCAC ACCAGACTAC GAGCTGCTGG TGGAGAGCGA CATGGTTCCC 540
AACAGAACCA AAGGCTCCGG CTTCCCGTGG GCGTCGGAGA ACCAGGAACC CACCCAGTTC 600
GAGGAGAGAC ACCTCATCTT CATCAAGCAG TTGGGAAAGG GAAACTTCGG CAGCGTGGAG 660
ATGTGCAGGT ACGACCCTCT GCAGGACAGC ACCGGCGAGG TGGTGGCGGT GAAGAAGCTG 720
CAGCACAGCA CGGCCGAGCA CCTGCGAGAC TTCGAGCGGG AAATCGAGAT CCTCAAATCG 780
CTCCACCACG AGAACATTGT CAAATACAAA GGAGTGTGCT ACAGCGCGGG ACGGAGGAAC 840
CTGCGCCTCA TCATGGAGTA CCTGCCCTAC GGCAGCCTGA GAGATTACCT CATCAAGCAC 900
AGGGAGCGCT TCCAACCCGC CAAGCTGCTG CTCTACGCCT CGCAGATCTG CAAGGGGATG 960
GACTACCTGG CAGGGAAGCG GTACATCCAC CGAGACCTGG CCACCCGGAA CATCCTCGTG 1020
GAGAGCGAGA TGAGGGTGAA AATCGGCGAT TTCGGCCTGA CCAAGGTGCT GCCGCAGGAT 1080
AAAGAGTATT ACACAGTGAG GGAACCGGGA GAGAGCCCCA TCTTCTGGTA CGCGCCAGAG 1140
TCCCTCACAG AGAGCAAGTT CTCCGTGGCC TCGGACGTGT GGAGCTTCGG CGTCGTCCTC 1200
TACGAACTCT TCACGTACAG CGACAAGACC TGCAGCCCGC CGGCGGTGTT CATGGAGAAG 1260
ATGGGGAAGG AGAAACAGGG CCAGATGATC GTCTACCACC TGATAGACCT GCTGAAACAG 1320
GGCTACAGGC TGCCTGCTCC GGACAGCTGC CCAGCAGAGA TCCACACCAT CATGATGGAA 1380
TGCTGGAGCA GCAACCTAGG GCTGCGACCC TCCTTCAACT CCTTGATGCA CCGCGTGGAG 1440
GCCGTCCGCG GCAGCCTGGA CAGCAATACG GACTTCCCCC CCTTT 1485
Domain Profile
S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlsheh  61
          +i++Lgkg+f++v+++r+d+ +dst+e va+k L++s+ ++ rdf+re+eil++l+he+
Q: 206   IFIKQLGKGNFGSVEMCRYDPLQDSTGEVVAVKKLQHSTAEHLRDFEREIEILKSLHHEN  265
         6899********************************************************
S: 62    ivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLed  119
         ivk+kgvc++ g++  rl+mey+++GsL++yL k++e+ + ++ll +a+q++k+m+YL  
Q: 266   IVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLIKHRERFQPAKLLLYASQICKGMDYLAG  325
         *********999888*********************************************
S: 120   kklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwlap  178
         k+++hrd+a+rn+Lve+e +      vk++d+gl+k+++qd eYy+vre+++s+i+w+ap
Q: 326   KRYIHRDLATRNILVESEMR------VKIGDFGLTKVLPQDkEYYTVREPGESPIFWYAP  379
         ********************......**********************************
S: 179   eclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklell  225
         e+l+e+k +s+asdvWsFgv+lyel+t  +k +sp    +++++ e        +++ ll
Q: 380   ESLTESK-FSVASDVWSFGVVLYELFTySDKTCSPpavfMEKMGKEkqgqmivyHLIDLL  438
         *******.*******************99999**9**997777777899999********
S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailed  264
         +++ rlp+p+ cpae++++m++c+s +   rpsF+ ++++
Q: 439   KQGYRLPAPDsCPAEIHTIMMECWSSNLGLRPSFNSLMHR  478
         ***********************************99875
Domain Sequence
(FASTA)
IFIKQLGKGN FGSVEMCRYD PLQDSTGEVV AVKKLQHSTA EHLRDFEREI EILKSLHHEN 60
IVKYKGVCYS AGRRNLRLIM EYLPYGSLRD YLIKHRERFQ PAKLLLYASQ ICKGMDYLAG 120
KRYIHRDLAT RNILVESEMR VKIGDFGLTK VLPQDKEYYT VREPGESPIF WYAPESLTES 180
KFSVASDVWS FGVVLYELFT YSDKTCSPPA VFMEKMGKEK QGQMIVYHLI DLLKQGYRLP 240
APDSCPAEIH TIMMECWSSN LGLRPSFNSL MHR 273
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
Created Date20-Feb-2013