EKS-TAR-00365

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00365

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	408.7	2.9E-122	164	451	288

Status

Unreviewed

Ensembl Protein

ENSTRUP00000010920

UniProt Accession

H2SET7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A (1 of 3)

Gene Synonyms/Alias

ACVR2A (1 of 3);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000004589	ENSTRUP00000010920	ENSTRUT00000010979
ENSTRUG00000004589	ENSTRUP00000010921	ENSTRUT00000010980
ENSTRUG00000004589	ENSTRUP00000010919	ENSTRUT00000010978
ENSTRUG00000004589	ENSTRUP00000010918	ENSTRUT00000010977
ENSTRUG00000004589	ENSTRUP00000010917	ENSTRUT00000010976
ENSTRUG00000004589	ENSTRUP00000010916	ENSTRUT00000010975

Organism

Takifugu rubripes

Functional Description

Protein Length

485

Protein Sequence
(FASTA)

ETQECAYYNS SWEKDRTNRS GIEPCPSGEK DKRRHCFSTW KNISGTVLIV KQGCWLDDVN 60

CYDSNECVER KESPDVFFCC CEGNMCNEKF LYAPEVTTSN PFSQKPQLLS TLLYSLVPII 120

GLVAVVLFSF WMWRHHKLAY PAALVPTHDP GPSPPSPVLG HKPLQLIEVK ARGRFGCVWK 180

AQLLNEHVAV KIFPIQDKLS WQNEYEIYSL NGMKHENLLH FIGVEKRNNN LDLELWLITT 240

YHDKGSLTDY LKANVVSWNE LCLITQTAAR GLAYLHEDIP GHKDGHKPSI AHRDIKSKNV 300

LLKNNLTACI ADFGLALQFE AGKSAGDTHG QVGTRRYMAP EVLEGAINFQ RDAFLRIDMY 360

AFGLVLWELV ARCTAADGPV DEYMLPFEEE VGQHPSLEDM QEVVVHKKLR PCLRDCWQKH 420

TGLAMLCETI EDCWDHEAEA RLSAGCVEER IGQMQRQAPI IGPEEIVTVV TMVTNVDLPP 480

KESSL 485

Nucleotide Sequence
(FASTA)

GAGACACAAG AGTGCGCCTA CTACAACTCC AGCTGGGAGA AGGATCGCAC CAACCGCAGT 60

GGGATTGAAC CCTGCCCCTC TGGAGAGAAA GACAAGCGGC GGCATTGCTT CTCCACTTGG 120

AAGAACATCT CGGGCACCGT GTTGATTGTC AAGCAGGGTT GCTGGCTAGA CGATGTCAAC 180

TGCTATGACA GTAACGAGTG CGTTGAGAGG AAGGAGAGTC CTGACGTCTT CTTTTGCTGC 240

TGTGAGGGCA ACATGTGCAA CGAGAAGTTC CTGTATGCCC CTGAGGTGAC CACCTCCAAC 300

CCATTTTCCC AGAAGCCCCA GCTCCTCAGC ACTCTGCTGT ACTCCCTGGT TCCCATCATC 360

GGACTGGTTG CTGTGGTTCT CTTCTCTTTC TGGATGTGGC GACATCACAA ACTGGCGTAC 420

CCAGCAGCCC TCGTCCCCAC ACATGATCCT GGACCCTCAC CCCCGTCCCC TGTTCTGGGA 480

CACAAACCAC TGCAACTGAT CGAGGTGAAA GCCAGGGGGC GCTTTGGTTG TGTCTGGAAG 540

GCCCAGCTGC TGAACGAACA TGTGGCTGTG AAGATCTTCC CCATCCAGGA CAAGCTGTCT 600

TGGCAAAATG AGTATGAGAT CTACAGTTTA AACGGCATGA AACATGAAAA CCTCCTTCAC 660

TTCATCGGCG TGGAGAAGAG GAACAACAAC TTGGACCTGG AACTGTGGCT CATCACCACC 720

TACCACGACA AGGGATCGCT GACCGACTAT CTGAAGGCCA ACGTGGTGTC TTGGAATGAG 780

CTCTGCCTCA TCACTCAAAC AGCAGCCCGT GGATTAGCCT ATCTCCATGA AGACATCCCA 840

GGACACAAGG ATGGACACAA ACCTTCTATT GCCCACAGGG ACATCAAGAG TAAGAATGTG 900

CTGCTGAAGA ACAACCTGAC TGCCTGCATA GCCGACTTTG GCTTGGCGCT CCAGTTTGAG 960

GCAGGAAAGT CTGCAGGAGA CACTCACGGA CAGGTGGGAA CGCGGCGCTA CATGGCACCC 1020

GAGGTTCTGG AGGGCGCCAT CAACTTCCAG CGCGACGCCT TCCTGCGCAT CGACATGTAC 1080

GCTTTTGGGC TGGTGCTGTG GGAGCTGGTG GCTCGATGCA CCGCCGCCGA CGGTCCGGTG 1140

GACGAGTACA TGCTGCCGTT CGAAGAGGAG GTGGGTCAGC ATCCGTCTCT GGAGGACATG 1200

CAGGAGGTGG TCGTTCACAA GAAGCTGAGG CCCTGCCTGC GAGACTGCTG GCAGAAACAC 1260

ACGGGTCTGG CCATGCTCTG TGAAACCATC GAGGACTGCT GGGACCACGA GGCCGAGGCT 1320

CGCCTGTCCG CCGGCTGTGT GGAGGAGCGC ATCGGCCAAA TGCAGCGCCA GGCGCCCATC 1380

ATTGGCCCCG AGGAGATCGT TACCGTCGTC ACCATGGTGA CCAACGTGGA CCTCCCGCCC 1440

AAGGAGTCCA GCTTATGA 1458

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+l+e+ ++Gr+g+Vwka+l +e+vAvKif+ +d+ sw++E eiy+++ ++hen+l+fi+

Q: 164   LQLIEVKARGRFGCVWKAQLLNEHVAVKIFPIQDKLSWQNEYEIYSLNGMKHENLLHFIG  223

         689*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

          +k+++++  el+l+t+yh+kgsL+dyLk+++++++el+ +++++a+Gla+LHe+i+g+k

Q: 224   VEKRNNNLDLELWLITTYHDKGSLTDYLKANVVSWNELCLITQTAARGLAYLHEDIPGHK  283

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kp+iaHRD+kskN+l+k++lt+ciaD+GLal++e+ k++ d  ++ qvGt+RYmaPE

Q: 284   DGHKPSIAHRDIKSKNVLLKNNLTACIADFGLALQFEAGKSAGD--THGQVGTRRYMAPE  341

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE++ Rc+++d+ v+ey+lpfee+vg++Psle+m

Q: 342   VLEGAINFQR-DAFLRIDMYAFGLVLWELVARCTAADGPVDEYMLPFEEEVGQHPSLEDM  400

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evvv+kklrP +++ w+k+  l++l++++e+cWd+++eaRl+a +v++r+

Q: 401   QEVVVHKKLRPCLRDCWQKHTGLAMLCETIEDCWDHEAEARLSAGCVEERI  451

         ************************************************985

Domain Sequence
(FASTA)

LQLIEVKARG RFGCVWKAQL LNEHVAVKIF PIQDKLSWQN EYEIYSLNGM KHENLLHFIG 60

VEKRNNNLDL ELWLITTYHD KGSLTDYLKA NVVSWNELCL ITQTAARGLA YLHEDIPGHK 120

DGHKPSIAHR DIKSKNVLLK NNLTACIADF GLALQFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAFG LVLWELVARC TAADGPVDEY MLPFEEEVGQ HPSLEDMQEV 240

VVHKKLRPCL RDCWQKHTGL AMLCETIEDC WDHEAEARLS AGCVEERI 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013