EKS-TAR-00511

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00511

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	520.7	4.7E-156	558	899	342

Status

Unreviewed

Ensembl Protein

ENSTRUP00000016090

UniProt Accession

H2SUK2;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

CSF1R (1 of 2)

Gene Synonyms/Alias

CSF1R (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000006553	ENSTRUP00000016090	ENSTRUT00000016162
ENSTRUG00000006553	ENSTRUP00000016089	ENSTRUT00000016161
ENSTRUG00000006553	ENSTRUP00000016088	ENSTRUT00000016160
ENSTRUG00000006553	ENSTRUP00000016087	ENSTRUT00000016159
ENSTRUG00000006553	ENSTRUP00000016086	ENSTRUT00000016158

Organism

Takifugu rubripes

Functional Description

Protein Length

903

Protein Sequence
(FASTA)

VVVKPGTSLE LKCGGDGPVN WQTRLPKHKR YMSRSPGNLR TIRVARPTAE FTGTYKCFYS 60

AWAQHRHLTS SVHVYVKALD PNRVFWTSST SLRVVRKEGE DYLLPCLLTD PEATDLGLRM 120

DNGTTVPPEM NYTVYRHRGI LIRSLQPSFN ADYVCTAKVK GVEKTSKTFS INVIQKLRFP 180

PYVFLEMDEY VRIVGEELQI RCMTHNPNFN YNVTWNYTTN PQRVTIEERV RSSGENRLDI 240

QSILTISAVD LADTGNISCI GTNEAGVNSS NTYLLVVEKP YIRLWPQLIP KLASQGLSVE 300

VNEGEDLELG VMVEAYPQIT DHRWHTPTSP STSMQEHMFV RYNNRYHARL QLKRMNAQEQ 360

GQYTFYAKSN LANGSISFHV KMYQKPIAVV RWENITTLTC TSFGYPAPQI IWYQCSGIRP 420

TCNGNNTGLP KQNHPQALTV EVQREEYGAV EVESVFTVGL SNHRMTVECV AFNLVGVSSD 480

TFTVEVSDKL FTSTLIGAAG VLAIFLLLLV FLLYKYKQKP RFEIRWKIIE AREGNNYTFI 540

DPTQLPYNEK WEFPRDKLKL GKVLGAGAFG KVVEATAFGL GEDKDNTLRV AVKMLKANAH 600

SDEREALMSE LKILSHLGHH QNIVNLLGAC TYGGPVLVIT EYCSLGDLLN FLRQKAETFV 660

NLVMNIPEIM ENSNDYKNIC NQKCDSGISS TSSSTYLEMR PSQQSHIEAS GRSHTTAAAE 720

SFSPYKVESL CEDNGDWPLD IDDLLRFSLQ VAQGLDFLAS RNCIHRDVAA RNVLLTDKRV 780

AKICDFGLAR DIMNDSNYVV KGNARLPVKW MAPESIFDCV YTVQSDVWSY GILLWEIFSL 840

GKSPYPSMAV DSRFYKMVKR GYQMSQPDFA LPEIYMIMKM CWNLEPTERP TFSMISQMIN 900

RLL 903

Nucleotide Sequence
(FASTA)

GTCGTGGTCA AACCCGGAAC CTCTCTGGAG CTGAAGTGCG GGGGCGACGG GCCTGTAAAC 60

TGGCAAACAA GACTCCCTAA ACACAAACGC TACATGTCCA GGAGCCCCGG CAACCTCCGC 120

ACCATAAGGG TCGCGCGTCC CACCGCAGAA TTCACCGGAA CCTACAAGTG TTTTTACAGC 180

GCCTGGGCGC AGCACCGTCA CCTGACCTCC TCGGTTCACG TGTACGTAAA AGCTTTAGAT 240

CCAAACCGTG TGTTCTGGAC CAGCAGCACA TCTCTGAGGG TGGTGAGGAA GGAGGGGGAG 300

GACTACCTGT TGCCCTGCCT GCTGACGGAC CCAGAAGCCA CAGATCTGGG CCTCCGCATG 360

GACAACGGCA CCACGGTGCC CCCAGAGATG AACTACACAG TTTACCGACA CCGCGGGATT 420

CTCATCCGCA GCCTCCAGCC CAGCTTCAAC GCCGACTACG TCTGCACAGC CAAGGTGAAA 480

GGGGTGGAGA AGACATCCAA GACCTTTTCC ATCAACGTCA TACAGAAGCT TCGTTTCCCT 540

CCATATGTCT TCTTGGAGAT GGATGAATAC GTGCGTATCG TTGGGGAGGA ACTCCAGATC 600

CGGTGCATGA CGCACAACCC CAACTTTAAC TACAACGTCA CCTGGAATTA CACCACCAAT 660

CCTCAGAGGG TAACAATAGA GGAGAGGGTT CGCTCCAGCG GAGAGAACCG CCTGGACATC 720

CAGAGCATAC TCACCATCTC GGCTGTAGAC CTCGCAGACA CTGGAAACAT TTCCTGTATC 780

GGCACGAATG AAGCAGGCGT GAACAGTTCC AACACTTACC TGCTGGTTGT AGAAAAGCCC 840

TACATTAGGC TGTGGCCCCA GCTGATCCCC AAACTGGCCA GCCAGGGTTT ATCGGTGGAG 900

GTGAATGAGG GCGAAGATCT GGAGCTCGGC GTGATGGTGG AAGCGTACCC CCAGATCACA 960

GACCACAGAT GGCACACCCC GACGTCTCCC AGCACATCCA TGCAGGAGCA CATGTTTGTG 1020

CGATACAACA ACAGATACCA CGCTAGGCTG CAGTTGAAGA GGATGAATGC ACAGGAGCAG 1080

GGACAGTACA CATTCTACGC CAAGAGCAAC TTGGCCAATG GCTCCATTAG CTTCCATGTC 1140

AAAATGTATC AGAAACCCAT CGCTGTGGTG AGGTGGGAAA ATATAACCAC GCTCACCTGC 1200

ACCTCCTTTG GATATCCTGC TCCCCAAATC ATCTGGTACC AGTGTTCTGG GATACGGCCG 1260

ACGTGCAATG GGAACAACAC AGGACTGCCA AAGCAGAACC ATCCCCAGGC TCTCACGGTG 1320

GAGGTGCAGC GGGAGGAGTA CGGAGCCGTG GAGGTGGAGA GCGTCTTCAC CGTGGGCCTG 1380

TCCAACCACA GGATGACGGT GGAGTGCGTG GCCTTCAACC TCGTTGGCGT CAGCAGCGAC 1440

ACCTTCACTG TGGAGGTCTC TGATAAGCTC TTCACTTCCA CCCTCATCGG GGCAGCGGGT 1500

GTCCTGGCCA TCTTCCTATT GCTACTGGTT TTCCTGCTTT ATAAATACAA ACAAAAACCC 1560

AGATTTGAGA TCCGTTGGAA GATCATTGAA GCAAGAGAGG GAAACAACTA CACCTTCATC 1620

GACCCCACTC AGCTGCCCTA CAATGAGAAG TGGGAGTTTC CAAGAGACAA GCTTAAGCTA 1680

GGGAAGGTTC TGGGGGCAGG AGCTTTTGGG AAGGTTGTGG AGGCCACTGC CTTTGGTTTA 1740

GGAGAGGACA AGGACAACAC ACTGCGTGTG GCTGTGAAAA TGTTAAAAGC CAACGCTCAC 1800

TCAGATGAGA GGGAGGCTCT GATGTCTGAG CTGAAGATCC TGAGTCACCT GGGCCACCAT 1860

CAGAACATTG TCAACCTTCT GGGAGCCTGC ACCTACGGAG GACCAGTTCT TGTGATCACA 1920

GAGTACTGCA GCCTGGGCGA CCTCTTGAAC TTTCTTCGTC AGAAGGCAGA AACATTTGTA 1980

AACTTAGTTA TGAATATTCC TGAGATCATG GAGAACTCCA ACGACTACAA AAACATCTGC 2040

AACCAGAAGT GTGACAGCGG CATCTCCAGC ACGTCTTCAA GCACATATTT GGAGATGAGA 2100

CCAAGCCAGC AGTCGCATAT TGAAGCATCA GGTAGGAGTC ACACAACAGC AGCAGCTGAA 2160

AGCTTCTCAC CTTATAAAGT AGAATCTTTA TGTGAGGACA ATGGCGACTG GCCGCTGGAC 2220

ATTGACGACT TGCTGAGGTT TTCCCTTCAG GTGGCTCAGG GCCTTGACTT CCTGGCCAGC 2280

AGGAATTGCA TCCACAGAGA CGTGGCTGCT CGCAACGTCC TCTTGACCGA CAAGCGAGTG 2340

GCCAAGATCT GCGACTTTGG TTTGGCACGA GACATCATGA ACGACTCCAA CTACGTGGTG 2400

AAGGGCAACG CGCGTCTTCC AGTCAAGTGG ATGGCTCCTG AGAGTATCTT CGATTGCGTC 2460

TACACCGTCC AGAGCGACGT CTGGTCCTAC GGCATCCTCC TGTGGGAGAT CTTCTCCTTA 2520

GGCAAGAGCC CCTATCCCAG CATGGCCGTG GACTCCAGGT TCTACAAGAT GGTCAAGCGT 2580

GGCTACCAGA TGTCCCAACC AGATTTCGCC CTTCCCGAGA TCTACATGAT CATGAAGATG 2640

TGCTGGAACC TGGAGCCCAC GGAGCGTCCC ACCTTTAGCA TGATCAGTCA GATGATAAAC 2700

AGATTACTC 2709

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsk.sdavlkvavkmlkstarssekealmselkilshl  59

         l+lGkvlG+GafGkvveata+Gl++ +d +l+vavkmlk +a+s+e+ealmselkilshl

Q: 558   LKLGKVLGAGAFGKVVEATAFGLGEdKDNTLRVAVKMLKANAHSDEREALMSELKILSHL  617

         78*********************972689*******************************

S: 60    GehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldsk  119

         G+h+nivnllGact gGp++viteyc  Gdlln+lr+k+e+f++  +++ +  e++ d+k

Q: 618   GHHQNIVNLLGACTYGGPVLVITEYCSLGDLLNFLRQKAETFVNLVMNIPEIMENSNDYK  677

         *************************************************999********

S: 120   alladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179

         ++    + + +s +ss ss++y++++++ ++  +++  +++ +  +s+   +v++  e++

Q: 678   NIC---NQKCDSGISSTSSSTYLEMRPSQQSHIEASGRSHTTAAAESFSPYKVESLCEDN  734

         994...456788899999*********98776677778888888899*************

S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239

          + +l+++dll fs qva+G++flas+nc+hrd+aarnvllt+ +v+kicdfGlardim+

Q: 735   GDWPLDIDDLLRFSLQVAQGLDFLASRNCIHRDVAARNVLLTDKRVAKICDFGLARDIMN  794

         9***********************************************************

S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299

         dsnyvvkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pyp + vds+f

Q: 795   DSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGKSPYPSMAVDSRF  854

         ************************************************************

S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         yk++k+Gy+m+qp++a  eiy im+ cw+ ep++rp+f+ +++++

Q: 855   YKMVKRGYQMSQPDFALPEIYMIMKMCWNLEPTERPTFSMISQMI  899

         *****************************************9986

Domain Sequence
(FASTA)

LKLGKVLGAG AFGKVVEATA FGLGEDKDNT LRVAVKMLKA NAHSDEREAL MSELKILSHL 60

GHHQNIVNLL GACTYGGPVL VITEYCSLGD LLNFLRQKAE TFVNLVMNIP EIMENSNDYK 120

NICNQKCDSG ISSTSSSTYL EMRPSQQSHI EASGRSHTTA AAESFSPYKV ESLCEDNGDW 180

PLDIDDLLRF SLQVAQGLDF LASRNCIHRD VAARNVLLTD KRVAKICDFG LARDIMNDSN 240

YVVKGNARLP VKWMAPESIF DCVYTVQSDV WSYGILLWEI FSLGKSPYPS MAVDSRFYKM 300

VKRGYQMSQP DFALPEIYMI MKMCWNLEPT ERPTFSMISQ MI 342

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 4.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013