EKS-TAR-00476

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00476

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	411.6	2.5E-123	209	458	250

Status

Unreviewed

Ensembl Protein

ENSTRUP00000015829

UniProt Accession

H2STU2;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000006468	ENSTRUP00000015829	ENSTRUT00000015899

Organism

Takifugu rubripes

Functional Description

Protein Length

474

Protein Sequence
(FASTA)

MGCTCSGQNK VKDDKRRHKG QGNHTSEHVF VALHDFKSTN SSDLPFKEGD KLKVLQSDGQ 60

WWVAKSLESG LEGFIPCNYV ARAETMEMEK WFFNDMSRKE TERLLLAPGN QTGSFLVRES 120

ETSPGSYSLS IRDYEPQQGD VVKHYKIRTM DKGGYYISPY NTFPTLQKLV TYYTGTADGL 180

CQQLYAPCKP KATQQPWAHD EWEIPRETLK MVKKLGAGQF GEVWMGYYKS TQKVAIKTLK 240

EGTMEPAAFL QEANLMKQLQ HERLVRLHAV VTKEPILIVT EFMVNGSLLD FLKSDEGKKL 300

KVNKLIDMAA QIAEGMAYIE VKNYIHRDLR AANILVSETL HCKIADFGLA RIIESEYTAQ 360

EGAKFPIKWT APEAINFGTF SIKSDVWSFG ILLTEIVTFG RTPYPAPGMT NPEVIRSLDR 420

SYRMPCPDSC PVELYDVMMM CWKQKAEERP TFEFLQTTLN DFFIATEGQY EMQP 474

Nucleotide Sequence
(FASTA)

ATGGGCTGCA CCTGCAGTGG CCAGAACAAA GTCAAAGATG ACAAAAGGAG GCACAAGGGT 60

CAGGGCAACC ACACATCAGA GCACGTGTTC GTCGCTTTGC ACGACTTCAA GTCGACCAAC 120

AGCAGCGATC TCCCCTTCAA AGAGGGGGAT AAACTTAAAG TTCTCCAGTC GGATGGCCAA 180

TGGTGGGTGG CGAAGTCCCT GGAATCAGGC CTGGAGGGCT TCATACCCTG CAACTATGTG 240

GCCAGAGCAG AAACCATGGA GATGGAGAAG TGGTTTTTCA ATGACATGAG CAGAAAGGAG 300

ACCGAGCGTC TGCTTTTGGC ACCCGGGAAT CAAACCGGCT CTTTTCTGGT TCGAGAGAGC 360

GAGACCTCCC CAGGGTCCTA CTCGCTGTCA ATCAGGGATT ACGAACCCCA GCAGGGAGAT 420

GTGGTAAAAC ACTACAAAAT CCGCACCATG GACAAAGGTG GATACTACAT CTCCCCCTAC 480

AACACCTTCC CCACCCTGCA GAAGCTGGTT ACATACTACA CAGGTACAGC AGATGGGTTG 540

TGTCAGCAGC TCTATGCCCC CTGTAAGCCC AAAGCCACCC AGCAGCCATG GGCTCACGAC 600

GAGTGGGAGA TTCCCAGAGA GACCCTGAAG ATGGTGAAGA AACTGGGAGC CGGTCAGTTT 660

GGGGAGGTGT GGATGGGTTA CTACAAAAGC ACCCAGAAAG TGGCCATCAA GACCCTGAAG 720

GAGGGGACGA TGGAGCCCGC CGCCTTCCTG CAGGAGGCCA ACCTGATGAA GCAGCTGCAG 780

CACGAGCGGC TGGTGCGTCT GCACGCCGTG GTCACTAAGG AGCCCATCCT CATCGTCACC 840

GAGTTCATGG TCAACGGCAG TCTCCTGGAC TTTCTGAAAA GTGATGAAGG AAAGAAACTG 900

AAAGTGAATA AACTGATCGA CATGGCAGCG CAGATCGCTG AAGGCATGGC CTACATCGAG 960

GTGAAGAACT ACATCCACCG AGACTTACGC GCAGCCAACA TCCTCGTCAG TGAGACCCTG 1020

CACTGCAAGA TAGCGGACTT TGGCCTGGCC AGGATAATCG AGTCAGAGTA CACGGCTCAA 1080

GAAGGTGCTA AGTTTCCCAT CAAGTGGACG GCTCCTGAGG CCATTAATTT TGGAACATTT 1140

AGCATCAAAT CAGATGTCTG GTCCTTTGGA ATCCTCCTGA CAGAGATAGT CACTTTTGGA 1200

AGAACACCAT ACCCAGCACC AGGAATGACA AACCCAGAGG TCATCAGGAG TCTGGACCGG 1260

TCATACCGGA TGCCATGCCC GGACAGTTGT CCCGTAGAAC TTTATGATGT GATGATGATG 1320

TGCTGGAAGC AGAAGGCCGA GGAACGGCCC ACTTTTGAGT TCCTGCAGAC CACCCTCAAT 1380

GATTTCTTTA TCGCCACAGA GGGACAATAT GAGATGCAGC CCTGA 1425

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lk+vkklG+GqfGevw+g++k++ kva+ktlkegt++p+afl+ea+++k+l+he+lv+l+

Q: 209   LKMVKKLGAGQFGEVWMGYYKSTQKVAIKTLKEGTMEPAAFLQEANLMKQLQHERLVRLH  268

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePi+ivte+m +Gslldflk++egkklk++kl+d+aaq+aeGmay+e kn+ihr

Q: 269   AVVTK-EPILIVTEFMVNGSLLDFLKSDEGKKLKVNKLIDMAAQIAEGMAYIEVKNYIHR  327

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e+l +k+adfGlar+i ++eyta+egak+PikWtaPeai++g+f+iksdv

Q: 328   DLRAANILVSETLHCKIADFGLARII-ESEYTAQEGAKFPIKWTAPEAINFGTFSIKSDV  386

         **************************.789******************************

S: 181   WsfGillteivtkGkvPyp..Gmtneevleqvergyrlprpeecpeelyelllecwkkdp  238

         WsfGillteivt G++Pyp  Gmtn ev+++++r+yr+p+p++cp ely+++++cwk+++

Q: 387   WSFGILLTEIVTFGRTPYPapGMTNPEVIRSLDRSYRMPCPDSCPVELYDVMMMCWKQKA  446

         ******************555***************************************

S: 239   eerPtfetlqev  250

         eerPtfe+lq++

Q: 447   EERPTFEFLQTT  458

         *********986

Domain Sequence
(FASTA)

LKMVKKLGAG QFGEVWMGYY KSTQKVAIKT LKEGTMEPAA FLQEANLMKQ LQHERLVRLH 60

AVVTKEPILI VTEFMVNGSL LDFLKSDEGK KLKVNKLIDM AAQIAEGMAY IEVKNYIHRD 120

LRAANILVSE TLHCKIADFG LARIIESEYT AQEGAKFPIK WTAPEAINFG TFSIKSDVWS 180

FGILLTEIVT FGRTPYPAPG MTNPEVIRSL DRSYRMPCPD SCPVELYDVM MMCWKQKAEE 240

RPTFEFLQTT 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013