EKS-TAR-00137
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAR-00137
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec407.64.0E-122375623249
StatusUnreviewed
Ensembl ProteinENSTRUP00000010466
UniProt AccessionH2SDI5;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTRUG00000004405ENSTRUP00000010466ENSTRUT00000010524
ENSTRUG00000004405ENSTRUP00000010467ENSTRUT00000010525
ENSTRUG00000004405ENSTRUP00000010468ENSTRUT00000010526
OrganismTakifugu rubripes
Functional Description
Protein Length627
Protein Sequence
(FASTA)
MFPRVILKDT LIKKSQQKKR TSPCNYKERF FVLDTQDLRY SENRPGKKPT LKGCINLSKI 60
KCVEIVCCDV PIPCNYKYPF QNNIFLQVFY DNHYLYIFAP DNECRQRWVQ ALKDETKDNN 120
LVAKYHPNFW MDSKWRCCQQ TEKLAAGCHV YDPLGFASKK PLPQLPDPKS CLNNLFQVNA 180
DSERIVIALQ EYVPSRDTDL PLEKGHEYIL INKSNIDWWT VRNSNGDTGF VPSTYVAEKN 240
CGSFERFQWY SKNMNRMQAQ ELLMREGKEG AFMVRDSSHM GVYTVSVFTK APSQSGEKNP 300
KVKHYQIRQT ETGAGPFYLA ENYLFNTIPE LIHYHQHNAA GLITRLRHPV SPDGSSAQQV 360
SAPFEDQWEL NPDELTLGQE IGSGQFGLVL EGWWKKKKVA VKMIRDGCMS EDDLQEEARV 420
MMKLSHHKLV QLYAVSSQRS PLCLVFEFME NGCLSDYLRA RKGSLSQETL LNMCMDVSEG 480
MAYLESSNFL HRDLAARNCL VSENNEVKVS DFGMTRFVLD DKYTSSQCSK FPVKWSAPEV 540
IKYCKFSSKS DIWSFGVLMW EVYSEGRLPY DNRTNTEVLE ALSTGLRLLK PRLAPDTVYL 600
LMEWCWKEKP EDRPCFAVLL HELASIS 627
Nucleotide Sequence
(FASTA)
ATGTTCCCCA GGGTGATTTT GAAGGACACC CTAATTAAAA AATCTCAACA AAAGAAAAGA 60
ACATCACCAT GCAACTACAA GGAGCGTTTT TTTGTATTGG ACACCCAAGA CCTGAGGTAT 120
TCTGAGAACC GTCCTGGGAA AAAGCCCACG TTGAAGGGTT GCATCAATCT CAGCAAAATC 180
AAGTGTGTGG AAATCGTGTG CTGTGATGTA CCCATTCCCT GTAACTATAA GTATCCATTC 240
CAAAATAACA TATTTCTCCA GGTGTTTTAC GACAACCATT ACCTCTACAT TTTTGCCCCA 300
GACAATGAAT GTCGTCAAAG ATGGGTCCAA GCTCTCAAAG ACGAGACGAA GGACAATAAT 360
CTGGTGGCAA AATATCACCC AAACTTCTGG ATGGACAGTA AATGGAGGTG TTGCCAACAA 420
ACAGAGAAGC TGGCGGCAGG TTGTCATGTG TATGACCCAC TGGGGTTTGC TTCTAAAAAG 480
CCACTTCCTC AACTACCAGA TCCAAAGTCA TGTTTAAACA ATCTCTTCCA GGTTAACGCA 540
GATTCAGAGA GGATTGTCAT TGCCCTGCAA GAGTACGTGC CGTCTAGAGA CACGGACTTG 600
CCGCTTGAGA AAGGCCACGA GTACATCCTG ATCAACAAGT CCAACATTGA CTGGTGGACT 660
GTGAGGAACA GCAATGGGGA CACCGGCTTT GTACCCAGCA CATATGTGGC AGAAAAAAAT 720
TGCGGCAGTT TTGAAAGATT TCAATGGTAT AGCAAAAATA TGAACAGAAT GCAAGCACAG 780
GAGCTGTTAA TGAGAGAGGG AAAAGAAGGT GCCTTCATGG TTCGGGACTC AAGCCACATG 840
GGAGTCTACA CAGTGTCAGT TTTCACAAAG GCACCTAGCC AAAGTGGGGA GAAAAATCCA 900
AAAGTGAAGC ATTACCAGAT CAGACAGACA GAAACAGGAG CAGGACCGTT TTATTTGGCT 960
GAAAATTACC TGTTCAACAC CATTCCAGAG CTTATTCATT ACCACCAACA CAATGCTGCC 1020
GGTCTGATAA CCCGTTTGAG ACACCCTGTA TCTCCAGATG GAAGTAGCGC CCAGCAAGTT 1080
TCTGCTCCCT TTGAAGATCA GTGGGAGCTA AACCCCGATG AACTGACCCT GGGTCAGGAG 1140
ATAGGCAGCG GTCAGTTCGG GCTCGTGCTG GAAGGTTGGT GGAAGAAGAA GAAGGTGGCG 1200
GTGAAAATGA TCAGAGACGG GTGCATGTCT GAAGACGATC TGCAGGAGGA GGCCAGAGTT 1260
ATGATGAAGC TGTCGCACCA CAAGCTGGTT CAACTCTACG CGGTGAGCAG CCAGCGTTCT 1320
CCCCTGTGCC TGGTGTTCGA GTTCATGGAG AATGGCTGCC TCTCCGACTA CCTGCGGGCC 1380
AGGAAAGGCA GTTTGTCTCA GGAGACGTTG CTGAACATGT GCATGGACGT CAGCGAGGGG 1440
ATGGCCTACC TGGAGAGCTC CAACTTCCTC CACAGAGATC TGGCTGCCAG AAACTGTCTC 1500
GTTTCAGAAA ATAACGAGGT GAAGGTGTCT GATTTTGGTA TGACCAGGTT TGTGCTCGAT 1560
GATAAGTACA CGAGCTCCCA GTGTTCCAAG TTCCCTGTCA AGTGGTCGGC GCCGGAGGTC 1620
ATCAAATACT GCAAGTTCAG CAGCAAATCT GACATCTGGT CTTTTGGTGT ACTCATGTGG 1680
GAGGTGTACA GCGAGGGCCG CCTCCCTTAT GACAACCGCA CCAACACCGA GGTGTTGGAG 1740
GCCCTGAGCA CAGGCCTGCG GCTCCTGAAG CCACGCTTGG CCCCGGACAC CGTCTACCTG 1800
CTCATGGAGT GGTGCTGGAA GGAGAAACCG GAGGACCGCC CCTGCTTCGC CGTCCTGCTG 1860
CACGAGCTGG CCTCCATCTC CTGA 1884
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         ltl +e+gsgqfg+v  g w+ k++va+k+i++g+mse+d+ eea+vmmklsh+klvqly
Q: 375   LTLGQEIGSGQFGLVLEGWWK-KKKVAVKMIRDGCMSEDDLQEEARVMMKLSHHKLVQLY  433
         67889*************998.569***********************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
          v +++ p+++v+e++engcl++ylr +k++l++e+ll+mc+dv+egm+yle+++f+hrd
Q: 434   AVSSQRSPLCLVFEFMENGCLSDYLRARKGSLSQETLLNMCMDVSEGMAYLESSNFLHRD  493
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++ vkvsdfg++r+vldd+y+ss+ +kfpvkws+pev++y k+ssksd+w
Q: 494   LAARNCLVSENNEVKVSDFGMTRFVLDDKYTSSQCSKFPVKWSAPEVIKYCKFSSKSDIW  553
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwev+seg+lpy++++n+ev e++s+glrl +p+la+++vy +m+ cwkekpe+r
Q: 554   SFGVLMWEVYSEGRLPYDNRTNTEVLEALSTGLRLLKPRLAPDTVYLLMEWCWKEKPEDR  613
         ************************************************************
S: 241   ptfkellsal  250
         p+f+ ll++l
Q: 614   PCFAVLLHEL  623
         *******987
Domain Sequence
(FASTA)
LTLGQEIGSG QFGLVLEGWW KKKKVAVKMI RDGCMSEDDL QEEARVMMKL SHHKLVQLYA 60
VSSQRSPLCL VFEFMENGCL SDYLRARKGS LSQETLLNMC MDVSEGMAYL ESSNFLHRDL 120
AARNCLVSEN NEVKVSDFGM TRFVLDDKYT SSQCSKFPVK WSAPEVIKYC KFSSKSDIWS 180
FGVLMWEVYS EGRLPYDNRT NTEVLEALST GLRLLKPRLA PDTVYLLMEW CWKEKPEDRP 240
CFAVLLHEL 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-CIS-00119
EKS-DAR-00357
EKS-DAN-00037
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORN-00134
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-PEM-00054
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-SUS-00093
EKS-TAG-00138
EKS-TEN-00127
EKS-XET-00091
EKS-XIM-00131
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013