EKS-TAR-00355

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00355

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	465.4	1.6E-139	214	500	287

Status

Unreviewed

Ensembl Protein

ENSTRUP00000011315

UniProt Accession

H2SFY3;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1 (1 of 2)

Gene Synonyms/Alias

TGFBR1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000004751	ENSTRUP00000011314	ENSTRUT00000011374
ENSTRUG00000004751	ENSTRUP00000011315	ENSTRUT00000011375

Organism

Takifugu rubripes

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

PASPGVGRRR PGLCVVMVLP ASALPPALQC YCDRCSANSS CVTDGVCFVA IRKSGSQLTT 60

ERRQCVHEKE LIPRDRPFIC APSVKHDTGI YPMCCTADYC NKEPDLDVFP VPTVKTQSLG 120

PVALAAVIAG PVCVLCLLLV LAFYVCHNHR GLGAGGAGAH HHHHRVPNEE DPSMDHPFIT 180

VGTTLKDLIY DMTTSGSGSG LPLLVQRTIA RTIILQESIG KGRFGEVWRG KWRGEEVAVK 240

IFSSREERSW FREAEIYQTV MLRHENILGF IAADNKDNGT WTQLWLVSDY HEHGSLFDYL 300

NRYTVTVEGM IKLSLSTASG LAHLHMEIVG TQGKPAIAHR DLKSKNILVK KNGTCCIADL 360

GLAVRHDSAT DTIDIAPNHR VGTKRYMAPE VLDDSINMKH FESFKRADIY AMGLVFWEIA 420

NRCSMGGIHE DYQLPYYDLV QSDPSVEEMR KVVCEQKLRP NIPNRWQSCE ALRVMAKIMR 480

ECWYANSAAR LTALRIKKTL SQLSQQEGIK M 511

Nucleotide Sequence
(FASTA)

CCGGCGTCTC CGGGCGTTGG GCGGCGCCGC CCTGGATTAT GTGTGGTCAT GGTTCTACCT 60

GCCTCAGCTC TTCCTCCAGC TCTTCAGTGT TACTGCGACC GCTGCAGCGC CAACTCCAGC 120

TGCGTCACCG ATGGCGTCTG CTTTGTCGCC ATCCGTAAGT CGGGGAGCCA GCTGACCACC 180

GAGCGGCGCC AGTGCGTTCA CGAGAAGGAG CTGATTCCCC GGGATCGCCC GTTTATCTGC 240

GCCCCCTCGG TCAAGCACGA CACGGGCATC TACCCCATGT GCTGCACCGC CGACTACTGC 300

AACAAGGAGC CCGACCTGGA CGTGTTCCCC GTTCCCACGG TGAAGACCCA GTCCCTCGGA 360

CCCGTGGCCC TCGCTGCAGT GATTGCCGGA CCCGTCTGTG TGCTCTGCCT GCTCTTGGTC 420

TTGGCTTTCT ATGTCTGCCA CAACCACAGA GGTCTGGGGG CCGGGGGGGC CGGGGCCCAT 480

CATCATCACC ACCGGGTGCC TAATGAGGAA GACCCGTCTA TGGATCACCC CTTCATTACT 540

GTGGGAACCA CGCTGAAGGA CCTGATCTAC GACATGACCA CGTCTGGATC TGGCTCAGGA 600

CTGCCGCTGC TGGTCCAGAG GACCATCGCC AGGACCATCA TCCTCCAGGA GAGCATAGGG 660

AAGGGCCGGT TCGGGGAGGT GTGGCGGGGG AAATGGCGTG GGGAGGAGGT GGCGGTGAAG 720

ATCTTCTCAT CCCGTGAGGA GCGCTCCTGG TTCCGCGAGG CTGAGATTTA CCAGACGGTG 780

ATGCTGAGAC ACGAGAACAT CCTGGGCTTC ATCGCCGCTG ACAACAAGGA CAACGGGACG 840

TGGACGCAGC TGTGGCTGGT GTCCGACTAC CACGAGCACG GGTCGCTCTT TGACTACCTG 900

AACCGCTACA CCGTGACGGT GGAGGGCATG ATCAAGCTGT CCCTGTCCAC GGCCAGCGGC 960

CTCGCCCACC TCCACATGGA GATCGTGGGC ACTCAAGGCA AACCAGCAAT AGCTCACAGG 1020

GACCTGAAGT CCAAGAACAT CCTGGTGAAG AAGAACGGGA CGTGTTGTAT CGCAGACCTG 1080

GGTCTGGCCG TGCGCCACGA CTCCGCCACC GACACCATCG ACATCGCTCC CAACCACCGC 1140

GTGGGGACCA AGAGGTACAT GGCTCCAGAG GTCCTGGACG ACTCCATAAA CATGAAGCAC 1200

TTTGAGTCCT TCAAGCGTGC AGACATATAC GCCATGGGCC TGGTCTTCTG GGAGATCGCC 1260

AACCGCTGCT CGATGGGAGG AATCCACGAG GACTACCAGC TGCCCTACTA CGACCTGGTC 1320

CAGTCAGACC CCTCTGTGGA GGAGATGAGG AAGGTGGTGT GTGAGCAGAA GCTGCGACCC 1380

AACATTCCCA ACCGCTGGCA GAGCTGTGAG GCCTTACGGG TGATGGCCAA GATCATGAGG 1440

GAGTGTTGGT ACGCCAACAG CGCCGCCCGC CTCACCGCGC TCCGCATCAA AAAGACGCTG 1500

TCTCAGCTCA GCCAGCAGGA GGGCATCAAG ATGTAG 1536

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61

          l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fiaa

Q: 214   ILQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAA  273

         58899*******************************************************

S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121

         d+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++l ls+asGlahLH+eivgt+g

Q: 274   DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQG  333

         ************************************************************

S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181

           KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPEv

Q: 334   --KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEV  391

         ..**********************************************************

S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241

         l++++n+k+fe+fkraD+Y++gLv+WE+a Rc++ ++++e+y+lp+++ v+sdPs+eem+

Q: 392   LDDSINMKHFESFKRADIYAMGLVFWEIANRCSM-GGIHEDYQLPYYDLVQSDPSVEEMR  450

         **********************************.*************************

S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 451   KVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANSAARLTALRIKKTL  500

         ************************************************97

Domain Sequence
(FASTA)

ILQESIGKGR FGEVWRGKWR GEEVAVKIFS SREERSWFRE AEIYQTVMLR HENILGFIAA 60

DNKDNGTWTQ LWLVSDYHEH GSLFDYLNRY TVTVEGMIKL SLSTASGLAH LHMEIVGTQG 120

KPAIAHRDLK SKNILVKKNG TCCIADLGLA VRHDSATDTI DIAPNHRVGT KRYMAPEVLD 180

DSINMKHFES FKRADIYAMG LVFWEIANRC SMGGIHEDYQ LPYYDLVQSD PSVEEMRKVV 240

CEQKLRPNIP NRWQSCEALR VMAKIMRECW YANSAARLTA LRIKKTL 287

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013