EKS-TAR-00477

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00477

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	411.5	2.7E-123	245	498	254

Status

Unreviewed

Ensembl Protein

ENSTRUP00000015524

UniProt Accession

H2SSY6;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000006360	ENSTRUP00000015524	ENSTRUT00000015593
ENSTRUG00000006360	ENSTRUP00000015523	ENSTRUT00000015592

Organism

Takifugu rubripes

Functional Description

Protein Length

515

Protein Sequence
(FASTA)

MEIQKRLSAC WNSFLACFKK PTQSGGNEEQ RATVLANAGA ITEPNPRATR PPAPVATSGQ 60

FYVALYDYSA RTEEDLSFNA GDTLEALDKS NGDWWYAQAV SGVSANKEGY IPANYVAPVE 120

SIDAEPWYFP ETKRLDAEKM LLSEGNRHGA FLIRNCESQK GELSLSVLDK GSVKHYKLRK 180

TETGQYFVSR SRIFPTLKKL VEHYSDQADG LCTCLGEPCR KMEAPQTHGL SYNTVDQWEI 240

DRKSIKLLRK LGAGQFGEVF EGLWNDTTPV AVKTLKPGTM DPEDFLREAQ IMKRLRHGKL 300

IQLYAVCTLE DPIYIITELM KNGSLLDYLQ KNKEPKLRIS DQIEMAAQVA SGMAFLELQN 360

YIHRDLAARN VLVGENNICK VADFGLARVF MKDNDNVYEA KEGTKFPVKW TAPEAIHSNK 420

FSIKSDVWSF GILLYEIMTF GQMPYPTMTN LQVVQRVPLG YRMPCPPNCP KIMYDIMMDC 480

WKEKEQDRPT FETLQWKLED FFDMDVTSYD DANRY 515

Nucleotide Sequence
(FASTA)

ATGGAGATCC AAAAAAGACT TTCGGCATGC TGGAACTCTT TCCTGGCGTG CTTTAAAAAG 60

CCGACTCAGT CCGGGGGGAA TGAAGAGCAG CGGGCCACAG TTTTGGCAAA TGCCGGAGCA 120

ATCACGGAAC CGAACCCTCG GGCCACGAGG CCCCCGGCGC CGGTGGCCAC GTCCGGACAG 180

TTCTATGTGG CCCTCTACGA TTACTCTGCT CGTACCGAGG AGGACCTGAG TTTTAACGCC 240

GGGGACACGT TGGAAGCCCT GGACAAGAGC AACGGGGACT GGTGGTATGC TCAAGCAGTG 300

AGCGGAGTGT CGGCCAACAA AGAGGGTTAT ATCCCTGCCA ACTACGTGGC CCCTGTGGAG 360

AGTATCGATG CTGAACCGTG GTATTTTCCC GAAACAAAGA GGTTGGATGC GGAGAAGATG 420

CTGCTATCTG AGGGGAATCG GCACGGTGCT TTCCTCATCA GAAACTGTGA AAGCCAGAAA 480

GGAGAGCTTT CTCTCTCAGT GCTGGACAAG GGGAGCGTGA AGCATTACAA GCTGAGGAAG 540

ACAGAGACTG GACAGTACTT TGTGTCGAGG AGCAGAATCT TTCCCACCTT GAAGAAGCTG 600

GTAGAGCATT ACTCCGACCA GGCTGATGGT TTGTGTACAT GTCTGGGTGA GCCATGCAGG 660

AAGATGGAGG CTCCTCAAAC TCACGGCCTG TCCTACAACA CCGTGGACCA ATGGGAGATT 720

GACCGTAAAT CCATTAAGCT TCTGAGGAAG CTGGGGGCTG GTCAGTTTGG GGAAGTGTTT 780

GAAGGTCTCT GGAATGACAC CACGCCAGTA GCAGTGAAGA CCCTTAAACC TGGTACCATG 840

GATCCTGAGG ACTTCCTGAG AGAGGCCCAG ATCATGAAGA GGTTACGACA TGGCAAACTA 900

ATCCAGCTAT ATGCTGTGTG CACCCTGGAG GATCCCATCT ACATCATCAC AGAGCTAATG 960

AAGAACGGCA GTCTGCTGGA TTACCTCCAG AAAAATAAAG AGCCCAAGCT GCGTATATCC 1020

GACCAGATTG AGATGGCTGC CCAGGTGGCT TCAGGCATGG CTTTCCTGGA GTTGCAGAAC 1080

TACATCCACA GAGACCTGGC AGCCAGAAAC GTTTTGGTGG GCGAGAACAA CATTTGCAAA 1140

GTGGCTGACT TTGGCCTCGC GAGAGTCTTC ATGAAAGATA ATGACAATGT GTATGAGGCC 1200

AAAGAGGGGA CTAAATTCCC TGTGAAGTGG ACTGCACCAG AGGCCATTCA CAGTAACAAG 1260

TTCTCCATAA AATCAGATGT TTGGTCCTTT GGGATTTTGC TTTATGAGAT CATGACCTTT 1320

GGACAGATGC CTTACCCAAC CATGACAAAC CTGCAGGTGG TCCAGAGGGT TCCGCTGGGC 1380

TACAGGATGC CATGTCCTCC CAACTGCCCT AAAATCATGT ATGACATAAT GATGGACTGC 1440

TGGAAGGAGA AAGAACAGGA CCGGCCAACA TTCGAGACCT TGCAGTGGAA ACTGGAGGAC 1500

TTTTTTGACA TGGACGTGAC ATCTTATGAT GACGCCAACC GTTATTAG 1548

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +kl++klG+GqfGev++g+w+++++vavktlk+gt++pe+fl+eaqi+k+lrh kl++ly

Q: 245   IKLLRKLGAGQFGEVFEGLWNDTTPVAVKTLKPGTMDPEDFLREAQIMKRLRHGKLIQLY  304

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gslld+l+++++ kl++++++++aaqva+Gma+le +n+ihr

Q: 305   AVCTLEDPIYIITELMKNGSLLDYLQKNKEPKLRISDQIEMAAQVASGMAFLELQNYIHR  364

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar++    d+ y+akeg+k+P+kWtaPeai+ +kf+ik

Q: 365   DLAARNVLVGENNICKVADFGLARVFMkdnDNVYEAKEGTKFPVKWTAPEAIHSNKFSIK  424

         ************************764466899***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t G++Pyp mtn +v+++v  gyr+p+p +cp+ +y++++ cwk++

Q: 425   SDVWSFGILLYEIMTFGQMPYPTMTNLQVVQRVPLGYRMPCPPNCPKIMYDIMMDCWKEK  484

         ************************************************************

S: 238   peerPtfetlqevl  251

          ++rPtfetlq++l

Q: 485   EQDRPTFETLQWKL  498

         ***********986

Domain Sequence
(FASTA)

IKLLRKLGAG QFGEVFEGLW NDTTPVAVKT LKPGTMDPED FLREAQIMKR LRHGKLIQLY 60

AVCTLEDPIY IITELMKNGS LLDYLQKNKE PKLRISDQIE MAAQVASGMA FLELQNYIHR 120

DLAARNVLVG ENNICKVADF GLARVFMKDN DNVYEAKEGT KFPVKWTAPE AIHSNKFSIK 180

SDVWSFGILL YEIMTFGQMP YPTMTNLQVV QRVPLGYRMP CPPNCPKIMY DIMMDCWKEK 240

EQDRPTFETL QWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013