EKS-TAR-00366

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00366

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	391.7	4.5E-117	192	478	287

Status

Unreviewed

Ensembl Protein

ENSTRUP00000009844

UniProt Accession

H2SBR5;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000004161	ENSTRUP00000009844	ENSTRUT00000009900
ENSTRUG00000004161	ENSTRUP00000009845	ENSTRUT00000009901

Organism

Takifugu rubripes

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

GTARPVVLLI LRRWFSRGYS LGEAETRECV YYNDNWRTER TNQSGFERCE GEKDKRLHCY 60

ASWLNSSGTI KLVKKGCWLD DFNCYDRQEC VSMEENPQVF FCCCEGNYCN ERFTHLPDMI 120

GSGNRVKIRP PPRVPSLLNV LVYSLLPLCV LSLALLLALW MYRHRKPPYG HVDLSEDPGP 180

APPSPLVGLK PLQLLEIKAR GRFGCVWKAQ LMSKYVAVKI FPFQNKQSWQ NERDIFLTPG 240

MRHENLLRYI AAEKHGTNLE TELWIITEFH ERGSLTDHLK GNAISWNELC HIAETMSRGL 300

AYLHEDIPSY KGEGPKPTIA HRDFKSKNVL LRDDLTAVIG DFGLAVRFEP GKPPGDTHGQ 360

VGTRRYMAPE VLEGAINFQR DSFLRIDMYA MGLVLWELVA RCSEADGGEY MLPFEEEVGQ 420

HPSLEDLQDV VVHKKMRPVM KDCWLKHPGL SQMCETIEEC WDHDAEARLS AGCVEERIGQ 480

IARTVSSTTS DGPISIVTSL TNEDLPPKES ST 512

Nucleotide Sequence
(FASTA)

GGGACCGCGA GGCCTGTGGT CCTTTTGATC CTCCGCCGAT GGTTCTCACG AGGGTACAGT 60

CTGGGCGAAG CAGAGACCCG GGAATGTGTG TACTACAATG ATAACTGGCG CACGGAGAGG 120

ACCAACCAGA GCGGCTTTGA GCGCTGCGAG GGTGAAAAGG ACAAGCGGCT GCATTGCTAC 180

GCCTCTTGGC TCAACTCCTC AGGGACCATC AAGCTGGTGA AGAAAGGCTG CTGGCTGGAC 240

GACTTCAACT GCTATGACAG GCAAGAGTGT GTCTCCATGG AGGAAAACCC TCAGGTCTTC 300

TTCTGCTGCT GCGAGGGGAA CTACTGCAAT GAACGATTCA CTCACCTTCC TGACATGATT 360

GGCAGCGGAA ACCGAGTAAA AATCCGACCT CCTCCTCGAG TGCCATCCCT GCTCAACGTG 420

CTTGTGTACT CGCTGCTGCC TCTGTGCGTC CTCTCTCTGG CCCTTCTGCT GGCTTTGTGG 480

ATGTATCGCC ATCGCAAGCC TCCCTATGGC CACGTAGACC TGAGTGAGGA TCCTGGACCC 540

GCTCCTCCAT CCCCTTTAGT GGGTCTTAAA CCATTGCAGT TGCTGGAAAT CAAAGCTAGG 600

GGGCGCTTTG GCTGCGTTTG GAAGGCCCAG CTGATGAGCA AATATGTCGC TGTAAAGATC 660

TTCCCTTTCC AGAATAAACA GTCGTGGCAG AACGAACGGG ACATATTCCT GACGCCGGGG 720

ATGAGGCATG AAAATCTCCT GCGTTACATT GCGGCTGAGA AACACGGAAC GAACCTGGAG 780

ACAGAGCTGT GGATCATCAC CGAGTTTCAT GAGAGGGGCT CATTGACGGA CCATCTGAAG 840

GGTAACGCCA TAAGCTGGAA TGAGCTGTGT CACATAGCGG AGACGATGTC TCGTGGGTTG 900

GCCTACCTCC ATGAAGACAT TCCCAGCTAT AAGGGAGAGG GCCCCAAACC TACCATTGCA 960

CACAGGGACT TCAAGAGTAA GAATGTATTG CTGCGCGATG ATCTGACCGC AGTTATTGGA 1020

GATTTTGGAC TCGCTGTTCG ATTCGAACCT GGAAAACCTC CAGGAGATAC ACACGGTCAG 1080

GTTGGTACAA GGCGCTACAT GGCTCCAGAG GTGCTCGAGG GAGCCATCAA CTTCCAGCGT 1140

GACTCTTTCT TGAGGATAGA CATGTACGCT ATGGGCCTGG TGCTGTGGGA GCTGGTGGCT 1200

CGCTGCTCCG AGGCCGACGG TGGCGAATAT ATGCTGCCAT TCGAGGAGGA AGTGGGTCAG 1260

CATCCATCCC TGGAGGATCT CCAGGATGTG GTAGTGCACA AAAAGATGCG TCCAGTCATG 1320

AAGGACTGCT GGCTCAAACA TCCGGGTCTG AGCCAGATGT GCGAGACCAT CGAGGAATGT 1380

TGGGACCACG ACGCAGAGGC GCGGTTGTCG GCGGGCTGTG TGGAAGAGCG CATTGGTCAA 1440

ATCGCCAGGA CGGTCAGCAG CACTACCTCA GACGGCCCCA TCTCCATTGT GACGTCTCTC 1500

ACTAACGAGG ACCTACCTCC CAAAGAGTCC AGCACCTGA 1539

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+ ++vAvKif+ ++++sw++E++i+ t+ +rhen+l++ia

Q: 192   LQLLEIKARGRFGCVWKAQLMSKYVAVKIFPFQNKQSWQNERDIFLTPGMRHENLLRYIA  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++++tel+++te+he+gsL+d+Lk + ++++el+++a+++++Gla+LHe+i+  k

Q: 252   AEKHGTNLETELWIITEFHERGSLTDHLKGNAISWNELCHIAETMSRGLAYLHEDIPSYK  311

         ********************************************************9999

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g   Kp+iaHRD+kskN+l+++dlt++i+D+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 312   GeGPKPTIAHRDFKSKNVLLRDDLTAVIGDFGLAVRFEPGKPPGD--THGQVGTRRYMAP  369

         989***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ ++f r+D+Y++gLvlWE++ Rc+e      ey+lpfee+vg++Psle+

Q: 370   EVLEGAINFQR-DSFLRIDMYAMGLVLWELVARCSE--ADGGEYMLPFEEEVGQHPSLED  426

         **********9.9***********************..55689*****************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +++vvv+kk+rP +++ w k++ l+++++++eecWd+d+eaRl+a +v++r+

Q: 427   LQDVVVHKKMRPVMKDCWLKHPGLSQMCETIEECWDHDAEARLSAGCVEERI  478

         *************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MSKYVAVKIF PFQNKQSWQN ERDIFLTPGM RHENLLRYIA 60

AEKHGTNLET ELWIITEFHE RGSLTDHLKG NAISWNELCH IAETMSRGLA YLHEDIPSYK 120

GEGPKPTIAH RDFKSKNVLL RDDLTAVIGD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD SFLRIDMYAM GLVLWELVAR CSEADGGEYM LPFEEEVGQH PSLEDLQDVV 240

VHKKMRPVMK DCWLKHPGLS QMCETIEECW DHDAEARLSA GCVEERI 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013