EKS-TAR-00470

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00470

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	441.8	1.5E-132	279	526	248

Status

Unreviewed

Ensembl Protein

ENSTRUP00000014545

UniProt Accession

H2SQ58;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC (1 of 2)

Gene Synonyms/Alias

SRC (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000005980	ENSTRUP00000014546	ENSTRUT00000014614
ENSTRUG00000005980	ENSTRUP00000014545	ENSTRUT00000014613

Organism

Takifugu rubripes

Functional Description

Protein Length

544

Protein Sequence
(FASTA)

MGGHKSKPKD VGQRSRSLDG TLSSGGGAGG HHHNSNQQSL TPNRSPTVEG GLGGGQSMPN 60

NAELALFGGV DNNSLTAPSR ITLAAGGVTT FVALYDYESR TASDLSFRKG ERLQIVNNTR 120

KLNCREGDWW LARSLTTGDS GYIPSNYVAP SDSIQAEEWY FGKITRRDSE RLLLSLENRR 180

GTFLVRESET TKGAYCLSVL DYDNTKGLNV KHYKIRKLDS GGFYITSRTQ FSSLQHLVNH 240

YRKHADGLCH SLTDICPVLK PQTQGLSKDA WEIPRESLRL DLKLGQGCFG EVWMGTWNGT 300

TRVAIKTLKP GTMSPEAFLQ EAQVMKKLRH EKLVQLYAVV SEEPIYIVTE YMGQGSLLDF 360

LKGDMGKMLR LPQLVDMAAQ IASGMAYVER MNYVHRDLRA ANILVGDNLV CKVADFGLAR 420

LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG ILLTELATKG RVPYPGMVNR 480

EVLDQVERGY RMPCPAECPE SMHDLMLTCW KKEPEERPTF EYLQGFLEDY FTSTEPQYQP 540

GENL 544

Nucleotide Sequence
(FASTA)

ATGGGGGGAC ATAAGAGTAA GCCCAAAGAT GTAGGCCAAC GAAGTCGCAG CCTTGATGGA 60

ACCCTCAGCT CTGGGGGAGG GGCTGGCGGC CACCACCACA ACTCCAATCA ACAGTCTTTG 120

ACACCAAACC GCAGCCCGAC AGTGGAGGGA GGCCTTGGCG GTGGCCAGTC TATGCCTAAT 180

AACGCGGAGC TGGCCCTGTT TGGGGGTGTG GACAATAACA GTCTCACCGC TCCCAGCAGA 240

ATCACCCTCG CAGCAGGAGG TGTGACGACC TTTGTGGCGC TGTATGATTA TGAATCGAGA 300

ACAGCGTCCG ATCTGTCTTT CAGGAAGGGC GAACGCCTCC AGATTGTCAA CAACACGAGG 360

AAATTAAACT GCAGAGAAGG AGACTGGTGG CTGGCTCGCT CCCTGACCAC CGGCGACAGC 420

GGCTACATCC CCAGCAATTA TGTGGCTCCA TCCGACTCCA TCCAGGCAGA AGAGTGGTAC 480

TTTGGCAAAA TTACCCGCAG GGACTCCGAG AGGCTGCTGC TCAGCTTGGA GAACCGGCGA 540

GGAACATTCC TGGTGCGAGA GAGTGAGACC ACCAAAGGTG CCTACTGCCT GTCCGTGTTG 600

GACTATGACA ACACTAAAGG GCTGAACGTG AAGCACTACA AGATCAGGAA GCTGGACAGT 660

GGCGGCTTCT ACATCACGTC GCGCACGCAG TTCAGCAGCT TGCAGCATCT CGTCAATCAC 720

TATCGCAAGC ACGCCGACGG CCTGTGTCAC AGCCTGACGG ACATTTGTCC CGTCCTGAAG 780

CCTCAGACTC AGGGATTATC CAAGGATGCC TGGGAGATCC CCAGAGAATC CCTCCGCCTT 840

GATCTCAAGC TTGGACAGGG CTGCTTTGGA GAGGTCTGGA TGGGAACCTG GAACGGTACA 900

ACCAGAGTTG CAATAAAGAC TCTGAAGCCT GGCACCATGT CTCCTGAGGC CTTCCTCCAG 960

GAAGCTCAGG TCATGAAGAA ACTGAGGCAC GAGAAGCTGG TTCAGCTCTA CGCTGTGGTG 1020

TCTGAAGAAC CCATCTATAT TGTCACAGAG TACATGGGTC AAGGCAGCTT ACTGGATTTC 1080

CTGAAAGGTG ACATGGGGAA GATGCTCCGC CTCCCACAGC TGGTGGACAT GGCGGCTCAG 1140

ATTGCCTCGG GGATGGCGTA CGTGGAGAGG ATGAACTACG TGCACCGGGA CCTGAGAGCC 1200

GCTAACATCC TGGTGGGAGA CAACCTGGTG TGCAAAGTGG CTGATTTCGG TTTGGCTCGT 1260

CTCATCGAGG ATAACGAATA TACAGCCAGA CAAGGAGCCA AGTTCCCCAT CAAGTGGACA 1320

GCCCCCGAGG CCGCCCTGTA CGGACGCTTC ACCATCAAGT CTGACGTCTG GTCATTTGGG 1380

ATCCTGCTGA CCGAACTGGC CACCAAAGGC CGCGTTCCCT ATCCAGGGAT GGTGAACCGG 1440

GAGGTGTTGG ACCAGGTGGA GCGGGGCTAC AGGATGCCGT GTCCGGCTGA ATGCCCAGAA 1500

TCTATGCACG ACCTGATGCT AACCTGCTGG AAGAAAGAGC CCGAGGAGAG GCCCACATTT 1560

GAGTACCTGC AGGGCTTCCT GGAGGACTAC TTCACCTCCA CGGAGCCTCA GTACCAGCCG 1620

GGAGAGAACC TGTAG 1635

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

         +l  klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+lya

Q: 279   RLDLKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA  338

         67889*******************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         vvse ePiyivte+m +Gslldflk + gk+l+lp+lvd+aaq+a+Gmay+e++n++hrd

Q: 339   VVSE-EPIYIVTEYMGQGSLLDFLKGDMGKMLRLPQLVDMAAQIASGMAYVERMNYVHRD  397

         ***9.*******************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         l+a+n+lvg++lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdvW

Q: 398   LRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW  457

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfGillte+ tkG+vPypGm n+evl+qvergyr+p+p+ecpe++++l+l+cwkk+peer

Q: 458   SFGILLTELATKGRVPYPGMVNREVLDQVERGYRMPCPAECPESMHDLMLTCWKKEPEER  517

         ************************************************************

S: 242   Ptfetlqev  250

         Ptfe+lq +

Q: 518   PTFEYLQGF  526

         ******976

Domain Sequence
(FASTA)

RLDLKLGQGC FGEVWMGTWN GTTRVAIKTL KPGTMSPEAF LQEAQVMKKL RHEKLVQLYA 60

VVSEEPIYIV TEYMGQGSLL DFLKGDMGKM LRLPQLVDMA AQIASGMAYV ERMNYVHRDL 120

RAANILVGDN LVCKVADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALYG RFTIKSDVWS 180

FGILLTELAT KGRVPYPGMV NREVLDQVER GYRMPCPAEC PESMHDLMLT CWKKEPEERP 240

TFEYLQGF 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013