EKS-TAR-00318

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00318

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	312.7	3.8E-93	13	265	253

Status

Unreviewed

Ensembl Protein

ENSTRUP00000010375

UniProt Accession

H2SD98;

Protein Name

Protein Synonyms/Alias

Gene Name

MELK

Gene Synonyms/Alias

MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000004362	ENSTRUP00000010377	ENSTRUT00000010435
ENSTRUG00000004362	ENSTRUP00000010376	ENSTRUT00000010434
ENSTRUG00000004362	ENSTRUP00000010378	ENSTRUT00000010436
ENSTRUG00000004362	ENSTRUP00000010374	ENSTRUT00000010432
ENSTRUG00000004362	ENSTRUP00000010375	ENSTRUT00000010433

Organism

Takifugu rubripes

Functional Description

Protein Length

646

Protein Sequence
(FASTA)

TEHRGAEELY KYYEVYETIG SGGFAKVKLG RHILTGEKVA IKIMNKKDLG DDLPRVKVEI 60

EAMKNLSHQH ICRLYHVIET STQIFMVIEY CTGGELFDYI IAKDRLSEQE TRVFFRQIVS 120

AMAYVHSQGY AHRDLKPENL LIDEDHNLKL IDFGLCAKPK GGLGYELMTC CGSPAYAAPE 180

LIQGKAYIGS EADVWSMGVL LFALLCGYLP FDDDNFMILY KKITRGKYDN PQWLSPGSIL 240

LLNQMMQVEP KRRLTVQQLL GHPWVMKDYN SPVEWHSRQP LGHIDIDCIT EMAVSMKRTR 300

ESTTALVQQW RYDQTTATYL LLLSKKQRGK PVRLRPEPAV CEDSSSLLHQ GLQVTTDVPG 360

VFGLNSCIPL ERFSQQTVCL IIPQLKLVSP SVERKCASNP TSERGRMTPQ HCQERRGRER 420

TTENKENVAA HSKEVDLFAL PPPRTPVSSK KNARQRNVLT TPNQNSTSTK GHAGTPKVIY 480

KGRTAVDSLT LTHTHTDPER RSRSLDLAVT EDSGKKKRGG KVFGSLERGL DKVINMLTPS 540

KRRALRDGPR KIKPQYNVTL TSQTNPDQVL NQILSILPEK NVAFTQKGYT LKCRTKGDFG 600

KVTMEFELEV CLLQRPEVVG VRRQRLKGDA WVYKHLVEDI LSTSSI 646

Nucleotide Sequence
(FASTA)

ACGGAGCATC GCGGAGCCGA AGAGCTCTAC AAATACTACG AGGTTTATGA GACCATCGGA 60

TCGGGGGGTT TTGCTAAAGT CAAGCTGGGT CGGCACATCC TGACAGGAGA GAAAGTTGCA 120

ATTAAAATCA TGAACAAGAA GGATTTAGGA GATGACCTGC CCCGGGTCAA GGTGGAAATC 180

GAGGCTATGA AGAATTTGAG TCACCAGCAC ATCTGTCGTC TGTATCACGT CATCGAGACC 240

TCCACCCAGA TCTTCATGGT GATAGAGTAC TGTACAGGCG GGGAGCTGTT TGACTACATC 300

ATCGCAAAGG ATCGCCTGTC GGAGCAGGAG ACTAGGGTGT TTTTCAGGCA AATTGTGTCA 360

GCGATGGCTT ACGTGCACAG CCAAGGATAC GCTCACAGGG ACCTCAAACC GGAGAACTTG 420

CTGATCGATG AAGACCACAA CTTGAAGCTA ATAGATTTTG GATTGTGTGC GAAACCAAAG 480

GGAGGTTTGG GTTATGAGCT CATGACATGT TGTGGAAGTC CTGCATATGC TGCTCCTGAA 540

CTCATCCAGG GGAAAGCGTA CATTGGCTCA GAGGCTGATG TGTGGAGTAT GGGGGTGTTG 600

CTGTTTGCTC TGCTCTGTGG ATACCTTCCC TTTGATGATG ACAACTTCAT GATCCTCTAC 660

AAGAAGATTA CAAGAGGTAA ATATGACAAC CCCCAGTGGC TTTCTCCTGG TAGCATCCTC 720

CTCCTCAATC AAATGATGCA GGTGGAGCCC AAGCGGCGTC TCACAGTGCA ACAGCTTCTG 780

GGCCATCCTT GGGTCATGAA AGACTACAAC AGCCCGGTGG AGTGGCACAG CCGGCAGCCG 840

CTCGGCCACA TTGATATAGA CTGTATCACT GAGATGGCTG TCAGCATGAA GCGAACGAGG 900

GAGAGCACCA CAGCACTAGT GCAGCAGTGG CGGTATGACC AGACGACAGC CACCTACCTT 960

CTGCTGCTGT CAAAGAAGCA AAGGGGCAAA CCTGTCCGTC TGCGCCCTGA ACCAGCAGTC 1020

TGTGAGGACT CCAGCTCTCT CCTGCATCAA GGATTACAGG TCACTACAGA TGTCCCTGGT 1080

GTCTTTGGTC TTAACAGCTG CATCCCTCTT GAACGGTTTT CACAGCAGAC TGTTTGCTTA 1140

ATCATTCCCC AGCTTAAACT AGTGTCTCCA TCTGTGGAGA GAAAATGTGC CTCCAACCCG 1200

ACTTCAGAGA GGGGGCGAAT GACTCCACAG CACTGCCAAG AGAGGAGGGG CAGAGAGAGA 1260

ACCACTGAGA ACAAGGAGAA CGTTGCTGCA CACAGCAAAG AGGTTGACCT GTTTGCACTG 1320

CCGCCTCCGC GCACTCCAGT GTCCAGTAAG AAGAACGCAC GCCAGAGGAA CGTGCTCACC 1380

ACGCCCAATC AAAACTCAAC CTCCACCAAA GGTCATGCCG GCACGCCTAA AGTTATCTAT 1440

AAAGGAAGGA CAGCAGTCGA CTCATTAACC TTGACACACA CACACACAGA TCCTGAGAGG 1500

AGGTCCCGGT CTCTGGACCT GGCTGTAACA GAAGACAGCG GGAAGAAGAA ACGAGGAGGG 1560

AAGGTCTTCG GCTCTCTGGA GCGAGGCCTG GATAAGGTCA TCAACATGCT GACTCCGAGC 1620

AAGAGACGAG CTCTGCGCGA CGGCCCGCGC AAGATCAAGC CACAGTACAA CGTTACTCTG 1680

ACCAGTCAGA CCAACCCAGA CCAGGTTCTT AACCAGATCC TCTCCATTCT ACCAGAGAAA 1740

AATGTCGCTT TCACACAGAA AGGGTATACC CTCAAGTGTC GGACCAAGGG CGACTTTGGG 1800

AAGGTAACCA TGGAGTTTGA GCTGGAGGTG TGCCTACTGC AGAGGCCAGA GGTCGTCGGA 1860

GTCCGCAGGC AGAGGCTAAA GGGCGACGCC TGGGTCTATA AACATCTGGT GGAAGACATC 1920

CTCTCCACAT CTAGTATCTG A 1941

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +t+G+g f+kVkl +h +t+ekva+Ki++kk l ++ l ++k Eie++k+l+h++i

Q: 13    YEVYETIGSGGFAKVKLGRHILTGEKVAIKIMNKKDLGDD-LPRVKVEIEAMKNLSHQHI  71

         99********************************999755.89*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++viet++++++v+ey++ggeLfdyi +k rl+e+e+r +f+q+vsa+ Y+hs+g +

Q: 72    CRLYHVIETSTQIFMVIEYCTGGELFDYIIAKDRLSEQETRVFFRQIVSAMAYVHSQGYA  131

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+++n+k++DFGl+++ k g    l t+cGsp+YaaPel++gk Y g++

Q: 132   HRDLKPENLLIDEDHNLKLIDFGLCAKPKGGlgYELMTCCGSPAYAAPELIQGKAYIGSE  191

         **************************998887799*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +DvWs+Gv+L+al++g lPfd++n+  l++ki++gk++ p++ls+  + Ll+++++v+p+

Q: 192   ADVWSMGVLLFALLCGYLPFDDDNFMILYKKITRGKYDNPQWLSPGSILLLNQMMQVEPK  251

         ************************************************************

S: 239   kRatieeilkhewl  252

         +R+t++++l h+w+

Q: 252   RRLTVQQLLGHPWV  265

         *************7

Domain Sequence
(FASTA)

YEVYETIGSG GFAKVKLGRH ILTGEKVAIK IMNKKDLGDD LPRVKVEIEA MKNLSHQHIC 60

RLYHVIETST QIFMVIEYCT GGELFDYIIA KDRLSEQETR VFFRQIVSAM AYVHSQGYAH 120

RDLKPENLLI DEDHNLKLID FGLCAKPKGG LGYELMTCCG SPAYAAPELI QGKAYIGSEA 180

DVWSMGVLLF ALLCGYLPFD DDNFMILYKK ITRGKYDNPQ WLSPGSILLL NQMMQVEPKR 240

RLTVQQLLGH PWV 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013