EKS-TAR-00391
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00391
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR475.68.4E-143644900257
StatusUnreviewed
Ensembl ProteinENSTRUP00000010284
UniProt AccessionH2SCZ9;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000004330ENSTRUP00000010284ENSTRUT00000010342
ENSTRUG00000004330ENSTRUP00000010282ENSTRUT00000010340
ENSTRUG00000004330ENSTRUP00000010283ENSTRUT00000010341
ENSTRUG00000004330ENSTRUP00000010280ENSTRUT00000010338
ENSTRUG00000004330ENSTRUP00000010281ENSTRUT00000010339
ENSTRUG00000004330ENSTRUP00000010278ENSTRUT00000010336
ENSTRUG00000004330ENSTRUP00000010279ENSTRUT00000010337
OrganismTakifugu rubripes
Functional Description
Protein Length958
Protein Sequence
(FASTA)
CMGTDMKLSL PSSLENHYEM LRLLYTGCQV VHGNLEITHL HGNPDLSFLQ GIVEVQGYVL 60
VARVSVSLVP LDNLRIIRGS QLYNSSYALA ALDNTLDGQG LRTLALRSLT GPNCSSQCLT 120
SCWGETVQDC QTSKVTHSNC ALGCQRCKGS LTNDCCHKQC SAGCTGPKDS DCLACRHFND 180
SGVCKENCPP PTIYDPTMFQ SKPNPDRKFS FGATCVKTCP YNYLAMDVAC TLNYPKPNQE 240
VIITQPCGND TQKCEKCEGD CPKACYGPGM DNSGVMDSHG NTMVNSSNVE QFNKCTKIFG 300
SLAFYPQSFT RDPVTNASGL SPQQLSVFRN LEEITGYLYI EAWPQEWMNL SVFDNLKVIR 360
GRMLYKGVFS LAIQHLQITS LGLRSLRSIS GGLVLLHNNS QLCYTSSLPW ENIVHPTQGP 420
HRIVSKNQDP QICEKQGRVC HPLCEGGCWG PGPSQCASCR TFQRGSECVE QCDIYQGSVR 480
EYANESVCVA CHPECQPLNS SASCHGPGAE HCAECRNFQD GDVCVAHCPS GAKEDHQTVW 540
KYSNATGHCL PCNTNCTLSC TVMDERGCPV DTSLGTTIAA AVGGVVLFFI LLGLLFFYLR 600
RQKKLKRKET MRRILQEHEL VEPLAPSGAS PNQAQMRILK ETELKKLKVL GAGAFGTVYK 660
GVWAPDGENV KIPVAIKVLR ENTSPKANKE ILDEAYVMAG VASPYVCRLL GICLTSTVQL 720
VTQLMSYGCL LEYVRKNKDR IGSQLLLNWC VQIAKGMSYL EEVRLVHRDL AARNVLVKNP 780
NHVKITDFGL ARLLDIDETE YHADGGKVPI KWMALESILH RRFTHQSDVW SYGVTVWELM 840
TFGAKPYDMI PAREIPEVLE GGERLPQPLI CTIDVYMIMV KCWMIDPEYR PRFKDLVKEF 900
TAMARDPPRY VVIQNEEQMS MSSPVDNQFF RMFLAEEGNN LRELLDAEEY LVPQPNHF 958
Nucleotide Sequence
(FASTA)
TGCATGGGTA CTGACATGAA GCTGTCGCTG CCCTCCAGCC TGGAAAATCA CTATGAAATG 60
CTGAGGCTGT TGTACACAGG CTGCCAGGTT GTTCATGGAA ACCTAGAAAT TACACACCTT 120
CACGGAAACC CTGACCTCTC GTTCCTGCAG GGGATCGTGG AGGTGCAGGG TTATGTGCTT 180
GTGGCCCGAG TGTCGGTGAG TCTCGTGCCT TTGGACAATC TGCGGATCAT CAGAGGCAGC 240
CAGCTGTATA ACTCCAGCTA TGCCCTCGCT GCCCTGGATA ACACCCTGGA TGGACAAGGG 300
CTCAGGACTC TTGCTCTCCG CAGCCTTACG GGCCCCAACT GTTCCTCTCA GTGTTTGACA 360
AGCTGTTGGG GAGAAACCGT ACAGGACTGC CAGACCTCCA AAGTGACCCA TAGTAACTGT 420
GCATTGGGCT GCCAGCGATG TAAAGGTTCC CTTACCAACG ACTGCTGCCA CAAGCAGTGT 480
TCTGCTGGAT GCACCGGACC CAAAGATTCA GACTGTCTGG CTTGTCGTCA CTTCAATGAC 540
AGCGGTGTGT GTAAGGAGAA CTGTCCCCCT CCTACGATCT ACGACCCAAC CATGTTTCAG 600
TCCAAACCAA ACCCTGACAG GAAGTTCAGC TTTGGAGCTA CCTGTGTGAA GACGTGTCCT 660
TATAACTATC TGGCCATGGA TGTCGCTTGT ACCCTGAACT ACCCCAAACC CAACCAGGAA 720
GTTATCATCA CCCAGCCCTG TGGGAATGAC ACCCAGAAAT GTGAGAAGTG TGAAGGGGAC 780
TGTCCCAAAG CTTGTTATGG TCCCGGTATG GACAACAGTG GTGTCATGGA TAGCCATGGC 840
AACACAATGG TAAATTCCTC TAACGTGGAG CAATTCAACA AATGTACGAA GATTTTTGGC 900
AGTCTGGCTT TCTACCCCCA GAGCTTCACT AGGGACCCTG TGACTAACGC ATCAGGCCTG 960
TCCCCACAGC AGCTAAGTGT CTTCAGGAAC CTGGAGGAGA TCACGGGTTA TTTGTATATT 1020
GAGGCCTGGC CACAGGAATG GATGAATTTA AGTGTGTTTG ATAATCTGAA GGTGATCAGA 1080
GGCAGAATGC TCTACAAGGG TGTGTTTTCA CTTGCTATCC AGCACCTGCA GATCACGTCT 1140
TTGGGGTTGC GTTCACTACG CAGCATTAGT GGAGGTTTAG TCCTGTTGCA TAATAATTCC 1200
CAGTTATGCT ACACCAGCTC GCTACCGTGG GAGAATATCG TCCACCCTAC CCAGGGACCC 1260
CACCGCATTG TCAGCAAAAA TCAGGACCCC CAGATCTGTG AGAAACAGGG GCGTGTTTGT 1320
CACCCGCTGT GCGAGGGTGG CTGCTGGGGC CCGGGGCCCA GCCAGTGTGC ATCCTGCAGG 1380
ACATTCCAAC GTGGCTCTGA GTGTGTTGAG CAGTGTGACA TCTATCAGGG GTCTGTGCGT 1440
GAATACGCAA ATGAATCTGT GTGTGTCGCC TGTCACCCCG AGTGTCAGCC GCTCAACAGC 1500
TCTGCTTCCT GTCACGGCCC GGGAGCAGAA CATTGCGCCG AGTGCAGAAA CTTCCAGGAT 1560
GGAGACGTCT GTGTGGCTCA CTGCCCCAGT GGTGCGAAGG AAGACCACCA GACTGTGTGG 1620
AAGTACAGCA ATGCTACGGG ACACTGTCTG CCCTGCAACA CCAACTGCAC GCTGTCCTGC 1680
ACTGTGATGG ACGAGAGAGG CTGCCCTGTT GACACAAGCC TGGGTACAAC CATCGCGGCT 1740
GCAGTAGGTG GGGTGGTGCT CTTCTTCATC TTGCTGGGTC TACTTTTCTT TTACCTGAGG 1800
AGGCAGAAGA AGCTGAAGAG GAAGGAGACA ATGAGAAGGA TCCTGCAAGA ACACGAGCTG 1860
GTGGAACCTC TGGCCCCCAG CGGGGCGTCA CCCAATCAGG CTCAGATGCG CATCCTGAAA 1920
GAGACGGAGC TGAAGAAGCT GAAAGTGTTG GGTGCTGGGG CGTTCGGTAC CGTTTACAAG 1980
GGGGTGTGGG CTCCTGACGG GGAAAACGTG AAAATACCAG TAGCCATTAA AGTGTTGCGG 2040
GAGAATACTT CCCCAAAAGC CAATAAAGAA ATACTTGACG AGGCCTACGT CATGGCAGGA 2100
GTGGCCAGCC CTTACGTGTG CCGTCTGCTG GGGATCTGCC TGACCTCCAC TGTGCAGCTG 2160
GTCACCCAGC TGATGTCGTA CGGCTGCCTG CTTGAATACG TCAGGAAGAA CAAGGATCGC 2220
ATCGGTTCCC AGTTGCTCCT TAATTGGTGT GTCCAGATTG CTAAGGGCAT GAGTTATCTG 2280
GAGGAAGTCC GCTTGGTGCA CAGAGATTTA GCTGCTCGCA ATGTCCTGGT GAAGAATCCA 2340
AACCACGTGA AGATCACCGA CTTCGGACTG GCCCGTCTGC TCGATATAGA CGAGACTGAA 2400
TATCATGCTG ATGGAGGGAA GGTGCCGATT AAGTGGATGG CCCTGGAATC AATTCTGCAC 2460
AGGAGGTTCA CTCATCAGAG TGACGTGTGG AGCTACGGGG TGACCGTCTG GGAGTTGATG 2520
ACCTTTGGTG CGAAACCGTA TGACATGATC CCGGCTAGAG AGATCCCTGA AGTTTTAGAG 2580
GGAGGGGAAC GACTTCCCCA GCCTCTGATC TGCACCATTG ATGTCTACAT GATCATGGTC 2640
AAATGTTGGA TGATTGATCC AGAGTACAGG CCCAGGTTTA AGGACTTGGT AAAAGAATTT 2700
ACTGCGATGG CCAGAGATCC TCCTCGTTAT GTTGTAATTC AGAACGAGGA GCAGATGAGC 2760
ATGTCCAGCC CCGTGGACAA CCAGTTCTTC CGGATGTTTC TGGCGGAGGA AGGCAACAAC 2820
TTGAGGGAAC TGCTGGACGC TGAGGAGTAC CTGGTGCCAC AGCCGAATCA CTTC 2874
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkklkvlG+GafGtvykG+w p+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 644   LKKLKVLGAGAFGTVYKGVWAPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVAS  703
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+ +Gcll+yvr++kd++Gsq llnwcvqiakGmsylee 
Q: 704   PYVCRLLGICLTSTVQLVTQLMSYGCLLEYVRKNKDRIGSQLLLNWCVQIAKGMSYLEEV  763
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+pnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 764   RLVHRDLAARNVLVKNPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILHRRF  823
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpyd ipa+eip++le Gerl+qp ictidvym++vkcw
Q: 824   THQSDVWSYGVTVWELMTFGAKPYDMIPAREIPEVLEGGERLPQPLICTIDVYMIMVKCW  883
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+e rp+fk+l++ef
Q: 884   MIDPEYRPRFKDLVKEF  900
         ****************9
Domain Sequence
(FASTA)
LKKLKVLGAG AFGTVYKGVW APDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVAS 60
PYVCRLLGIC LTSTVQLVTQ LMSYGCLLEY VRKNKDRIGS QLLLNWCVQI AKGMSYLEEV 120
RLVHRDLAAR NVLVKNPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILHRRF 180
THQSDVWSYG VTVWELMTFG AKPYDMIPAR EIPEVLEGGE RLPQPLICTI DVYMIMVKCW 240
MIDPEYRPRF KDLVKEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAF-00305
EKS-CAP-00334
EKS-CIS-00072
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 2.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013