EKS-TAR-00548

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00548

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Syk	420.2	5.7E-126	340	587	248

Status

Unreviewed

Ensembl Protein

ENSTRUP00000014704

UniProt Accession

H2SQL6;

Protein Name

Protein Synonyms/Alias

Gene Name

ZAP70

Gene Synonyms/Alias

ZAP70;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000006051	ENSTRUP00000014703	ENSTRUT00000014771
ENSTRUG00000006051	ENSTRUP00000014704	ENSTRUT00000014772

Organism

Takifugu rubripes

Functional Description

Protein Length

603

Protein Sequence
(FASTA)

MSTDPAAELP FFYGSISRTD AEQHLKLAGM DDGLFLLRQC IRSLGGYVLS VVWNLEFHHY 60

SIEKQLNGTY SMAGGKPHCG PAELCEFHSK DPDGLVCLLR KPCLRPPDMP IRAGTFDTMK 120

EKMVREYVKQ TWNLEGEAME LAIDSQASQL EKLIAITAHE KMPWFHGKIP RQEGERRLYS 180

GAQPDGKFLV RERDEPGTFA LSVMYGKTVY HYQILQAKSG KYSMPEGTKF DTIWQLVEYQ 240

KMKPDGLVTV LGEACTNGKA VEICEIFLSE ICCKIFQRPQ RQNGYTPPPG GLGAEARAPA 300

KQPTAKTSVT LTPDDDTDNN PYHNPNEVRK FNIQRSQLLI DELELGSGNF GCVKKGVLKT 360

DLGQTDVAIK VLKSDNERLV KEEMMREAEI MYQLSNRYIV RMLGLCNAEN LMLVMEMASA 420

GPLNKFLSSN RDTVTVENIV LLMHQVSMGM KYLEEKNFVH RDLAARNVLL VNQRFAKISD 480

FGLSKALGAD DSYYKARTAG KWPLKWYAPE CINFRKFSSK SDVWSFGITM WEAFSFGGKP 540

YKKMKGPEVN QFIEAGNRME RPEACPEGMY TVMKECWTYK HEDRPDFKKV EESMKSYHSS 600

MPK 603

Nucleotide Sequence
(FASTA)

ATGTCCACGG ACCCCGCGGC CGAGCTGCCC TTCTTCTACG GCAGCATCAG TCGCACAGAC 60

GCCGAGCAGC ACCTTAAGCT GGCCGGGATG GACGACGGAC TCTTCCTGTT GCGACAGTGC 120

ATCCGCAGCC TGGGCGGCTA CGTCCTGTCT GTTGTGTGGA ACCTGGAGTT TCACCATTAC 180

TCCATAGAAA AGCAGCTAAA TGGGACTTAC TCCATGGCTG GAGGGAAGCC TCACTGCGGA 240

CCCGCCGAGC TCTGCGAGTT CCACAGCAAA GACCCGGACG GGCTGGTGTG CCTCCTGAGG 300

AAACCCTGTC TGCGGCCCCC AGATATGCCC ATACGAGCAG GCACCTTTGA CACCATGAAG 360

GAGAAGATGG TCAGGGAGTA CGTGAAGCAG ACCTGGAACC TGGAGGGGGA GGCCATGGAG 420

CTGGCCATCG ACAGTCAGGC GTCCCAGCTG GAGAAACTGA TCGCCATCAC CGCTCACGAA 480

AAGATGCCTT GGTTCCACGG TAAAATCCCC CGCCAGGAGG GCGAGAGGCG GCTTTACTCT 540

GGAGCCCAAC CGGATGGAAA GTTCCTAGTG AGAGAACGAG ATGAGCCGGG TACTTTTGCT 600

CTCTCTGTCA TGTACGGGAA AACAGTGTAC CACTATCAAA TCCTCCAAGC CAAATCAGGG 660

AAATATTCGA TGCCGGAGGG AACAAAGTTT GACACAATCT GGCAGCTGGT CGAGTACCAG 720

AAAATGAAAC CTGATGGCCT GGTGACAGTT CTCGGCGAGG CATGCACGAA CGGCAAAGCT 780

GTTGAAATCT GCGAGATTTT TCTGTCTGAA ATCTGCTGCA AAATATTTCA GCGGCCGCAG 840

CGACAAAATG GCTACACACC GCCCCCTGGC GGCCTCGGGG CTGAGGCGCG CGCTCCAGCG 900

AAGCAGCCAA CCGCAAAGAC GTCTGTGACA CTGACTCCTG ATGACGACAC AGACAACAAC 960

CCCTACCACA ACCCCAATGA AGTGAGGAAG TTCAACATCC AGAGGAGCCA ACTTCTGATC 1020

GACGAGCTGG AGCTCGGCTC TGGGAACTTC GGCTGCGTCA AGAAAGGCGT CCTCAAGACT 1080

GATTTAGGCC AGACGGACGT GGCCATCAAA GTGCTGAAGA GCGATAACGA GAGGCTGGTG 1140

AAGGAGGAGA TGATGCGGGA GGCAGAGATC ATGTACCAGC TGAGCAACCG CTACATCGTT 1200

CGCATGCTGG GCCTGTGCAA CGCTGAGAAC CTGATGCTTG TCATGGAAAT GGCCTCTGCT 1260

GGACCCCTCA ACAAGTTCCT CTCTTCAAAT AGAGATACTG TGACCGTGGA GAACATCGTC 1320

CTGCTCATGC ACCAGGTCTC CATGGGAATG AAGTATCTGG AGGAGAAGAA CTTTGTGCAC 1380

AGAGATTTGG CCGCTCGTAA CGTCCTGCTG GTCAACCAGC GTTTTGCCAA GATCAGCGAC 1440

TTTGGGCTCT CCAAGGCCCT GGGAGCAGAC GACAGCTATT ACAAGGCTCG CACTGCAGGG 1500

AAATGGCCCC TGAAGTGGTA CGCTCCAGAA TGTATTAACT TCCGCAAGTT CTCCAGTAAG 1560

AGTGACGTGT GGAGCTTCGG CATCACCATG TGGGAGGCCT TCTCCTTCGG AGGCAAACCC 1620

TACAAGAAAA TGAAGGGACC AGAGGTGAAC CAATTCATCG AGGCCGGGAA CCGCATGGAG 1680

CGTCCAGAGG CATGTCCAGA GGGAATGTAC ACAGTGATGA AGGAGTGTTG GACATACAAG 1740

CACGAGGATC GCCCCGACTT CAAGAAGGTC GAGGAGTCCA TGAAGTCCTA CCACAGTTCC 1800

ATGCCTAAG 1809

Domain Profile

S: 2     vedkelGsGnfGsvkkGyyrmkkkrlevaikvlkeadekadkdellreasvmqqldnkyi  61

         + + elGsGnfG+vkkG+++    + +vaikvlk  +e+  k+e++rea++m ql n+yi

Q: 340   IDELELGSGNFGCVKKGVLKTDLGQTDVAIKVLKSDNERLVKEEMMREAEIMYQLSNRYI  399

         6788********************************************************

S: 62    vrliGiakaealmlvmelaelGpllkylldkreeikaknvlelvhqvamGmkyleeknfv  121

         vr++G+++ae lmlvme+a+ Gpl+k+l  +r+ ++++n++ l+hqv+mGmkyleeknfv

Q: 400   VRMLGLCNAENLMLVMEMASAGPLNKFLSSNRDTVTVENIVLLMHQVSMGMKYLEEKNFV  459

         ************************************************************

S: 122   hrdlaarnvllvarhyakisdfGlskalradesyykarsaGkwpvkwyapecinlrkfss  181

         hrdlaarnvllv++ +akisdfGlskal+ad+syykar+aGkwp+kwyapecin+rkfss

Q: 460   HRDLAARNVLLVNQRFAKISDFGLSKALGADDSYYKARTAGKWPLKWYAPECINFRKFSS  519

         ************************************************************

S: 182   ksdvwsfGvtlweafsyGqkpykelkgsevlalvekGerlecpaecpaelyalmsscwky  241

         ksdvwsfG+t+weafs+G kpyk++kg+ev +++e G+r+e p+ cp+ +y +m++cw+y

Q: 520   KSDVWSFGITMWEAFSFGGKPYKKMKGPEVNQFIEAGNRMERPEACPEGMYTVMKECWTY  579

         ************************************************************

S: 242   kvedrpdf  249

         k edrpdf

Q: 580   KHEDRPDF  587

         *******9

Domain Sequence
(FASTA)

IDELELGSGN FGCVKKGVLK TDLGQTDVAI KVLKSDNERL VKEEMMREAE IMYQLSNRYI 60

VRMLGLCNAE NLMLVMEMAS AGPLNKFLSS NRDTVTVENI VLLMHQVSMG MKYLEEKNFV 120

HRDLAARNVL LVNQRFAKIS DFGLSKALGA DDSYYKARTA GKWPLKWYAP ECINFRKFSS 180

KSDVWSFGIT MWEAFSFGGK PYKKMKGPEV NQFIEAGNRM ERPEACPEGM YTVMKECWTY 240

KHEDRPDF 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR023420	; Kinase_SYK/ZAP-70_inter-SH2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 2.

SMARTs

SM00252	; SH2; 2.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 2.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013