EKS-TAR-00193

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00193

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	536.5	2.4E-161	578	854	277

Status

Unreviewed

Ensembl Protein

ENSTRUP00000010030

UniProt Accession

H2SCA1;

Protein Name

Protein Synonyms/Alias

Gene Name

FGFR4

Gene Synonyms/Alias

FGFR4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000004233	ENSTRUP00000010030	ENSTRUT00000010086

Organism

Takifugu rubripes

Functional Description

Protein Length

956

Protein Sequence
(FASTA)

MSRVTFYALL LCLMDRISAR VIADGRTKDL RVFKPLMVPG FPENTTAVVG GQAKLVCKVH 60

RPLSTKVQWL KKEDSVSGQT LEGPPRPREL TSNASKMYTL HLHNVTTEDA GEYICMAKNP 120

TGQAMQSAWL EVLPADVLEE LNEDTSEHLV LEPGNVLKLR CDINTRPGMA FNWYKDGLRV 180

LPTPRVQIRG PVIEIADVTY EDSGVYVCVL RGHKEPNRNF TITVADSMGS GDDDEDNDLQ 240

DSSAEIENDQ VYISKGPYWT HIQRMEKKLY AVPAGNTVKF RCPAMGSPMP SIRWLKNGRE 300

FRGEHRIGGI KLRHQHWSLV MESVVPSDRG NYTCVVENKY GSIYHSYVLD VLERSPHRPI 360

LQAGLPANTT AVVGTDVQLH CKVYSDAQPH IQWLKHIERN GSRYSPDGTP YVQILKTGSL 420

NMSDVEVLYL SKVTMEDAGE YTCLAGNSIG FAHQSAWLTV ISVEEEAADS MDTMETKYTD 480

IIIYVCGFLA LIMATIIVVL CRMQVQPRRE PFDALPVQKL SKFPLRRQYS VESNSSGKSS 540

ASLMRVARLS SSCSPMLAGV LEFELPYDPD WEFPRENLTL GKPLGEGCFG QVVRAEAYGI 600

NKDSPDQATT VAVKMLKDDA TDKDLADLIS EMELMKVMDK HKNIINLLGV CTQDGPLYVL 660

VEYASKGSLR EYLRARRPPG MDYTFDVTKV PEEQLTFKDL LSCAYQVARG MEYLASKRCI 720

HRDLAARNVL VTEDNVMKIA DFGLARGVHQ IDYYKKTTNG RLPVKWMAPE ALFDRIYTHQ 780

SDVWSFGVLM WEIFTLGGSP YPGIPVEELF KLLKEGHRMD KPSNCTHELY MMMRECWHAV 840

PSQRPTFKQL VEELDRVLLS ISDEVGPTHF HSPLIRMHAR IFLLVGKICH PDVRSAINGE 900

IPLTPELLVP TQYLDLSTPF EQYSPSCEDT SSSCSSDNDS VFTHDALSTE PCLLGY 956

Nucleotide Sequence
(FASTA)

ATGTCCAGGG TCACATTTTA CGCTCTCCTG CTGTGTTTGA TGGACAGGAT CTCAGCTCGT 60

GTCATCGCCG ACGGAAGGAC TAAAGATCTT AGGGTGTTCA AGCCCCTGAT GGTGCCAGGC 120

TTCCCAGAAA ACACCACAGC AGTGGTCGGT GGCCAGGCCA AGCTGGTGTG TAAGGTCCAT 180

CGACCGTTGT CCACCAAGGT TCAGTGGCTG AAGAAGGAGG ACAGCGTGTC TGGACAGACC 240

CTAGAAGGAC CACCACGCCC TCGGGAACTG ACTAGCAATG CATCAAAGAT GTACACACTA 300

CACCTGCACA ACGTCACAAC AGAGGACGCT GGAGAATACA TCTGCATGGC CAAGAACCCC 360

ACAGGCCAGG CGATGCAGTC CGCATGGCTG GAAGTTCTGC CTGCAGATGT TCTGGAAGAG 420

CTGAACGAAG ACACCTCAGA ACATCTTGTG CTGGAGCCGG GGAATGTTCT CAAGTTGCGT 480

TGTGACATCA ACACCAGACC CGGCATGGCC TTCAATTGGT ACAAGGATGG CCTCCGGGTT 540

CTGCCCACGC CCCGCGTTCA GATCCGTGGT CCTGTCATAG AAATCGCAGA TGTGACATAC 600

GAGGACTCTG GAGTTTATGT TTGTGTCCTC AGGGGGCACA AAGAACCCAA TCGAAACTTC 660

ACCATCACTG TGGCAGATTC AATGGGGTCA GGTGACGACG ATGAGGATAA TGACTTGCAG 720

GACTCATCGG CAGAAATAGA GAACGACCAG GTTTACATCT CCAAAGGTCC CTACTGGACA 780

CATATCCAGC GTATGGAGAA GAAGCTGTAC GCTGTTCCAG CAGGAAACAC AGTCAAGTTT 840

CGTTGTCCGG CAATGGGCAG TCCCATGCCG AGTATCAGGT GGCTCAAAAA TGGGCGCGAA 900

TTTAGGGGAG AGCATCGCAT TGGAGGTATC AAGCTAAGAC ATCAGCATTG GAGTTTGGTA 960

ATGGAGAGTG TGGTACCTTC AGACAGAGGA AACTACACCT GCGTGGTGGA GAACAAATAT 1020

GGATCCATCT ATCACAGCTA TGTCCTCGAT GTCCTTGAAC GTTCTCCACA CCGGCCAATC 1080

CTTCAGGCTG GACTGCCTGC AAACACCACA GCGGTGGTCG GCACTGATGT CCAGTTACAC 1140

TGTAAGGTCT ACAGCGATGC TCAGCCTCAC ATTCAGTGGC TCAAACACAT AGAACGAAAC 1200

GGGAGCCGCT ACAGCCCTGA TGGAACACCC TATGTTCAGA TACTCAAGAC TGGCAGTTTG 1260

AACATGTCCG ATGTGGAGGT GCTCTACCTG TCTAAAGTCA CCATGGAAGA TGCAGGAGAG 1320

TACACCTGTC TGGCAGGAAA TTCAATTGGA TTTGCCCATC AGTCTGCCTG GCTCACTGTC 1380

ATTTCAGTAG AAGAGGAAGC AGCAGACTCT ATGGACACCA TGGAAACCAA GTACACTGAC 1440

ATCATCATCT ATGTTTGTGG TTTCCTGGCT CTGATTATGG CCACTATTAT TGTGGTGTTG 1500

TGTCGGATGC AAGTGCAGCC CAGAAGAGAA CCATTTGATG CTCTGCCAGT GCAGAAACTG 1560

TCCAAGTTTC CCCTTCGCAG ACAGTATTCA GTGGAGTCCA ACTCATCGGG AAAGTCCAGT 1620

GCGTCACTAA TGAGGGTGGC CCGTCTCTCA TCCAGCTGCT CGCCCATGCT GGCTGGTGTC 1680

TTGGAGTTTG AATTGCCCTA TGACCCAGAC TGGGAGTTCC CCCGGGAGAA TTTAACGCTG 1740

GGCAAACCTC TAGGAGAGGG CTGCTTCGGA CAAGTGGTCA GAGCCGAGGC CTACGGTATC 1800

AACAAGGACT CCCCTGATCA AGCCACCACT GTGGCAGTTA AGATGCTCAA AGATGATGCC 1860

ACGGACAAAG ATCTGGCTGA CCTCATCTCA GAAATGGAGC TGATGAAGGT GATGGATAAA 1920

CACAAGAACA TCATCAACTT GCTCGGAGTT TGCACACAAG ATGGCCCTCT CTATGTTCTG 1980

GTGGAGTATG CCTCTAAAGG TAGTCTGAGG GAATACCTGC GGGCACGGAG ACCCCCGGGC 2040

ATGGACTACA CCTTTGATGT CACCAAGGTG CCTGAAGAAC AGCTCACCTT CAAAGACCTG 2100

CTTTCCTGCG CCTACCAGGT TGCCAGAGGG ATGGAGTACC TTGCATCTAA AAGGTGTATT 2160

CACAGAGATC TAGCTGCAAG AAATGTCCTA GTAACAGAGG ACAACGTGAT GAAGATCGCT 2220

GATTTTGGCC TGGCCAGGGG GGTCCATCAA ATCGATTATT ACAAGAAAAC TACTAATGGA 2280

CGGCTGCCAG TGAAATGGAT GGCACCTGAA GCCTTGTTTG ACAGAATCTA CACACACCAG 2340

AGTGACGTGT GGTCGTTCGG TGTTCTCATG TGGGAGATCT TTACGCTGGG TGGCTCACCG 2400

TACCCGGGCA TCCCCGTGGA GGAGCTCTTC AAATTGCTGA AGGAAGGACA CCGCATGGAC 2460

AAACCCTCTA ACTGCACACA TGAACTCTAC ATGATGATGC GTGAGTGCTG GCATGCTGTT 2520

CCCAGTCAGA GACCGACCTT CAAACAGCTG GTGGAAGAGC TGGACAGAGT GCTGCTGTCC 2580

ATCTCTGATG AGGTGGGTCC CACACACTTT CATTCACCGC TGATAAGGAT GCATGCGCGC 2640

ATTTTTCTAC TGGTGGGTAA AATCTGCCAT CCAGATGTGC GATCTGCCAT CAACGGTGAA 2700

ATTCCTCTAA CTCCTGAACT CCTTGTTCCC ACGCAGTACT TGGACCTGTC AACTCCCTTC 2760

GAGCAATACT CCCCATCGTG CGAGGACACC TCCAGCTCCT GCTCATCTGA TAACGATTCC 2820

GTTTTCACTC ACGATGCCTT GTCCACCGAG CCCTGCCTGC TGGGCTAC 2868

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea g++kd +++++tvavkmlk+datdkdladl+seme++k+

Q: 578   LTLGKPLGEGCFGQVVRAEAYGINKDSPDQATTVAVKMLKDDATDKDLADLISEMELMKV  637

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         + khkniinllG+ctq+Gplyv+veya+kG lre+lrarrp+g++++ d +k++eeqlt+

Q: 638   MDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTF  697

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdl+s+ayqvarGmeylask+cihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt

Q: 698   KDLLSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKT  757

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 758   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  817

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mrecwha++s+rptfkqlve+l

Q: 818   RMDKPSNCTHELYMMMRECWHAVPSQRPTFKQLVEEL  854

         ***********************************86

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVRAEA YGINKDSPDQ ATTVAVKMLK DDATDKDLAD LISEMELMKV 60

MDKHKNIINL LGVCTQDGPL YVLVEYASKG SLREYLRARR PPGMDYTFDV TKVPEEQLTF 120

KDLLSCAYQV ARGMEYLASK RCIHRDLAAR NVLVTEDNVM KIADFGLARG VHQIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPSNCTH ELYMMMRECW HAVPSQRPTF KQLVEEL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 4.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013