EKS-TAR-00071

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00071

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	403.3	1.3E-120	319	574	256

Status

Unreviewed

Ensembl Protein

ENSTRUP00000016253

UniProt Accession

H2SV11;

Protein Name

Protein Synonyms/Alias

Gene Name

raf1

Gene Synonyms/Alias

raf1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000006611	ENSTRUP00000016249	ENSTRUT00000016321
ENSTRUG00000006611	ENSTRUP00000016253	ENSTRUT00000016325
ENSTRUG00000006611	ENSTRUP00000016250	ENSTRUT00000016322
ENSTRUG00000006611	ENSTRUP00000016252	ENSTRUT00000016324
ENSTRUG00000006611	ENSTRUP00000016251	ENSTRUT00000016323

Organism

Takifugu rubripes

Functional Description

Protein Length

614

Protein Sequence
(FASTA)

MPDSKTSSTI RVYLPNQQRT VVNVRPGMTL HSCLIKALKV RGLQPQCCAV FRLHPGQSSK 60

KLRMDWNTDS TSLIGQELLV EVLDHVPLTT HNFVRKTYLK LAFCDICQKF LLNGFRCQTC 120

GYKFHEHCST KVPTMCVDWS NIRQLLASET DPLACLSERN VHADRTRLFP SPGDGGGPSL 180

PPLTSRRMRE SLTRFPRYST PHAFNYNTSY PPAGGGLSQR QRSTSTPNVH MVSTTLPVDS 240

SMIELSEVMK NLNQSSTSGA GSSPNQSPTG WSQSQSKAPA PSQRERATSF NTQEKNKIRP 300

RDKRDSSYYW EIEASEVYLH SRIGSGSFGT VYKGKWHGDV AVKILKVTNP TPEQFQAFRN 360

EVAVLRKTRH VNILLFMGYM TKDNLAIVTQ WCEGSSLYKH IHVLETNFKI IQLIDIARQT 420

AQGMDYLHAK NIIHRDMKSN NIFLHEGLTV KIGDFGLATV KSRWSGSNQV EQPSGSILWM 480

SPEVIRMQDN NPYSFQSDVY SYGIVLFELM TGELPYSQTG NRDQIIYMVG RGYLSPDLSK 540

LYKNCPKAMK RLVADCIKKS KDERPLFPQI LSSIELLQHA LPKINRSASE PSLHRASHTE 600

DINACTLTST RLPV 614

Nucleotide Sequence
(FASTA)

ATGCCAGACT CCAAGACGAG CAGCACGATC CGCGTCTACC TCCCGAATCA GCAGCGCACC 60

GTGGTCAACG TGCGACCAGG CATGACTCTG CACAGCTGCC TGATCAAAGC GTTAAAGGTG 120

CGAGGTCTGC AGCCTCAGTG CTGTGCCGTT TTCAGGCTGC ATCCGGGACA GAGTAGTAAG 180

AAATTACGGA TGGACTGGAA CACCGATTCC ACGTCCCTCA TTGGCCAAGA GCTGCTGGTG 240

GAGGTCTTGG ATCACGTCCC GCTGACGACG CATAACTTTG TTCGGAAAAC ATACCTGAAG 300

CTAGCCTTCT GTGATATATG TCAGAAGTTT CTTCTGAATG GATTCCGTTG CCAAACGTGC 360

GGCTACAAGT TTCACGAGCA CTGCAGCACC AAAGTGCCCA CGATGTGCGT GGACTGGAGC 420

AACATCAGGC AACTCCTCGC ATCAGAAACT GACCCTCTCG CCTGCCTCTC GGAGCGGAAT 480

GTGCACGCAG ACAGAACGAG GTTGTTCCCG TCGCCCGGAG ACGGCGGCGG CCCGTCCCTG 540

CCCCCGCTGA CCTCCCGAAG AATGAGAGAA TCCTTAACGC GGTTTCCAAG GTATTCCACC 600

CCTCACGCCT TCAACTACAA CACGTCCTAC CCACCCGCAG GCGGTGGTCT CTCCCAGAGG 660

CAGCGCTCCA CCTCCACACC CAACGTCCAC ATGGTCAGCA CCACCCTGCC TGTCGACAGC 720

AGCATGATTG AGCTTTCAGA GGTCATGAAG AATCTAAATC AATCCTCCAC CAGTGGGGCA 780

GGGAGTTCTC CCAACCAGAG CCCCACAGGC TGGTCCCAGT CTCAGTCCAA AGCTCCGGCA 840

CCATCCCAGC GAGAGAGGGC CACTTCTTTC AACACTCAGG AGAAAAATAA GATTAGGCCT 900

CGGGACAAGC GGGACTCCAG TTATTACTGG GAAATAGAGG CCAGCGAGGT GTACCTGCAC 960

TCCCGCATTG GTTCTGGCTC CTTTGGGACA GTGTACAAAG GGAAATGGCA TGGTGACGTC 1020

GCGGTGAAGA TTCTAAAGGT GACCAACCCC ACGCCAGAGC AGTTCCAGGC ATTCAGGAAC 1080

GAAGTGGCGG TCTTGAGAAA AACGCGACAT GTCAACATCC TGTTGTTCAT GGGCTACATG 1140

ACGAAGGATA ACCTGGCCAT CGTGACCCAG TGGTGCGAGG GCAGCAGCCT CTACAAACAC 1200

ATTCACGTCC TGGAGACCAA CTTCAAGATA ATCCAGCTCA TAGATATCGC CAGGCAGACG 1260

GCTCAGGGCA TGGACTACCT GCACGCGAAG AACATCATTC ATCGCGACAT GAAGTCCAAC 1320

AACATCTTCT TGCATGAAGG TCTGACGGTG AAGATCGGGG ACTTTGGCCT GGCCACGGTG 1380

AAGAGCCGAT GGAGCGGCTC CAATCAGGTG GAGCAGCCTT CCGGGTCCAT TCTTTGGATG 1440

TCTCCCGAGG TCATCCGGAT GCAGGACAAC AACCCTTACA GTTTCCAGTC CGACGTCTAC 1500

TCTTATGGAA TAGTCCTGTT TGAGCTGATG ACGGGCGAGC TGCCGTACTC CCAGACTGGA 1560

AACAGAGATC AGATCATCTA CATGGTGGGG AGGGGCTATT TGTCCCCCGA CCTCAGCAAG 1620

CTCTACAAGA ACTGCCCCAA AGCCATGAAA AGGCTGGTGG CCGACTGCAT CAAGAAGTCC 1680

AAGGATGAGA GGCCGCTCTT CCCGCAGATC TTGTCCTCCA TCGAGCTTCT CCAGCACGCT 1740

CTGCCCAAGA TCAACCGCAG TGCCTCAGAA CCGTCCCTGC ACAGAGCCTC CCACACCGAG 1800

GACATCAACG CTTGCACCCT GACCTCCACC AGACTGCCTG TT 1842

Domain Profile

S: 3     laekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFmG  62

         l+++iGsG+fGtvy+gkwhGdvavk+l+v+++++eq++aF++eva+++ktRh+ni+LFmG

Q: 319   LHSRIGSGSFGTVYKGKWHGDVAVKILKVTNPTPEQFQAFRNEVAVLRKTRHVNILLFMG  378

         7899********************************************************

S: 63    yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkDlk  122

         y++k++laivt++c+gssLyk++h+ et++++ +lidiarq+aqgmdYLhak+i+h+D+k

Q: 379   YMTKDNLAIVTQWCEGSSLYKHIHVLETNFKIIQLIDIARQTAQGMDYLHAKNIIHRDMK  438

         ************************************************************

S: 123   sknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleqde  182

         s+ni+l+egl+v+i+DFgl++vk+++sg  ++q+e+p+g+il+++pevir+      qd+

Q: 439   SNNIFLHEGLTVKIGDFGLATVKSRWSG--SNQVEQPSGSILWMSPEVIRM------QDN  490

         ****************************..*********************......***

S: 183   lpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpkelk  240

         +p+s++sDvy++Givl+el+++elpy++  ++dqi+++vgrG l+pdlsk+++++pk++k

Q: 491   NPYSFQSDVYSYGIVLFELMTGELPYSQtGNRDQIIYMVGRGyLSPDLSKLYKNCPKAMK  550

         ***************************999******************************

S: 241   ellleClkfekeeRPlftqilkkl  264

         +l+++C+k++k+eRPlf+qil+++

Q: 551   RLVADCIKKSKDERPLFPQILSSI  574

         ********************9875

Domain Sequence
(FASTA)

LHSRIGSGSF GTVYKGKWHG DVAVKILKVT NPTPEQFQAF RNEVAVLRKT RHVNILLFMG 60

YMTKDNLAIV TQWCEGSSLY KHIHVLETNF KIIQLIDIAR QTAQGMDYLH AKNIIHRDMK 120

SNNIFLHEGL TVKIGDFGLA TVKSRWSGSN QVEQPSGSIL WMSPEVIRMQ DNNPYSFQSD 180

VYSYGIVLFE LMTGELPYSQ TGNRDQIIYM VGRGYLSPDL SKLYKNCPKA MKRLVADCIK 240

KSKDERPLFP QILSSI 256

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005057	; F:receptor signaling protein activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR003116	; Raf-like_ras-bd.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF07714	; Pkinase_Tyr; 1.
PF02196	; RBD; 1.

SMARTs

SM00109	; C1; 1.
SM00455	; RBD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50898	; RBD; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013