EKS-TAR-00515

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00515

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	287.4	2.8E-85	208	510	303

Status

Unreviewed

Ensembl Protein

ENSTRUP00000016336

UniProt Accession

H2SV98;

Protein Name

Protein Synonyms/Alias

Gene Name

IRAK1

Gene Synonyms/Alias

IRAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000006646	ENSTRUP00000016336	ENSTRUT00000016408
ENSTRUG00000006646	ENSTRUP00000016337	ENSTRUT00000016409
ENSTRUG00000006646	ENSTRUP00000016338	ENSTRUT00000016410

Organism

Takifugu rubripes

Functional Description

Protein Length

708

Protein Sequence
(FASTA)

LTGLGPDCGH TQRPQSGDQF LYDLPPRVLW EFCRVMDALS DLDWTRFASM VLDDQTALRL 60

AQKQEKRTDW VMNQWEIRNG RVGELVNLLE GLELLRPRDV ILLKPPPPPA PAAPPTAPAA 120

PRVPSPPFNT VWSKRSSPRP AALNVSLLVP RASTVAQQCI DATPQPSIMY GPETHQGCPN 180

FLQRGPDLIT SGLMCWSYEE VHAGTKGFSP TLQVGEGGFG VVYKATLSNT VCAVKVLKED 240

RLLDWKVLNQ SFQTEMEKLS KFRHPNIVDL LGFSKGPGTV CLIYSYMENK SLEHKLHNGD 300

QQSSYLSWSQ RVSVVTEAST ALQFLHSPPS GNTPLIHGDV KSSNILLDHH MTAKLGDFGL 360

ARFAPRPSPS ETKPLGRTTT IRGTLAYLPH EYVRTGKLGT VVDVYSFGVV LLEVLTGRRA 420

LEEDQDLGQK YLKDLVEEIR ESPSGSPEES WRKQLDHRLL AVTWSRSTAA VSAEGATEPA 480

GWMEMVALAC RCLANNRKGR PAMAEVFDKL QDINTLVKRS SPHMDLSGAC LSKEPAQSSQ 540

SSSCSSSCSL QSPHRLRSPS SHVSSSSSCS PSPSSFAGPC ETDESRGFSH PCLQSGHLSQ 600

VGPATFWGLV KVGLKAEHPS GGAACGPGPA SASRDRYTVY LCVRACVCAC VCVCAVLMNP 660

SKQHLLQKKT LYEEGRIETP ELLSSEDIYG GTSSVALTGP EESDEQDW 708

Nucleotide Sequence
(FASTA)

TTGACAGGTC TCGGTCCGGA CTGCGGTCAC ACCCAGCGAC CACAATCTGG AGACCAGTTT 60

TTGTACGACC TGCCGCCCAG GGTCCTGTGG GAGTTCTGTC GAGTCATGGA TGCACTGTCT 120

GACCTGGACT GGACCCGCTT TGCCTCGATG GTACTCGACG ACCAGACCGC TCTACGATTG 180

GCTCAGAAGC AGGAGAAGCG GACTGACTGG GTGATGAACC AGTGGGAGAT CAGGAACGGT 240

CGAGTCGGTG AGCTGGTTAA CCTGTTGGAA GGTCTGGAGC TGCTGCGTCC TCGGGATGTC 300

ATCCTGCTGA AGCCTCCTCC TCCTCCTGCT CCTGCTGCTC CTCCTACTGC TCCTGCTGCT 360

CCTAGGGTTC CGTCGCCACC TTTCAATACG GTATGGTCCA AGAGATCCTC TCCTCGGCCA 420

GCTGCTTTGA ACGTTTCACT CTTAGTACCT CGTGCCTCCA CGGTGGCGCA GCAGTGTATC 480

GACGCAACTC CTCAGCCGTC TATAATGTAT GGACCTGAGA CACACCAGGG GTGTCCAAAC 540

TTTTTGCAAA GAGGGCCAGA TTTGATAACC AGTGGCCTGA TGTGCTGGTC ATATGAAGAG 600

GTGCATGCTG GGACAAAGGG GTTCTCGCCC ACCCTTCAGG TGGGAGAGGG GGGGTTTGGG 660

GTAGTGTACA AAGCAACCCT GAGTAACACC GTCTGCGCTG TGAAGGTTCT GAAAGAGGAC 720

CGCCTGCTGG ATTGGAAAGT CCTGAATCAG AGTTTTCAGA CAGAAATGGA GAAGCTGTCA 780

AAGTTCAGGC ACCCGAACAT TGTGGATCTG CTGGGTTTCA GTAAAGGACC AGGAACAGTG 840

TGTCTGATCT ACAGCTACAT GGAGAACAAG TCACTGGAGC ACAAACTGCA CAATGGGGAT 900

CAGCAGAGCT CCTACTTGTC CTGGTCCCAG AGAGTCAGTG TTGTGACCGA AGCCTCAACG 960

GCCCTGCAGT TCCTTCACAG CCCCCCCAGT GGAAACACAC CCCTCATCCA TGGGGACGTG 1020

AAGAGCTCAA ATATCCTGTT GGACCACCAC ATGACCGCTA AGCTGGGCGA CTTTGGCCTG 1080

GCTCGCTTCG CTCCTAGACC CTCGCCATCT GAGACGAAGC CGCTCGGCCG CACCACCACC 1140

ATCAGAGGAA CGCTGGCTTA CCTTCCTCAT GAATACGTGA GGACTGGGAA GCTGGGCACG 1200

GTTGTGGACG TGTACAGCTT CGGCGTGGTG CTGCTGGAAG TCTTAACGGG TCGTCGCGCG 1260

CTGGAGGAAG ACCAAGATTT GGGACAAAAA TACCTGAAGG ACCTGGTGGA AGAAATCAGG 1320

GAGAGTCCTT CTGGTTCTCC TGAAGAAAGT TGGAGAAAAC AGCTGGATCA CCGGCTGTTG 1380

GCGGTCACCT GGTCACGTTC CACTGCTGCT GTGTCTGCAG AGGGCGCCAC TGAGCCTGCT 1440

GGGTGGATGG AGATGGTGGC GCTGGCCTGC AGATGTCTGG CAAACAACAG GAAGGGGAGA 1500

CCAGCCATGG CAGAAGTCTT TGACAAACTT CAGGATATCA ACACCCTGGT GAAGAGGAGC 1560

AGTCCTCACA TGGACCTTAG TGGTGCATGT CTCTCTAAAG AGCCTGCCCA GTCCTCTCAG 1620

TCATCATCCT GCTCCTCTTC CTGCTCCCTC CAGTCTCCCC ACAGACTCCG TTCTCCTTCG 1680

TCCCACGTCT CCAGCTCTTC TTCCTGCTCC CCATCCCCCT CCTCCTTCGC TGGTCCCTGT 1740

GAAACTGACG AGAGCCGAGG CTTTTCCCAC CCCTGTCTCC AGTCAGGACA CCTGTCTCAG 1800

GTAGGTCCTG CCACGTTTTG GGGTTTAGTT AAGGTCGGGC TAAAAGCAGA GCATCCTAGC 1860

GGGGGCGCCG CCTGTGGTCC CGGCCCGGCG TCTGCATCAC GGGACCGTTA CACAGTTTAC 1920

CTGTGTGTGC GTGCGTGCGT GTGCGCGTGT GTGTGTGTGT GTGCAGTCCT TATGAATCCC 1980

AGTAAGCAGC ATCTTCTACA GAAGAAGACG CTGTATGAAG AGGGACGGAT CGAGACCCCT 2040

GAGCTGCTCT CGTCTGAGGA TATCTATGGA GGGACCAGCT CTGTGGCTCT GACAGGACCG 2100

GAGGAGAGTG ACGAGCAGGA CTGG 2124

Domain Profile

S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60

         fs   ++geGgfg+vy+++l nt+ avk+lke   l++k l+qsf+tE++ l++frH+ni

Q: 208   FSPTLQVGEGGFGVVYKATLSNTVCAVKVLKEDRLLDWKVLNQSFQTEMEKLSKFRHPNI  267

         677889******************************************************

S: 61    lellgysaeseklcLvYqymknGsLedrLqcq.kgsepLsWpqRlsillGtaraiefLHe  119

         ++llg+s   +++cL+Y+ym+n sLe +L+   ++s+ LsW qR+s+++ ++ a++fLH+

Q: 268   VDLLGFSKGPGTVCLIYSYMENKSLEHKLHNGdQQSSYLSWSQRVSVVTEASTALQFLHS  327

         *****************************98768999**********************9

S: 120   asp...slihgdiksaNiLLDekltpKlgDfglarfape.sekqsstvlrtskvrgtlaY  175

           +   +lihgd+ks+NiLLD+++t+KlgDfglarfap+ s++ ++ + rt ++rgtlaY

Q: 328   PPSgntPLIHGDVKSSNILLDHHMTAKLGDFGLARFAPRpSPSETKPLGRTTTIRGTLAY  387

         6323369****************************998725566677889**********

S: 176   lpeefirvgqltvkvDvySfGiVllEvltGlra..vdedrktkyLkdllkeeieeekv..  231

         lp e++r+g+l + vDvySfG+VllEvltG+ra   d+d  +kyLkdl++ ei+e+

Q: 388   LPHEYVRTGKLGTVVDVYSFGVVLLEVLTGRRAleEDQDLGQKYLKDLVE-EIRESPSgs  446

         *********************************544555679******75.555555558

S: 232   .................eilekfldkkagkl............eeellealielalacla  262

                                                    e++  + ++ la++cla

Q: 447   peeswrkqldhrllavtW------------SrstaavsaegatEPAGWMEMVALACRCLA  494

         997777766666666542............03333333333449999999**********

S: 263   ekakkrPtmsqvlell  278

         +++k rP m++v ++l

Q: 495   NNRKGRPAMAEVFDKL  510

         ************9876

Domain Sequence
(FASTA)

FSPTLQVGEG GFGVVYKATL SNTVCAVKVL KEDRLLDWKV LNQSFQTEME KLSKFRHPNI 60

VDLLGFSKGP GTVCLIYSYM ENKSLEHKLH NGDQQSSYLS WSQRVSVVTE ASTALQFLHS 120

PPSGNTPLIH GDVKSSNILL DHHMTAKLGD FGLARFAPRP SPSETKPLGR TTTIRGTLAY 180

LPHEYVRTGK LGTVVDVYSF GVVLLEVLTG RRALEEDQDL GQKYLKDLVE EIRESPSGSP 240

EESWRKQLDH RLLAVTWSRS TAAVSAEGAT EPAGWMEMVA LACRCLANNR KGRPAMAEVF 300

DKL 303

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013