EKS-TAR-00224

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00224

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	443.6	5.9E-133	120	388	269

Status

Unreviewed

Ensembl Protein

ENSTRUP00000013499

UniProt Accession

H2SM61;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCI

Gene Synonyms/Alias

PRKCI;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000005596	ENSTRUP00000013497	ENSTRUT00000013559
ENSTRUG00000005596	ENSTRUP00000013499	ENSTRUT00000013561
ENSTRUG00000005596	ENSTRUP00000013498	ENSTRUT00000013560

Organism

Takifugu rubripes

Functional Description

Protein Length

462

Protein Sequence
(FASTA)

QCSHAYQRSL ACPVQEKTRA HCAICADRIW GLGRQGYKCI NCKLLVHKKC HKLVTVECGR 60

PVIQDPVMHD TPSSPVDPNE QPGPQTKDSR ESLPYEGEEK EAWRSREAGK SPSSLGLADF 120

ELLRVIGRGS YAKVLLVQLK KTERIYAMKV VKKELVNDDE DIDWVQTEKH VFEQASNHPF 180

LVGLHSCFQT ESRLFFVIEY VNGGDLMFHM QRQRKLPEEH ARFYSAEISL ALNYLHERGI 240

IYRDLKLDNV LLDSEGHIKL TDYGMCKEGL RPGDTTSTFC GTPNYIAPEI LRGEDYGFSV 300

DWWALGVLMF EMMAGRSPFD IVGSSDNPDQ NTEDYLFQVI LEKQIRIPRS LSVKAASVLK 360

GFLNKDPKER LGCHPQTGFA DIMGHPFFRN VDWDLLEQKQ MVPPFKPNIS GEFGLDNFDA 420

QFTNEPIQLT PDDDDVVKKI DQSEFEGFEY INPLLMSAEE CV 462

Nucleotide Sequence
(FASTA)

CAGTGTTCCC ATGCGTACCA GAGAAGCCTG GCATGCCCTG TCCAGGAGAA GACACGAGCC 60

CACTGTGCCA TCTGTGCAGA TCGTATCTGG GGTTTAGGAA GACAAGGCTA CAAATGCATT 120

AACTGCAAAC TCCTGGTGCA TAAAAAATGT CATAAACTGG TCACGGTGGA ATGTGGCAGA 180

CCAGTCATTC AGGATCCAGT GATGCACGAC ACACCATCAA GTCCAGTAGA CCCAAATGAA 240

CAGCCAGGTC CCCAGACAAA AGACTCAAGA GAAAGTTTGC CTTATGAAGG AGAAGAGAAA 300

GAGGCGTGGC GAAGTAGGGA AGCAGGGAAG TCACCTTCCA GCCTGGGTCT GGCAGACTTC 360

GAGCTGCTGA GGGTGATCGG ACGAGGCAGC TACGCTAAGG TGCTGTTGGT GCAGCTGAAG 420

AAGACAGAGC GGATCTACGC CATGAAAGTG GTTAAGAAAG AGCTGGTCAA CGACGACGAG 480

GATATTGATT GGGTCCAAAC AGAAAAGCAC GTATTTGAAC AGGCGTCTAA TCATCCCTTC 540

CTGGTTGGCC TACATTCCTG TTTTCAGACA GAAAGCAGAC TTTTCTTTGT TATTGAATAT 600

GTAAACGGTG GCGATCTCAT GTTCCACATG CAGAGACAAA GGAAACTCCC TGAGGAACAT 660

GCCAGGTTCT ACTCAGCAGA GATTAGCTTG GCACTCAACT ACCTTCACGA GCGAGGAATC 720

ATCTACAGAG ATTTAAAACT GGACAATGTG CTTTTGGACT CTGAAGGACA CATCAAACTT 780

ACAGACTACG GGATGTGCAA GGAGGGATTG AGACCCGGTG ATACAACAAG CACTTTCTGT 840

GGTACTCCCA ATTACATTGC CCCTGAAATA CTCCGAGGAG AGGATTATGG GTTCAGTGTA 900

GACTGGTGGG CCTTAGGAGT GTTGATGTTT GAAATGATGG CGGGCCGGTC ACCATTCGAC 960

ATCGTGGGGA GCTCTGACAA TCCCGACCAG AACACAGAAG ACTACCTCTT CCAAGTTATA 1020

TTGGAAAAAC AGATCAGAAT CCCGCGCTCA TTGTCAGTTA AAGCTGCCAG CGTCCTCAAG 1080

GGATTCCTCA ACAAGGATCC CAAGGAGCGT CTCGGCTGCC ACCCTCAGAC AGGCTTTGCT 1140

GACATCATGG GTCATCCATT CTTTAGAAAC GTTGACTGGG ATCTTCTGGA GCAGAAGCAG 1200

ATGGTTCCTC CTTTTAAGCC CAACATCTCA GGGGAATTTG GATTGGACAA CTTTGACGCC 1260

CAGTTTACCA ACGAACCCAT TCAGCTCACT CCGGACGATG ATGATGTAGT AAAGAAGATT 1320

GACCAGTCTG AGTTTGAAGG ATTTGAGTAC ATCAACCCAC TGCTGATGTC GGCGGAGGAG 1380

TGTGTGTGA 1389

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         fell+v+G+Gs++kvll++lkkt+++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 120   FELLRVIGRGSYAKVLLVQLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  179

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 180   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  239

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 240   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  299

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+++l

Q: 300   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAASVL  359

         *****************************99*****************************

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         kg+l+kdp++rlG++ ++g +di+ h+ff

Q: 360   KGFLNKDPKERLGCHpQTGFADIMGHPFF  388

         **************989***********9

Domain Sequence
(FASTA)

FELLRVIGRG SYAKVLLVQL KKTERIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAASVL 240

KGFLNKDPKE RLGCHPQTGF ADIMGHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR012233	; PKC_zeta.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013