EKS-TAR-00207

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00207

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	479.1	7.5E-144	406	663	258

Status

Unreviewed

Ensembl Protein

ENSTRUP00000014478

UniProt Accession

H2SPZ0;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA3

Gene Synonyms/Alias

RPS6KA3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000005953	ENSTRUP00000014479	ENSTRUT00000014547
ENSTRUG00000005953	ENSTRUP00000014481	ENSTRUT00000014549
ENSTRUG00000005953	ENSTRUP00000014480	ENSTRUT00000014548
ENSTRUG00000005953	ENSTRUP00000014482	ENSTRUT00000014550
ENSTRUG00000005953	ENSTRUP00000014478	ENSTRUT00000014546
ENSTRUG00000005953	ENSTRUP00000014477	ENSTRUT00000014545

Organism

Takifugu rubripes

Functional Description

Protein Length

724

Protein Sequence
(FASTA)

VRTSLREREN GRERLFQPTE TRESPPVCLL QDDVPIKEIS ITHHVKEGSE KADPRQFELR 60

KVLGQGSFGK VFLVRKVTGP DAGQLYAMKV LKKATLKVRD RVRTKMERDI LVEVNHPFIV 120

KLHYAFQTEG KLYLILDFLR GGDLFTRLSK EVMFTEEDVK FYLAELALAL DHLHGLGIIY 180

RDLKPENILL DEEGHIKLTD FGLSKESVDH DNKAYSFCGT VEYMAPEVVN RRGHSHYADW 240

WSYGVLMYEM LTGSLPFQGK DRKDTMTMIL KAKLGMPQFL STEAQSLLRN LFKRNPSNRL 300

GAGPDGVEEI KRHQFFNTID WNKLFRREIY PPFKPAAGRP DDTFYFDPEF TAKTPRDSPG 360

VPPSANAHQL FRGFSFVAIT EEDTEPAPNT IVQQLHRSTS QFSDTYEIKE DIGVGSYSVC 420

KRCLHKGTGM EYAVKIISKA KKDPTEEVEI LLRYGQHPNI ITLKDVYDDG RSVFLVTELM 480

KGGELLDKIL RQKFFSEREA SAVLYTITKT VEYLHVQGVV HRDLKPSNIL YVDESGNAES 540

IRICDFGFSK QLRAENGLLM TPCYTANFVA PEVLKKQGYD AACDIWSLGV LLYTMLTGFT 600

PFANGPEDTP EEILARIGSG KFSLTGGYWN SVSNEAKDLV SRMLHVDPHR RLTAAQVLRH 660

PWVTHRDQLP KYTLNRQDAP HLVKGAMAAT YSALNRNVPP VLEPVGCSTL AQRRGMKKIT 720

STAL 724

Nucleotide Sequence
(FASTA)

GTGAGGACTT CATTGAGGGA GAGAGAAAAT GGGAGAGAGA GATTGTTCCA ACCGACGGAG 60

ACACGTGAAA GTCCGCCTGT GTGTCTGTTA CAGGATGACG TCCCGATCAA AGAGATCAGC 120

ATCACTCACC ATGTGAAGGA GGGGTCCGAG AAGGCCGACC CACGACAGTT CGAGCTCCGC 180

AAAGTCCTAG GACAGGGCTC CTTTGGCAAG GTGTTCCTGG TGAGGAAGGT CACGGGGCCG 240

GACGCCGGTC AGCTGTACGC CATGAAAGTC CTGAAGAAAG CGACGCTGAA AGTACGCGAC 300

CGGGTCAGGA CCAAGATGGA GAGAGACATC CTGGTGGAGG TCAACCACCC CTTCATTGTT 360

AAACTGCACT ACGCGTTCCA GACGGAAGGG AAGCTGTATC TGATCTTGGA CTTCCTCAGA 420

GGAGGAGATC TTTTCACACG CCTTTCCAAG GAGGTGATGT TCACAGAGGA GGATGTGAAG 480

TTTTACCTGG CAGAGCTCGC TTTGGCCCTG GACCACCTTC ACGGCCTGGG CATCATTTAT 540

AGAGACCTCA AGCCAGAGAA CATCCTGCTC GATGAGGAGG GGCACATCAA GCTGACTGAC 600

TTCGGCCTCA GTAAAGAGTC CGTCGATCAT GACAACAAGG CGTATTCCTT CTGTGGCACT 660

GTGGAGTACA TGGCTCCTGA GGTGGTGAAC AGACGGGGAC ACTCGCACTA CGCCGACTGG 720

TGGTCCTATG GAGTTCTTAT GTATGAGATG CTGACAGGAT CGCTGCCGTT CCAAGGCAAA 780

GACCGGAAAG ACACGATGAC CATGATCCTC AAGGCCAAGT TGGGAATGCC ACAGTTTTTG 840

AGTACAGAAG CACAGAGCCT CCTCAGAAAC CTCTTCAAAC GCAACCCTTC CAACAGATTA 900

GGAGCTGGAC CAGACGGCGT GGAAGAGATC AAGAGGCATC AGTTCTTCAA CACTATCGAC 960

TGGAATAAAC TCTTCCGTAG GGAGATTTAC CCTCCCTTCA AACCAGCTGC AGGACGACCT 1020

GACGATACAT TCTATTTCGA TCCAGAGTTC ACCGCGAAAA CTCCCAGAGA CTCTCCAGGG 1080

GTTCCTCCCA GCGCCAATGC CCATCAGCTG TTCAGAGGAT TCAGTTTTGT GGCCATAACG 1140

GAAGAGGACA CAGAACCAGC CCCCAACACG ATTGTTCAGC AGCTTCACAG AAGCACATCC 1200

CAGTTTTCAG ACACCTATGA AATCAAAGAG GACATTGGAG TCGGGTCCTA TTCCGTCTGT 1260

AAACGCTGCT TACACAAAGG AACGGGCATG GAGTACGCTG TCAAGATCAT CAGCAAGGCT 1320

AAGAAAGATC CGACCGAGGA GGTGGAGATC CTGCTGAGAT ATGGACAACA TCCCAACATC 1380

ATCACCCTGA AGGATGTGTA TGATGATGGG CGCTCGGTGT TCTTGGTGAC TGAGCTGATG 1440

AAAGGAGGTG AGCTGCTGGA CAAAATCCTA CGCCAGAAGT TTTTCTCGGA GAGAGAAGCC 1500

AGCGCCGTCC TCTACACCAT CACAAAGACT GTAGAGTACC TGCATGTGCA GGGGGTGGTG 1560

CACAGAGACC TGAAGCCCAG CAACATCCTG TATGTGGACG AGAGCGGGAA CGCCGAGTCC 1620

ATCAGGATCT GTGACTTTGG TTTCTCCAAA CAGCTGAGGG CGGAGAACGG TCTGCTCATG 1680

ACGCCGTGCT ACACTGCTAA CTTTGTTGCA CCTGAGGTGC TGAAGAAACA GGGTTACGAT 1740

GCTGCCTGTG ACATCTGGAG TCTGGGAGTT CTGCTCTACA CGATGCTAAC AGGTTTCACT 1800

CCTTTTGCCA ACGGCCCAGA GGACACGCCA GAAGAGATTT TGGCTCGTAT CGGCAGCGGC 1860

AAGTTCTCTC TCACTGGAGG ATACTGGAAC TCTGTCTCTA ATGAGGCCAA GGACCTGGTG 1920

TCAAGGATGC TGCACGTCGA CCCTCACCGG CGGCTGACGG CTGCTCAGGT CCTTCGACAC 1980

CCCTGGGTGA CGCACAGAGA CCAGCTCCCC AAATACACCC TGAACAGACA GGATGCCCCA 2040

CATCTGGTCA AGGGTGCAAT GGCAGCCACT TACTCAGCCC TCAACAGGAA TGTTCCTCCA 2100

GTCCTGGAAC CAGTGGGCTG TTCCACTCTG GCCCAGCGGA GGGGTATGAA GAAGATCACC 2160

TCCACTGCCC TGTGA 2175

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         ye+ked+GvGsysvckrc+hk t++e+avkii+k k+d++ee+eillry+qhpni+tlkd

Q: 406   YEIKEDIGVGSYSVCKRCLHKGTGMEYAVKIISKAKKDPTEEVEILLRYGQHPNIITLKD  465

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddg+ v+lv+el+kGGelld+i+++kffsereasa+l+t++k+veylh qGvvhrdlk

Q: 466   VYDDGRSVFLVTELMKGGELLDKILRQKFFSEREASAVLYTITKTVEYLHVQGVVHRDLK  525

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+naesi+i+dfGf+k++raengll+tpcyt+nfvapevlk+qGyd+acd+

Q: 526   PSNILYVDESGNAESIRICDFGFSKQLRAENGLLMTPCYTANFVAPEVLKKQGYDAACDI  585

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytml+G++pfangpedt+eeila+i++Gkfsl G++w+svs+eakdlvs++l+

Q: 586   WSLGVLLYTMLTGFTPFANGPEDTPEEILARIGSGKFSLTGGYWNSVSNEAKDLVSRMLH  645

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 646   VDPHRRLTAAQVLRHPWV  663

         *****************7

Domain Sequence
(FASTA)

YEIKEDIGVG SYSVCKRCLH KGTGMEYAVK IISKAKKDPT EEVEILLRYG QHPNIITLKD 60

VYDDGRSVFL VTELMKGGEL LDKILRQKFF SEREASAVLY TITKTVEYLH VQGVVHRDLK 120

PSNILYVDES GNAESIRICD FGFSKQLRAE NGLLMTPCYT ANFVAPEVLK KQGYDAACDI 180

WSLGVLLYTM LTGFTPFANG PEDTPEEILA RIGSGKFSLT GGYWNSVSNE AKDLVSRMLH 240

VDPHRRLTAA QVLRHPWV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013